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Skeletal Muscle Ischemia And Heat Shock Proteins
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Book Synopsis Skeletal Muscle Ischemia and Heat Shock Proteins by :
Download or read book Skeletal Muscle Ischemia and Heat Shock Proteins written by and published by . This book was released on 1994 with total page 9 pages. Available in PDF, EPUB and Kindle. Book excerpt: This research effort is directed at subobjective 2 as defined in the recent shock trauma mediators review memo from the U.S. Army Institute of Surgical Research. Specifically, we aimed at the prevention of secondary damage after hemorrhage by temporizing fundamental physiological or biochemical processes leading to cell death and organ failure. For this purpose, increased expression of the inducible heat shock 70 (hsp70I) will be employed. Hsp7OI works as a chaperone attaching to short hydrophobic peptide sequences as they are exposed in ischemic cells in which proteins undergo denaturation. By the association of hsp70 with such protein sequences further protein aggregation and cell damage is prevented. This leads to a faster recovery of cell function after the ischemic or hemorrhage episodes. Our results which are further summarized in the body indicate that overexpression of hsp70 in the heart of transgenic mice leads to marked protection against cardiac ischemic injury (1). In preliminary studies in collaboration with Dr. P. Lyden, UCSD and Dr. B. Nishimura, UCLA, we have found that the hsp70 transgene is also expressed in CNS-neurons and exerts a protective effect against ischemic damage in the brain as judged by behavioral scores in these transgenic mice.
Book Synopsis Effect of Aerobic Exercise and the Induced Increase in Heat Shock Proteins on Recovery of Skeletal Muscle Function After Ischemia/reperfusion Injury by : Edward Kelly Merritt
Download or read book Effect of Aerobic Exercise and the Induced Increase in Heat Shock Proteins on Recovery of Skeletal Muscle Function After Ischemia/reperfusion Injury written by Edward Kelly Merritt and published by . This book was released on 2004 with total page 86 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this study was to determine the effect of exercise training on the recovery of skeletal muscle function following ischemia reperfusion injury. Three groups of animals underwent 6 weeks of aerobic training to increase heat shock protein content of skeletal muscle. After training, 2 groups were subjected to a 2-hour ischemic bout induced by pneumatic tourniquet (TK). In one group 7 days following TK application in vivo force was measured in a method similar to Ashton-Miller (1992). Another group recovered 14 days before in vivo force was measured. Force of the TK leg vs. contralateral leg measured 7 and 14 days following TK application was 29.6 +/- 2.3% and 55.0 +/- 3.3% respectively. Non-exercised control rat’s TK leg force production was 22.0 +/- 2.9% and 53.1 +/-5.2% when compared to the contralateral leg. These data suggest that exercise training prior to I/R allows for greater maximal force production 7 days following TK application
Author :Alexzander A. A. Asea Publisher :Springer Science & Business Media ISBN 13 :9048133815 Total Pages :431 pages Book Rating :4.0/5 (481 download)
Book Synopsis Heat Shock Proteins and Whole Body Physiology by : Alexzander A. A. Asea
Download or read book Heat Shock Proteins and Whole Body Physiology written by Alexzander A. A. Asea and published by Springer Science & Business Media. This book was released on 2009-12-10 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heat Shock Proteins and Whole Body Physiology is an exciting new book in the Heat Shock Proteins series which provides the most up-to-date review on novel mechanisms insights into the important role played by heat shock proteins in human physiology. Written by leaders in the field of heat shock protein exercise physiology, neuroscience and aging, the chapters systematically and in a step wise fashion takes the reader through the fascinating mechanisms by which heat shock proteins modulate human disease and pathophysiology and provides answers as to its biological significance to the host. Section I, introduces the readers to the role played by heat shock proteins in various diseases and disorders (Heat Shock Proteins and Disease). Section II, addresses the role heat shock proteins play in psychological disorders including post traumatic stress disorders and learning (Heat Shock Proteins and Psychological Stress). Section III, present a detailed review of the role played by heat shock proteins in exercise physiology (Heat Shock Proteins and Exercise Physiology). This book is a must read for heat shock protein researchers, graduate and postgraduate fellows in the field of Medicine in general and specialities in Excersie Physiology, Neuroscience, Immunology, Aging and Pathology.
Book Synopsis Time course of the fall of heat-shock protein 72 in cardiac and skeletal muscle by : Daniel Joseph Olson
Download or read book Time course of the fall of heat-shock protein 72 in cardiac and skeletal muscle written by Daniel Joseph Olson and published by . This book was released on 2001 with total page 56 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Role of Heat Shock Proteins in Skeletal Muscle by : Thiago Gomes Heck
Download or read book Role of Heat Shock Proteins in Skeletal Muscle written by Thiago Gomes Heck and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Role of Heat Shock Proteins in Skeletal Muscle.
Book Synopsis The Chaperonopathies by : Alberto J.L. Macario
Download or read book The Chaperonopathies written by Alberto J.L. Macario and published by Springer Science & Business Media. This book was released on 2013-04-10 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Brief provides a concise review of chaperonopathies, i.e., diseases in which molecular chaperones play an etiologic-pathogenic role. Introductory chapters deal with the chaperoning system and chaperoning teams and networks, HSP-chaperone subpopulations, the locations and functions of chaperones, and chaperone genes in humans. Other chapters present the chaperonopathies in general, including their molecular features and mechanistic classification into by defect, excess, or mistake. Subsequent chapters discuss the chaperonopathies in more detail, focusing on their distinctive characteristics: primary or secondary; quantitative and/or qualitative; structural and hereditary or acquired; genetic polymorphisms; gene dysregulation; age-related; associated with cancer, chronic inflammatory conditions, and autoimmune diseases. The interconnections between the chaperoning and the immune systems in cancer development, chronic inflammation, autoimmunity, and ageing are outlined, which leads to a discussion on the future prospects of chaperonotherapy. The latter may consist of chaperone gene and protein replacement/supplementation in cases of deficiency and of gene or protein blocking when the chaperone actively promotes disease. The last chapter presents the extracellular chaperones and details on how the chaperone Hsp60 is secreted into the extracellular space and, thus, appears in the blood of cancer patients with potential to participate in carcinogenesis and chronic inflammation and autoimmunity. Chaperones as clinically useful biomarkers are mentioned when pertinent. Likewise, guidelines for clinical evaluation of chaperonopathies and for their histopathological and molecular identification are provided throughout. The book also provides extensive bibliography organized by chapter and topic with comments.
Book Synopsis Role of Heat Shock Proteins in Skeletal Muscle by : Thiago Gomes Heck
Download or read book Role of Heat Shock Proteins in Skeletal Muscle written by Thiago Gomes Heck and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Regulation of Heat Shock Protein Responses by : Alexzander A A Asea
Download or read book Regulation of Heat Shock Protein Responses written by Alexzander A A Asea and published by Springer. This book was released on 2018-05-01 with total page 471 pages. Available in PDF, EPUB and Kindle. Book excerpt: This books provides the most up-to-date reviews on current advances in our understanding of the regulation of heat shock protein responses. Key basic scientists and clinical research laboratories from major universities, academic medical centers and pharmaceutical companies around the world have contributed chapters that review present research activity and importantly project this field into the future. For easy readability, the book is sub divided into four sections, including, Section I - HSP and Stress Responses; Section II - Chaperone Functions of HSP; Section III - HSP in Human Diseases; Section IV - Prognosis & Diagnosis of HSP. The book is a must read for researchers involved in biomedical research, drug discovery and design to improve human health.
Book Synopsis Biochemical & Physiological Studies of Heat Shock Proteins in Skeletal Muscle by : Noni Tegan Larkins
Download or read book Biochemical & Physiological Studies of Heat Shock Proteins in Skeletal Muscle written by Noni Tegan Larkins and published by . This book was released on 2011 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Heat Shock Protein (HSP70) Expression in Cardiac and Skeletal Muscle from Mice with an Inherited Capacity for Hypoxic Exercise by : Martyn Knowles
Download or read book Heat Shock Protein (HSP70) Expression in Cardiac and Skeletal Muscle from Mice with an Inherited Capacity for Hypoxic Exercise written by Martyn Knowles and published by . This book was released on 2003 with total page 50 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis A Comparison of Heat Shock Protein Expression in Rat Skeletal Muscle After Lengthening Or Shortening Contractions by : Andrew Holwerda
Download or read book A Comparison of Heat Shock Protein Expression in Rat Skeletal Muscle After Lengthening Or Shortening Contractions written by Andrew Holwerda and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Role of Heat Shock Proteins in Skeletal Muscle Adaptation to Resistance Training in Young and Old Rats by :
Download or read book The Role of Heat Shock Proteins in Skeletal Muscle Adaptation to Resistance Training in Young and Old Rats written by and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Heat Shock Protein 60 in Human Diseases and Disorders by : Alexzander A. A. Asea
Download or read book Heat Shock Protein 60 in Human Diseases and Disorders written by Alexzander A. A. Asea and published by Springer Nature. This book was released on 2019-10-31 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book Heat Shock Protein 60 in Human Diseases and Disorders provides the most comprehensive review on contemporary knowledge on the role of HSP60 in human diseases and disorders. Using an integrative approach, the contributors provide a synopsis of novel mechanisms and signal transduction pathways. To enhance the ease of reading and comprehension the book has further been subdivided into various section including; Section I: Biomolecular Aspects of HSP60; Section II: HSP60 and Cancer; Section III: HSP60 and Inflammatory Diseases and Disorders; Section IV: HSP60 and Cardiovascular Diseases and Disorders; Section V: HSP60 and Neurological and Neurosciences; Section VI: Biomolecular Aspects of HSP60; Section VII: HSP60 and Skeletal Muscle Diseases and Disorders; and Section VIII: HSP60 in Human Health. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Neurology & Neuroscience, Oncology, Cardiovascular Disease, Skeletal Muscle Diseases and Disorders, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.
Book Synopsis Heat Shock Proteins and Cytoprotection by : Alexander E. Kabakov
Download or read book Heat Shock Proteins and Cytoprotection written by Alexander E. Kabakov and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Disorders of Voluntary Muscle by : George Karpati
Download or read book Disorders of Voluntary Muscle written by George Karpati and published by Cambridge University Press. This book was released on 2001-07-12 with total page 800 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rewritten and redesigned, this remains the one essential text on the diseases of skeletal muscle.
Book Synopsis Heat Shock Proteins in Cancer by : Stuart K. Calderwood
Download or read book Heat Shock Proteins in Cancer written by Stuart K. Calderwood and published by Springer Science & Business Media. This book was released on 2007-09-09 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heat shock proteins are emerging as important molecules in the development of cancer and as key targets in cancer therapy. These proteins enhance the growth of cancer cells and protect tumors from treatments such as drugs or surgery. However, new drugs have recently been developed particularly those targeting heat shock protein 90. As heat shock protein 90 functions to stabilize many of the oncogenes and growth promoting proteins in cancer cells, such drugs have broad specificity in many types of cancer cell and offer the possibility of evading the development of resistance through point mutation or use of compensatory pathways. Heat shock proteins have a further property that makes them tempting targets in cancer immunotherapy. These proteins have the ability to induce an inflammatory response when released in tumors and to carry tumor antigens to antigen presenting cells. They have thus become important components of anticancer vaccines. Overall, heat shock proteins are important new targets in molecular cancer therapy and can be approached in a number of contrasting approaches to therapy.
Book Synopsis Heat Shock Proteins in Signaling Pathways by : Alexzander A. A. Asea
Download or read book Heat Shock Proteins in Signaling Pathways written by Alexzander A. A. Asea and published by . This book was released on 2019 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited volume offers an insightful overview of contemporary research on signaling pathways. These signaling processes are the comprehensive mechanisms by which all cellular organisms communicate internally and externally with their microenvironment. The volume is focused on heat shock proteins (HSP), which are uniquely involved in a number of critical signaling pathways. Errors in signaling pathways and in the processing of cellular information are known to be responsible for the majority of diseases including cancer, inflammatory and neurological disorders. The knowledge gained from better understanding these mechanisms can help in elucidating disease processes and will assist in development and design of novel targeted treatment therapies to combat human diseases and disorders. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.
