Chronotherapeutics

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Publisher : Pharmaceutical Press
ISBN 13 : 9780853694885
Total Pages : 456 pages
Book Rating : 4.6/5 (948 download)

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Book Synopsis Chronotherapeutics by : P. H. Redfern

Download or read book Chronotherapeutics written by P. H. Redfern and published by Pharmaceutical Press. This book was released on 2003 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: In nature, many physical processes are governed by the passage of time. The study of these processes - chronobiology - reveals rhythmic patterns which may be yearly, monthly, daily or more frequent. Novel drug delivery systems are currently being delivered that will release varying quantities of a drug at optimum times to coincide with these rhythmic patterns.Chronotherapeutics considers the pharmaceutical and therapeutic implications associated with biological clocks. The book presents a comprehensive discussion of specific diseases that are time dependent, and the drugs and new drug formulations that can be used as treatments.Written by leading international experts in the field, Chronotherapeutics provides up-to-date information on chronobiology for non-chronobiologists in pharmaceutical and medical sciences. Peter Redfern is Professor of Pharmacology at the University of Bath, UK.

Salicylic Acid Signaling Networks

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Publisher : Frontiers Media SA
ISBN 13 : 2889198278
Total Pages : 190 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Salicylic Acid Signaling Networks by : Hua Lu

Download or read book Salicylic Acid Signaling Networks written by Hua Lu and published by Frontiers Media SA. This book was released on 2016-05-26 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: The small phenolic compound salicylic acid (SA) is critical for plant defense against a broad spectrum of pathogens. SA is also involved in multi-layered defense responses, from pathogen-associated molecular pattern triggered basal defense, resistance gene-mediated defense, to systemic acquired resistance. Recent decades have witnessed tremendous progress towards our understanding of SA-mediated signaling networks. Many genes have been identified to have direct or indirect effect on SA biosynthesis or to regulate SA accumulation. Several SA receptors have been identified and characterization of these receptors has shed light on the mechanisms of SA-mediated defense signaling, which encompass chromosomal remodeling, DNA repair, epigenetics, to transcriptional reprogramming. Molecules from plant-associated microbes have been identified, which manipulate SA levels signaling. SA does not act alone. It engages in crosstalk with other signaling pathways, such as those mediated by other phytohormones, in an agonistic or antagonistic manner, depending on hormones and pathosystems. Besides affecting plant innate immunity, SA has also been implicated in other cellular processes, such as flowering time determination, lipid metabolism, circadian clock control, and abiotic stress responses, possibly contributing to the regulation of plant development. The multifaceted function of SA makes it critically important to further identify genes involved in SA signaling networks, understand their modes of action, and delineate interactions among the components of SA signaling networks. In addition, genetic manipulation of genes involved in SA signaling networks has also provided a promising approach to enhance disease resistance in economically important plants. This ebook collects articles in the research topic “Salicylic Acid Signaling Networks.” For this collection we solicited reviews, perspectives, and original research articles that highlight recent exciting progress on the understanding of molecular mechanisms underlying SA-mediated defense, SA-crosstalk with other pathways and how microbes impact these events.

Human Circadian Physiology

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Publisher :
ISBN 13 :
Total Pages : 692 pages
Book Rating : 4.:/5 (84 download)

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Book Synopsis Human Circadian Physiology by : Charles A. Czeisler

Download or read book Human Circadian Physiology written by Charles A. Czeisler and published by . This book was released on 1978 with total page 692 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Neuronal Input Pathways to the Brain's Biological Clock and their Functional Significance

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 3540277897
Total Pages : 84 pages
Book Rating : 4.5/5 (42 download)

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Book Synopsis Neuronal Input Pathways to the Brain's Biological Clock and their Functional Significance by : Jens Hannibal

Download or read book Neuronal Input Pathways to the Brain's Biological Clock and their Functional Significance written by Jens Hannibal and published by Springer Science & Business Media. This book was released on 2006-06-07 with total page 84 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rhythmic changes in physiology and behaviour within a 24 h period occur in living organisms on earth to meet the challenges associated with the daily changes in the external environment. The circadian pacemaker responsible for the temporal internal organisation and the generation of endogenous rhythms of approximately 24 h is located in the hypothalamic suprachiasmatic nucleus (SCN) in mammals. The endogenous period generated by the pacemaker is close to, but generally not equal to 24 h and the biological clock therefore needs to be daily adjusted (entrained) by external cues. The daily alteration of light and darkness due to the rotation of our planet on its own axis in relation to the sun is the most prominent "zeitgeber" which adjusts the phase of the circadian rhythms to the astronomical day length, a process known as photoentrainment. In mammals, light is perceived only through photoreceptors located in the retina. Light information is mediated to the SCN via the retinohypothalamic tract (RHT) by activation of the classical photoreceptor system of rods and cones and a more recently identified system of intrinsic photosensitive retinal ganglion cells (ipRGCs) using melanopsin as a photopigment.

The Circadian Clock

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Publisher : Springer Science & Business Media
ISBN 13 : 1441912622
Total Pages : 306 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis The Circadian Clock by : Urs Albrecht

Download or read book The Circadian Clock written by Urs Albrecht and published by Springer Science & Business Media. This book was released on 2010-01-23 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the invitation to edit this volume, I wanted to take the opportunity to assemble reviews on different aspects of circadian clocks and rhythms. Although most c- tributions in this volume focus on mammalian circadian clocks, the historical int- duction and comparative clocks section illustrate the importance of various other organisms in deciphering the mechanisms and principles of circadian biology. Circadian rhythms have been studied for centuries, but only recently, a mole- lar understanding of this process has emerged. This has taken research on circadian clocks from mystic phenomenology to a mechanistic level; chains of molecular events can describe phenomena with remarkable accuracy. Nevertheless, current models of the functioning of circadian clocks are still rudimentary. This is not due to the faultiness of discovered mechanisms, but due to the lack of undiscovered processes involved in contributing to circadian rhythmicity. We know for example, that the general circadian mechanism is not regulated equally in all tissues of m- mals. Hence, a lot still needs to be discovered to get a full understanding of cir- dian rhythms at the systems level. In this respect, technology has advanced at high speed in the last years and provided us with data illustrating the sheer complexity of regulation of physiological processes in organisms. To handle this information, computer aided integration of the results is of utmost importance in order to d- cover novel concepts that ultimately need to be tested experimentally.

The Rhythms Of Life

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Publisher : Profile Books
ISBN 13 : 1847653723
Total Pages : 288 pages
Book Rating : 4.8/5 (476 download)

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Book Synopsis The Rhythms Of Life by : Leon Kreitzman

Download or read book The Rhythms Of Life written by Leon Kreitzman and published by Profile Books. This book was released on 2011-09-30 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Popular science at its most exciting: the breaking new world of chronobiology - understanding the rhythm of life in humans and all plants and animals. The entire natural world is full of rhythms. The early bird catches the worm -and migrates to an internal calendar. Dormice hibernate away the winter. Plants open and close their flowers at the same hour each day. Bees search out nectar-rich flowers day after day. There are cicadas that can breed for only two weeks every 17 years. And in humans: why are people who work anti-social shifts more illness prone and die younger? What is jet-lag and can anything help? Why do teenagers refuse to get up in the morning, and are the rest of us really 'larks' or 'owls'? Why are most people born (and die) between 3am-5am? And should patients be given medicines (and operations) at set times of day, because the body reacts so differently in the morning, evening and at night? The answers lie in our biological clocks the mechanisms which give order to all living things. They impose a structure that enables us to change our behaviour in relation to the time of day, month or year. They are reset at sunrise and sunset each day to link astronomical time with an organism's internal time.

Circadian Rhythms and Metabolism

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Author :
Publisher : Frontiers Media SA
ISBN 13 : 2889452824
Total Pages : 190 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Circadian Rhythms and Metabolism by : Etienne Challet

Download or read book Circadian Rhythms and Metabolism written by Etienne Challet and published by Frontiers Media SA. This book was released on 2017-09-18 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the major breakthroughs of the last decade in the understanding of energy homeostasis is the identification of a reciprocal control between circadian rhythmicity and cellular metabolism. Circadian rhythmicity is a fundamental endogenous process of almost every organism living on Earth. For instance, the alternation of hunger and satiety is not continuous over 24 h, but is instead structured in time along the light/dark cycle. In mammals, the temporal organization of metabolism, physiology and behavior around 24 h is controlled by a network of multiple cellular clocks, synchronized via neuronal and hormonal signals by a master clock located in the suprachiasmatic nuclei of the hypothalamus. This central circadian conductor in the brain is mainly reset by ambient light perceived by the retina, while secondary circadian clocks in other brain areas and peripheral organs can be reset by meal timing. Chronic disruption of circadian rhythms, as seen in human shift-workers (up to 20% of the active population), has been associated with the development of a number of adverse mental and metabolic conditions. Understanding of the functional links between circadian desynchronization and overall health in animal models and humans, however, is still scarce. Interactions between circadian clocks and metabolism can occur at different levels: the molecular clockwork, internal synchronization via neuro-hormonal signals, or external synchronization via photic or feeding cues. This Research Topic comprises a number of reviews as well as research and methods articles that feature recent advancements in the mechanisms linking circadian clocks with energy metabolism, and the pathophysiological implications of these interactions for metabolic health.

Guide for the Care and Use of Laboratory Animals

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Publisher : National Academies Press
ISBN 13 : 0309154006
Total Pages : 246 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Guide for the Care and Use of Laboratory Animals by : National Research Council

Download or read book Guide for the Care and Use of Laboratory Animals written by National Research Council and published by National Academies Press. This book was released on 2011-01-27 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: A respected resource for decades, the Guide for the Care and Use of Laboratory Animals has been updated by a committee of experts, taking into consideration input from the scientific and laboratory animal communities and the public at large. The Guide incorporates new scientific information on common laboratory animals, including aquatic species, and includes extensive references. It is organized around major components of animal use: Key concepts of animal care and use. The Guide sets the framework for the humane care and use of laboratory animals. Animal care and use program. The Guide discusses the concept of a broad Program of Animal Care and Use, including roles and responsibilities of the Institutional Official, Attending Veterinarian and the Institutional Animal Care and Use Committee. Animal environment, husbandry, and management. A chapter on this topic is now divided into sections on terrestrial and aquatic animals and provides recommendations for housing and environment, husbandry, behavioral and population management, and more. Veterinary care. The Guide discusses veterinary care and the responsibilities of the Attending Veterinarian. It includes recommendations on animal procurement and transportation, preventive medicine (including animal biosecurity), and clinical care and management. The Guide addresses distress and pain recognition and relief, and issues surrounding euthanasia. Physical plant. The Guide identifies design issues, providing construction guidelines for functional areas; considerations such as drainage, vibration and noise control, and environmental monitoring; and specialized facilities for animal housing and research needs. The Guide for the Care and Use of Laboratory Animals provides a framework for the judgments required in the management of animal facilities. This updated and expanded resource of proven value will be important to scientists and researchers, veterinarians, animal care personnel, facilities managers, institutional administrators, policy makers involved in research issues, and animal welfare advocates.

Sleep and Mental Illness

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Publisher : Cambridge University Press
ISBN 13 : 1139483706
Total Pages : 451 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Sleep and Mental Illness by : S. R. Pandi-Perumal

Download or read book Sleep and Mental Illness written by S. R. Pandi-Perumal and published by Cambridge University Press. This book was released on 2010-04-01 with total page 451 pages. Available in PDF, EPUB and Kindle. Book excerpt: The diagnosis of mental illness is frequently accompanied by sleep problems; conversely, people experiencing sleep problems may subsequently develop mental illness. Sleep and Mental Illness looks at this close correlation and considers the implications of research findings that have emerged in the last few years. Additionally, it surveys the essential concepts and practical tools required to deal with sleep and co-morbid psychiatric problems. The volume is divided into three main sections: basic science, neuroendocrinology, and clinical science. Included are over 30 chapters on topics such as neuropharmacology, insomnia, depression, dementia, autism, and schizophrenia. Relevant questionnaires for the assessment of sleep disorders, including quality-of-life measurement tools, are provided. There is also a summary table of drugs for treating sleep disorders. This interdisciplinary text will be of interest to clinicians working in psychiatry, behavioral sleep medicine, neurology, pulmonary and critical care medicine.

The Interplay Between Immune Activation and Cardiovascular Disease During Infection, Autoimmunity and Aging: The Role of T Cells

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Publisher : Frontiers Media SA
ISBN 13 : 288971232X
Total Pages : 167 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis The Interplay Between Immune Activation and Cardiovascular Disease During Infection, Autoimmunity and Aging: The Role of T Cells by : Marta Catalfamo

Download or read book The Interplay Between Immune Activation and Cardiovascular Disease During Infection, Autoimmunity and Aging: The Role of T Cells written by Marta Catalfamo and published by Frontiers Media SA. This book was released on 2021-08-25 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Circadian Medicine

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Publisher : John Wiley & Sons
ISBN 13 : 1118467787
Total Pages : 405 pages
Book Rating : 4.1/5 (184 download)

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Book Synopsis Circadian Medicine by : Christopher S. Colwell

Download or read book Circadian Medicine written by Christopher S. Colwell and published by John Wiley & Sons. This book was released on 2015-07-07 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: Circadian rhythms, the biological oscillations based around our 24-hour clock, have a profound effect on human physiology and healthy cellular function. Circadian Rhythms: Health and Disease is a wide-ranging foundational text that provides students and researchers with valuable information on the molecular and genetic underpinnings of circadian rhythms and looks at the impacts of disruption in our biological clocks in health and disease. Circadian Rhythms opens with chapters that lay the fundamental groundwork on circadian rhythm biology. Section II looks at the impact of circadian rhythms on major organ systems. Section III then turns its focus to the central nervous system. The book then closes with a look at the role of biological rhythms in aging and neurodegeneration. Written in an accessible and informative style, Circadian Rhythms: Health and Disease,will be an invaluable resource and entry point into this fascinating interdisciplinary field that brings together aspects of neuroscience, cell and molecular biology, and physiology.

Plant Pathology

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Publisher : BoD – Books on Demand
ISBN 13 : 9535104896
Total Pages : 378 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Plant Pathology by : Christian Joseph Cumagun

Download or read book Plant Pathology written by Christian Joseph Cumagun and published by BoD – Books on Demand. This book was released on 2012-04-04 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plant pathology is an applied science that deals with the nature, causes and control of plant diseases in agriculture and forestry. The vital role of plant pathology in attaining food security and food safety for the world cannot be overemphasized.

Exercise Immunology

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Publisher : Routledge
ISBN 13 : 113645585X
Total Pages : 581 pages
Book Rating : 4.1/5 (364 download)

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Book Synopsis Exercise Immunology by : Michael Gleeson

Download or read book Exercise Immunology written by Michael Gleeson and published by Routledge. This book was released on 2013-06-26 with total page 581 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exercise immunology is an important, emerging sub-discipline within exercise physiology, concerned with the relationship between exercise, immune function and infection risk. This book offers a comprehensive, up-to-date and evidence-based introduction to exercise immunology, including the physiological and molecular mechanisms that determine immune function and the implications for health and performance in sport and everyday life. Written by a team of leading exercise physiologists, the book describes the characteristics of the immune system and how its components are organised to form an immune response. It explains the physiological basis of the relationship between stress, physical activity, immune function and infection risk, and identifies the ways in which exercise and nutrition interact with immune function in athletes and non-athletes. The book shows students how to evaluate the strengths and limitations of the evidence linking physical activity, immune system integrity and health, and explains why exercise is associated with anti-inflammatory effects that are potentially beneficial to long-term health. Every chapter includes useful features, such as clear summaries, definitions of key terms, discussions of seminal research studies and practical guidelines for athletes on ways to minimise infection risk, with additional learning resources available on a companion website. This is an essential textbook for any course on exercise immunology or advanced exercise physiology.

Circadian Rhythm Sleep-Wake Disorders

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Publisher : Springer Nature
ISBN 13 : 3030438031
Total Pages : 251 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Circadian Rhythm Sleep-Wake Disorders by : R. Robert Auger

Download or read book Circadian Rhythm Sleep-Wake Disorders written by R. Robert Auger and published by Springer Nature. This book was released on 2020-05-26 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book resolves to bridge the communication gap between research and clinical practice for circadian rhythm sleep-wake disorders. Beginning with a scientific background on biological timekeeping, opening chapters describe the crucial nature of maintaining delicate temporal organization of physiological and molecular events within the body. Following this are discussions on circadian physiology and methods of circadian assessments. Subsequent chapters then relay comprehensive information regarding the International Classification of Sleep Disorders-defined circadian rhythm sleep-wake disorders (CRSWDs), specifically discussing etiology and epidemiology, but focusing on evidence-based treatment data. Concluding discussions provide guidance for the application of light therapy and discuss future roles for optimized lighting environments. Nuanced and market-demanded, Circadian Rhythm Sleep-Wake Disorders: An Evidence-Based Guide for Clinicians and Investigators is an invaluable resource for Sleep Medicine clinicians, circadian researchers, and other interested parties.

Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research

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Author :
Publisher : National Academies Press
ISBN 13 : 030916785X
Total Pages : 223 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research by : National Research Council

Download or read book Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research written by National Research Council and published by National Academies Press. This book was released on 2003-08-22 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expanding on the National Research Council's Guide for the Care and Use of Laboratory Animals, this book deals specifically with mammals in neuroscience and behavioral research laboratories. It offers flexible guidelines for the care of these animals, and guidance on adapting these guidelines to various situations without hindering the research process. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research offers a more in-depth treatment of concerns specific to these disciplines than any previous guide on animal care and use. It treats on such important subjects as: The important role that the researcher and veterinarian play in developing animal protocols. Methods for assessing and ensuring an animal's well-being. General animal-care elements as they apply to neuroscience and behavioral research, and common animal welfare challenges this research can pose. The use of professional judgment and careful interpretation of regulations and guidelines to develop performance standards ensuring animal well-being and high-quality research. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research treats the development and evaluation of animal-use protocols as a decision-making process, not just a decision. To this end, it presents the most current, in-depth information about the best practices for animal care and use, as they pertain to the intricacies of neuroscience and behavioral research.

Sleep: A Very Short Introduction

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Author :
Publisher : Oxford University Press
ISBN 13 : 019958785X
Total Pages : 169 pages
Book Rating : 4.1/5 (995 download)

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Book Synopsis Sleep: A Very Short Introduction by : Steven W. Lockley

Download or read book Sleep: A Very Short Introduction written by Steven W. Lockley and published by Oxford University Press. This book was released on 2012-03-22 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: Explores sleep disorders, describes breakthroughs in the study of sleep, and considers the impact of modern society on it.

The Primate Malarias

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Publisher :
ISBN 13 :
Total Pages : 388 pages
Book Rating : 4.:/5 (31 download)

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Book Synopsis The Primate Malarias by : George Robert Coatney

Download or read book The Primate Malarias written by George Robert Coatney and published by . This book was released on 1971 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: