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Author : Tung-Lin Wu
Publisher :
ISBN 13 :
Total Pages : 56 pages
Book Rating : 4.:/5 (945 download)
Download or read book Studies of Functional Connectivity in White Matter written by Tung-Lin Wu and published by . This book was released on 2016 with total page 56 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Karl J. Friston
Publisher : Elsevier
ISBN 13 : 0080472958
Total Pages : 1161 pages
Book Rating : 4.0/5 (84 download)
Download or read book Human Brain Function written by Karl J. Friston and published by Elsevier. This book was released on 2004-01-26 with total page 1161 pages. Available in PDF, EPUB and Kindle. Book excerpt: This updated second edition provides the state of the art perspective of the theory, practice and application of modern non-invasive imaging methods employed in exploring the structural and functional architecture of the normal and diseased human brain. Like the successful first edition, it is written by members of the Functional Imaging Laboratory - the Wellcome Trust funded London lab that has contributed much to the development of brain imaging methods and their application in the last decade. This book should excite and intrigue anyone interested in the new facts about the brain gained from neuroimaging and also those who wish to participate in this area of brain science. * Represents an almost entirely new book from 1st edition, covering the rapid advances in methods and in understanding of how human brains are organized* Reviews major advances in cognition, perception, emotion and action* Introduces novel experimental designs and analytical techniques made possible with fMRI, including event-related designs and non-linear analysis
Author : Kostas Fountas
Publisher : BoD – Books on Demand
ISBN 13 : 9535109235
Total Pages : 236 pages
Book Rating : 4.5/5 (351 download)
Download or read book Novel Frontiers of Advanced Neuroimaging written by Kostas Fountas and published by BoD – Books on Demand. This book was released on 2013-01-09 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emerging imaging modalities continuously increase the diagnostic sensitivity and accuracy of neuroimaging, and have transformed diagnostic radiology into a powerful research and clinical tool. Various novel neuroimaging modalities have become of paramount importance, not only in establishing diagnosis but also in guiding surgical intervention, and in evaluating the treatment effect. Advanced MR based techniques such as Fractional Anisotropy, Diffusion Tensor Imaging, Proton Spectroscopy, and task-generated as well as resting-state functional MRI have tremendously increased the power of the modern neuroscientist’s armamentarium. The employment of advanced neuroimaging techniques have been expanded in the scientific fields of neuropsychology, consumer’s psychology, and forensic medicine. Our current textbook presents exactly a collection of such innovative work, and explores new frontiers, and future applications of neuroimaging
Author : Karin Kantarovich
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (136 download)
Download or read book Investigating White Matter Lesion Load, Intrinsic Functional Connectivity, and Cognitive Abilities in Older Adults written by Karin Kantarovich and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Changes to the while matter of the brain disrupt neural communication between spatially distributed brain regions and are associated with cognitive changes in later life. While approximately 95% of older adults experience these brain changes, not everyone who has significant white matter damage displays cognitive impairment. Few studies have investigated the association between white matter changes and cognition in the context of functional brain network integrity. This study used a data-driven, multivariate analytical model to investigate intrinsic functional connectivity patterns associated with individual variability in white matter lesion load as related to fluid and crystallized intelligence in a sample of healthy older adults (n = 84). Several primary findings were noted. First, a reliable pattern emerged associating whole-brain resting-state functional connectivity with individual variability in measures of white matter lesion load, as indexed by total white matter lesion volume and number of lesions. Secondly, white matter lesion load was associated with increased network disintegration and dedifferentiation. Specifically, lower white matter lesion load was associated with greater within- versus between-network connectivity. Higher white matter lesion load was associated with greater between-network connectivity compared to within. These associations between intrinsic functional connectivity and white matter lesion load were not reliably associated with crystallized and fluid intelligence performance. These results suggest that changes to the white matter of the brain in typically aging older adults are characterized by increased functional brain network dedifferentiation. The findings highlight the role of white matter lesion load in altering the functional network architecture of the brain.
Author : Graziano Serrao
Publisher : Frontiers Media SA
ISBN 13 : 2832509509
Total Pages : 167 pages
Book Rating : 4.8/5 (325 download)
Download or read book Current State of the Art of Human Brain White Matter: From Structural and Functional Connectivity to Neurosurgical Applications written by Graziano Serrao and published by Frontiers Media SA. This book was released on 2022-12-22 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Henry Kennedy
Publisher : Springer
ISBN 13 : 3319277774
Total Pages : 173 pages
Book Rating : 4.3/5 (192 download)
Download or read book Micro-, Meso- and Macro-Connectomics of the Brain written by Henry Kennedy and published by Springer. This book was released on 2016-03-10 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book has brought together leading investigators who work in the new arena of brain connectomics. This includes ‘macro-connectome’ efforts to comprehensively chart long-distance pathways and functional networks; ‘micro-connectome’ efforts to identify every neuron, axon, dendrite, synapse, and glial process within restricted brain regions; and ‘meso-connectome’ efforts to systematically map both local and long-distance connections using anatomical tracers. This book highlights cutting-edge methods that can accelerate progress in elucidating static ‘hard-wired’ circuits of the brain as well as dynamic interactions that are vital for brain function. The power of connectomic approaches in characterizing abnormal circuits in the many brain disorders that afflict humankind is considered. Experts in computational neuroscience and network theory provide perspectives needed for synthesizing across different scales in space and time. Altogether, this book provides an integrated view of the challenges and opportunities in deciphering brain circuits in health and disease.
Author : Carl Faingold
Publisher : Academic Press
ISBN 13 : 0124158641
Total Pages : 537 pages
Book Rating : 4.1/5 (241 download)
Download or read book Neuronal Networks in Brain Function, CNS Disorders, and Therapeutics written by Carl Faingold and published by Academic Press. This book was released on 2013-12-26 with total page 537 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuronal Networks in Brain Function, CNS Disorders, and Therapeutics, edited by two leaders in the field, offers a current and complete review of what we know about neural networks. How the brain accomplishes many of its more complex tasks can only be understood via study of neuronal network control and network interactions. Large networks can undergo major functional changes, resulting in substantially different brain function and affecting everything from learning to the potential for epilepsy. With chapters authored by experts in each topic, this book advances the understanding of: How the brain carries out important tasks via networks How these networks interact in normal brain function Major mechanisms that control network function The interaction of the normal networks to produce more complex behaviors How brain disorders can result from abnormal interactions How therapy of disorders can be advanced through this network approach This book will benefit neuroscience researchers and graduate students with an interest in networks, as well as clinicians in neuroscience, pharmacology, and psychiatry dealing with neurobiological disorders. Utilizes perspectives and tools from various neuroscience subdisciplines (cellular, systems, physiologic), making the volume broadly relevant Chapters explore normal network function and control mechanisms, with an eye to improving therapies for brain disorders Reflects predominant disciplinary shift from an anatomical to a functional perspective of the brain Edited work with chapters authored by leaders in the field around the globe – the broadest, most expert coverage available
Author : Barry Horwitz
Publisher : Frontiers E-books
ISBN 13 : 288919020X
Total Pages : 314 pages
Book Rating : 4.8/5 (891 download)
Download or read book Brain Connectivity Analysis: Investigating Brain Disorders written by Barry Horwitz and published by Frontiers E-books. This book was released on with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last few years, advances in human structural and functional neuroimaging (fMRI, PET, EEG/MEG) have resulted in an explosion of studies investigating the anatomical and functional connectivity between different regions of the brain. More and more studies have employed resting and task-related connectivity analyses to assess functional interactions, and diffusion-weighted tractography to study white matter organization. Many of these studies have addressed normal human function, but recently, a number of investigators have turned their attention to examining brain disorders. The study of brain disorders is a complex endeavor; not only does it require understanding the normal brain, and the regions involved in a particular function, but also it needs a deeper understanding of brain networks and their dynamics. This Research Topic will provide the scientific community with an overview of how to apply connectivity methods to study brain disease, and with perspectives on what are the strength and limitations of each modality. For this Research Topic, we solicit both reviews and original research articles on the use of brain connectivity analysis, with non-human or human models, to explore neurological, psychiatric, developmental and neurodegenerative disorders from a system perspective. Connectivity studies that have focused on one or more of the following will be of particular interest: (1) detection of abnormal functional/structural connectivity; (2) neural plasticity, assessed by changes in connectivity, in patients with brain disorders; (3) assessment of therapy using connectivity measures; (4) relation of connectivity changes to behavioral changes.
Author : Nicole Seiberlich
Publisher : Academic Press
ISBN 13 : 0128170581
Total Pages : 1094 pages
Book Rating : 4.1/5 (281 download)
Download or read book Quantitative Magnetic Resonance Imaging written by Nicole Seiberlich and published by Academic Press. This book was released on 2020-11-18 with total page 1094 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantitative Magnetic Resonance Imaging is a ‘go-to’ reference for methods and applications of quantitative magnetic resonance imaging, with specific sections on Relaxometry, Perfusion, and Diffusion. Each section will start with an explanation of the basic techniques for mapping the tissue property in question, including a description of the challenges that arise when using these basic approaches. For properties which can be measured in multiple ways, each of these basic methods will be described in separate chapters. Following the basics, a chapter in each section presents more advanced and recently proposed techniques for quantitative tissue property mapping, with a concluding chapter on clinical applications. The reader will learn: The basic physics behind tissue property mapping How to implement basic pulse sequences for the quantitative measurement of tissue properties The strengths and limitations to the basic and more rapid methods for mapping the magnetic relaxation properties T1, T2, and T2* The pros and cons for different approaches to mapping perfusion The methods of Diffusion-weighted imaging and how this approach can be used to generate diffusion tensor maps and more complex representations of diffusion How flow, magneto-electric tissue property, fat fraction, exchange, elastography, and temperature mapping are performed How fast imaging approaches including parallel imaging, compressed sensing, and Magnetic Resonance Fingerprinting can be used to accelerate or improve tissue property mapping schemes How tissue property mapping is used clinically in different organs Structured to cater for MRI researchers and graduate students with a wide variety of backgrounds Explains basic methods for quantitatively measuring tissue properties with MRI - including T1, T2, perfusion, diffusion, fat and iron fraction, elastography, flow, susceptibility - enabling the implementation of pulse sequences to perform measurements Shows the limitations of the techniques and explains the challenges to the clinical adoption of these traditional methods, presenting the latest research in rapid quantitative imaging which has the possibility to tackle these challenges Each section contains a chapter explaining the basics of novel ideas for quantitative mapping, such as compressed sensing and Magnetic Resonance Fingerprinting-based approaches
Author : William D. Penny
Publisher : Elsevier
ISBN 13 : 0080466508
Total Pages : 689 pages
Book Rating : 4.0/5 (84 download)
Download or read book Statistical Parametric Mapping: The Analysis of Functional Brain Images written by William D. Penny and published by Elsevier. This book was released on 2011-04-28 with total page 689 pages. Available in PDF, EPUB and Kindle. Book excerpt: In an age where the amount of data collected from brain imaging is increasing constantly, it is of critical importance to analyse those data within an accepted framework to ensure proper integration and comparison of the information collected. This book describes the ideas and procedures that underlie the analysis of signals produced by the brain. The aim is to understand how the brain works, in terms of its functional architecture and dynamics. This book provides the background and methodology for the analysis of all types of brain imaging data, from functional magnetic resonance imaging to magnetoencephalography. Critically, Statistical Parametric Mapping provides a widely accepted conceptual framework which allows treatment of all these different modalities. This rests on an understanding of the brain's functional anatomy and the way that measured signals are caused experimentally. The book takes the reader from the basic concepts underlying the analysis of neuroimaging data to cutting edge approaches that would be difficult to find in any other source. Critically, the material is presented in an incremental way so that the reader can understand the precedents for each new development. This book will be particularly useful to neuroscientists engaged in any form of brain mapping; who have to contend with the real-world problems of data analysis and understanding the techniques they are using. It is primarily a scientific treatment and a didactic introduction to the analysis of brain imaging data. It can be used as both a textbook for students and scientists starting to use the techniques, as well as a reference for practicing neuroscientists. The book also serves as a companion to the software packages that have been developed for brain imaging data analysis. An essential reference and companion for users of the SPM software Provides a complete description of the concepts and procedures entailed by the analysis of brain images Offers full didactic treatment of the basic mathematics behind the analysis of brain imaging data Stands as a compendium of all the advances in neuroimaging data analysis over the past decade Adopts an easy to understand and incremental approach that takes the reader from basic statistics to state of the art approaches such as Variational Bayes Structured treatment of data analysis issues that links different modalities and models Includes a series of appendices and tutorial-style chapters that makes even the most sophisticated approaches accessible
Author : Sarina Jennifer Iwabuchi
Publisher :
ISBN 13 :
Total Pages : 270 pages
Book Rating : 4.:/5 (826 download)
Download or read book Unravelling the Link Between the Structure and Function of the Human Brain written by Sarina Jennifer Iwabuchi and published by . This book was released on 2013 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The brain structure-function relationship has been one of the most fundamental issues in neuroscience and the precise underpinnings of such a link has remained elusive. To address this, investigations have discovered associations between cortical structure or white matter architecture and function in the forms of brain activation, task performance, and/or cognitive dysfunctions. However, limited attention has been given to the search for a more direct link between task-related regions of cortical activation and how they are wired together. The overarching goal of this thesis is to gain a further understanding of this relationship by directly assessing functionally coupled regions and the underlying white matter architecture. The first study used diffusion tensor imaging (DTI) and tractography to provide a global outlook of structural asymmetries of white matter in the major lobes, and the extent to which they relate to known functional asymmetries. With the inclusion of the individual diffusion measures (mean diffusion [MD], parallel diffusion and perpendicular diffusion) in combination with fractional anisotropy (FA), the microstructure of the pathways generated from each lobe was closely examined. Structurally, asymmetries did indeed follow expected patterns of functional laterality in terms of language and visuospatial function. In order to validate this anatomo-functional relationship, studies two and three combined the methodologies of functional magnetic resonance imaging (fMRI) with DTI and tractography. In each individual, the regions that were shown to be functionally connected during particular cognitive tasks were identified. These sites were then used to track white matter pathways using tractography. As expected, study two showed a leftward functional network for language production and comprehension. A significant correlation between functional and structural measures was found for the fronto-motor pathway recruited during the generation of verbs. It is theorised that this pathway may be specific to verb generation, given previous reports of a possible motor component in the processing of verbs, while the longer-range connection to temporal regions may be involved in a more diverse range of functions than language alone. Interestingly, tractography between the regions involved in comprehension revealed a ventral as well as a dorsal white matter pathway, which is in accord with the previously proposed dual route theory of reading. Using the same approach, study three explored the more widely and bilaterally distributed circuitry of working memory to investigate whether a structure-function relationship could be established in more complex networks. To further extend the work on cerebral asymmetries, spatial and verbal elements were also included. Functionally, a typical fronto-parietal network was identified for both spatial and verbal working memory. In terms of functional and structural connectivity however, subtle yet significant differences were revealed within both networks that may reflect distinct cognitive processes required for each task. Functional connectivity showed a leftward pattern for the spatial task and rightward connectivity for verbal, contrary to early studies. Measures of white matter integrity on the other hand, were much more symmetrical across the tasks, though variations in the individual diffusion measures revealed possible differences in underlying axonal properties. However, the spatial working memory network almost exclusively yielded significant correlations between structural and functional measures in the parietal-premotor pathways, which may reflect the specificity of the pathways for spatial working memory. Furthermore, comparisons between the two tasks revealed increased activity in the left precentral gyrus during verbal working memory, consistent with the idea that spatial working memory involves a generic system for working memory, while verbal working memory requires additional recruitment of left hemispheric regions for processing linguistic stimuli".
Author : Luis M. Colon-Perez
Publisher : Frontiers Media SA
ISBN 13 : 288945472X
Total Pages : 104 pages
Book Rating : 4.8/5 (894 download)
Download or read book Novel Tools for the Study of Structural and Functional Networks in the Brain written by Luis M. Colon-Perez and published by Frontiers Media SA. This book was released on 2018-04-27 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt: Throughout the history of neuroscience, technological advances are the drivers behind many major advances in our understanding of the nervous system. Investigations of the structure and function of the brain take place on multiple scales, including macroscale at the level of brain regions, mesoscale at the level of neuronal populations, and microscale at the level of single neurons and neuron to neuron interactions. Integration of knowledge over these scales requires novel techniques and interpretations. In this research topic, we highlight nine articles that integrate structural and functional approaches to study brain networks.
Author : Dewen Hu
Publisher : Springer Nature
ISBN 13 : 9813295236
Total Pages : 258 pages
Book Rating : 4.8/5 (132 download)
Download or read book Pattern Analysis of the Human Connectome written by Dewen Hu and published by Springer Nature. This book was released on 2019-11-12 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents recent advances in pattern analysis of the human connectome. The human connectome, measured by magnetic resonance imaging at the macroscale, provides a comprehensive description of how brain regions are connected. Based on machine learning methods, multiviarate pattern analysis can directly decode psychological or cognitive states from brain connectivity patterns. Although there are a number of works with chapters on conventional human connectome encoding (brain-mapping), there are few resources on human connectome decoding (brain-reading). Focusing mainly on advances made over the past decade in the field of manifold learning, sparse coding, multi-task learning, and deep learning of the human connectome and applications, this book helps students and researchers gain an overall picture of pattern analysis of the human connectome. It also offers valuable insights for clinicians involved in the clinical diagnosis and treatment evaluation of neuropsychiatric disorders.
Author : Alfonso Nieto-Castanon
Publisher : Hilbert Press
ISBN 13 : 0578644002
Total Pages : 108 pages
Book Rating : 4.5/5 (786 download)
Download or read book Handbook of functional connectivity Magnetic Resonance Imaging methods in CONN written by Alfonso Nieto-Castanon and published by Hilbert Press. This book was released on 2020-01-31 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook describes methods for processing and analyzing functional connectivity Magnetic Resonance Imaging (fcMRI) data using the CONN toolbox, a popular freely-available functional connectivity analysis software. Content description [excerpt from introduction] The first section (fMRI minimal preprocessing pipeline) describes standard and advanced preprocessing steps in fcMRI. These steps are aimed at correcting or minimizing the influence of well-known factors affecting the quality of functional and anatomical MRI data, including effects arising from subject motion within the scanner, temporal and spatial image distortions due to the sequential nature of the scanning acquisition protocol, and inhomogeneities in the scanner magnetic field, as well as anatomical differences among subjects. Even after these conventional preprocessing steps, the measured blood-oxygen-level-dependent (BOLD) signal often still contains a considerable amount of noise from a combination of physiological effects, outliers, and residual subject-motion factors. If unaccounted for, these factors would introduce very strong and noticeable biases in all functional connectivity measures. The second section (fMRI denoising pipeline) describes standard and advanced denoising procedures in CONN that are used to characterize and remove the effect of these residual non-neural noise sources. Functional connectivity Magnetic Resonance Imaging studies attempt to quantify the level of functional integration across different brain areas. The third section (functional connectivity measures) describes a representative set of functional connectivity measures available in CONN, each focusing on different indicators of functional integration, including seed-based connectivity measures, ROI-to-ROI measures, graph theoretical approaches, network-based measures, and dynamic connectivity measures. Second-level analyses allow researchers to make inferences about properties of groups or populations, by generalizing from the observations of only a subset of subjects in a study. The fourth section (General Linear Model) describes the mathematics behind the General Linear Model (GLM), the approach used in CONN for all second-level analyses of functional connectivity measures. The description includes GLM model definition, parameter estimation, and hypothesis testing framework, as well as several practical examples and general guidelines aimed at helping researchers use this method to answer their specific research questions. The last section (cluster-level inferences) details several approaches implemented in CONN that allow researchers to make meaningful inferences from their second-level analysis results while providing appropriate family-wise error control (FWEC), whether in the context of voxel-based measures, such as when studying properties of seed-based maps across multiple subjects, or in the context of ROI-to-ROI measures, such as when studying properties of ROI-to-ROI connectivity matrices across multiple subjects.
Author : Viktor K. Jirsa
Publisher : Springer
ISBN 13 : 3540715126
Total Pages : 525 pages
Book Rating : 4.5/5 (47 download)
Download or read book Handbook of Brain Connectivity written by Viktor K. Jirsa and published by Springer. This book was released on 2007-08-16 with total page 525 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our contemporary understanding of brain function is deeply rooted in the ideas of the nonlinear dynamics of distributed networks. Cognition and motor coordination seem to arise from the interactions of local neuronal networks, which themselves are connected in large scales across the entire brain. The spatial architectures between various scales inevitably influence the dynamics of the brain and thereby its function. But how can we integrate brain connectivity amongst these structural and functional domains? Our Handbook provides an account of the current knowledge on the measurement, analysis and theory of the anatomical and functional connectivity of the brain. All contributors are leading experts in various fields concerning structural and functional brain connectivity. In the first part of the Handbook, the chapters focus on an introduction and discussion of the principles underlying connected neural systems. The second part introduces the currently available non-invasive technologies for measuring structural and functional connectivity in the brain. Part three provides an overview of the analysis techniques currently available and highlights new developments. Part four introduces the application and translation of the concepts of brain connectivity to behavior, cognition and the clinical domain.
Author : Donald W. Pfaff
Publisher : Springer
ISBN 13 : 9781493934737
Total Pages : 0 pages
Book Rating : 4.9/5 (347 download)
Download or read book Neuroscience in the 21st Century written by Donald W. Pfaff and published by Springer. This book was released on 2016-10-27 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited and authored by a wealth of international experts in neuroscience and related disciplines, this key new resource aims to offer medical students and graduate researchers around the world a comprehensive introduction and overview of modern neuroscience. Neuroscience research is certain to prove a vital element in combating mental illness in its various incarnations, a strategic battleground in the future of medicine, as the prevalence of mental disorders is becoming better understood each year. Hundreds of millions of people worldwide are affected by mental, behavioral, neurological and substance use disorders. The World Health Organization estimated in 2002 that 154 million people globally suffer from depression and 25 million people from schizophrenia; 91 million people are affected by alcohol use disorders and 15 million by drug use disorders. A more recent WHO report shows that 50 million people suffer from epilepsy and 24 million from Alzheimer’s and other dementias. Because neuroscience takes the etiology of disease—the complex interplay between biological, psychological, and sociocultural factors—as its object of inquiry, it is increasingly valuable in understanding an array of medical conditions. A recent report by the United States’ Surgeon General cites several such diseases: schizophrenia, bipolar disorder, early-onset depression, autism, attention deficit/ hyperactivity disorder, anorexia nervosa, and panic disorder, among many others. Not only is this volume a boon to those wishing to understand the future of neuroscience, it also aims to encourage the initiation of neuroscience programs in developing countries, featuring as it does an appendix full of advice on how to develop such programs. With broad coverage of both basic science and clinical issues, comprising around 150 chapters from a diversity of international authors and including complementary video components, Neuroscience in the 21st Century in its second edition serves as a comprehensive resource to students and researchers alike.
Author : Leonardo Pantoni
Publisher : Cambridge University Press
ISBN 13 : 1107031664
Total Pages : 375 pages
Book Rating : 4.1/5 (7 download)
Download or read book Cerebral Small Vessel Disease written by Leonardo Pantoni and published by Cambridge University Press. This book was released on 2014-05 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: Up-to-date discussion of the etiology, diagnosis, treatment, and prevention of this common cause of stroke and cognitive impairment.
