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Author : Sébastien Porcher
Publisher :
ISBN 13 :
Total Pages : 281 pages
Book Rating : 4.:/5 (428 download)
Download or read book Synthesis of Modified Nucleosides for the Incorporation Into TRNAs written by Sébastien Porcher and published by . This book was released on 2006 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : G. Nass
Publisher : Springer Science & Business Media
ISBN 13 : 3642819478
Total Pages : 441 pages
Book Rating : 4.6/5 (428 download)
Download or read book Modified Nucleosides and Cancer written by G. Nass and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book comprises the lectures presented at the workshop Modified Nuc1eosides and Cancer held from 28 September to 2 October, 1981 in Freiburg, West Germany. The workshop was organized by Gisela Nass and sponsored by the Deutsche Forschungsgemeinschaft. The purpose of the workshop was to cover the varied analytical methods for quantitative and qualitative determination of modified nucleosides and their metabolism including bio synthesis, all in relation to the function of these compounds in the origin and growth of cancer cells. The potential signi ficance of measuring modified nucleosides in body fluids for tumor diagnosis in humans received particular attention. Various fields of research which have previously been segregat ed are thus unified in this volume. Emphasis was also placed on the fact that modified nucleosides are constituents of the genetic material, the desoxyribonucleic> acid, on the one hand, and of the transfer ribonucleic acids on the other hand, with the latter macromolecules participating not only in the translation of genetic information into protein, but also in many regulatory processes in all single- and multi-, cellular organisms including man.
Author : Daniel Globisch
Publisher : Cuvillier Verlag
ISBN 13 : 3736937350
Total Pages : 218 pages
Book Rating : 4.7/5 (369 download)
Download or read book Synthesis of natural modified nucleosides and their mass spectrometric quantification in cells and tissue written by Daniel Globisch and published by Cuvillier Verlag. This book was released on 2011-05-13 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jesús Fernández Lucas
Publisher : John Wiley & Sons
ISBN 13 : 3527343768
Total Pages : 348 pages
Book Rating : 4.5/5 (273 download)
Download or read book Enzymatic and Chemical Synthesis of Nucleic Acid Derivatives written by Jesús Fernández Lucas and published by John Wiley & Sons. This book was released on 2019-04-29 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: A review of innovative tools for creative nucleic acid chemists that open the door to novel probes and therapeutic agents Nucleic acids continue to gain importance as novel diagnostic and therapeutic agents. With contributions from noted scientists and scholars, Enzymatic and Chemical Synthesis of Nucleic Acid Derivatives is a practical reference that includes a wide range of approaches for the synthesis of designer nucleic acids and their derivatives. The book covers enzymatic (including chemo-enzymatic) methods, with a focus on the synthesis and incorporation of modified nucleosides. The authors also offer a review of innovative approaches for the non-enzymatic chemical synthesis of nucleic acids and their analogs and derivatives, highlighting especially challenging species. The book offers a concise review of the methods that prepare novel and heavily modified polynucleotides in sufficient amount and purity for most clinical and research applications. This important book: -Presents a timely and topical guide to the synthesis of designer nucleic acids and their derivatives -Addresses the growing market for nucleotide-derived pharmaceuticals used as anti-infectives and chemotherapeutic agents, as well as fungicides and other agrochemicals. -Covers novel methods and the most recent trends in the field -Contains contributions from an international panel of noted scientistics Written for biochemists, medicinal chemists, natural products chemists, organic chemists, and biotechnologists, Enzymatic and Chemical Synthesis of Nucleic Acid Derivatives is a practice-oriented guide that reviews innovative methods for the enzymatic as well as non-enzymatic synthesis of nucleic acid species.
Author : S. C. Holmes
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (595 download)
Download or read book The Synthesis of Modified Nucleosides and Their Incorporation Into the Hairpin Ribozyme Catalytic Motif for Future Structural and Kinetic Analyses written by S. C. Holmes and published by . This book was released on 2000 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Dieter Söll
Publisher :
ISBN 13 : 9781555818333
Total Pages : 572 pages
Book Rating : 4.8/5 (183 download)
Download or read book TRNA written by Dieter Söll and published by . This book was released on 1995 with total page 572 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Henri Grosjean
Publisher : Springer
ISBN 13 : 3540314547
Total Pages : 0 pages
Book Rating : 4.5/5 (43 download)
Download or read book Fine-Tuning of RNA Functions by Modification and Editing written by Henri Grosjean and published by Springer. This book was released on 2005-05-11 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Naturally occurring RNA always contains numerous biochemically altered nucleotides. They are formed by enzymatic modification of the primary transcripts during the complex RNA maturation process designated RNA modification. A large number of enzymes catalyzing the formation of these modified nucleosides or converting one canonical base into another at the posttranscriptional level have been studied for many years, but only recently have systematic and comparative studies begun. The functions of individual enzymes and/or the modified/edited nucleosides in RNA, however, have remained largely ignored. This book provides advance information on RNA modification, including the associated editing machinery, while offering the reader some perspective on the significance of such modifications in fine-tuning the structure and functions of mature RNA molecules and hence the ability to influence the efficiency and accuracy of genetic expression. Outstanding scientists who are actively working on RNA modification/editing processes have provided up-to-date information on these intriguing cellular processes that have been generated over the course of millions of years in all living organisms. Each review has been written and illustrated for a large audience of readers, not only specialists in the field, but also for advanced students or researchers who want to learn more about recent progress in RNA modification and editing.
Author : Kazuhiko Nakatani
Publisher : Springer
ISBN 13 : 3319271113
Total Pages : 280 pages
Book Rating : 4.3/5 (192 download)
Download or read book Modified Nucleic Acids written by Kazuhiko Nakatani and published by Springer. This book was released on 2016-04-04 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book spans diverse aspects of modified nucleic acids, from chemical synthesis and spectroscopy to in vivo applications, and highlights studies on chemical modifications of the backbone and nucleobases. Topics discussed include fluorescent pyrimidine and purine analogs, enzymatic approaches to the preparation of modified nucleic acids, emission and electron paramagnetic resonance (EPR) spectroscopy for studying nucleic acid structure and dynamics, non-covalent binding of low- and high-MW ligands to nucleic acids and the design of unnatural base pairs. This unique book addresses new developments and is designed for graduate level and professional research purposes.
Author : Jennifer Hannant
Publisher :
ISBN 13 :
Total Pages : 153 pages
Book Rating : 4.:/5 (759 download)
Download or read book Synthesis of Pyrrolo-modified Nucleotides and Their Incorporation Into DNA Via Enzymatic Extension written by Jennifer Hannant and published by . This book was released on 2011 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : A. Abragam
Publisher : Oxford University Press
ISBN 13 : 9780198520146
Total Pages : 666 pages
Book Rating : 4.5/5 (21 download)
Download or read book The Principles of Nuclear Magnetism written by A. Abragam and published by Oxford University Press. This book was released on 1961 with total page 666 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Principles of Nuclear Magnetism
Author : Henri Grosjean
Publisher :
ISBN 13 : 9781555811334
Total Pages : 0 pages
Book Rating : 4.8/5 (113 download)
Download or read book Modification and Editing of RNA written by Henri Grosjean and published by . This book was released on 1998 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Comprehensive, current text explores the manifold ways in which living cells respond to genomic injury and alterations, including both spontaneous and environmentally induced DNA damage. With more than 4,000 complete references to primary research literature and over 380 color figures throughout, this book is an important text for all courses in DNA repair and mutagenesis. It will also serve as a major reference for all molecular biologists working in cancer biology, recombination, transcription and gene regulation, DNA replication, environmental studies, and biological evolution.
Author : Tobias Brückl
Publisher : Cuvillier Verlag
ISBN 13 : 3736937946
Total Pages : 252 pages
Book Rating : 4.7/5 (369 download)
Download or read book Synthesis of natural and isotope-labeled tRNA nucleosides and their mass spectrometric quantification written by Tobias Brückl and published by Cuvillier Verlag. This book was released on 2011-06-29 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Olena Maydanovych
Publisher :
ISBN 13 :
Total Pages : 402 pages
Book Rating : 4.:/5 (243 download)
Download or read book Synthesis and Oligonucleotide Incorporation of Modified Nucleoside Analogs to Investigate RNA-editing and RNA Interference written by Olena Maydanovych and published by . This book was released on 2008 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Stefan Jurga
Publisher : Springer
ISBN 13 : 3319341758
Total Pages : 456 pages
Book Rating : 4.3/5 (193 download)
Download or read book Modified Nucleic Acids in Biology and Medicine written by Stefan Jurga and published by Springer. This book was released on 2016-07-29 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is comprised of 18 chapters, covering various aspects of DNA modification and RNA modified bases. It also discusses in detail circular RNA, therapeutic oligonucleotides and their different properties. The chemical nature of DNA, RNA, protein and lipids makes these macromolecules easily modifiable, but they are also susceptible to damage from both endogenous and exogenous agents. Alkylation and oxidation show a potential to disrupt the cellular redox equilibrium and cause cellular damage leading to inflammation and even chronic disease. Furthermore, DNA damage can drive mutagenesis and the resulting DNA sequence changes can induce carcinogenesis and cancer progression. Modified nucleosides can occur as a result of oxidative DNA damage and RNA turnover, and are used as markers for various diseases. To function properly some RNA needs to be chemically modified post-transcriptionally. Dysregulation of the RNA-modification pattern or of the levels of the enzymes that catalyze these modifications alters RNA functionality and can result in complex phenotypes, likely due to defects in protein translation. While modifications are best characterized in noncoding ribonucleic acids like tRNA and rRNA, coding mRNAs have also been found to contain modified nucleosides. This book is a valuable resource, not only for graduate students but also researchers in the fields of molecular medicine and molecular biology.
Author : Henri Grosjean
Publisher : CRC Press
ISBN 13 : 1498713157
Total Pages : 682 pages
Book Rating : 4.4/5 (987 download)
Download or read book DNA and RNA Modification Enzymes written by Henri Grosjean and published by CRC Press. This book was released on 2009-06-11 with total page 682 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is a timely and comprehensive description of the many facets of DNA and RNA modification-editing processes and to some extent repair mechanisms. Each chapter offers fundamental principles as well as up to date information on recent advances in the field (up to end 2008). They ended by a shortconclusion and future prospect' section and
Author : Ke-wei Chang
Publisher :
ISBN 13 :
Total Pages : 60 pages
Book Rating : 4.:/5 (945 download)
Download or read book Synthesis of Modified Ribose Spin-label written by Ke-wei Chang and published by . This book was released on 2016 with total page 60 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transfer ribonucleic acids (tRNAs) from all organisms contain modified nucleosides, which are derived from four different nucleosides. Research has indicated that tRNA modifications affect translation and various metabolic pathways. Among these modifications, some of them need more than one enzyme to produce specific nucleosides. Researchers are interested in investigating the fundamental mechanisms and function of post-transcriptional modifying enzymes. A number of these enzymes are metal-dependent, such as MiaB and MiaE. MiaE enzyme (2-methylthio-N6-isopentenyl-adenosine(37)-tRNA monooxygenase) stereospecifically hydroxylates an adeonosine derivative at the 37th position of tRNA, ms2i6A37, to complete the hypermodification of 2-methylthio-N6-(4-hydroxyisopentenyl)-adenosine (ms2io6A37). Several studies showed that the ms2io6A37 modification of tRNA seems to influence the central metabolic pathways. Therefore, in order to study the biological activity of iron-dependent enzymes, such as MiaE, or other enzymes with radical mechanisms. We planned to synthesize spin-labeled analogs of ms2io6A37, the substrate of MiaE. Chapter 1 describes the background of tRNA modifications and the MiaA, MiaB, and MiaE pathway for A37 modification in bacterial tRNA. Chapter 2 shows different strategies to synthesize the desired nucleoside spin probe. Chapter 3 proposes several reactions to improve this synthesis in the future. Last, chapter 4 provides the experimental details used in this project to help other chemists to investigate the modified ribose spin-label chemistry.
Author : Jeffrey Allan Jenson
Publisher :
ISBN 13 :
Total Pages : 204 pages
Book Rating : 4.:/5 (198 download)
Download or read book Synthesis of Modified Nucleotides to Incorporate Into Oligonucleotides written by Jeffrey Allan Jenson and published by . This book was released on 1988 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt:
