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Study Of The Primary Isotope Dependence Of Secondary Kinetic Isotope Effects In Hydride Transfer Reactions In Solution
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Book Synopsis Study of the Primary Isotope Dependence of Secondary Kinetic Isotope Effects in Hydride Transfer Reactions in Solution by : Li Ma
Download or read book Study of the Primary Isotope Dependence of Secondary Kinetic Isotope Effects in Hydride Transfer Reactions in Solution written by Li Ma and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Study of the Primary Isotope Dependence of the Secondary Kinetic Isotope Effects and Hammett Correlations in Hydride Transfer Reactions in Solution by : Paniz Rahmani
Download or read book Study of the Primary Isotope Dependence of the Secondary Kinetic Isotope Effects and Hammett Correlations in Hydride Transfer Reactions in Solution written by Paniz Rahmani and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Primary Isotope Dependence of Secondary Kinetic Isotope Effects in a Hydride-Transfer Reaction in Solution by : Jonathan Lefton
Download or read book Primary Isotope Dependence of Secondary Kinetic Isotope Effects in a Hydride-Transfer Reaction in Solution written by Jonathan Lefton and published by . This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Primary Isotope Dependence of the Near and Remote Secondary Kinetic Isotope Effects in Hydride Transfer Reactions in Solution by : Shabnam Jafari
Download or read book Primary Isotope Dependence of the Near and Remote Secondary Kinetic Isotope Effects in Hydride Transfer Reactions in Solution written by Shabnam Jafari and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Enzyme Mechanism from Isotope Effects by : Paul F. Cook
Download or read book Enzyme Mechanism from Isotope Effects written by Paul F. Cook and published by CRC Press. This book was released on 1991-09-20 with total page 656 pages. Available in PDF, EPUB and Kindle. Book excerpt: Isotope effects have become one of the most powerful tools available to the enzymologist for probing enzymic mechanisms. Enzyme Mechanism from Isotope Effects presents the basic theory underlying isotope effects, including the latest findings on proton tunneling and coupled atomic notions. Specific theoretical applications are emphasized in regard to the types of information that can be obtained using isotope effects. The book also examines recent theoretical treatments of the product dependence of deuterium isotope effects, multiple isotope effects and isotope effects on intermediate partitioning. Other topics include a complete discussion of methods for measuring isotope effects, including a detailed description of the use of the isotope ratio mass spectrometer to obtain isotope effects, and a review of the literature regarding mechanistic information obtained from isotope effects for individual classes of enzyme-catalyzed reactions. Enzyme Mechanism from Isotope Effects is an excellent reference source for investigators using isotope effects in their research. The book is also valuable for reference libraries and instructors teaching courses in enzyme mechanism.
Book Synopsis Primary Isotope Effect on Secondary Kinetic Isotope Effects and Hammett Correlations in Hydride Transfer Reactions by : Zhimeng Yang
Download or read book Primary Isotope Effect on Secondary Kinetic Isotope Effects and Hammett Correlations in Hydride Transfer Reactions written by Zhimeng Yang and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Measurement and Analysis of Kinetic Isotope Effects by :
Download or read book Measurement and Analysis of Kinetic Isotope Effects written by and published by Academic Press. This book was released on 2017-09-12 with total page 634 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experimental Analysis of Enzyme Mechanism Using Isotope Effects, Volume 596, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Chapters in this comprehensive update include Measurement of enzyme binding isotope effects, Chemical ligation and isotope labeling to locate dynamic effects, Measurement of heavy enzyme isotope effects, Extracting kinetic isotope effects from a global analysis of reaction progress curves, KIE of metabolic flux and enzymes, Solvent and Primary KIE on Flavin Enzymes, and The Rapid Determination of Primary Deuterium Isotope Effects on Enzyme-Catalyzed Proton Transfer at Carbon in 50/50 HOH/DOD. Readers who are interested in applying or understanding this research will find useful methods currently used for measuring isotope effects on solution and enzyme reactions. Written by pioneers of modern isotope effect research Is the only collection of modern kinetic isotope effect methods currently available
Book Synopsis Isotope Effects In Chemistry and Biology by : Amnon Kohen
Download or read book Isotope Effects In Chemistry and Biology written by Amnon Kohen and published by CRC Press. This book was released on 2005-11-01 with total page 1092 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of isotope effects has expanded exponentially in the last decade, and researchers are finding isotopes increasingly useful in their studies. Bringing literature on the subject up to date, Isotope Effects in Chemistry and Biology covers current principles, methods, and a broad range of applications of isotope effects in the physical, biolo
Book Synopsis Heavy-atom Kinetic Isotope Effects by : Marvin J. Stern
Download or read book Heavy-atom Kinetic Isotope Effects written by Marvin J. Stern and published by . This book was released on 1972 with total page 44 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Effect of the Donor-Acceptor Distance on the Secondary Kinetic Isotope Effects in Hydride Transfer Reactions within the Marcus Like H Tunneling Model by : Xiaojun Li
Download or read book The Effect of the Donor-Acceptor Distance on the Secondary Kinetic Isotope Effects in Hydride Transfer Reactions within the Marcus Like H Tunneling Model written by Xiaojun Li and published by . This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Isotope Effects written by Max Wolfsberg and published by Springer Science & Business Media. This book was released on 2009-12-15 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt: As the title suggests, Isotope Effects in the Chemical, Geological and Bio Sciences deals with differences in the properties of isotopically substituted molecules, such as differences in the chemical and physical properties of water and the heavy waters. Since the various fields in which isotope effects are applied do not only share fundamental principles but also experimental techniques, this book includes a discussion of experimental apparatus and experimental techniques. Isotope Effects in the Chemical, Geological and Bio Sciences is an educational monograph addressed to graduate students and others undertaking isotope effect research. The fundamental principles needed to understand isotope effects are presented in appropriate detail. While it is true that these principles are more familiar to students of physical chemistry and some background in physical chemistry is recommended, the text provides enough detail to make the book an asset to students in organic and biochemistry, and geochemistry.
Download or read book Nuclear Science Abstracts written by and published by . This book was released on 1976 with total page 934 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Novel Uses of Isotope Effects to Elucidate Enzyme Reaction Mechanisms by : Jeffrey D. Hermes
Download or read book Novel Uses of Isotope Effects to Elucidate Enzyme Reaction Mechanisms written by Jeffrey D. Hermes and published by . This book was released on 1983 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nuclear Science Abstracts written by and published by . This book was released on 1973 with total page 1162 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Application of Kinetic Isotope Effects and Theoretical Calculations to the Study of Interesting Reaction Mechanisms by : Jennifer Sue Hirschi
Download or read book Application of Kinetic Isotope Effects and Theoretical Calculations to the Study of Interesting Reaction Mechanisms written by Jennifer Sue Hirschi and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: A variety of biological and organic reaction mechanisms are studied using powerful tools from experimental and theoretical chemistry. These tools include the precise measurement of kinetic isotope effects (KIEs) and the use of theoretical calculations to predict KIEs as well as determine factors that contribute to reaction acceleration and selectivity. Theoretical analysis of the Swain-Schaad relationship involves the prediction of a large number of isotope effects and establishes the semiclassical boundaries of the relationship. Studies on the mechanism of oxidosqualene cyclase involve the determination of a large number of precise KIEs simultaneously. Transition state models for the Sharpless asymmetric epoxidation have been developed that explain the versatility, high selectivities, and ligand accelerated catalysis of the reaction. Theoretical predictions on the proposed enzymatic mechanism of flavin dependent amine oxidation suggest a hydride transfer mechanism and rules out mechanisms involving covalent intermediates. Finally, a theoretical analysis of Diels-Alder reactions successfully describes the unexpected exo selectivity in some of these reactions.
Book Synopsis The Use of Kinetic Isotope Effects in Studies of Hydrogen Transfers by : Daniel Harris Roston
Download or read book The Use of Kinetic Isotope Effects in Studies of Hydrogen Transfers written by Daniel Harris Roston and published by . This book was released on 2013 with total page 115 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present dissertation seeks to deepen our understanding of hydrogen transfers and especially C-H bond activations in enzymes. Hydrogen transfers are ubiquitous in chemistry and biology and a thorough understanding of how they occur and what factors influence them will facilitate developments in biomimetic catalysis, rational drug design, and other fields. A particular difficulty with H-transfers is the importance of nuclear quantum effects to the reaction, particularly tunneling. The overall scope of the work here aims to examine how experimental kinetic isotope effects (KIEs) can be interpreted with a particular type of tunneling model, referred to as Marcus-like models, to yield a semi-quantitative picture of the physical mechanisms of H-transfers. Previous work had used this kind of model to qualitatively interpret experimental data using a combination of intuition and generalized theories. The work here examines these theories in quantitative detail, testing and calibrating our intuition in the context of several experimental systems. The first chapter of research (ch. II) focusses on the temperature dependence of primary KIEs and how these experiments can be quantitatively interpreted as a probe for certain kinds of enzyme or solvent dynamics. The subsequent chapters (ch. III-VI) focus on the use of secondary KIEs to determine the detailed structures of tunneling ready states (TRSs) and how the dynamics of H-tunneling affect those structures. These chapters focus primarily on the TRS of the enzyme alcohol dehydrogenase, but by examining an uncatalyzed analogue to that reaction (ch. VI), the work gains some insight about similarities and differences between catalyzed and uncatalyzed reactions. In summary, the work uncovers some principles of catalysis, not just the mechanism of a catalyzed reaction. The mechanism of C-H activation presented here provides an elegant solution to problems that have been vexing to accommodate within traditional models. This work constitutes some initial steps in making Marcus-like models quantitatively useful as a supplement or even replacement for traditional models of reactivity.
Book Synopsis Heavy Atom Isotope Effects by : E. Buncel
Download or read book Heavy Atom Isotope Effects written by E. Buncel and published by . This book was released on 1992 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt:
