Studies From The Rockefeller Institute For Medical Research Index Authors And Subjects Volumes I Xxv 1904 1916

Author : Rockefeller Medical Research Institute
Publisher : Forgotten Books
ISBN 13 : 9781528407182
Total Pages : 600 pages
Book Rating : 4.4/5 (71 download)

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Download or read book Studies From the Rockefeller Institute for Medical Research, 1916, Vol. 23 (Classic Reprint) written by Rockefeller Medical Research Institute and published by Forgotten Books. This book was released on 2017-12-11 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: Excerpt from Studies From the Rockefeller Institute for Medical Research, 1916, Vol. 23 About two years ago, Dr. Noguchi and I announced that cul tures of a very minute organism had been obtained which might be regarded as the possible microbic agent of epidemic poliomyelitis. The cultures were derived from the central nervous organs of human beings and monkeys who had had poliomyelitis. As evidence of the nature of the cultures it co'uld then be stated that experimental poliomyelitis had been produced in monkeys by inoculation of the cultures. We have recently confirmed this result in an interesting manner. The culture employed for inoculation had been isolated about eighteen months before and had gone through a number of generations in artificial mediums. It was cultivated finally in a mixture of ascitic fluid and broth, and the fluid carrying large num bers of the microorganisms - which are of extremely minute size was injected, in some cases intraspinally, in others intraperitoneally into rhesus monkeys. The injection produced no immediate effect; indeed, a single injection caused no effect whatever. But when the intraperitoneal and intraspinal injections were repeated three or four times, the animals developed paralysis, and the paralyzed animals showed the peculiar histologic changes of the central nervous system indicative Of poliomyelitis. In other words, these experiments Showed that a culture Of the microorganism mentioned, long removed from the nervous tissues, is capable of causing infection of monkeys, and that by this means the symptoms and lesions of epidemic polio myelitis are produced. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works.