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Statistical And Computational Pharmacogenomics
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Book Synopsis Statistical and Computational Pharmacogenomics by : Rongling Wu
Download or read book Statistical and Computational Pharmacogenomics written by Rongling Wu and published by CRC Press. This book was released on 2008-08-08 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to the tremendous accumulation of data for genetic markers, pharmacogenomics, the study of the functions and interactions of all genes in the overall variability of drug response, is one of the hottest areas of research in biomedical science. Statistical and Computational Pharmacogenomics presents recent developments in statistical metho
Book Synopsis Statistical and Computational Pharmacogenomics by : Min Lin
Download or read book Statistical and Computational Pharmacogenomics written by Min Lin and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to the tremendous accumulation of data for genetic markers, pharmacogenetics, the study of inherited variation in drug response, is one of the hottest areas of research in biomedical science. "Statistical Methods for Pharmacogenetics" presents recent developments in statistical methodology with a number of detailed worked examples that outline how these methods can be applied. The book provides the necessary background on genetics and modeling as well as the tools needed to understand and model the genetic variation for drug response. Accessible and comprehensive, it equips statisticians with a thorough understanding of this complex field and how computational skills can be employed.
Book Synopsis Quantitative Methods for Precision Medicine by : Rongling Wu
Download or read book Quantitative Methods for Precision Medicine written by Rongling Wu and published by CRC Press. This book was released on 2022-12-26 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modern medicine is undergoing a paradigm shift from a "one-size-fits-all" strategy to a more precise patient-customized therapy and medication plan. While the success of precision medicine relies on the level of pharmacogenomic knowledge, dissecting the genetic mechanisms of drug response in a sufficient detail requires powerful computational tools. Quantitative Methods for Precision Medicine: Pharmacogenomics in Action presents the advanced statistical methods for mapping pharmacogenetic control by integrating pharmacokinetic and pharmacodynamic principles of drug-body interactions. Beyond traditional reductionist-based statistical genetic approaches, statistical formulization in this book synthesizes elements of multiple disciplines to infer, visualize, and track how pharmacogenes interact together as an intricate but well-coordinated system to mediate patient-specific drug response. Features: Functional and systems mapping models to characterize the genetic architecture of multiple medication processes Statistical methods for analyzing informative missing data in pharmacogenetic association studies Functional graph theory of inferring genetic interaction networks from association data Leveraging the concept of epistasis to capture its bidirectional, signed and weighted properties Modeling gene-induced cell-cell crosstalk and its impact on drug response A graph model of drug-drug interactions in combination therapies Critical methodological issues to improve pharmacogenomic research as the cornerstone of precision medicine This book is suitable for graduate students and researchers in the fields of biology, medicine, bioinformatics and drug design and delivery who are interested in statistical and computational modelling of biological processes and systems. It may also serve as a major reference for applied mathematicians, computer scientists, and statisticians who attempt to develop algorithmic tools for genetic mapping, systems pharmacogenomics and systems biology. It can be used as both a textbook and research reference. Professionals in pharmaceutical sectors who design drugs and clinical doctors who deliver drugs will also find it useful.
Book Synopsis Pacific Symposium on Biocomputing 2005 by : Russ Altman
Download or read book Pacific Symposium on Biocomputing 2005 written by Russ Altman and published by World Scientific. This book was released on 2005 with total page 572 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Pacific Symposium on Biocomputing (PSB 2005) is an international, multidisciplinary conference for the presentation and discussion of current research in the theory and application of computational methods in problems of biological significance. This latest volume in the prestigious conference series contains the contributions of top researchers from the US, the Asia-Pacific region and around the world. Sections are devoted to databases, algorithms, interfaces, visualization, modeling and other computational methods, as applied to biological problems, with emphasis on applications in data-rich areas of molecular biology. The book is an essential source of ideas, discoveries and references for academics in biocomputing, bioinformatics researchers and computer scientists.
Book Synopsis Biocomputing 2005 - Proceedings Of The Pacific Symposium by : Russ B Altman
Download or read book Biocomputing 2005 - Proceedings Of The Pacific Symposium written by Russ B Altman and published by World Scientific. This book was released on 2004-12-16 with total page 565 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Pacific Symposium on Biocomputing (PSB 2005) is an international, multidisciplinary conference for the presentation and discussion of current research in the theory and application of computational methods in problems of biological significance. This latest volume in the prestigious conference series contains the contributions of top researchers from the US, the Asia-Pacific region and around the world. Sections are devoted to databases, algorithms, interfaces, visualization, modeling and other computational methods, as applied to biological problems, with emphasis on applications in data-rich areas of molecular biology.The book is an essential source of ideas, discoveries and references for academics in biocomputing, bioinformatics researchers and computer scientists.The proceedings have been selected for coverage in:
Book Synopsis Biocomputing 2006 - Proceedings Of The Pacific Symposium by : A Keith Dunker
Download or read book Biocomputing 2006 - Proceedings Of The Pacific Symposium written by A Keith Dunker and published by World Scientific. This book was released on 2005-12-08 with total page 627 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Pacific Symposium on Biocomputing (PSB) 2006 is an international, multidisciplinary conference for the presentation and discussion of current research in the theory and application of computational methods in problems of biological significance. Presentations are rigorously peer reviewed and are published in an archival proceedings volume. PSB 2006 will be held January 3-7, 2006 at the Grand Wailea, Maui. Tutorials will be offered prior to the start of the conference.PSB 2006 will bring together top researchers from the US, the Asian Pacific nations, and around the world to exchange research results and address open issues in all aspects of computational biology. It is a forum for the presentation of work in databases, algorithms, interfaces, visualization, modeling, and other computational methods, as applied to biological problems, with emphasis on applications in data-rich areas of molecular biology.The PSB has been designed to be responsive to the need for critical mass in sub-disciplines within biocomputing. For that reason, it is the only meeting whose sessions are defined dynamically each year in response to specific proposals. PSB sessions are organized by leaders of research in biocomputing's “hot topics.” In this way, the meeting provides an early forum for serious examination of emerging methods and approaches in this rapidly changing field.
Book Synopsis Quantitative Methods for Precision Medicine by : Rongling Wu
Download or read book Quantitative Methods for Precision Medicine written by Rongling Wu and published by CRC Press. This book was released on 2022-12-26 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modern medicine is undergoing a paradigm shift from a "one-size-fits-all" strategy to a more precise patient-customized therapy and medication plan. While the success of precision medicine relies on the level of pharmacogenomic knowledge, dissecting the genetic mechanisms of drug response in a sufficient detail requires powerful computational tools. Quantitative Methods for Precision Medicine: Pharmacogenomics in Action presents the advanced statistical methods for mapping pharmacogenetic control by integrating pharmacokinetic and pharmacodynamic principles of drug-body interactions. Beyond traditional reductionist-based statistical genetic approaches, statistical formulization in this book synthesizes elements of multiple disciplines to infer, visualize, and track how pharmacogenes interact together as an intricate but well-coordinated system to mediate patient-specific drug response. Features: Functional and systems mapping models to characterize the genetic architecture of multiple medication processes Statistical methods for analyzing informative missing data in pharmacogenetic association studies Functional graph theory of inferring genetic interaction networks from association data Leveraging the concept of epistasis to capture its bidirectional, signed and weighted properties Modeling gene-induced cell-cell crosstalk and its impact on drug response A graph model of drug-drug interactions in combination therapies Critical methodological issues to improve pharmacogenomic research as the cornerstone of precision medicine This book is suitable for graduate students and researchers in the fields of biology, medicine, bioinformatics and drug design and delivery who are interested in statistical and computational modelling of biological processes and systems. It may also serve as a major reference for applied mathematicians, computer scientists, and statisticians who attempt to develop algorithmic tools for genetic mapping, systems pharmacogenomics and systems biology. It can be used as both a textbook and research reference. Professionals in pharmaceutical sectors who design drugs and clinical doctors who deliver drugs will also find it useful.
Book Synopsis Capture-Recapture Methods for the Social and Medical Sciences by : Dankmar Bohning
Download or read book Capture-Recapture Methods for the Social and Medical Sciences written by Dankmar Bohning and published by CRC Press. This book was released on 2017-07-28 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: Capture-recapture methods have been used in biology and ecology for more than 100 years. However, it is only recently that these methods have become popular in the social and medical sciences to estimate the size of elusive populations such as illegal immigrants, illicit drug users, or people with a drinking problem. Capture-Recapture Methods for the Social and Medical Sciences brings together important developments which allow the application of these methods. It has contributions from more than 40 researchers, and is divided into eight parts, including topics such as ratio regression models, capture-recapture meta-analysis, extensions of single and multiple source models, latent variable models and Bayesian approaches. The book is suitable for everyone who is interested in applying capture-recapture methods in the social and medical sciences. Furthermore, it is also of interest to those working with capture-recapture methods in biology and ecology, as there are some important developments covered in the book that also apply to these classical application areas.
Book Synopsis Bayesian Disease Mapping by : Andrew B. Lawson
Download or read book Bayesian Disease Mapping written by Andrew B. Lawson and published by CRC Press. This book was released on 2013-03-18 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the publication of the first edition, many new Bayesian tools and methods have been developed for space-time data analysis, the predictive modeling of health outcomes, and other spatial biostatistical areas. Exploring these new developments, Bayesian Disease Mapping: Hierarchical Modeling in Spatial Epidemiology, Second Edition provides an up-to-date, cohesive account of the full range of Bayesian disease mapping methods and applications. A biostatistics professor and WHO advisor, the author illustrates the use of Bayesian hierarchical modeling in the geographical analysis of disease through a range of real-world datasets. New to the Second Edition Three new chapters on regression and ecological analysis, putative hazard modeling, and disease map surveillance Expanded material on case event modeling and spatiotemporal analysis New and updated examples Two new appendices featuring examples of integrated nested Laplace approximation (INLA) and conditional autoregressive (CAR) models In addition to these new topics, the book covers more conventional areas such as relative risk estimation, clustering, spatial survival analysis, and longitudinal analysis. After an introduction to Bayesian inference, computation, and model assessment, the text focuses on important themes, including disease map reconstruction, cluster detection, regression and ecological analysis, putative hazard modeling, analysis of multiple scales and multiple diseases, spatial survival and longitudinal studies, spatiotemporal methods, and map surveillance. It shows how Bayesian disease mapping can yield significant insights into georeferenced health data. WinBUGS and R are used throughout for data manipulation and simulation.
Book Synopsis Clinical Trials in Oncology by : Stephanie Green
Download or read book Clinical Trials in Oncology written by Stephanie Green and published by CRC Press. This book was released on 2012-05-09 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new edition of the bestselling Clinical Trials in Oncology provides a concise, nontechnical, and now thoroughly up-to-date review of methods and issues related to clinical trials. The authors emphasize the importance of proper study design, analysis, and data management and identify the pitfalls inherent in these processes. This edition includes a new section covering innovations in Phase I designs and another on overcoming the challenges of array data. As always, the authors use clear, lucid prose and a multitude of real-world trials as examples to convey the principles of successful trials without the need for a strong statistics or mathematics background.
Book Synopsis Age-Period-Cohort Analysis by : Yang Yang
Download or read book Age-Period-Cohort Analysis written by Yang Yang and published by CRC Press. This book was released on 2016-04-19 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores the ways in which statistical models, methods, and research designs can be used to open new possibilities for APC analysis. Within a single, consistent HAPC-GLMM statistical modeling framework, the authors synthesize APC models and methods for three research designs: age-by-time period tables of population rates or proportions, repeated cross-section sample surveys, and accelerated longitudinal panel studies. They show how the empirical application of the models to various problems leads to many fascinating findings on how outcome variables develop along the age, period, and cohort dimensions.
Book Synopsis Analysis of Capture-Recapture Data by : Rachel S. McCrea
Download or read book Analysis of Capture-Recapture Data written by Rachel S. McCrea and published by CRC Press. This book was released on 2014-08-01 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: An important first step in studying the demography of wild animals is to identify the animals uniquely through applying markings, such as rings, tags, and bands. Once the animals are encountered again, researchers can study different forms of capture-recapture data to estimate features, such as the mortality and size of the populations. Capture-recapture methods are also used in other areas, including epidemiology and sociology. With an emphasis on ecology, Analysis of Capture-Recapture Data covers many modern developments of capture-recapture and related models and methods and places them in the historical context of research from the past 100 years. The book presents both classical and Bayesian methods. A range of real data sets motivates and illustrates the material and many examples illustrate biometry and applied statistics at work. In particular, the authors demonstrate several of the modeling approaches using one substantial data set from a population of great cormorants. The book also discusses which computer programs to use for implementing the models and contains 130 exercises that extend the main material. The data sets, computer programs, and other ancillaries are available at www.capturerecapture.co.uk. The book is accessible to advanced undergraduate and higher-level students, quantitative ecologists, and statisticians. It helps readers understand model formulation and applications, including the technicalities of model diagnostics and checking.
Book Synopsis Time Series Modeling of Neuroscience Data by : Tohru Ozaki
Download or read book Time Series Modeling of Neuroscience Data written by Tohru Ozaki and published by CRC Press. This book was released on 2012-01-26 with total page 561 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent advances in brain science measurement technology have given researchers access to very large-scale time series data such as EEG/MEG data (20 to 100 dimensional) and fMRI (140,000 dimensional) data. To analyze such massive data, efficient computational and statistical methods are required.Time Series Modeling of Neuroscience Data shows how to
Book Synopsis Flexible Imputation of Missing Data by : Stef van Buuren
Download or read book Flexible Imputation of Missing Data written by Stef van Buuren and published by CRC Press. This book was released on 2012-03-29 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: Missing data form a problem in every scientific discipline, yet the techniques required to handle them are complicated and often lacking. One of the great ideas in statistical science—multiple imputation—fills gaps in the data with plausible values, the uncertainty of which is coded in the data itself. It also solves other problems, many of which are missing data problems in disguise. Flexible Imputation of Missing Data is supported by many examples using real data taken from the author's vast experience of collaborative research, and presents a practical guide for handling missing data under the framework of multiple imputation. Furthermore, detailed guidance of implementation in R using the author’s package MICE is included throughout the book. Assuming familiarity with basic statistical concepts and multivariate methods, Flexible Imputation of Missing Data is intended for two audiences: (Bio)statisticians, epidemiologists, and methodologists in the social and health sciences Substantive researchers who do not call themselves statisticians, but who possess the necessary skills to understand the principles and to follow the recipes This graduate-tested book avoids mathematical and technical details as much as possible: formulas are accompanied by a verbal statement that explains the formula in layperson terms. Readers less concerned with the theoretical underpinnings will be able to pick up the general idea, and technical material is available for those who desire deeper understanding. The analyses can be replicated in R using a dedicated package developed by the author.
Book Synopsis Survival Analysis with Interval-Censored Data by : Kris Bogaerts
Download or read book Survival Analysis with Interval-Censored Data written by Kris Bogaerts and published by CRC Press. This book was released on 2017-11-20 with total page 617 pages. Available in PDF, EPUB and Kindle. Book excerpt: Survival Analysis with Interval-Censored Data: A Practical Approach with Examples in R, SAS, and BUGS provides the reader with a practical introduction into the analysis of interval-censored survival times. Although many theoretical developments have appeared in the last fifty years, interval censoring is often ignored in practice. Many are unaware of the impact of inappropriately dealing with interval censoring. In addition, the necessary software is at times difficult to trace. This book fills in the gap between theory and practice. Features: -Provides an overview of frequentist as well as Bayesian methods. -Include a focus on practical aspects and applications. -Extensively illustrates the methods with examples using R, SAS, and BUGS. Full programs are available on a supplementary website. The authors: Kris Bogaerts is project manager at I-BioStat, KU Leuven. He received his PhD in science (statistics) at KU Leuven on the analysis of interval-censored data. He has gained expertise in a great variety of statistical topics with a focus on the design and analysis of clinical trials. Arnošt Komárek is associate professor of statistics at Charles University, Prague. His subject area of expertise covers mainly survival analysis with the emphasis on interval-censored data and classification based on longitudinal data. He is past chair of the Statistical Modelling Society and editor of Statistical Modelling: An International Journal. Emmanuel Lesaffre is professor of biostatistics at I-BioStat, KU Leuven. His research interests include Bayesian methods, longitudinal data analysis, statistical modelling, analysis of dental data, interval-censored data, misclassification issues, and clinical trials. He is the founding chair of the Statistical Modelling Society, past-president of the International Society for Clinical Biostatistics, and fellow of ISI and ASA.
Book Synopsis Missing Data Analysis in Practice by : Trivellore Raghunathan
Download or read book Missing Data Analysis in Practice written by Trivellore Raghunathan and published by CRC Press. This book was released on 2015-10-28 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt: Missing Data Analysis in Practice provides practical methods for analyzing missing data along with the heuristic reasoning for understanding the theoretical underpinnings. Drawing on his 25 years of experience researching, teaching, and consulting in quantitative areas, the author presents both frequentist and Bayesian perspectives. He describes ea
Book Synopsis Modern Directional Statistics by : Christophe Ley
Download or read book Modern Directional Statistics written by Christophe Ley and published by CRC Press. This book was released on 2017-08-03 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modern Directional Statistics collects important advances in methodology and theory for directional statistics over the last two decades. It provides a detailed overview and analysis of recent results that can help both researchers and practitioners. Knowledge of multivariate statistics eases the reading but is not mandatory. The field of directional statistics has received a lot of attention over the past two decades, due to new demands from domains such as life sciences or machine learning, to the availability of massive data sets requiring adapted statistical techniques, and to technological advances. This book covers important progresses in distribution theory,high-dimensional statistics, kernel density estimation, efficient inference on directional supports, and computational and graphical methods. Christophe Ley is professor of mathematical statistics at Ghent University. His research interests include semi-parametrically efficient inference, flexible modeling, directional statistics and the study of asymptotic approximations via Stein’s Method. His achievements include the Marie-Jeanne Laurent-Duhamel prize of the Société Française de Statistique and an elected membership at the International Statistical Institute. He is associate editor for the journals Computational Statistics & Data Analysis and Econometrics and Statistics. Thomas Verdebout is professor of mathematical statistics at Université libre de Bruxelles (ULB). His main research interests are semi-parametric statistics, high- dimensional statistics, directional statistics and rank-based procedures. He has won an annual prize of the Belgian Academy of Sciences and is an elected member of the International Statistical Institute. He is associate editor for the journals Statistics and Probability Letters and Journal of Multivariate Analysis.
