Synthesis Characterization And Group Modification Of Carbosilane Based Dendrimers

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Synthesis, Characterization and Group Modification of Carbosilane Based Dendrimers

Author : Richard Hooper
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (993 download)

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Book Synopsis Synthesis, Characterization and Group Modification of Carbosilane Based Dendrimers by : Richard Hooper

Download or read book Synthesis, Characterization and Group Modification of Carbosilane Based Dendrimers written by Richard Hooper and published by . This book was released on 1997 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbosilane dendrimers have been prepared via iterative hydrosilylation/alkenylation reactions using a variety of chlorosilanes (HSiMe3−nC1n)and alkenyl nucleophiles (CH2=CHCH2MgBr and CH2=CHMgBr). Characterization by multinuclear NMR spectroscopy of the stepwise trifurctate dendrimers RED3 (E=Si; R=Ph; D=Dendritic carbosilane fragment) assists end-group counting (NMR, R vs D) and can be related to analogous spheroidal ED4 and hexafunctional E2D6 systems (E=Si or Ge). Typical D units contain (prnSiMe3−n)N Nb linkers; where pr=(CH2)3, N=generation number, Nb=branch multiplicity at silicon. For higher symmetry ED4 and E2D6 systems (and also trifurcate) the Nb=1 (1B series) or Nb=2 (2B series) also allows for end-group counting by proton NMR spectroscopy (Ph:D:Me). 29Si NMR chemical shifts have been developed for topographical mapping of dendritic structure. Peripheral and core substitution reactions have been examined for a series of trifurcate and related Ge2D6 'masked trifurcate' dendrimers. Replacement of end groups with a range of substrates is facilitated by the reactivity of the intermediate silicon chlorine bonds formed by hydrosilylation reactions. Selective removal of the core phenyl group (via triflic acid), or alternatively oxidative Ge-Ge cleavage, allows for unprecedented 'bifunctionalization'; offering routes into dendrimer periphery:core electron transfer ('photon-harvesting') processes. Methodology for a 'rapid-synthesis' of hyperbranched structures has been developed and examined on a range of initial core molecules. Use of multinuclear NMR spectroscopy via comparison with step-wise products, as well as GPC chromatography, gives some insight into the overall architectures produced. Alteration of Si branch point from Nb=2 to Nb=3, using presynthesised 'hypercores' facilitates an alternate method of end group counting for higher symmetry cores. This methodology allows for population counting at large N in dendrimer generation G(N) (D interior vs D periphery).

Synthesis, Characterization and Group Modification of Carbosilane Based Dendrimers

Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (654 download)

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Book Synopsis Synthesis, Characterization and Group Modification of Carbosilane Based Dendrimers by :

Download or read book Synthesis, Characterization and Group Modification of Carbosilane Based Dendrimers written by and published by . This book was released on 1998 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Synthesis and characterization of carbosilane dendrimers with perfluoroalkyl end groups

Author : Matthew Paul Cashion
Publisher :
ISBN 13 :
Total Pages : 94 pages
Book Rating : 4.:/5 (557 download)

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Book Synopsis Synthesis and characterization of carbosilane dendrimers with perfluoroalkyl end groups by : Matthew Paul Cashion

Download or read book Synthesis and characterization of carbosilane dendrimers with perfluoroalkyl end groups written by Matthew Paul Cashion and published by . This book was released on 2004 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Dendrimer Chemistry

Author : Michael Malkoch
Publisher : Royal Society of Chemistry
ISBN 13 : 1788011325
Total Pages : 327 pages
Book Rating : 4.7/5 (88 download)

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Book Synopsis Dendrimer Chemistry by : Michael Malkoch

Download or read book Dendrimer Chemistry written by Michael Malkoch and published by Royal Society of Chemistry. This book was released on 2020 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: An overview of the latest advances in the synthesis, characterization and applications of dendrimers and other complex dendritic architectures.

Dendrimer Chemistry

Author : Fritz Vögtle
Publisher : John Wiley & Sons
ISBN 13 : 3527626964
Total Pages : 354 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Dendrimer Chemistry by : Fritz Vögtle

Download or read book Dendrimer Chemistry written by Fritz Vögtle and published by John Wiley & Sons. This book was released on 2009-03-09 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by internationally acclaimed authors, this textbook contains everything you need to know about this versatile class of compounds. Starting with a historical overview, definitions and other fundamentals, it goes on to look at characterization, analysis and properties of dendrimers. While the focus is on synthesis and applications, it also contains chapters on analytics and other applications. Essential reading for organic and polymer chemists, undergraduate and graduate students, students and lecturers in chemistry.

Dendrimers

Author : Anne-Marie Caminade
Publisher : John Wiley & Sons
ISBN 13 : 1119977576
Total Pages : 764 pages
Book Rating : 4.1/5 (199 download)

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Book Synopsis Dendrimers by : Anne-Marie Caminade

Download or read book Dendrimers written by Anne-Marie Caminade and published by John Wiley & Sons. This book was released on 2011-08-31 with total page 764 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will be mainly focussed on the properties and uses of dendrimers and dendrons. The aim of this book is to be the reference book about dendrimers applications. It will not describe all details, but it will give the reader a unique overview of what has currently been done with dendrimers, with numerous references and illustrations. It will be divided in four main parts: Part 1) Generalities, syntheses, characterizations and properties; Part 2) Applications in catalysis; Part 3) Applications for the elaboration or modification of materials; and Part 4) Applications in biology/medicine. The role of the nanometric size and the multiple functions of dendrimers on the properties will be emphasized.

Dendrimers II

Author : Fritz Vögtle
Publisher : Springer
ISBN 13 : 3540465774
Total Pages : 317 pages
Book Rating : 4.5/5 (44 download)

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Book Synopsis Dendrimers II by : Fritz Vögtle

Download or read book Dendrimers II written by Fritz Vögtle and published by Springer. This book was released on 2003-07-01 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second volume on dendrimers is again written by pioneers in the field. Their contributions illuminate the aspects of dendrimers mentioned in the subtitle, and also touch on areas beyond chemistry, namely material sciences as well as biological, medicinal, analytical, and nano aspects.

Dissertation Abstracts International

Author :
Publisher :
ISBN 13 :
Total Pages : 994 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis Dissertation Abstracts International by :

Download or read book Dissertation Abstracts International written by and published by . This book was released on 2008 with total page 994 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Dendrimer-Based Nanotherapeutics

Author : Prashant Kesharwani
Publisher : Academic Press
ISBN 13 : 0128212519
Total Pages : 486 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Dendrimer-Based Nanotherapeutics by : Prashant Kesharwani

Download or read book Dendrimer-Based Nanotherapeutics written by Prashant Kesharwani and published by Academic Press. This book was released on 2021-04-14 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dendrimer-Based Nanotherapeutics delivers a comprehensive resource on the use of dendrimer-based drug delivery. Advances in the application of nanotechnology in medicine have given rise to multifunctional smart nanocarriers that can be engineered with tunable physicochemical characteristics to deliver one or more therapeutic agent(s) safely and selectively to cancer cells, including intracellular organelle-specific targeting. This book compiles the contribution of dendrimers in the field of nanotechnology to aid researchers in exploring dendrimers in the field of drug delivery and related applications. This book covers the history of the area to the most recent research. The starting chapter covers detailed information about basic properties about dendrimers i.e. properties, nomenclature, synthesis methods, types, characterization of dendrimers, safety and toxicity issues of dendrimers. Further chapters discuss the most recent advancements in the field of dendrimer i.e. dendrimer-drug conjugates, PEGylated dendrimer, dendrimer surface engineering, dendrimer hybrids, dendrimers as solubility enhancement, in targeting and delivery of drugs, as photodynamic therapy, in tissue engineering, as imaging contrast agents, as antimicrobial agents, advances in targeted dendrimers for cancer therapy and future considerations of dendrimers. Dendrimer-Based Nanotherapeutics will help the readers to understand the most recent progress in the field of dendrimer-based research, suitable for pharmaceutical scientists, advanced students, and those working in related healthcare fields. - Discusses various routes such as oral, pulmonary, transdermal, delivery and local administration of dendrimer delivery of bioactive - Explores a wide range of applications of dendrimer-based drug delivery using the latest advancements in nanomedicine - Provides the most recent research on dendrimers as well as context and background, providing a useful resource for all levels of researcher

Synthesis and Characterization of Novel Carbosilane Dendrimers as Supports

Author : Luke C. De Selm
Publisher :
ISBN 13 :
Total Pages : 198 pages
Book Rating : 4.:/5 (66 download)

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Book Synopsis Synthesis and Characterization of Novel Carbosilane Dendrimers as Supports by : Luke C. De Selm

Download or read book Synthesis and Characterization of Novel Carbosilane Dendrimers as Supports written by Luke C. De Selm and published by . This book was released on 2004 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Dendrimers in Biomedical Applications

Author : Barbara Klajnert
Publisher : Royal Society of Chemistry
ISBN 13 : 1849736111
Total Pages : 215 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis Dendrimers in Biomedical Applications by : Barbara Klajnert

Download or read book Dendrimers in Biomedical Applications written by Barbara Klajnert and published by Royal Society of Chemistry. This book was released on 2013 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will provide comprehensive coverage of dendrimer applications and clear indications for future research. It will appeal to chemists, biologists and materials scientists, working in both academia and industry.

Soft Nanoparticles for Biomedical Applications

Author : José Callejas-Fernández
Publisher : Royal Society of Chemistry
ISBN 13 : 1782625216
Total Pages : 411 pages
Book Rating : 4.7/5 (826 download)

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Book Synopsis Soft Nanoparticles for Biomedical Applications by : José Callejas-Fernández

Download or read book Soft Nanoparticles for Biomedical Applications written by José Callejas-Fernández and published by Royal Society of Chemistry. This book was released on 2014-06-18 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanoparticles are attractive for many biomedical applications such as imaging, therapeutics and diagnostics. This new book looks at different soft nanoparticles and their current and potential uses in medicine and health including magnetoliposomes, micro/nanogels, polymeric micelles, DNA particles, dendrimers and bicelles. Each chapter provides a description of the synthesis of the particles and focus on the techniques used to characterize the size, shape, surface charge, internal structure, and surface microstructure of the nanoparticles together with modeling and simulation methods. By giving a strong physical-chemical approach to the topic, readers will gain a good background into the subject and an overview of recent developments. The multidisciplinary point of view makes the book suitable for postgraduate students and researchers in physics, chemistry, and biology interested in soft matter and its uses.

Designing Dendrimers

Author : Sebastiano Campagna
Publisher : John Wiley & Sons
ISBN 13 : 1118111060
Total Pages : 726 pages
Book Rating : 4.1/5 (181 download)

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Book Synopsis Designing Dendrimers by : Sebastiano Campagna

Download or read book Designing Dendrimers written by Sebastiano Campagna and published by John Wiley & Sons. This book was released on 2011-09-26 with total page 726 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research on dendrimers has exploded in the last 15 years, moving from the establishment of synthetic methodologies, particularly in the early years up to the end of nineties, towards sophisticated and wide-ranging applications. Dendrimers play an important role in many different areas, spanning from basic synthetic approaches to artificial photosynthesis, to medicine, to catalysis. The great potential of dendrimers is well-recognized by the hundreds of papers in the field and the increasing number of patents, and stimulated developments in other areas of knowledge, including new characterization techniques. However, some basic principles and methods still continue to give a unity to the field. Although several books on dendrimers have been published during these 15 years, the very recent progresses in new areas now requires a new point of view, trying to give a unifying and comprehensive outlook of the field. Since the first dendrimer was synthesized by Vögtle in 1978, dendrimers have experienced an explosion of scientific interest because of their unique molecular architecture. This resulted in over 5,000 scientific papers and patents published by the end of 2005. The proposed book will cover both fundamental and applicative aspects of dendrimer research. Chapters devoted to basic principles, synthetic methods and strategies, and advanced characterization techniques will be integrated by chapters illustrating the full potential of dendrimers in various fields, like artificial photosynthesis, multi-redox pool systems, diagnostics, biomedical and sensing purposes, design of functional nanostructures. Particular emphasis will be devoted to possible future developments.

Smart Inorganic Polymers

Author : Evamarie Hey-Hawkins
Publisher : John Wiley & Sons
ISBN 13 : 3527819134
Total Pages : 463 pages
Book Rating : 4.5/5 (278 download)

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Book Synopsis Smart Inorganic Polymers by : Evamarie Hey-Hawkins

Download or read book Smart Inorganic Polymers written by Evamarie Hey-Hawkins and published by John Wiley & Sons. This book was released on 2019-02-07 with total page 463 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides complete and undiluted knowledge on making inorganic polymers functional. This comprehensive book reflects the state of the art in the field of inorganic polymers, based on research conducted by a number of internationally leading research groups working in this area. It covers the synthesis aspects of synthetic inorganic polymers and looks at multiple inorganic monomers as building blocks, which exhibit unprecedented electronic, redox, photo-emissive, magnetic, self-healing and catalytic properties. It also looks at the applications of inorganic polymers in areas such as optoelectronics, energy storage, industrial chemistry, and biology. Beginning with an overview of the use of smart inorganic polymers in daily life, Smart Inorganic Polymers: Synthesis, Properties and Emerging Applications in Materials and Life Sciences goes on to study the synthesis, properties, and applications of polymers incorporating different heteroelements such as boron, phosphorus, silicon, germanium, and tin. The book also examines inorganic polymers in flame-retardants, as functional materials, and in biology. An excellent addition to the polymer scientists' and synthetic chemists' toolbox Summarizes the state of the art on how to make and use functional inorganic polymers, from synthesis to applications Edited by the coordinator of a highly funded European community research program (COST action) that focuses specifically on the exploration of inorganic polymers Features contributions from top experts in the field Aimed at academics and industrial researchers in this field, Smart Inorganic Polymers: Synthesis, Properties and Emerging Applications in Materials and Life Sciences will also benefit scientists who want to get a better overview on the state-of-the-art of this rapidly advancing area.

Silicon-Containing Dendritic Polymers

Author : Petar R. Dvornic
Publisher : Springer Science & Business Media
ISBN 13 : 140208174X
Total Pages : 428 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Silicon-Containing Dendritic Polymers by : Petar R. Dvornic

Download or read book Silicon-Containing Dendritic Polymers written by Petar R. Dvornic and published by Springer Science & Business Media. This book was released on 2009-01-09 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the last two decades silicon-containing dendritic polymers have become one of the fastest growing areas of development in polymer science. The eruption of interest in these new polymers stems from their unprecedented molecular architecture, unique resulting properties and the realization that they represent ideal building blocks for chemical nanotechnology. This is the first book to solely focus on silicon-containing dendritic polymers. The contributions of those experts who originally introduced each field or played a major role in its progress are reported. The developments in all major areas of this field are presented from their origins to the present. It is anticipated that this text will become an invaluable guide and vanguard of reference for experienced scientists interested in the fields of polymer and material science, synthetic chemistry, and nanotechnology. It will also serve advanced graduate students either as a source of creative inspiration or as a textbook for appropriate courses.

Synthesis, Characterization, and Applications of a Melamine Based Dendrimer with Twelve Cysteine Groups on the Periphery

Author : Brandon Mark Vittur
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (663 download)

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Book Synopsis Synthesis, Characterization, and Applications of a Melamine Based Dendrimer with Twelve Cysteine Groups on the Periphery by : Brandon Mark Vittur

Download or read book Synthesis, Characterization, and Applications of a Melamine Based Dendrimer with Twelve Cysteine Groups on the Periphery written by Brandon Mark Vittur and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: A potential drug delivery vehicle based on a melamine dendrimer with twelve free thiols on the periphery for constructing bio-labile disulfides has been synthesized. Under ideal conditions for the native chemical ligation reaction, attempts for attaching the cell penetrating peptide TAT, via native chemical ligation proved difficult due to the low solubility of the dendrimer. A camptothecin derivative containing a reactive disulfide was prepared for disulfide exchange with the melamine dendrimer. Up to 7 exchange reactions were achieved as determined by mass spectroscopy. NMR and mass spectroscopy was used to characterize all of the intermediates. Capping groups to replace the hydrophobic piperidine with more water-soluble groups to aid the ligation reaction and optimization of the disulfide exchange step to give 12 substitutions have been proposed for future studies. The end target is a peptide dendrimer containing a cell penetrating peptide to mediate endocytosis and a bio-labile linker connecting an anti-tumor drug to the dendrimer, which would ultimately be released inside the cancerous cell.

Dendrimers in Nanomedicine

Author : Neelesh Kumar Mehra
Publisher : CRC Press
ISBN 13 : 1000333175
Total Pages : 401 pages
Book Rating : 4.0/5 (3 download)

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Book Synopsis Dendrimers in Nanomedicine by : Neelesh Kumar Mehra

Download or read book Dendrimers in Nanomedicine written by Neelesh Kumar Mehra and published by CRC Press. This book was released on 2021-03-24 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dendrimers, hyperbranched macromolecules, emerged just few decades ago but show promising potential as drug delivery nanocarriers, theranostic agents and gene vectors; in the pharmaceutical research and innovation area as well as in other healthcare applications. Although tremendous advancements have been made in dendrimer chemistry and their applications since their emergence, the synthesis, development and design of pure and safe dendrimer-based products have been a major challenge in this area. This book, edited by well-known researchers in the area of nanomaterials and drug-based drug delivery applications, exhaustively covers the nanotechnological aspects, concepts, properties, characterisation, application, biofate and regulatory aspects of dendrimers. It includes sixteen vivid chapters by renowned formulators, researchers and academicians from all over the world, highlighting their specialised areas of interest in the fields of chemistry, biology, pharmacy and nanomedicine. Features: • Highlights dendrimers’ advancements in nanomedicine in the development of safe healthcare and biotechnological products • Covers physicochemical aspects, biofate, drug delivery aspects and gene therapy using dendrimers • Covers biomedical application of dendrimers in the field of biological sciences • Gives examples of dendrimer–guest interaction chemistry Dendrimers in Nanomedicine: Concept, Theory and Regulatory Perspectives provides the comprehensive overview of the latest research efforts in designing, optimising, development and scale-up of dendrimer-mediated delivery systems. It analyses the key challenges of synthesis, design, molecular modelling, fundamental concepts, drug delivery aspects, analytical tools and biological fate as well as regulatory consideration to the practical use of dendrimer application. Dr. Neelesh Kumar Mehra Assistant Professor of Pharmaceutics in the Department of Pharmaceutics at the National Institute of Pharmaceutical Education & Research (NIPER), Hyderabad, India. He has authored more than sixty peer-reviewed publications in highly reputed international journals, as well as book chapters and contributions on two patents. Dr. Mehra has 11 years of rich research and teaching experience in the formulation and development of complex, innovative biopharmaceutical products including micro- and nanotechnologies for regulated markets. Dr. Keerti Jain Assistant Professor of Pharmaceutics in the Department of Pharmaceutics, NIPER, Raebareli, India. For more than 10 years, she has been actively engaged in formulation and development of nanomedicines. Dr. Jain has supervised masters and doctoral pharmaceutics students in their research works which have been published in high quality, good impact factor journals. She has also authored more than 60 international manuscripts in peer reviewed high impact journals. In 2019, she was awarded the prestigious ICMR-Amir Shakuntala Award.