Stereochemical Aspects Of Drug Action And Disposition

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Stereochemical Aspects of Drug Action and Disposition

Author : Michel F. Eichelbaum
Publisher : Springer Science & Business Media
ISBN 13 : 3642558429
Total Pages : 455 pages
Book Rating : 4.6/5 (425 download)

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Book Synopsis Stereochemical Aspects of Drug Action and Disposition by : Michel F. Eichelbaum

Download or read book Stereochemical Aspects of Drug Action and Disposition written by Michel F. Eichelbaum and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to guide and inspire drug researchers as they enter the 21st century. Stereochemistry is an essential dimension in pharmacology and should be understood as such by all drug researchers whatever their background. When used as probes or medicines, stereoisomeric drugs offer invaluable insights or innovative therapeutic strategies. The book spans the subject from the molecular to the clinical. The first section on chemical aspects contains chapters on chemical synthesis, analysis, natural products, chiral stability (racemezation) and physical properties. The second section is on experimental pharmacology, with chapters on drug-receptor interactions, chiral recognition, ion channels, and molecular toxicology. The third section focuses on drug disposition, with chapters on absorption, distribution, protein binding, metabolism and elimination. The final section is dedicated to regulatory and clinical aspects.

Toxicology in Transition

Author : Gisela H. Degen
Publisher : Springer Science & Business Media
ISBN 13 : 3642794513
Total Pages : 559 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Toxicology in Transition by : Gisela H. Degen

Download or read book Toxicology in Transition written by Gisela H. Degen and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 559 pages. Available in PDF, EPUB and Kindle. Book excerpt: The volume contains the main papers presented at the 1994 EUROTOX Congress, Basel, Switzerland, August 21-24, 1994. Toxicology has become a less descriptive science because more importance has been placed on the mechanisms underlying toxic effects. This is reflected in symposia and workshops devoted to species differences in organ toxicity, receptor-mediated toxicity and stereochemical effects of xenobiotics. Recent progress in the fields of immunotoxicology, ecotoxicology, and neurotoxicology is highlighted and documented together with the present discussion on harmonized regulatory guidelines.

Chirality in Drug Design and Development

Author : Indra K. Reddy
Publisher : CRC Press
ISBN 13 : 0824751094
Total Pages : 406 pages
Book Rating : 4.8/5 (247 download)

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Book Synopsis Chirality in Drug Design and Development by : Indra K. Reddy

Download or read book Chirality in Drug Design and Development written by Indra K. Reddy and published by CRC Press. This book was released on 2004-03-15 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering every essential element in the development of chiral products, this reference provides a solid overview of the formulation, biopharmaceutical characteristics, and regulatory issues impacting the production of these pharmaceuticals. It supports researchers as they evaluate the pharmacodynamic, pharmacokinetic, and toxicological characteristics of specific enantiomers and chiral drug compounds and addresses in one convenient reference all the major challenges pertaining to drug chirality that have been neglected in the literature. Chirality in Drug Design and Development collects the latest studies from an interdisciplinary team of experts on chiral drug design.

Smith and Williams' Introduction to the Principles of Drug Design and Action

Author : H. Jphn Smith
Publisher : CRC Press
ISBN 13 : 0203304152
Total Pages : 684 pages
Book Rating : 4.2/5 (33 download)

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Book Synopsis Smith and Williams' Introduction to the Principles of Drug Design and Action by : H. Jphn Smith

Download or read book Smith and Williams' Introduction to the Principles of Drug Design and Action written by H. Jphn Smith and published by CRC Press. This book was released on 2005-10-10 with total page 684 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in knowledge and technology have revolutionized the process of drug development, making it possible to design drugs for a given target or disease. Building on the foundation laid by the previous three editions, Smith and Williams Introduction to the Principles of Drug Design and Action, Fourth Edition includes the latest informatio

Differentiation of Enantiomers I

Author : Volker Schurig
Publisher : Springer
ISBN 13 : 3319032399
Total Pages : 280 pages
Book Rating : 4.3/5 (19 download)

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Book Synopsis Differentiation of Enantiomers I by : Volker Schurig

Download or read book Differentiation of Enantiomers I written by Volker Schurig and published by Springer. This book was released on 2013-12-16 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: The series Topics in Current Chemistry presents critical reviews of the present and future trends in modern chemical research. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field.

Advances in Drug Research

Author :
Publisher : Elsevier
ISBN 13 : 9780080526713
Total Pages : 374 pages
Book Rating : 4.5/5 (267 download)

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Book Synopsis Advances in Drug Research by :

Download or read book Advances in Drug Research written by and published by Elsevier. This book was released on 1996-07-02 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume continues the trend for Advances in Drug Research of shorter, but more frequent volumes. In line with the tradition of the series, chapters on general themes are interspersed with chapters on specific drug classes and targets.

Drug Stereochemistry

Author : Irving Wainer
Publisher : CRC Press
ISBN 13 : 9780824788193
Total Pages : 450 pages
Book Rating : 4.7/5 (881 download)

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Book Synopsis Drug Stereochemistry by : Irving Wainer

Download or read book Drug Stereochemistry written by Irving Wainer and published by CRC Press. This book was released on 1993-02-24 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: Maintaining and enhancing its focus on key issues in the development, regulatory approval and use of stereoisomeric compounds, this edition continues to cover in detail all aspects of chiral drugs from the academic, governmental, industrial and clinical points of view.;Completely rewritten and updated throughout, Drug Stereochemistry: illustrates current indirect chromatographic methods for the resolution of drug enantiomers; treats the rapidly growing area of enantioselective gas chromatography; discusses the latest in HPLC resolution of enantiomeric drugs; uses verapamil as a model to show how stereoselective pharmacokinetics affect pharmacodynamics; and supplies an in-depth study on the effect of stereoselective plasma protein binding.;This edition offers entirely new chapters that: discuss the recent decisions and present position of the US Food and Drug Administration on the development of stereoisomeric drugs; explicate enzymatic synthesis of stereochemically pure drugs; review the toxicological, pharmacokinetic and pharmacodynamic differences found among stereoisomers; elucidate the stereoselective transport of drugs across epithelia; and give a physician's perspective on the questions and problems caused by stereoisomeric drugs in practice as well as the pharmaceutical industry's collective viewpoint based on a national survey.

Pharmacokinetics of Drugs

Author : Peter G. Welling
Publisher : Springer Science & Business Media
ISBN 13 : 3642786804
Total Pages : 546 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Pharmacokinetics of Drugs by : Peter G. Welling

Download or read book Pharmacokinetics of Drugs written by Peter G. Welling and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt: A compilation of researchers' experience in the areas of bioanalysis, pharmacokinetics, and drug metabolism, to present an up-to-date and comprehensive treatise on the application of these and related technologies in drug discovery, development, and clinical use. Contents cover descriptions of analytical methods, in vitro metabolism technology and membrane transport, reappraisal of classical pharmacokinetic problems, and the time course of drug action. The book concludes with a description of PET and imaging methods in pharmacokinetics and an appendix containing a critical appraisal of computer methods and pharmacokinetic software available for PCs.

Drug Metabolism

Author : Mino R. Caira
Publisher : Springer Science & Business Media
ISBN 13 : 140204142X
Total Pages : 422 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Drug Metabolism by : Mino R. Caira

Download or read book Drug Metabolism written by Mino R. Caira and published by Springer Science & Business Media. This book was released on 2006-07-10 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Metabolism: Current Concepts provides a comprehensive understanding of the processes that take place following ingestion of a medicinal agent or xenobiotic, with an emphasis on the crucial role of metabolism (biotransformation). How a sound knowledge of these phenomena is incorporated into the design of effective new drug candidates is also explained. The user-friendly text focuses on concepts rather than extraneous details and is supported by many illustrated examples of biotransformations as well as frequent references to current critical reviews and articles highlighting the nature of research objectives in this vibrant area of medicinal development. The final topic on strategies for drug design relies on the background provided by the rest of the book. This book is ideally suited as an advanced text for courses in drug metabolism for students of medicine, pharmacy, pharmacology, biochemistry; and for courses in drug design and drug delivery for students of medicinal chemistry. It is also appropriate for professional seminars or courses that relate to the fate of a drug in the body, drug interactions, adverse reactions and drug design.

Generic Drug Product Development

Author : Isadore Kanfer
Publisher : CRC Press
ISBN 13 : 1420020013
Total Pages : 288 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Generic Drug Product Development by : Isadore Kanfer

Download or read book Generic Drug Product Development written by Isadore Kanfer and published by CRC Press. This book was released on 2007-11-15 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: The assessment of bioequivalence is an important process whereby the bioavailability of a generic drug product is compared with its brand-name counterpart. Generic pharmaceutical products must be approved as therapeutic equivalents to the brand name alternative in order to be interchangeable. The demonstration of bioequivalence is an important component of therapeutic equivalence. Bioequivalence studies are very expensive, time consuming and always have the possibility of failure. The objective of this textbook is to describe some of those specific bioequivalence issues which need to be considered for the design and conduct of bioequivalence studies. By exploring scientific, legal, and international regulatory challenges, Generic Drug Development, discusses the use of alternative approaches to the measurement of plasma drug concentrations for the demonstration of bioequivalence, and covers bioequivalence procedures for drug products that are not easily assessed - based upon the physical and chemical properties of the active drug and the nature of the drug product.

Textbook of Organic Medicinal and Pharmaceutical Chemistry

Author : Charles Owens Wilson
Publisher : Lippincott Williams & Wilkins
ISBN 13 :
Total Pages : 1140 pages
Book Rating : 4.:/5 (43 download)

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Book Synopsis Textbook of Organic Medicinal and Pharmaceutical Chemistry by : Charles Owens Wilson

Download or read book Textbook of Organic Medicinal and Pharmaceutical Chemistry written by Charles Owens Wilson and published by Lippincott Williams & Wilkins. This book was released on 1977 with total page 1140 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Essentials of Organic Chemistry

Author : Paul M. Dewick
Publisher : John Wiley & Sons
ISBN 13 : 1118681967
Total Pages : 711 pages
Book Rating : 4.1/5 (186 download)

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Book Synopsis Essentials of Organic Chemistry by : Paul M. Dewick

Download or read book Essentials of Organic Chemistry written by Paul M. Dewick and published by John Wiley & Sons. This book was released on 2013-03-20 with total page 711 pages. Available in PDF, EPUB and Kindle. Book excerpt: Essentials of Organic Chemistry is an accessible introduction to the subject for students of Pharmacy, Medicinal Chemistry and Biological Chemistry. Designed to provide a thorough grounding in fundamental chemical principles, the book focuses on key elements of organic chemistry and carefully chosen material is illustrated with the extensive use of pharmaceutical and biochemical examples. In order to establish links and similarities the book places prominence on principles and deductive reasoning with cross-referencing. This informal text also places the main emphasis on understanding and predicting reactivity rather than synthetic methodology as well as utilising a mechanism based layout and featuring annotated schemes to reduce the need for textual explanations. * tailored specifically to the needs of students of Pharmacy Medical Chemistry and Biological Chemistry * numerous pharmaceutical and biochemical examples * mechanism based layout * focus on principles and deductive reasoning This will be an invaluable reference for students of Pharmacy Medicinal and Biological Chemistry.

Chirality in Drug Research

Author : Eric Francotte
Publisher : John Wiley & Sons
ISBN 13 : 3527608710
Total Pages : 370 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Chirality in Drug Research by : Eric Francotte

Download or read book Chirality in Drug Research written by Eric Francotte and published by John Wiley & Sons. This book was released on 2007-09-24 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Divided into the three main sections of synthesis, analysis and drug development, this handbook covers all stages of the drug development process, including large-scale synthesis and purification of chirally pure pharmaceuticals. The two editors from academia and a major pharmaceutical company have assembled an experienced, international team who provide first-hand practical advice and report previously unpublished data. In the first section, the isolation of chiral drugs from natural sources, their production in enzymatic processes and the resolution of racemic mixtures in preparative chromatography are outlined in separate chapters. For the section on qualitative and quantitative analysis, enantioselective chromatographic methods are presented as well as optical methods and CE-MS, while the final section deals with the pharmacology, pharmacokinetics and metabolic aspects of chiral drugs, devoting whole chapters to stereoselective drug binding and modeling chiral drug-receptor interactions. With its unique industry-relevant aspects, this is a must for medicinal and pharmaceutical chemists.

Chirality and Biological Activity

Author : Hartmut Frank
Publisher : Wiley-Liss
ISBN 13 :
Total Pages : 312 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Chirality and Biological Activity by : Hartmut Frank

Download or read book Chirality and Biological Activity written by Hartmut Frank and published by Wiley-Liss. This book was released on 1990 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reporting on the latest advances in molecular asymmetry, it explores the development of stereochemical analysis and its applications to the biosciences. Applications to pharmacology and therapeutics, food and beverage chemistry, the study of pesticides and other zenobiotics are also covered. Chapters examine the molecular principles of chiral recognition and biological selectivity and discuss stereoselectivity in drug action and metabolism. Some of the specific issues covered include: gas and liquid chromatography of enantiomers on chiral stationary phases; stereochemical assays of chiral drugs; pyrethroid isomers; configurational modification of peptide hormones; chiral fruit flavors; and human pharmacokinetics of enantiomers administered as racemates.

Recent Advances in Anaesthesia and Intensive Care: Volume 22

Author : A. P. Adams
Publisher : Cambridge University Press
ISBN 13 : 9781841101170
Total Pages : 326 pages
Book Rating : 4.1/5 (11 download)

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Book Synopsis Recent Advances in Anaesthesia and Intensive Care: Volume 22 by : A. P. Adams

Download or read book Recent Advances in Anaesthesia and Intensive Care: Volume 22 written by A. P. Adams and published by Cambridge University Press. This book was released on 2002-01-12 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent Advances in Anaesthesia and Intensive Care 22 is the latest volume in this very successful and long-established series (previously entitled Recent Advances in Anaesthesia and Analgesia) to present a series of cutting-edge topics for anaesthetists from some of the world's leading authorities in their subjects. As the title suggests, this and future volumes will have increased input from the field of intensive care, but the emphasis will remain on producing articles of high quality and interest to the reader and providing exceptional value for money.

Biocatalysis in the Pharmaceutical and Biotechnology Industries

Author : Ramesh N. Patel
Publisher : CRC Press
ISBN 13 : 1420019376
Total Pages : 893 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Biocatalysis in the Pharmaceutical and Biotechnology Industries by : Ramesh N. Patel

Download or read book Biocatalysis in the Pharmaceutical and Biotechnology Industries written by Ramesh N. Patel and published by CRC Press. This book was released on 2006-09-26 with total page 893 pages. Available in PDF, EPUB and Kindle. Book excerpt: Because enzyme-catalyzed reactions exhibit higher enantioselectivity, regioselectivity, substrate specificity, and stability, they require mild conditions to react while prompting higher reaction efficiency and product yields. Biocatalysis in the Pharmaceutical and Biotechnology Industries examines the use of catalysts to produce fine chemicals and chiral intermediates in a variety of pharmaceutical, agrochemical, and other biotechnological applications. Written by internationally recognized scientists in biocatalysis, the authors analyze the synthesis of chiral intermediates for over 60 brand-name pharmaceuticals for a wide range of drug therapies and treatments. From starting material to product, the chapters offer detailed mechanisms that show chiral intermediates and other by-products for each reaction—including hydrolytic, acylation, halogenation, esterification, dehalogenation, oxidation-reduction, oxygenation, hydroxylation, deamination, transamination, and C–C, C–N, C–O bonds formation. Cutting-edge topics include advanced methodologies for gene shuffling and directed evolution of biocatalysts; the custom engineering of enzymes; the use of microbial cells and isolated biocatalysts; the use of renewable starting materials; and generating novel molecules by combinatorial biocatalysis and high-throughput screening. Focusing on industrial applications, the book also considers factors such as bulk processes, instrumentation, solvent selection, and techniques for catalyst immobilization, reusability, and yield optimization throughout. Biocatalysis in the Pharmaceutical and Biotechnology Industries showcases the practical advantages and methodologies for using biocatalysts to develop and produce chiral pharmaceuticals and fine chemicals.

Pharmacodynamics and Drug Development

Author : Neal R. Cutler
Publisher : John Wiley & Sons
ISBN 13 : 9780471950523
Total Pages : 514 pages
Book Rating : 4.9/5 (55 download)

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Book Synopsis Pharmacodynamics and Drug Development by : Neal R. Cutler

Download or read book Pharmacodynamics and Drug Development written by Neal R. Cutler and published by John Wiley & Sons. This book was released on 1994-09-20 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contains essential facts and concepts spanning many of the important drug classes. Features an authoritative section on general methodology and regulatory issues. The molecular biology and pharmacology of key receptor types are considered along with the detailed pharmacodynamics of a wide range of therapeutic drug groups.