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Author : Robert James Twieg
Publisher :
ISBN 13 :
Total Pages : 746 pages
Book Rating : 4.:/5 (35 download)
Download or read book Synthesis and Transition Metal Catalyzed Rearrangements of Strained Cage Compounds written by Robert James Twieg and published by . This book was released on 1976 with total page 746 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Dale Lawrence Whalen
Publisher :
ISBN 13 :
Total Pages : 402 pages
Book Rating : 4.:/5 (251 download)
Download or read book Synthesis and Rearrangements of Some Strained Cage Compounds written by Dale Lawrence Whalen and published by . This book was released on 1966 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Charles Herbert Schallhorn
Publisher :
ISBN 13 :
Total Pages : 238 pages
Book Rating : 4.:/5 (253 download)
Download or read book The Synthesis and Rearrangement of Strained Cage Compounds written by Charles Herbert Schallhorn and published by . This book was released on 1970 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jianbo Wang
Publisher : John Wiley & Sons
ISBN 13 : 3527347992
Total Pages : 450 pages
Book Rating : 4.5/5 (273 download)
Download or read book Transition Metal-Catalyzed Carbene Transformations written by Jianbo Wang and published by John Wiley & Sons. This book was released on 2022-05-16 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents an up-to-date overview of the rapidly growing field of carbene transformations Carbene transformations have had an enormous impact on catalysis and organometallic chemistry. With the growth of transition metal-catalyzed carbene transformations in recent decades, carbene transformations are today an important compound class in organic synthesis as well as in the pharmaceutical and agrochemical industries. Edited by leading experts in the field, Transition Metal-Catalyzed Carbene Transformations is a thorough summary of the most recent advances in the rapidly expanding research area. This authoritative volume covers different reaction types such as ring forming reactions and rearrangement reactions, details their conditions and properties, and provides readers with accurate information on a wide range of carbene reactions. Twelve in-depth chapters address topics including carbene C-H bond insertion in alkane functionalization, the application of engineered enzymes in asymmetric carbene transfer, progress in transition-metal-catalyzed cross-coupling using carbene precursors, and more. Throughout the text, the authors highlight novel catalytic systems, transformations, and applications of transition-metal-catalyzed carbene transfer. Highlights the dynamic nature of the field of transition-metal-catalyzed carbene transformations Summarizes the catalytic radical approach for selective carbene cyclopropanation, high enantioselectivity in X-H insertions, and bio-inspired carbene transformations Introduces chiral N,N'-dioxide and chiral guanidine-based catalysts and different transformations with gold catalysis Discusses approaches in cycloaddition reactions with metal carbenes and polymerization with carbene transformations Outlines multicomponent reactions through gem-difunctionalization and transition-metal-catalyzed cross-coupling using carbene precursors Transition Metal-Catalyzed Carbene Transformations is essential reading for all chemists involved in organometallics, including organic and inorganic chemists, catalytic chemists, and chemists working in industry.
Author : L. Brandsma
Publisher : Springer Science & Business Media
ISBN 13 : 3642603289
Total Pages : 349 pages
Book Rating : 4.6/5 (426 download)
Download or read book Application of Transition Metal Catalysts in Organic Synthesis written by L. Brandsma and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: Homogeneous catalysis is an important strategy for the synthesis of high-valued chemicals. L. Brandsma has carefully selected and checked the experimental procedures illustrating the catalytic use of copper, nickel, and palladium compounds in organic synthesis. All procedures are on a preparative scale, make economic use of solvents and catalysts, avoid toxic substances and have high yields.
Author : William R. Moser
Publisher :
ISBN 13 :
Total Pages : 650 pages
Book Rating : 4.X/5 (2 download)
Download or read book Homogeneous Transition Metal Catalyzed Reactions written by William R. Moser and published by . This book was released on 1992 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Xiao-Feng Wu
Publisher : Springer
ISBN 13 : 3319249630
Total Pages : 176 pages
Book Rating : 4.3/5 (192 download)
Download or read book Transition Metal Catalyzed Carbonylative Synthesis of Heterocycles written by Xiao-Feng Wu and published by Springer. This book was released on 2015-12-14 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: The series Topics in Heterocyclic Chemistry presents critical reviews on present and future trends in the research of heterocyclic compounds. Overall the scope is to cover topics dealing with all areas within heterocyclic chemistry, both experimental and theoretical, of interest to the general heterocyclic chemistry community. The series consists of topic related volumes edited by renowned editors with contributions of experts in the field. All chapters from Topics in Heterocyclic Chemistry are published Online First with an individual DOI. In references, Topics in Heterocyclic Chemistry is abbreviated as Top Heterocycl Chem and cited as a journal.
Author : François Diederich
Publisher : John Wiley & Sons
ISBN 13 : 3527612203
Total Pages : 540 pages
Book Rating : 4.5/5 (276 download)
Download or read book Metal-catalyzed Cross-coupling Reactions written by François Diederich and published by John Wiley & Sons. This book was released on 2008-07-11 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbon-carbon bond forming reactions are arguably the most important processes in chemistry, as they represent key steps in the building of complex molecules from simple precursors. Among these reactions, metal-catalyzed cross-coupling reactions are extensively employed in a wide range of areas of preparative organic chemistry, ranging from the synthesis of complex natural products, to supramolecular chemistry, and materials science. In this work, a dozen internationally renowned experts and leaders in the field bring the reader up to date by documenting and critically analyzing current developments and uses of metal-catalyzed cross-coupling reactions. A particularly attractive and useful feature, that enhances the practical value of this monograph, is the inclusion of key synthetic protocols, in experimental format, chosen for broad utility and application. This practice-oriented book can offer the practitioner short cuts to ensure they remain up-to-date with the latest developments.
Author : Louis S. Hegedus
Publisher :
ISBN 13 :
Total Pages : 380 pages
Book Rating : 4.3/5 (91 download)
Download or read book Transition Metals in the Synthesis of Complex Organic Molecules written by Louis S. Hegedus and published by . This book was released on 1994 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: A text for use in a one-semester course for upper-level students familiar with basic organic chemistry, or as a survey course for practicing organic chemists. Chapters 1 and 2 present a brief overview of the formalisms and mechanisms required to understand the processes discussed in chapters 3-10, which deal with the application of transition metal organometallic chemistry to organic synthesis with specific attention to applications with complex molecules. Updates and expands chapters 13-20 of Principles and Applications of Organotransition Metal Chemistry, 2nd ed. (1987). Published by University Science Books, 20 Edgehill Rd., Mill Valley, CA 94941. Annotation copyright by Book News, Inc., Portland, OR
Author : H.M. Colquhoun
Publisher : Springer
ISBN 13 : 9781461296539
Total Pages : 468 pages
Book Rating : 4.2/5 (965 download)
Download or read book New Pathways for Organic Synthesis written by H.M. Colquhoun and published by Springer. This book was released on 2011-10-01 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: The continually growing contribution of transition metal chemistry to synthetic organic chemistry is, of course, widely recognized. Equally well known is the difficulty in keeping up-to-date with the multifarious reactions and procedures that seem to be spawned at an ever-increasing rate. These can certainly be summarized on the basis of reviews under the headings of the individual transition metals. More useful to the bench organic chemist, however, would be the opposite type of concordance based on the structural type of the desired synthetic product. This is the approach taken in the present monograph, which presents for each structural entity a conspectus of the transition metal-mediated processes that can be employed in its production. The resulting comparative survey should be a great help in devising the optimum synthetic approach for a particular goal. It is presented from an essentially practical viewpoint, with detailed direc tions interspersed in the Houben-Weyl style. The wide scope of the volume should certainly encourage synthetic organic chemists to utilize fully the range and versatility of these transition metal-mediated processes. This will certainly be a well-thumbed reference book! R. A. RAPHAEL Cambridge University v Preface In recent years an enormous amount of work has been done on the catalysis of organic reactions by various transition metal species and on the organic reactivity of organo-transition-metal compounds.
Author : Christian A Malapit
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (119 download)
Download or read book Transition Metal Catalyzed Transformations of Strained Heterocycles written by Christian A Malapit and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Heterocycles are present in more than half of organic compounds. For organic chemists, they are valued as synthetic targets or scaffolds to construct valuable products. For the past two decades, the Howell group has made contributions towards the synthesis and applications of 4-membered heterocyclic compounds, such as oxetanes and beta-lactones. Most of the previously reported transformations that involve strained heterocyclic compounds rely on traditional methods in which rendering the reaction with good and predictable selectivity (regio-, chemo- and stereoselectivity) is challenging. The works described took advantage of the intrinsic reactivity of strained heterocycles and combined that with the highly selective transformations promoted by transition metal (TM) catalysts. Three successful methodologies were developed. Chapter 1 describes the discovery and scope of a novel Pt-catalyzed expansion of spirocyclopropyl oxetanes to synthetically useful 3-methylenetetrahydrofurans. This unprecedented oxetane expansion was realized via cyclopropane activation under platinum catalysis. Mechanistic studies, through 13C-labelling and 13C-DEPT NMR analyses, suggested that the oxetane expansion was promoted by a regioselective carbon-carbon bond activation of cyclopropane with platinum. Chapter 2 describes two transition metal catalyzed transformations of alpha-methylene-beta-lactones. First is a Rh-catalyzed conjugate addition with aryl boronic acids to access various beta-lactones. beta-Lactones are highly privileged synthetic products and intermediates. They have been shown to elicit serine hydrolase inhibition. They are also used as intermediates to obtain difunctionalized acyclic compounds, and this was the goal in the next method. The second method developed involves a chemoselective opening of beta-lactones to form beta-hydroxy amides. Ring opening of beta-lactones with several nucleophiles typically provide a mixture of two major products; opening via the (a) alkyl C–O bond, or (b) the acyl C–O bond. The selective ring-opening was realized via activation of acyl carbon-oxygen bond under palladium catalysis. Under the developed conditions, several beta-lactones were selectively opened with various amine nucleophiles and gave beta-hydroxy amides as sole product. This method was also translated to a Pd-catalyzed asymmetric kinetic resolution of racemic to enantioenriched beta-lactones.
Author :
Publisher :
ISBN 13 :
Total Pages : 980 pages
Book Rating : 4.F/5 ( download)
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2008 with total page 980 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Derek Schipper
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (759 download)
Download or read book Part 1 written by Derek Schipper and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Part 1: Transition-metal-catalyzed direct transformations of aromatic C-H bonds are emerging as valuable tools in organic synthesis. These reactions are attractive because of they allow for inherently efficient construction of organic building blocks by minimizing the pre-activation of substrates. Of these processes, direct arylation has recently received much attention due to the importance of the biaryl core in medicinal and materials chemistry. Also, alkyne hydroarylation has garnered interest because it allows for the atom-economical synthesis of functionalized alkenes directly from simple arenes and alkynes. Described in this thesis are number of advancements in these areas. First, palladium catalyzed direct arylation of azine N-oxides using synthetically important aryl triflates is described. Interesting reactivity of aryl triflates compared to aryl bromides was uncovered and exploited in the synthesis of a compound that exhibits antimalarial and antimicrobial activity. Also reported is the efficient, direct arylation enabled (formal) synthesis of six thiophene based organic electronic materials in high yields using simple starting materials. Additionally, the site-selective direct arylation of both sp2 and sp3 sites on azine N-oxide substrates is described. The arylation reactions are carried out in either a divergent manner or a sequential manner and is applied to the synthesis of the natural products, Papaverine and Crykonisine. Mechanistic investigations point towards the intimate involvement of the base in the mechanism of these reactions. Next, the rhodium(III)-catalyzed hydroarylation of internal alkynes is described. Good yields are obtained for a variety of alkynes and arenes with excellent regioselectivity for unsymmetrically substituted alkynes. Mechanistic investigations suggest that this reaction proceeds through arene metalation with the cationic rhodium catalyst, which enables challenging intermolecular reactivity. Part 2: Access to single enantiomer compounds is a fundamental goal in organic chemistry and despite remarkable advances in enantioselective synthesis, their preparation remains a challenge. Kinetic resolution of racemic products is an important method to access enantioenriched compounds, especially when alternative methods are scarce. Described in this thesis is the resolution of tertiary and secondary alcohols, which arise from ketone and aldehyde aldol additions. The method is technically simple, easily scalable, and provides tertiary and secondary alcohols in high enantiomeric ratios. A rationale for the unique reactivity/selectivity associated with (1S,2R)-N-methylephedrine in the resolution is proposed. Organocatalysis is a rapidly developing, powerful field for the construction of enantioenriched organic molecules. Described here is a complimentary class of organocatalysis using simple aldehydes as temporary tethers to perform challenging formally intermolecular reactions at room temperature. This strategy allows for the enantioselective, intermolecular cope-type hydroamination of allylic amines with hydroxyl amines. Also, interesting catalytic reactivity for dichloromethane is revealed.
Author : Andrei Nikolaev
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (136 download)
Download or read book Synthesis and Reactivity of Umpolung Reagents Through Transition Metal Catalysis written by Andrei Nikolaev and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cyclopropanol-derived palladium-homoenolates have previously been exploited as a unique class of cross-coupling partners in our group. The major advantage of using cyclopropanols as the cross-coupling partners is the fact that the functional group content is preserved. Specifically, cyclopropanol forms the corresponding -functionalized carbonyl product which can be used for further transformations. We developed an efficient method towards the synthesis of quinoline derivatives with broad functional group tolerance using series of cyclopropanols and ortho-bromoanilines as the cross-coupling partners in the presence of a palladium-catalyst. A deuterium labeling study revealed that a second equivalent of ortho-bromoaniline is the terminal oxidant in this reaction. Considering the importance of aza-aromatic heterocycles in biologically active drug molecules, there is a continuous demand for rapid and benign methods towards their functionalization. Hence, we wanted to exploit a transition-metal catalyzed free-radical ring opening reaction of cyclopropanols towards rapid and efficient functionalization of pyridine derivatives. We development a silver-catalyzed direct functionalization of heteroaromatic compounds with a well-defined silver catalyst. Through this study, we gained strong evidence which suggests that silver-pyridine complexes are the catalytically active species for free-radical ring-opening of the cyclopropanol. Acylsilanes are classic umpolung reagents with broad synthetic applications. Specifically, acylsilanes undergo polarity inversion at the carbonyl-carbon via the 1,2-Brook rearrangement with a concomitant reaction with an electrophile. Unfortunately, synthetic methods for acylsilanes often involve many steps and harsh conditions. We explored a mild synthetic method for the preparation of ,-unsaturated acylsilanes via perrhenate-catalyzed Meyer-Schuster rearrangement of 3-silyl propargylic alcohols.
Author : Yuri Bolshan
Publisher :
ISBN 13 : 9780494525340
Total Pages : 372 pages
Book Rating : 4.5/5 (253 download)
Download or read book Transition Metal-catalyzed Reactions of Organoboron Compounds written by Yuri Bolshan and published by . This book was released on 2009 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis describes research conducted since May 2003 at the University of Toronto in the laboratory of Professor Robert A. Batey. The manuscript is divided into three chapters. Chapter one provides a general introduction to the transition metal-catalyzed reactions of potassium organotrifluoroborate salts and methods for their preparation. A comparison in reactivity between organoboronic acids and organotrifluoroborate salts in metal-catalyzed reactions under similar reaction conditions and the importance of polar protic solvents during transmetalation step are also discussed.Chapter two provides an overview of the addition of organometallic and organometalloid reagents to imines. Particular attention is drawn to the metal-catalyzed additions of organozinc and organoboron compounds as well as the development of chiral ligands associated with these transformations. The synthesis, role and advantages of a chiral auxiliary over currently available methods in the synthesis of chiral amines are also described. In addition, chapter two provides a description of our contribution to this area of synthetic organic chemistry, including the synthesis of enantiomerically enriched amines via rhodium-catalyzed addition of arylboron compounds to N-tert-butanesulfinyl aldimines. The addition occurred at room temperature to afford the corresponding amides in good yields and high diastereoselectivities. The removal of the auxiliary is achieved under acidic conditions without detectable epimerization at a chiral center. The practical utility of this methodology was shown via the synthesis of a cetirizine precursor with high degree of diastereoselctivity.Chapter three introduces traditional and modern synthetic methods for the synthesis of the enamide functionality with an emphasis on palladium and copper-catalyzed transformations. The utility of enamides as synthetic intermediates in organic chemistry and their presence in natural products and biologically active compounds are also described. Our contribution to the field of enamide synthesis is discussed, including the optimization and scope of a novel copper-catalyzed cross-coupling between amides and potassium alkenyltrifluoroborate salts, which occurs under an atmosphere of oxygen in the presence of molecular sieves to afford enamides in good yields.
Download or read book Transition Metal Catalyzed Rearrangement of Dimethyl Vinylcyclobutene Dicarboxylate Derivatives to Dimethyl Cyclohexadiene Dicarboxylates and Phthalates written by and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Vinylcyclobutene derivatives rearrange in the presence of transition metals to form cyclohexadienes and phthalates. Previous work in our group showed that this rearrangement could be performed with Ni(l), Ti(lll), Fe(ll), and Sm(ll). For this thesis, a large variety of metals was studied for these rearrangements. In addition, these methods were applied to various derivatives of vinylcyclobutene. It was found that Pd(ll) would promote the rearrangement to yield phthalates, in the same manner as Ti(lll) and Sm(ll). In addition, a new type of rearrangement was found. Methyl dereivatives of vinylcyclobutene, bearing a methyl substituent on the vinyl group, rearranged to form cyclopentadienes. X-Ray crystallography was used to prove the structure of the dimethyl derivative of vinylcyclobutene. The structures of the other synthesized compounds were confirmed by various spectroscopic analyses.
Author : Arpan Pal
Publisher :
ISBN 13 :
Total Pages : 95 pages
Book Rating : 4.:/5 (11 download)
Download or read book Transition Metal-Catalyzed Synthesis And Applications Of Enamino Carbonyl Compounds written by Arpan Pal and published by . This book was released on 2019 with total page 95 pages. Available in PDF, EPUB and Kindle. Book excerpt:
