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Author : Yusuf A. Hannun
Publisher : Landes Bioscience
ISBN 13 : 9781570594366
Total Pages : 188 pages
Book Rating : 4.5/5 (943 download)
Download or read book Sphingolipid-mediated Signal Transduction written by Yusuf A. Hannun and published by Landes Bioscience. This book was released on 1997 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Yusuf A. Hannun
Publisher : Springer Science & Business Media
ISBN 13 : 3662224259
Total Pages : 346 pages
Book Rating : 4.6/5 (622 download)
Download or read book Sphingolipid-Mediated Signal Transduction written by Yusuf A. Hannun and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lipid-derived molecules are increasingly appreciated as key regulators of cell responses and signal transduction. Sphingolipid-derived bioactive molecules are emerging as critical regulators of some of the most exciting and, until recently, poorly-understood areas of biology such as growth suppression, programmed cell death and tumor invasion. Written by leading investigators in these areas of study, this book presents a thorough, current and accessible review of how sphingolipids function to regulate these important activities.
Author : Charles Chalfant
Publisher : Springer Science & Business Media
ISBN 13 : 1441967419
Total Pages : 311 pages
Book Rating : 4.4/5 (419 download)
Download or read book Sphingolipids as Signaling and Regulatory Molecules written by Charles Chalfant and published by Springer Science & Business Media. This book was released on 2011-01-12 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book attempts to analyze the latest discoveries in sphingolipid biology and how the alteration of their metabolism leads to altered signaling events and to the development of pathobiological disorders, such as cancer, cardiovascular diseases, asthma, diabetes, inflammation and infectious diseases.
Author : Alfred H. Merrill
Publisher : Academic Press
ISBN 13 : 0121822125
Total Pages : 787 pages
Book Rating : 4.1/5 (218 download)
Download or read book Sphingolipid Metabolism and Cell Signaling written by Alfred H. Merrill and published by Academic Press. This book was released on 2000 with total page 787 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sphingolipids are found in all eukaryotic and in some prokaryotic organisms and provide structure for cell membranes, lipoproteins, and other biological materials as well as participate in the regulation of cell growth, differentiation, and diverse cell functions, including cell-cell communication, cell-substratum interactions, and intracellular signal transduction. This volume presents methods used in studying enzymes of sphingolipid biosynthesis and turnover, including inhibitors of some of these enzymes, genetic approaches, and organic and enzymatic syntheses of sphingolipids and analogs. Its companion Volume 312 will contain information on analyzing sphingolipids, sphingolipid transport and trafficking, and sphingolipid-protein interactions and cellular targets. The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.
Author :
Publisher : Elsevier
ISBN 13 : 0080496687
Total Pages : 786 pages
Book Rating : 4.0/5 (84 download)
Download or read book Sphingolipid Metabolism and Cell Signaling, Part A written by and published by Elsevier. This book was released on 1999-11-01 with total page 786 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sphingolipids are found in all eukaryotic and in some prokaryotic organisms and provide structure for cell membranes, lipoproteins, and other biological materials as well as participate in the regulation of cell growth, differentiation, and diverse cell functions, including cell-cell communication, cell-substratum interactions, and intracellular signal transduction. This volume presents methods used in studying enzymes of sphingolipid biosynthesis and turnover, including inhibitors of some of these enzymes, genetic approaches, and organic and enzymatic syntheses of sphingolipids and analogs. Its companion Volume 312 will contain information on analyzing sphingolipids, sphingolipid transport and trafficking, and sphingolipid-protein interactions and cellular targets.The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.
Author :
Publisher : Elsevier
ISBN 13 : 0080496695
Total Pages : 687 pages
Book Rating : 4.0/5 (84 download)
Download or read book Sphingolipid Metabolism and Cell Signaling, Part B written by and published by Elsevier. This book was released on 2000-10-25 with total page 687 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains information on analyzing sphingolipids, sphingolipid transport and trafficking, and sphingolipid-protein interactions and cellular targets. Its companion Volume 311 presents methods used in studying enzymes of sphingolipid biosynthesis and turnover, including inhibitors of some of these enzymes, genetic approaches, and organic and enzymatic syntheses of sphingolipids and analogs. The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.
Author : Daniel G.S. Capelluto
Publisher : Springer Science & Business Media
ISBN 13 : 940076331X
Total Pages : 227 pages
Book Rating : 4.4/5 (7 download)
Download or read book Lipid-mediated Protein Signaling written by Daniel G.S. Capelluto and published by Springer Science & Business Media. This book was released on 2013-06-17 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the most updated information of how membrane lipids mediate protein signaling from studies carried out in animal and plant cells. Also, there are some chapters that go beyond and expand these studies of protein-lipid interactions at the structural level. The book begins with a literature review from investigations associated to sphingolipids, followed by studies that describe the role of phosphoinositides in signaling and closing with the function of other key lipids in signaling at the plasma membrane and intracellular organelles.
Author : Alfred H. Merrill
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (873 download)
Download or read book Sphingolipid Metabolism and Cell Signaling written by Alfred H. Merrill and published by . This book was released on 2000 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Eric J. Murphy
Publisher : CRC Press
ISBN 13 : 0849381428
Total Pages : 454 pages
Book Rating : 4.8/5 (493 download)
Download or read book Lipid-Mediated Signaling written by Eric J. Murphy and published by CRC Press. This book was released on 2010-03-05 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: As the highly anticipated update to Lipid Second Messengers (CRC Press, 1999), Lipid-Mediating Signaling is a current and comprehensive overview of research methods used in lipid-mediated signal transduction. Pioneering experts provide a much-needed distillation of a decade's worth of advances in research techniques that are pertinent in understand
Author : Anthony H. Futerman
Publisher : Springer Science & Business Media
ISBN 13 : 9780306474422
Total Pages : 198 pages
Book Rating : 4.4/5 (744 download)
Download or read book Ceramide Signaling written by Anthony H. Futerman and published by Springer Science & Business Media. This book was released on 2002 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: The volume assembles current information on the role of ceramide as a signalling molecule in 16 chapters written by leading workers in this area. Specific attention is given to mechanisms of analysis of ceramide and its biophysical properties, on enzymes of ceramide metabolism and down-stream targets of ceramide, on the cross-talk of ceramide signalling with other signalling pathways, and on the role of ceramide in neuronal signalling. Finally, the book closes with a section on the therapeutic implications of ceramide action, in the areas of cannabinoid action, chemotherapy, and atherosclerosis, and illustrates the potential medical significance of delineating the roles of ceramide in cell signalling. This is the first volume specifically devoted to ceramide signalling, and will act as an invaluable resource for basic and medical researchers and graduate students wishing to get a state of the art overview of this rapidly moving field.
Author : Y. Hirabayashi
Publisher : Springer
ISBN 13 : 9784431800460
Total Pages : 531 pages
Book Rating : 4.8/5 (4 download)
Download or read book Sphingolipid Biology written by Y. Hirabayashi and published by Springer. This book was released on 2009-09-03 with total page 531 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sphingolipids are fundamental to the structures of cell membranes, lipoproteins, and the stratum cornea of the skin. Many complex sphingolipids, as well as simpler sphingoid bases and derivatives, are highly bioactive as extra- and intracellular regulators of growth, differentiation, migration, survival, senescence, and numerous cellular responses to stress. This book reviews exciting new developments in sphingolipid biology/sphingolipidology that challenge our understanding of how multicellular organisms grow, develop, function, age, and die.
Author : Deron Raymond Herr
Publisher :
ISBN 13 :
Total Pages : 382 pages
Book Rating : 4.:/5 (318 download)
Download or read book Progress in Understanding the Roles of Sphingolipids in Animal Development written by Deron Raymond Herr and published by . This book was released on 2004 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: The study of the various cellular responses to sphingolipid metabolites has only recently become the subject of widespread interest. These responses are numerous and diverse which suggests important roles of these molecules during development. With few exceptions, most of the knowledge of their mechanisms has been derived from cell culture experiments that lack an appropriate organismal context to understand how these events translate into responses of intact tissues. The purpose of this dissertation is to develop an adequately tractable model system (Drosophila melanogaster) that can be used to manipulate sphingolipid metabolism in a developmentally relevant context. This initial work began by identifying and characterizing a number of Drosophila genes encoding enzymes in this metabolic pathway: sphingosine 1-phosphate lyase (Sply), sphingosine kinase 1 (Sk1), and sphingosine kinase 2 (Sk2). Analysis of Sply and Sk2 mutants revealed gross alterations of sphingolipid content and demonstrated that sphingolipid metabolites are involved in the development and maintenance of muscle and reproductive tissue. Furthermore, gene expression analysis demonstrates that altering sphingolipid content affects the integrity of a number of signal transduction pathways including Notch, Wingless, Hedgehog, and sterol regulatory element binding protein (SREBP). This work also led to the observation that chromosomal location is sufficient to favor coordinate transcriptional regulation of gene pairs, raising the possibility that these genes participate in common cellular functions. This dissertation describes the initiation of an ongoing project to establish the first model system in which sphingolipid metabolism may be precisely manipulated to strategically alter concentrations of individual sphingolipid metabolites in vivo.
Author : Erich Gulbins
Publisher : Springer Science & Business Media
ISBN 13 : 3709115116
Total Pages : 474 pages
Book Rating : 4.7/5 (91 download)
Download or read book Sphingolipids in Disease written by Erich Gulbins and published by Springer Science & Business Media. This book was released on 2013-04-06 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sphingolipids are lipid components of the plasma membrane of eukaryotic cells with an important function in signaling mechanisms in the cell. This book provides insight into the physiological and pathophysiological role of sphingolipids and in particular its derivative ceramide. The function of Sphingolipids in cell signaling with regard to infectious and lung diseases, cancer, cardiovascular diseases and neuropsychiatric disorders are described and treated in distinct parts. Together with Volume 215 from the same Editors, the collection represents a unique, comprehensive work on Sphingolipids, providing information on both: Sphingolipid basic biology as well as its important function in a (patho)physiological context. The book is written for scientists in pharmacology, biochemistry and cell biology with a focus on biomedical research as well as for clinicians in pharmacology, oncology, cardiology, neurology and infectious disease.
Author : Johnny Stiban
Publisher : Springer Nature
ISBN 13 : 3030211622
Total Pages : 153 pages
Book Rating : 4.0/5 (32 download)
Download or read book Bioactive Ceramides in Health and Disease written by Johnny Stiban and published by Springer Nature. This book was released on 2019-09-09 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is about the various roles of bioactive ceramides and other sphingolipids in cellular biology. The enigmatic biophysical and biochemical properties of ceramides and their propensity to influence membranes whether as rafts or protein-permeable channels are heavily discussed. Metabolism of ceramides and their metabolites is also focused with ceramide synthase family of proteins being a target of extensive review. Ceramide 1-phosphate and other sphingolipids are also presented in cellular physiology and pathophysiology. Prokaryotic origins of mitochondria at the level of membranes and the occurrence of apoptosis in bacteria are presented. Many aspects of ceramide and sphingolipid biology are addressed in this book. Its focus is the metabolism of ceramide in normal and diseased states and the biophysical and biochemical mechanisms governing the bioactivity of these molecules. Sphingolipid research has surged over the past thirty years and this book gathers the recent findings of various aspects of sphingolipid biochemistry. World-renowned scientists from the field of lipid biology, specifically sphingolipid biochemistry, were gathered to write this book. Scholars from most continents of the globe committed to write diligently about their expertise and the newest findings in the relevant fields. This book came to fruition after almost a year and a half of laborious preparation and diligent writings. This book is targeted to the experienced reader who is looking to read about the various aspects of bioactive ceramide signaling, as well as to the newcomer into the field, as the topics are explained in concise yet very informative manner. The authors and editor wish all readers a pleasant time reading this volume, and are adamant that this book will meet all expectations.
Author : Peter J. Quinn
Publisher : Springer Science & Business Media
ISBN 13 : 9780306484254
Total Pages : 528 pages
Book Rating : 4.4/5 (842 download)
Download or read book Membrane Dynamics and Domains written by Peter J. Quinn and published by Springer Science & Business Media. This book was released on 2004-07-02 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fluid-mosaic model of membrane structure formulated by Singer and Nicolson in the early 1970s has proven to be a durable concept in terms of the principles governing the organization of the constituent lipids and proteins. During the past 30 or so years a great deal of information has accumulated on the composition of various cell membranes and how this is related to the dif ferent functions that membranes perform. Nevertheless, the task of explaining particular functions at the molecular level has been hampered by lack of struc tural detail at the atomic level. The reason for this is primarily the difficulty of crystallizing membrane proteins which require strategies that differ from those used to crystallize soluble proteins. The unique exception is bacteriorhodopsin of the purple membrane of Halobacterium halobium which is interpolated into a membrane that is neither fluid nor in a mosaic configuration. To date only 50 or so membrane proteins have been characterised to atomic resolution by diffraction methods, in contrast to the vast data accumulated on soluble proteins. Another factor that has been difficult to explain is the reason why the lipid compliment of membranes is often extremely complex. Many hundreds of different molecular species of lipid can be identified in some membranes. Remarkably, the particular composition of each membrane appears to be main tained within relatively narrow limits and its identity distinguished from other morphologically-distinct membranes.
Author : Y. Hirabayashi
Publisher : Springer Science & Business Media
ISBN 13 : 4431342001
Total Pages : 528 pages
Book Rating : 4.4/5 (313 download)
Download or read book Sphingolipid Biology written by Y. Hirabayashi and published by Springer Science & Business Media. This book was released on 2007-12-31 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sphingolipids are fundamental to the structures of cell membranes, lipoproteins, and the stratum cornea of the skin. Many complex sphingolipids, as well as simpler sphingoid bases and derivatives, are highly bioactive as extra- and intracellular regulators of growth, differentiation, migration, survival, senescence, and numerous cellular responses to stress. This book reviews exciting new developments in sphingolipid biology/sphingolipidology that challenge our understanding of how multicellular organisms grow, develop, function, age, and die.
Author : Amy Lynn Cavalli
Publisher :
ISBN 13 :
Total Pages : 274 pages
Book Rating : 4.:/5 (318 download)
Download or read book Characterization of Sphingolipid Receptors in Cardiomyocytes written by Amy Lynn Cavalli and published by . This book was released on 2002 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt:
