Stem Cells And Cancer Stem Cells Volume 7

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Stem Cells and Cancer Stem Cells, Volume 4

Author : M.A. Hayat
Publisher : Springer Science & Business Media
ISBN 13 : 9400728271
Total Pages : 325 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Stem Cells and Cancer Stem Cells, Volume 4 by : M.A. Hayat

Download or read book Stem Cells and Cancer Stem Cells, Volume 4 written by M.A. Hayat and published by Springer Science & Business Media. This book was released on 2012-02-09 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vast therapeutic applications of the following specific stem cells in disease and tissue injury are discussed: embryonic stem cells, induced pluripotent stem cells, human hair follicle stem cells, bone marrow-derived human mesenchymal stem cells, adipose-derived stem cells, periodontal/progenitor cells, cancer stem cells, and breast cancer stem cells. Because human embryonic stem cells possess the potential to produce unlimited quantities of any human cell type, considerable focus is placed on this type of stem cells in this volume. The role of cancer stem cells, specifically in breast cancer is explained. Transplantation of mesenchymal stem cells to aid the injured brain is included. Immune recovery after stem cells transplantation in severe combined immunodeficiency patients is described. The role of mesenchymal stem cells in enhancing the growth and metastasis of colon cancer is discussed. Clinical application of human follicle stem cells is presented. Treatment of malignant gliomas using genetically-modified neural stem cells as a marker is discussed. The impact of cancer stem cell hypothesis on designing new cancer therapies is explained. In the field of regenerative medicine, the use of stem cells in the repair of the central nervous system, tendon injury, and as a cardiac regenerative medicine is described. The role of DNA methylation in maintaining stemness induced pluripotent stem cells from human extraembryonic amnion cells is discussed. Insights on the understanding of molecular pathways involved in tumor biology are explained, which lead to the development of effective drugs. Information on pathways, such as hedgehog, facilitates targeted therapies in cancer.

Cancer Stem Cells

Author : Huiping Liu
Publisher : Elsevier
ISBN 13 : 0128039345
Total Pages : 542 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Cancer Stem Cells by : Huiping Liu

Download or read book Cancer Stem Cells written by Huiping Liu and published by Elsevier. This book was released on 2016-08-16 with total page 542 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer Stem Cells: Targeting the Roots of Cancer, Seeds of Metastasis, and Sources of Therapy Resistance introduces the basic concepts and advanced understanding of cancer stem cells, covering general overviews, organ-specific identifications, and their characteristic mechanisms. The book also explores innovative therapeutic strategies in preclinical and clinical trials to target cancer stem cells, remove the roots of cancer, eliminate the seeds of metastasis, overcome the resistance of therapies, and contribute to the eradication of cancer. The book includes contributions from leading, worldwide experts in the field, helping readers embrace new hope in their quest to eradicate cancer with emerging clinical trials on treating cancer stem cells in combination with other therapies. Provides an authoritative and complete overview of cancer stem cells Includes comprehensive coverage of current therapeutic strategies targeting cancer stem cells Deepens a reader’s technical expertise in cancer stem cell biology

Stem Cells and Cancer Stem Cells, Volume 7

Author : M.A. Hayat
Publisher : Springer
ISBN 13 : 9789400742864
Total Pages : 278 pages
Book Rating : 4.7/5 (428 download)

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Book Synopsis Stem Cells and Cancer Stem Cells, Volume 7 by : M.A. Hayat

Download or read book Stem Cells and Cancer Stem Cells, Volume 7 written by M.A. Hayat and published by Springer. This book was released on 2012-06-12 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: The seventh in Springer’s landmark series of edited volumes on one of the highest-profile subjects in contemporary medicine and scientific endeavour, this volume sets out to cover a staggering range of research into the medical applications of stem cell research. While stem cells are the very stuff of life for multicellular organisms, including us humans, the cancer stem cell is a morbid entity with a robust resistance to therapies including conventional chemotherapy. This authoritative publication explains the regenerative potential of stem cells and their mesenchymal progeny, reviewing clinical applications of the latter in the treatment of cancer, diabetes and neurodegenerative pathologies. It covers the entire range of stem cells with known potential for therapeutic use, from human embryonic to germ cell-derived pluripotent stem cells and hematopoietic stem cells. The chapters also deal with the role of TGF-beta in propagating human embryonic stem cells, and in facilitating their differentiation. Featuring discussions of molecular signaling pathways that modulate mesenchymal stem cell self-renewal and much more, this book is certain to have broad appeal among academicians and physicians alike.

Stem Cells and Cancer Stem Cells,Volume 3

Author : M.A. Hayat
Publisher : Springer Science & Business Media
ISBN 13 : 9789400724150
Total Pages : 400 pages
Book Rating : 4.7/5 (241 download)

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Book Synopsis Stem Cells and Cancer Stem Cells,Volume 3 by : M.A. Hayat

Download or read book Stem Cells and Cancer Stem Cells,Volume 3 written by M.A. Hayat and published by Springer Science & Business Media. This book was released on 2011-11-22 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is pointed out that cancer stem cell is a cell type within a tumor that possesses the capacity of cell-renewal and can give rise to the heterogeneous lineages of cancer cells that comprise the tumor. It is emphasized that a cancer stem cell is a tumor initiating cell. That conventional chemotherapy kills most cells in a tumor, but cancer stem cells remain intact is discussed. Vast applications of stem cells, cancer stem cells, mesenchymal stem cells, and human pluripotent stem cells are discussed. Because human embryonic stem cells possess the potential of producing unlimited quantities of any human cell type, considerable focus is placed on their therapeutic potential in this volume. Because of the pluripotency of embryonic stem cells, this volume discusses various applications such as tissue engineering, regenerative medicine, pharmacological and toxicological uses. The role of these cells in cell differentiation is also included. The role of cancer stem cells of breast, colon, and melanoma tumors in response to antitumor therapy is detailed. The role of cancer stem cells, specifically in the deadliest brain cancer, glioblastoma multiforme, is explained. Transplantation of bone marrow-derived stem cells for myocardial infarcation and use of mesenchymal stem cells in orthopedics are described.

Cell Biology and Translational Medicine, Volume 7

Author : Kursad Turksen
Publisher : Springer Nature
ISBN 13 : 3030378454
Total Pages : 158 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis Cell Biology and Translational Medicine, Volume 7 by : Kursad Turksen

Download or read book Cell Biology and Translational Medicine, Volume 7 written by Kursad Turksen and published by Springer Nature. This book was released on 2020-02-03 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of SpringerNature’s longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the seventh volume of a continuing series. Chapter “Application of iPSC to Modelling of Respiratory Diseases” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Stem Cells and Cancer Stem Cells, Volume 1

Author : M.A. Hayat
Publisher : Springer Science & Business Media
ISBN 13 : 9789400717091
Total Pages : 200 pages
Book Rating : 4.7/5 (17 download)

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Book Synopsis Stem Cells and Cancer Stem Cells, Volume 1 by : M.A. Hayat

Download or read book Stem Cells and Cancer Stem Cells, Volume 1 written by M.A. Hayat and published by Springer Science & Business Media. This book was released on 2011-10-12 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Difference between tissue specific stem cells and embryonic stem cells is explained. The advantages of the latter are included. The application of human pluripotent stem cells, mesenchymal stem cells, and hematopoietic stem cells in cancer therapy and tissue/organ regeneration is detailed. Role of neural cancer stem cells in brain tumors, including their role in brain tumor therapy and the role of CD133 stem cell antigen in glioma patients, is emphasized. Therapeutic role of bone marrow-derived stem cells in myocardial infarction and the role of mesenchymal stem cells in orthopedics are explained. Transplantation of umbilical cord hematopoietic stem cells and allogeneic hematopoietic stem cell transplantation followed by graft-versus-host disease are presented. Role of cancer stem cells specifically in glioblastoma and medulloblastoma is included. It is also emphasized that CD133 is an appropriate stem cell marker for gliomas. Targeting of cancer cells is also explained.

Stem Cells and Cancer Stem Cells, Volume 9

Author : M.A. Hayat
Publisher : Springer Science & Business Media
ISBN 13 : 9400756453
Total Pages : 332 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Stem Cells and Cancer Stem Cells, Volume 9 by : M.A. Hayat

Download or read book Stem Cells and Cancer Stem Cells, Volume 9 written by M.A. Hayat and published by Springer Science & Business Media. This book was released on 2012-12-22 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fresh addition to the rapidly expanding Springer series on stem cells represents an additional forward step in our understanding of the causes, diagnosis, and cell-related therapies of major human diseases as well as debilitating injuries to human tissue and organs. Showcasing the work of more than 80 contributors from 13 nations, it offers an unrivalled breadth of differing perspectives on the subject, with dedicated sections covering umbilical cord, induced pluripotent, embryonic, and hematopoietic stem cells, in addition to stem cells in tumors and cancer, and the applications of stem cells in regenerative medicine. Enhanced by numerous color illustrations and tables that provide graphic clarification and summaries of key results, the volume succeeds in bringing together research results from oncologists, neurosurgeons, physicians, research scientists, and pathologists, whose accumulated wealth of practical experience will inform and inspire further developments in the vital and urgent work of cancer diagnosis, cure, and prevention.

Stem Cells and Cancer Stem Cells, Volume 13

Author : M.A. Hayat
Publisher : Springer
ISBN 13 : 9401772339
Total Pages : 123 pages
Book Rating : 4.4/5 (17 download)

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Book Synopsis Stem Cells and Cancer Stem Cells, Volume 13 by : M.A. Hayat

Download or read book Stem Cells and Cancer Stem Cells, Volume 13 written by M.A. Hayat and published by Springer. This book was released on 2015-10-26 with total page 123 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the thirteenth volume in a series which presents current understanding of stem cells and cancer stem cells. This book presents many relevant topics including the different sources of cancer stem cells: the features, roles and clinical potential of stem cells emerge from engaging with this comprehensive work. Chapters explore molecular mechanisms underlying human somatic cell reprogramming to generate induced pluripotent stem cells and provide expert discussion of the advantages and limitations of applications of some of the stem cell types (pluripotent stem cells, neural stem cells). Many advances are explored, including the importance of stem cell markers in diagnosis, the role of stem cells in angiogenesis and a method for isolating multi potent endothelial-like cells from human adipose tissue, to name a few. Readers will also find a consideration of mathematical models and other quantitative tools which could facilitate research and discovery in the field. The editor’s preface to the book and the series is particularly helpful in introducing the work presented in this volume. The detailed overviews, practical experience and insights of international expert authors presented in this handbook will be of value to both professional practitioners and scholars in basic research.

Stem Cells and Cancer Stem Cells, Volume 2

Author : M.A. Hayat
Publisher : Springer Science & Business Media
ISBN 13 : 9789400720169
Total Pages : 384 pages
Book Rating : 4.7/5 (21 download)

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Book Synopsis Stem Cells and Cancer Stem Cells, Volume 2 by : M.A. Hayat

Download or read book Stem Cells and Cancer Stem Cells, Volume 2 written by M.A. Hayat and published by Springer Science & Business Media. This book was released on 2011-10-17 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: As in volume 1 of this series, this volume presents information on stem cells and cancer stem cells; Therapeutic Applications in disease and tissue/organ injury. Methodologies of regenerative medicine and tissue engineering are major components of this volume. Specific stem cells discussed are: human embryonic stem cells, hematopoietic stem cells, cord blood stem cells, human pluripotent stem cells, gliosarcoma stem cells, induced pluripotent stem cells, intestinal stem cells, human thyroid cancer stem cells, tumor stem cells, menstrual stem-like cells, neural stem cells, breast cancer stem cells, allogeneic mesenchymal stem cells, fetal membrane-derived mesemchynmal stem cells, and omental stem cells. The method for isolating bone marrow stromal cells is explained. Method for generating marmoset-induced pluripotent stem cells, using transcription factors, is also explained. Use of stem cell lines in therapeutic applications is discussed. Programming of stem cells is described. Methods for transplantation of stem cells are presented. Use of various types of stem cells for conditions such as stroke, ischemia, heart diseases, Alzhemier’s disease, and neurogenerative diseases in general, is explained. For example, generation of human cardiac muscle cells from adipose-derived stem cells is included. Another example is repairing bone defects using mesenchymal stem cells and mesenchymal-derived endothelial cells. Differentiation of new neurons from neural stem cells is described. Method for repairing retina condition using human embryonic stem cells is explained; these cells can induce neural differentiation. Treatment of graft-versus-host disease resulting from hematopoietic stem cell transplantation is elaborated.

Stem Cells and Cancer Stem Cells, Volume 12

Author : M.A. Hayat
Publisher : Springer Science & Business Media
ISBN 13 : 9401780323
Total Pages : 256 pages
Book Rating : 4.4/5 (17 download)

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Book Synopsis Stem Cells and Cancer Stem Cells, Volume 12 by : M.A. Hayat

Download or read book Stem Cells and Cancer Stem Cells, Volume 12 written by M.A. Hayat and published by Springer Science & Business Media. This book was released on 2014-02-20 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 12 in this series explores the latest experimental and clinical uses of stem cells in the treatment of disease and of injuries and reviews methods for isolating multipotent endothelial-like cells from human adipose tissue and discusses clinical applications in cell therapy and regenerative medicine. The book is organized in five parts: Cancer Stem Cells, Pluripotent Stem Cells, Dendritic Stem Cells, Regenerative Medicine and General Applications. The first section includes chapters on histamine in the neural and cancer stem cell niches and emerging concepts of stem cell organization in the normal lung and in lung cancer. The section on Pluripotent Stem Cells includes discussion of the differentiation of dendritic cells from human induced pluripotent stem cell and the molecular mechanisms involved in reprogramming human somatic cells to generate induced pluripotent stem cells. Additional chapters cover the differentiation of induced pluripotent stem cells into functional cardiomyocytes, characteristics of satellite cells and multipotent adult stem cells in the skeletal muscle. The section on Dendritic Stem Cells explores the critical role of notch signaling in the differentiation and function of dendrite. Other chapters cover hypertensive emergencies in children after stem cell transplantation and overcoming the radio resistance of lung cancer stem cells. The section on Regenerative Medicine reports on experiments on improved renal revascularization in pigs using stem cells and phenotypic correction of murine Hemophilia A using cell-based therapy. The concluding section, General Applications, discusses such topics as methods in mathematical modeling for stem cells, as well as molecular and functional characterization of human adipocytes. Like its eleven predecessors in the series, this volume stands out for its comprehensive approach, its roster of some 51 expert contributors representing a dozen different countries and its up-to-date review of leading-edge technology and methods.

Stem Cells Handbook

Author : Stewart Sell
Publisher : Springer Science & Business Media
ISBN 13 : 1461476968
Total Pages : 534 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Stem Cells Handbook by : Stewart Sell

Download or read book Stem Cells Handbook written by Stewart Sell and published by Springer Science & Business Media. This book was released on 2013-08-16 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses critical areas of progress in stem cell research, including the most recent research and applications of pluripotent embryonic cells, induced pluripotent cells, oligopotent tissue stem cells and cancer stem cells. The text covers basic knowledge of stem cell biology, stem cell ethics, development of techniques for applying stem cell therapy, the technology of obtaining appropriate cells for transplantation as well as the role of stem cells in cancer and how therapy may be directed to cancer stem cells. This new volume is essential reading for all scientists currently in the field or allied research areas, and those for those graduate students who envision a career in stem cells.

Stem Cells and Cancer Stem Cells, Volume 6

Author : M.A. Hayat
Publisher : Springer Science & Business Media
ISBN 13 : 9400729936
Total Pages : 445 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Stem Cells and Cancer Stem Cells, Volume 6 by : M.A. Hayat

Download or read book Stem Cells and Cancer Stem Cells, Volume 6 written by M.A. Hayat and published by Springer Science & Business Media. This book was released on 2012-02-27 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: The difference among pluripotent stem cells, multipotent stem cells, and unipotent stem cells is pointed out. Vast therapeutic applications of the following specific stem cells in disease and tissue injury are discussed: human embryonic stem cells, human mesenchymal stem cells, germ cell-derived pluripotent stem cells, induced pluripotent stem cells, human umbilical cord blood-derived stem cells, breast tumor stem cells,and hematopoietic stem cells. Because of the potential of human embryonic stem cells to produce unlimited quantities of any human cell type, considerable focus is placed on their therapeutic potential. Because of their pluripotency, these cells have been used in various applications such as tissue engineering, regenerative medicine, pharmacological and toxicological studies, and fundamental studies of cell differentiation. The formation of embryoid bodies, which are three-dimensional aggregates of embryonic stem cells, is explained as this is the first step in cell differentiation. Such embryoid body culture has been widely used as a trigger for the in vitro differentiation of embryonic stem cells. The basic capacity of self-renewal of human embryogenic stem cells is explained. The role of TGF-beta in the propagation of human embryonic stem cells is discussed. The differentiation of human embryonic stem cells into neurons, hepatocytes, cardiomyocytes, and retinal cells is fully explained. Donor policies for hematopoietic stem cells are also explained.

Stem Cells and Cancer Stem Cells, Volume 10

Author : M.A. Hayat
Publisher : Springer Science & Business Media
ISBN 13 : 9400762623
Total Pages : 298 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Stem Cells and Cancer Stem Cells, Volume 10 by : M.A. Hayat

Download or read book Stem Cells and Cancer Stem Cells, Volume 10 written by M.A. Hayat and published by Springer Science & Business Media. This book was released on 2013-03-20 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presenting contributions by 66 experts representing 13 countries, Volume 10 of the series Stem Cells and Cancer Stem Cells synthesizes current understanding of the causes, diagnosis, and therapy of major human diseases and debilitating tissue and organ injuries, using cell-based treatment. This volume presents contemporary research into generation, preservation, and uses of stem cells in fighting disease and tissue/organ injuries. The contents of the volume are organized into five sections. Mesenchymal Stem Cells section includes chapters on the use of stem cells in bone regeneration, studies and trials of stem cells in autoimmune diseases, and differences between adipose tissue-derived mesenchymal stem cells and bone marrow-derived mesenchymal stem cells as regulators of immune response. Induced Pluripotent Stem Cells section offers chapters on drug discovery using human IPSC-based disease models, and on generation of antigen-specific lymphocytes from IPSCs. Neural Cells and Neural Stem Cells section discusses use of bacterial artificial chromosomes in the genetic identification of stem cell-derived neural cell types, and use of moderate low temperature to preserve the stemness of neural stem cells. The section, Role of Stem Cells in Disease, discusses stem cell support in high-dose chemotherapy of Non-Hodgkin’s Lymphomas; potential targets for drug resistant leukemic stem cells, bone marrow stem cell therapies for diabetes mellitus. This section also discusses the use of stem cells in treating thyroid, breast and bone cancers, hempophilia and Parkinson’s Disease. The section, Stem Cell Transplantation, includes chapters on reducing fungal infection in allogenic stem cell transplantation patients, use of Bulsufan/Fludarabine for conditioning in haematopoietic stem cell transplantation, and interleukin-7 receptor alpha polymorphisms in allogeneic stem cell transplantation. The editor, M.A. Hayat, is a Distinguished Professor in the Department of Biological, Sciences at Kean University, Union, New Jersey, USA.

Stem Cells and Cancer Stem Cells, Volume 5

Author : M.A. Hayat
Publisher : Springer Science & Business Media
ISBN 13 : 9400729006
Total Pages : 309 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Stem Cells and Cancer Stem Cells, Volume 5 by : M.A. Hayat

Download or read book Stem Cells and Cancer Stem Cells, Volume 5 written by M.A. Hayat and published by Springer Science & Business Media. This book was released on 2012-02-21 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is pointed out that a cancer stem cell is a type within a tumor that possesses the capacity of self-renewal and can give rise to the heterogeneous lineages of cancer cells, which comprise the tumor. It is emphasized that a unique feature of cancer stem cells is that, although conventional chemotherapy kills most cells in a tumor, cancer stem cells remain intact. Vast applications of the following specific stem cells in disease and tissue injury are discussed: embryonic stem cells, human mesenchymal stem cells, cancer stem cells, arterial stem cells, neural stem cells, cardiac stem cells, dental stem cells, limbal stem cells, and hematopoietic stem cells. Because human embryonic stem cells possess the potential to produce unlimited quantities of any human cell type, considerable focus is placed on their therapeutic potential in this volume. These cells are used in tissue engineering, regenerative medicine, pharmacological and toxicological studies, and fundamental studies of cell differentiation. It is pointed out that the formation of embryoid bodies, which are three-dimensional aggregates of embryonic cells, is the initial step in the differentiation of these cells. Therapeutic implications of signalling pathways in cancer stem cells are pointed out. Targeting self-renewal pathways in cancer stem cells are also included. Application of mesenchymal stem cells for treating ischemic brain injury is explained. Neural stem cells proliferation into the surrounding area of the traumatic brain injury is explained.

Stem Cells and Cancer Stem Cells, Volume 8

Author : M.A. Hayat
Publisher : Springer Science & Business Media
ISBN 13 : 9400747985
Total Pages : 392 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Stem Cells and Cancer Stem Cells, Volume 8 by : M.A. Hayat

Download or read book Stem Cells and Cancer Stem Cells, Volume 8 written by M.A. Hayat and published by Springer Science & Business Media. This book was released on 2012-10-08 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is my hope that subsequent volumes of the series will join this volume in assisting in the more complete understanding of the causes, diagnosis, and cell-based treatment of major human diseases and debilitating tissue/organ injuries. There exists a tremendous, urgent demand by the public and the scientific community to address to cancer diagnosis, treatment, cure, and hopefully prevention. Stem Cells are nature’s indispensable gift to multicellular organisms, including humans. The contents of the volume are divided into six subheadings: Stem Cell Culture, Bone Marrow Stem Cells, Mesenchymal Stem Cells, Reprogramming and Differentiation of Stem Cells, Treatment, and Transplantation for the convenience of the readers.

Stem Cells

Author : C. Potten
Publisher : Elsevier
ISBN 13 : 9780080541761
Total Pages : 474 pages
Book Rating : 4.5/5 (417 download)

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Book Synopsis Stem Cells by : C. Potten

Download or read book Stem Cells written by C. Potten and published by Elsevier. This book was released on 1996-10-09 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem cells are relatively undifferentiated cells which are the permanent lineage ancestor cells of tissues. Newly developed molecular biological techniques and probes have made possible dramatic advances in our ability to study the lineage development of stem cells. A major impetus to develop these techniques has been to identify specific stem cells for gene therapy purposes. The role that stem cells play in the development of cancer is also an important area. This book provides up-to-date reviews on a wide variety of stem cell systems by world experts. Chapters range from descriptions of the current knowledge of the biology of stem cells, to current molecular biological approaches and clinical implications. Oncologists and cell biologists will find this book of particular interest. It will also be usefule to radiobiologist, biotechnologists, and gene therapists. Provides reviews of stem cell systems by world experts Covers stem cell biology in plants, invertebrates, and mammals Presents clinical implications of stem cell differentiation

Stem Cells and Cancer Stem Cells, Volume 11

Author : M.A. Hayat
Publisher : Springer Science & Business Media
ISBN 13 : 9400773293
Total Pages : 280 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Stem Cells and Cancer Stem Cells, Volume 11 by : M.A. Hayat

Download or read book Stem Cells and Cancer Stem Cells, Volume 11 written by M.A. Hayat and published by Springer Science & Business Media. This book was released on 2013-10-21 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 11 in this series discusses therapeutic applications of stem cells in disease and tissue injury. Coverage includes pluripotent stem cells, which can give rise to the endodermal, ectodermal, and mesodermal lineages; multipotent stem cells, which can generate all cells in a particular lineage and unipotent stem cells, which can give rise to only one cell type. This volume also examines cancer stem cells, tumor-initiating cells which possesses the capacity of self-renewal and can give rise to the heterogeneous lineages of cancer cells that comprise the tumor. Coverage extends to molecular mechanisms underlying the derivation and expansion of human embryonic stem cells, the role of specific proteins in the maintenance and inhibition of extraembryonic differentiation of these cells and the role of signaling responsible for the self-renewal of mouse embryonic stem cells. Nine chapters discuss the clinical importance of cancer stem cells, encompassing glioma, leukemia, ovarian cancer, pediatric sarcomas and head and neck squamous cell carcinoma. The role of cancer stem cells is also elucidated in epithelial-to-mesenchymal transition in spreading head and neck squamous cell carcinoma. The book goes on to survey therapeutic application of stem cells of hematopoietic and non-hematopoietic origin for regeneration of bones, including in osteoporotic bone disease; to illuminate the application of hematopoietic stem cells in bone regeneration and to discuss their use as a biomarker to facilitate determination of a treatment. The contributors review cells as biomarkers for pediatric solid tumors, and weigh the advantages and limitations of hematopoietic stem cell transplantation. Also included are details of neural stem cell engraftment in the injured spinal cord; the regenerative potential of neural stem/progenitor cells of newborns and cancer gene therapy potential using neural stem cells. Like the preceding volumes in the series, this book is distinguished for its comprehensive approach, its distinguished roster of 58 contributors representing 10 different countries and its thorough review of leading-edge technology and methods.