Stochasticity and Synchrony in the Mammalian Circadian Network

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Publisher :
ISBN 13 : 9781339218670
Total Pages : 70 pages
Book Rating : 4.2/5 (186 download)

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Book Synopsis Stochasticity and Synchrony in the Mammalian Circadian Network by : John H. Abel

Download or read book Stochasticity and Synchrony in the Mammalian Circadian Network written by John H. Abel and published by . This book was released on 2015 with total page 70 pages. Available in PDF, EPUB and Kindle. Book excerpt: A vast majority of life on Earth exists in an environment where resource availability and environmental conditions are temporally periodic. There is therefore an evolutionary advantage for organisms to partition behavior into certain times of day. Circadian rhythms, endogenous near-24 hour oscillations in gene expression, perform this task. These rhythms exert control over a large fraction of biological processes, and as such are implicated in a wide range of diseases, especially metabolic and mental disorders. Circadian rhythms are generated at a single-cell level through a complex set of interlocked genetic feedback loops. Individual components of the circadian network are considered "sloppy" due to stochastic noise, and it is only through the interaction of cellular oscillators at a network level that precise rhythms are generated. Medically treating or reverse-engineering this complicated genetic architecture necessitates mathematical understanding at multiple physical scales, from cells to tissue.

Transients and Bifurcations of the Mammalian Circadian System

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Publisher : Logos Verlag Berlin GmbH
ISBN 13 : 3832529667
Total Pages : 143 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Transients and Bifurcations of the Mammalian Circadian System by : Adrián E. Granada

Download or read book Transients and Bifurcations of the Mammalian Circadian System written by Adrián E. Granada and published by Logos Verlag Berlin GmbH. This book was released on 2011 with total page 143 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many organisms have an endogenous oscillatory system that controls their daily rhythms in physiology, metabolism and behaviour. In mammals, these oscillations are found in almost every cell and are orchestrated by a tiny brain area: the suprachiasmatic nucleus (SCN). This central pacemaker contains thousands of heterogeneous neurons that oscillate in a synchronized fashion and generate a robust about-a-day pace for the body. One of the fundamental properties of the SCN is to keep its internal period in synchrony with the external 24 hour environmental cycle, i.e., to entrain to the external recurring environment. Many properties of this complex network of coupled entrainable oscillators are poorly understood and the present work deals with some of these open questions.

Modeling Biomolecular Networks in Cells

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Publisher : Springer Science & Business Media
ISBN 13 : 1849962146
Total Pages : 343 pages
Book Rating : 4.8/5 (499 download)

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Book Synopsis Modeling Biomolecular Networks in Cells by : Luonan Chen

Download or read book Modeling Biomolecular Networks in Cells written by Luonan Chen and published by Springer Science & Business Media. This book was released on 2010-07-05 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modeling Biomolecular Networks in Cells shows how the interaction between the molecular components of basic living organisms can be modelled mathematically and the models used to create artificial biological entities within cells. Such forward engineering is a difficult task but the nonlinear dynamical methods espoused in this book simplify the biology so that it can be successfully understood and the synthesis of simple biological oscillators and rhythm-generators made feasible. Such simple units can then be co-ordinated using intercellular signal biomolecules. The formation of such man-made multicellular networks with a view to the production of biosensors, logic gates, new forms of integrated circuitry based on "gene-chips" and even biological computers is an important step in the design of faster and more flexible "electronics". The book also provides theoretical frameworks and tools with which to analyze the nonlinear dynamical phenomena which arise from the connection of building units in a biomolecular network.

Handbook on Biological Networks

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Publisher : World Scientific
ISBN 13 : 9812838805
Total Pages : 465 pages
Book Rating : 4.8/5 (128 download)

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Book Synopsis Handbook on Biological Networks by : Stefano Boccaletti

Download or read book Handbook on Biological Networks written by Stefano Boccaletti and published by World Scientific. This book was released on 2010 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt: Networked systems are all around us. The accumulated evidence of systems as complex as a cell cannot be fully understood by studying only their isolated constituents, giving rise to a new area of interest in research OCo the study of complex networks . In a broad sense, biological networks have been one of the most studied networks, and the field has benefited from many important contributions. By understanding and modeling the structure of a biological network, a better perception of its dynamical and functional behavior is to be expected. This unique book compiles the most relevant results and novel insights provided by network theory in the biological sciences, ranging from the structure and dynamics of the brain to cellular and protein networks and to population-level biology. Sample Chapter(s). Chapter 1: Introduction (61 KB). Contents: Networks at the Cellular Level: The Structural Network Properties of Biological Systems (M Brilli & P Li); Dynamics of Multicellular Synthetic Gene Networks (E Ullner et al.); Boolean Networks in Inference and Dynamic Modeling of Biological Systems at the Molecular and Physiological Level (J Thakar & R Albert); Complexity of Boolean Dynamics in Simple Models of Signaling Networks and in Real Genetic Networks (A D az-Guilera & R ulvarez-Buylla); Geometry and Topology of Folding Landscapes (L Bongini & L Casetti); Elastic Network Models for Biomolecular Dynamics: Theory and Application to Membrane Proteins and Viruses (T R Lezon et al.); Metabolic Networks (M C Palumbo et al.); Brain Networks: The Human Brain Network (O Sporns); Brain Network Analysis from High-Resolution EEG Signals (F De Vico Fallani & F Babiloni); An Optimization Approach to the Structure of the Neuronal layout of C elegans (A Arenas et al.); Cultured Neuronal Networks Express Complex Patterns of Activity and Morphological Memory (N Raichman et al.); Synchrony and Precise Timing in Complex Neural Networks (R-M Memmesheimer & M Timme); Networks at the Individual and Population Levels: Ideas for Moving Beyond Structure to Dynamics of Ecological Networks (D B Stouffer et al.); Evolutionary Models for Simple Biosystems (F Bagnoli); Evolution of Cooperation in Adaptive Social Networks (S Van Segbroeck et al.); From Animal Collectives and Complex Networks to Decentralized Motion Control Strategies (A Buscarino et al.); Interplay of Network State and Topology in Epidemic Dynamics (T Gross). Readership: Advanced undergraduates, graduate students and researchers interested in the study of complex networks in a wide range of biological processes and systems."

Journal of the Royal Society, Interface

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Publisher :
ISBN 13 :
Total Pages : 590 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis Journal of the Royal Society, Interface by :

Download or read book Journal of the Royal Society, Interface written by and published by . This book was released on 2008 with total page 590 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Circadian Clocks

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Publisher : Springer Science & Business Media
ISBN 13 : 9780306465048
Total Pages : 820 pages
Book Rating : 4.4/5 (65 download)

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Book Synopsis Circadian Clocks by : Joseph S. Takahashi

Download or read book Circadian Clocks written by Joseph S. Takahashi and published by Springer Science & Business Media. This book was released on 2001-09-30 with total page 820 pages. Available in PDF, EPUB and Kindle. Book excerpt: The nature of the circadian clocks is described at the molecular, cellular, tissue, and system levels of organization in diverse organisms. The central role of the circadian clock in the regulation of the sleep-wake cycle as well as seasonal rhythms and other cyclical processes is also discussed. The importance of the circadian clock system for human health, safety, performance, and productivity is also reviewed in this volume."--BOOK JACKET.

Chronobiology

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Publisher : Sinauer Associates Incorporated
ISBN 13 : 9780878931491
Total Pages : 406 pages
Book Rating : 4.9/5 (314 download)

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Book Synopsis Chronobiology by : Jay C. Dunlap

Download or read book Chronobiology written by Jay C. Dunlap and published by Sinauer Associates Incorporated. This book was released on 2004 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: The study of how solar- and lunar- related rhythms are governed by living pacemakers within organisms constitutes the scientific discipline of chronobiology. Few fields encompass the breadth of science that is associated with this subject, which is at the cutting edge of fields ranging from microbial genetics to ethology to treatment of human psychiatric illnesses. In order to recognise that no individual could do justice to the field in writing a comprehensive text, a group of experienced editors and contributors have collaborated to produce Chronobiology. Written in a clear style and fully illustrated to elucidate difficult points, the book assumes no previous background in neuroscience or maths and reduces technical terminology to a minimum. Examples from the real world and from current and classic research are included.

Computational Systems Biology in Medicine and Biotechnology

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Publisher : Springer Nature
ISBN 13 : 1071618318
Total Pages : 494 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis Computational Systems Biology in Medicine and Biotechnology by : Sonia Cortassa

Download or read book Computational Systems Biology in Medicine and Biotechnology written by Sonia Cortassa and published by Springer Nature. This book was released on 2022-05-23 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume addresses the latest state-of-the-art systems biology-oriented approaches that--driven by big data and bioinformatics--are utilized by Computational Systems Biology, an interdisciplinary field that bridges experimental tools with computational tools to tackle complex questions at the frontiers of knowledge in medicine and biotechnology. The chapters in this book are organized into six parts: systems biology of the genome, epigenome, and redox proteome; metabolic networks; aging and longevity; systems biology of diseases; spatiotemporal patterns of rhythms, morphogenesis, and complex dynamics; and genome scale metabolic modeling in biotechnology. In every chapter, readers will find varied methodological approaches applied at different levels, from molecular, cellular, organ to organisms, genome to phenome, and health and disease. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics; criteria utilized for applying specific methodologies; lists of the necessary materials, reagents, software, databases, algorithms, mathematical models, and dedicated analytical procedures; step-by-step, readily reproducible laboratory, bioinformatics, and computational protocols all delivered in didactic and clear style and abundantly illustrated with express case studies and tutorials; and tips on troubleshooting and advice for achieving reproducibility while avoiding mistakes and misinterpretations. The overarching goal driving this volume is to excite the expert and stimulate the newcomer to the field of Computational Systems Biology. Cutting-edge and authoritative, Computational Systems Biology in Medicine and Biotechnology: Methods and Protocols is a valuable resource for pre- and post-graduate students in medicine and biotechnology, and in diverse areas ranging from microbiology to cellular and organismal biology, as well as computational and experimental biologists, and researchers interested in utilizing comprehensive systems biology oriented methods.

Rhythms of the Brain

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Publisher : Oxford University Press
ISBN 13 : 019804125X
Total Pages : 466 pages
Book Rating : 4.1/5 (98 download)

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Book Synopsis Rhythms of the Brain by : Gyorgy Buzsaki

Download or read book Rhythms of the Brain written by Gyorgy Buzsaki and published by Oxford University Press. This book was released on 2006-08-03 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides eloquent support for the idea that spontaneous neuron activity, far from being mere noise, is actually the source of our cognitive abilities. In a sequence of "cycles," György Buzsáki guides the reader from the physics of oscillations through neuronal assembly organization to complex cognitive processing and memory storage. His clear, fluid writing-accessible to any reader with some scientific knowledge-is supplemented by extensive footnotes and references that make it just as gratifying and instructive a read for the specialist. The coherent view of a single author who has been at the forefront of research in this exciting field, this volume is essential reading for anyone interested in our rapidly evolving understanding of the brain.

Intrinsic Clocks

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Publisher : Frontiers Media SA
ISBN 13 : 2889454517
Total Pages : 117 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Intrinsic Clocks by : Timo Partonen

Download or read book Intrinsic Clocks written by Timo Partonen and published by Frontiers Media SA. This book was released on 2018-03-19 with total page 117 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Intrinsic Clocks" presents an array of current research activities on intrinsic clocks and their contributions to biology and physiology. It elucidates the current models for the intrinsic clocks, their molecular components and key mechanisms as well as the key brain regions and animal models for their behavioral analysis. It provides a timely view on how these clocks guide behavior, and how their disruption may cause depressive-like behavior and impairment in cognitive functions. Thereby, any specific method by which the mood-related functions of the intrinsic clocks might be influenced bears therapeutic potential and has clinical interest. The importance of some of these mechanisms was highlighted by the 2017 award of the Nobel Prize in Physiology or Medicine to Jeffrey C. Hall, Michael Rosbash, and Michael W. Young for their discoveries of the genetic control of the daily biological rhythm. The key to the explanation was the discovery of transcription-translation feedback loops of the so-called “clock genes.”

Advanced Models of Neural Networks

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Publisher : Springer
ISBN 13 : 3662437643
Total Pages : 296 pages
Book Rating : 4.6/5 (624 download)

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Book Synopsis Advanced Models of Neural Networks by : Gerasimos G. Rigatos

Download or read book Advanced Models of Neural Networks written by Gerasimos G. Rigatos and published by Springer. This book was released on 2014-08-27 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a complete study on neural structures exhibiting nonlinear and stochastic dynamics, elaborating on neural dynamics by introducing advanced models of neural networks. It overviews the main findings in the modelling of neural dynamics in terms of electrical circuits and examines their stability properties with the use of dynamical systems theory. It is suitable for researchers and postgraduate students engaged with neural networks and dynamical systems theory.

Biological Timekeeping: Clocks, Rhythms and Behaviour

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Publisher : Springer
ISBN 13 : 8132236882
Total Pages : 663 pages
Book Rating : 4.1/5 (322 download)

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Book Synopsis Biological Timekeeping: Clocks, Rhythms and Behaviour by : Vinod Kumar

Download or read book Biological Timekeeping: Clocks, Rhythms and Behaviour written by Vinod Kumar and published by Springer. This book was released on 2017-02-15 with total page 663 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a concise, comprehensive and up-to-date account of fundamental concepts and potential applications of biological timekeeping mechanisms in animals and humans. It also discusses significant aspects of the organization and importance of timekeeping mechanisms in both groups. Divided into seven sections, it addresses important aspects including fundamental concepts; animal and human clocks; clock interactions; clocks and metabolism and immune functions; pineal, melatonin and timekeeping; and clocks, photoperiodism and seasonal behaviours. The book also focuses on biological clock applications in a 24x7 human society, particularly in connection with life-style associated disorders like obesity and diabetes. It is a valuable resource for advanced undergraduates, researchers and professionals engaged in the study of the science of biological timekeeping.

Elements of Applied Bifurcation Theory

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Publisher : Springer Science & Business Media
ISBN 13 : 1475739788
Total Pages : 648 pages
Book Rating : 4.4/5 (757 download)

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Book Synopsis Elements of Applied Bifurcation Theory by : Yuri Kuznetsov

Download or read book Elements of Applied Bifurcation Theory written by Yuri Kuznetsov and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 648 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing readers with a solid basis in dynamical systems theory, as well as explicit procedures for application of general mathematical results to particular problems, the focus here is on efficient numerical implementations of the developed techniques. The book is designed for advanced undergraduates or graduates in applied mathematics, as well as for Ph.D. students and researchers in physics, biology, engineering, and economics who use dynamical systems as model tools in their studies. A moderate mathematical background is assumed, and, whenever possible, only elementary mathematical tools are used. This new edition preserves the structure of the first while updating the context to incorporate recent theoretical developments, in particular new and improved numerical methods for bifurcation analysis.

Bacterial Circadian Programs

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Publisher : Springer Science & Business Media
ISBN 13 : 3540884319
Total Pages : 337 pages
Book Rating : 4.5/5 (48 download)

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Book Synopsis Bacterial Circadian Programs by : Jayna L. Ditty

Download or read book Bacterial Circadian Programs written by Jayna L. Ditty and published by Springer Science & Business Media. This book was released on 2009-02-01 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the discovery of circadian rhythms in cyanobacteria in the late 1980s, the field has exploded with new information. The cyanobacterial model system for studying circadian rhythms, "Synechococcus elongatus", has allowed a detailed genetic dissection of the bacterial clock due to the methods currently available in molecular, structural, and evolutionary biology. This book addresses multiple aspects of bacterial circadian programs: the history and background of the cyanobacteria and circadian rhythms in microorganisms, the molecular basis, structure, and evolution of the circadian clock, entrainment of the oscillator with the environment and the control of downstream processes by the clock, the demonstration of adaptive significance and the prokaryotic clock’s remarkable stability, and mathematical and synthetic oscillator models for clock function. Experts in the field provide a timely and comprehensive review and a stepping-stone for future work on this amazing group of microorganisms and timing.

Endocrine Rhythms

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Publisher :
ISBN 13 :
Total Pages : 352 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Endocrine Rhythms by : Dorothy T. Krieger

Download or read book Endocrine Rhythms written by Dorothy T. Krieger and published by . This book was released on 1979 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Networks of the Brain

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Publisher : MIT Press
ISBN 13 : 0262528983
Total Pages : 433 pages
Book Rating : 4.2/5 (625 download)

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Book Synopsis Networks of the Brain by : Olaf Sporns

Download or read book Networks of the Brain written by Olaf Sporns and published by MIT Press. This book was released on 2016-02-12 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: An integrative overview of network approaches to neuroscience explores the origins of brain complexity and the link between brain structure and function. Over the last decade, the study of complex networks has expanded across diverse scientific fields. Increasingly, science is concerned with the structure, behavior, and evolution of complex systems ranging from cells to ecosystems. In Networks of the Brain, Olaf Sporns describes how the integrative nature of brain function can be illuminated from a complex network perspective. Highlighting the many emerging points of contact between neuroscience and network science, the book serves to introduce network theory to neuroscientists and neuroscience to those working on theoretical network models. Sporns emphasizes how networks connect levels of organization in the brain and how they link structure to function, offering an informal and nonmathematical treatment of the subject. Networks of the Brain provides a synthesis of the sciences of complex networks and the brain that will be an essential foundation for future research.

Out-of-Equilibrium (Supra)molecular Systems and Materials

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Publisher : John Wiley & Sons
ISBN 13 : 3527821988
Total Pages : 448 pages
Book Rating : 4.5/5 (278 download)

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Book Synopsis Out-of-Equilibrium (Supra)molecular Systems and Materials by : Nicolas Giuseppone

Download or read book Out-of-Equilibrium (Supra)molecular Systems and Materials written by Nicolas Giuseppone and published by John Wiley & Sons. This book was released on 2021-03-30 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: A must-have resource that covers everything from out-of-equilibrium chemical systems and materials to dissipative self-assemblies Out-of-Equilibrium Supramolecular Systems and Materials presents a comprehensive overview of the synthetic approaches that use supramolecular bonds in various out-of-thermodynamic equilibrium situations. With contributions from noted experts on the topic, the text contains information on the design of dissipative self-assemblies that maintain their structures when fueled by an external source of energy. The contributors also examine molecules and nanoscale objects and materials that can produce mechanical work based on molecular machines. Additionally, the book explores non-equilibrium supramolecular polymers that can be trapped in kinetically stable states, as well as out-of-equilibrium chemical systems and oscillators that are important to understand the emergence of complex behaviors and, in particular, the origin of life. This important book: Offers comprehensive coverage of fields from design of dissipative self-assemblies to non-equilibrium supramolecular polymers Presents information on a highly emerging and interdisciplinary topic Includes contributions from internationally renowned scientists Written for chemists, physical chemists, biochemists, material scientists, Out-of-Equilibrium Supramolecular Systems and Materials is an indispensable resource written by top scientists in the field.