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Selective Autophagy
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Download or read book Autophagy written by Nicholas Ktistakis and published by Humana Press. This book was released on 2019-01-05 with total page 741 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume details a comprehensive and extensive set of protocols for the study of autophagy in vitro and in vivo. Chapters focus on mammals, various model organisms, and provide protocols for the study of autophagy-related processes outside of the canonical autophagy pathways. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Autophagy: Methods and Protocols aims to ensure successful results in the further study of this vital field.
Book Synopsis Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging by : M. A. Hayat
Download or read book Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging written by M. A. Hayat and published by Academic Press. This book was released on 2016-12-28 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging is an eleven volume series that discusses in detail all aspects of autophagy machinery in the context of health, cancer, and other pathologies. Autophagy maintains homeostasis during starvation or stress conditions by balancing the synthesis of cellular components and their deregulation by autophagy. This series discusses the characterization of autophagosome-enriched vaccines and its efficacy in cancer immunotherapy. Autophagy serves to maintain healthy cells, tissues, and organs, but also promotes cancer survival and growth of established tumors. Impaired or deregulated autophagy can also contribute to disease pathogenesis. Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward-thinking, these books offer a valuable guide to cellular processes while also inciting researchers to explore their potentially important connections. Presents the most advanced information regarding the role of the autophagic system in life and death Examines whether autophagy acts fundamentally as a cell survivor or cell death pathway or both Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid in preventing detrimental inflammation Features recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, including atherosclerosis and CNS tumors, and their development and treatment Includes chapters authored by leaders in the field around the globe—the broadest, most expert coverage available
Book Synopsis A Compendium of “Selective Autophagy”. by : Dr. Hakim Saboowala
Download or read book A Compendium of “Selective Autophagy”. written by Dr. Hakim Saboowala and published by Dr.Hakim Saboowala. This book was released on 2020-08-02 with total page 35 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Compendium of “Selective Autophagy”. There are various types of autophagy, which can be categorized as: § Non-selective or § Selective. · Non-selective macro-autophagy randomly engulfs a portion of the cytoplasm into autophagosomes and then delivers them to the vacuole (in fungi or plants) or the lysosome (in other higher eukaryotes) for degradation. · Selective macro-autophagy, however, specifically recognizes and degrades a particular cargo, either a protein complex, an organelle, or an invading microbe. The morphological hallmark of macro-autophagy is the formation of an initial sequestering compartment, the phagophore, which expands into the double-membrane autophagosome; the initial sequestration occurs in a compartment that is separate from the degradative organelle. Selective micro-autophagy utilizes the same cellular machinery, but in this case, the sequestration event takes place directly at the limiting membrane of the lysosome/vacuole. In higher eukaryotes, selective types of autophagy also include: · Chaperone-mediated autophagy (CMA), and · Two similar processes: 1. Endosomal microautophagy (e-MI) and 2. Chaperone-assisted selective autophagy (CASA), each of which involves uptake at the limiting membrane of either the lysosome or endosome. In all cases, how a substrate is targeted for sequestration and segregated from other parts of the cell is one of the major questions in this research field. An attempt has been made in this Booklet to present a Compendium of the Selective autophagy, along with several relevant illustrations, wherein cells use Selective autophagy for a variety of purposes, including remodeling to adapt to: · Changing Environmental or Nutritional conditions and · Eliminate damaged Organelles. Consequently, defects in Selective autophagy are associated with a range of pathophysiologies in humans, including certain types of Neuro-degenerative Diseases. …Dr. H. K. Saboowala. M.B.(Bom) .M.R.S.H.(London)
Book Synopsis Autophagy and Cancer by : Hong-Gang Wang
Download or read book Autophagy and Cancer written by Hong-Gang Wang and published by Springer Science & Business Media. This book was released on 2013-03-30 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the explosion of information on autophagy in cancer, this is an opportune time to speed the efforts to translate our current knowledge about autophagy regulation into better understanding of its role in cancer. This book will cover the latest advances in this area from the basics, such as the molecular machinery for autophagy induction and regulation, up to the current areas of interest such as modulation of autophagy and drug discovery for cancer prevention and treatment. The text will include an explanation on how autophagy can function in both oncogenesis and tumor suppression and a description of its function in tumor development and tumor suppression through its roles in cell survival, cell death, cell growth as well as its influences on inflammation, immunity, DNA damage, oxidative stress, tumor microenvironment, etc. The remaining chapters will cover topics on autophagy and cancer therapy. These pages will serve as a description on how the pro-survival function of autophagy may help cancer cells resist chemotherapy and radiation treatment as well as how the pro-death functions of autophagy may enhance cell death in response to cancer therapy, and how to target autophagy for cancer prevention and therapy − what to target and how to target it.
Book Synopsis Selective Autophagy by : Ioannis P. Nezis
Download or read book Selective Autophagy written by Ioannis P. Nezis and published by Springer Nature. This book was released on with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Autophagy: Biology and Diseases by : Zhiping Xie
Download or read book Autophagy: Biology and Diseases written by Zhiping Xie and published by Springer Nature. This book was released on 2021-07-14 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book series consists of 3 volumes covering the basic science (Volume 1), clinical science (Volume 2) and the technology and methodology (Volume 3) of autophagy. Volume 3 focuses on the technical aspects of autophagy research. It is comprised of two parts. The first part discusses the basic process of autophagy, including its overall classification and individual stages in the life cycle of autophagosomes. The second part discusses the tools, strategies, and model systems in current autophagy research, including cell and animal models, detection and manipulation methods, as well as screening, genomic, proteomic and bioinformatic approaches. The book is written and edited by a team of active scientists. It is intended as a practical reference resource for interested researchers to get started on autophagy studies.
Download or read book Autophagy written by Vladimir Rogov and published by Elsevier Inc. Chapters. This book was released on 2013-09-03 with total page 51 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autophagy, the evolutionarily conserved lysosome-based degradation system, has been the topic of intensive investigation for the past two decades. The recent explosion of interest can be explained in part by the emerging role of autophagy in pathogenesis and progression of major human diseases, such as neurodegeneration, infection diseases, and cancer. One of the key aspects of autophagy, which is of great importance for the disease-related roles of autophagy and yet remains frequently overlooked, is its remarkable selectivity. Aggregated proteins, damaged mitochondria, superfluous peroxisomes, or invading bacteria are specifically recognized and targeted to the lysosome for destruction by selective autophagy. Research over the past 5 years has identified a number of receptor proteins that bind molecular determinants of the autophagic cargo, leading to nucleation and expansion of the autophagosome around the target structure. Ubiquitin, the small protein modifier, has proven to be one such determinant, which, in addition to protein substrates, earmarks organelles and microbes for selective recognition by the autophagosome. Ubiquitin-like members of the Atg8/LC3/GABARAP protein family are core components of the autophagic machinery that become instrumental in the assembly of target-induced autophagosomes. The understanding of molecular mechanisms of selective clearance of pathogenic structures (protein aggregates, damaged or obsolete organelles and microbes) holds promise for developing new strategies to fight infection, neurodegeneration, and cancer.
Book Synopsis Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology by : Vladimir Uversky
Download or read book Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology written by Vladimir Uversky and published by Academic Press. This book was released on 2019-09-15 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Dancing protein clouds: Intrinsically disordered proteins in the norm and pathology" represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and their partners, as well as proteins from muscle sarcomere; representation of intrinsic disorder-related concept of protein structure-function continuum; discussion of the role of intrinsic disorder in phenotypic switching; consideration of the role of intrinsically disordered proteins in the pathogenesis of neurodegenerative diseases and cancer; discussion of the roles of intrinsic disorder in functional amyloids; demonstration of the usefulness of the analysis of translational diffusion of unfolded and intrinsically disordered proteins; consideration of various computational tools for evaluation of functions of intrinsically disordered regions; and discussion of the role of shear stress in the amyloid formation of intrinsically disordered regions in the brain. Provides some recent studies on the intrinsically disordered proteins and their functions, as well as on the involvement of intrinsically disordered proteins in pthogenesis of various diseases Contains numerous illustrative materials (color figures, diagrams, and tables) to help the readers to delve in the information provided Includes contributions from recognized experts in the field
Book Synopsis Autophagy Regulation of Innate Immunity by : Jun Cui
Download or read book Autophagy Regulation of Innate Immunity written by Jun Cui and published by Springer Nature. This book was released on 2019-11-14 with total page 203 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses novel concepts and discoveries concerning the regulation of innate immunity by autophagy and autophagy-related proteins. In the past decade, there have been major advances in our understanding of the molecular mechanisms of autophagy and its physiological functions. This book highlights emerging studies on the underlying mechanisms of autophagy regulation of innate immunity, including inflammation, antiviral immunity and anti-bacterial responses and the signaling pathways that prompt or inhibit the initiation and progression of related diseases. It also offers new ideas and strategies for future drugs based on manipulating autophagy, especially selective autophagy mediated by cargo receptors. Providing a comprehensive overview of the autophagy regulation of innate immunity, it is a valuable resource for graduate students and researchers in the fields of immunology, cell biology and translational medicine.
Book Synopsis Autophagy: from Big Data to Physiological Significance by : Ioannis Nezis
Download or read book Autophagy: from Big Data to Physiological Significance written by Ioannis Nezis and published by Frontiers Media SA. This book was released on 2020-02-10 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Autophagy written by Kelsey B. Law and published by Elsevier Inc. Chapters. This book was released on 2013-09-03 with total page 29 pages. Available in PDF, EPUB and Kindle. Book excerpt: Macroautophagy is mainly considered to be a mechanism for the bulk degradation of the cytoplasm in times of nutrient depletion. However, growing evidence suggests that macroautophagy is more substrate-specific than originally considered. Numerous cytosolic components are selectively degraded by macroautophagy, including aggresomes, damaged mitochondria, peroxisomes, ribosomes, midbodies, and bacteria and viruses. Although the specific molecular components may differ for each substrate, the general mechanism of selective macroautophagy involves the targeted ubiquitination of the substrate and the recruitment of autophagy receptors. Autophagy receptors are proteins that act as an interface between the substrate and the nascent autophagosome, the double-membrane structure that sequesters the cytoplasm for delivery to lysosomes for degradation. In this chapter we will describe the general mechanism of selective autophagy in the mammalian system, focusing on the most described autophagy receptor, p62. The emerging data suggest that selective autophagy is not only necessary for cell survival during nutrient starvation, but also plays a critical role in cell development, cellular responses to oxidative stress, and innate immunity.
Book Synopsis Normal and Malignant Hematopoiesis by : Enrico Mihich
Download or read book Normal and Malignant Hematopoiesis written by Enrico Mihich and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: ''An exciting glance at key issues in contemporary hematopoiesis.'' -The Quarterly Review of Biology
Book Synopsis Inter-Organellar Ca2+ Signaling in Health and Disease - Part B by :
Download or read book Inter-Organellar Ca2+ Signaling in Health and Disease - Part B written by and published by Academic Press. This book was released on 2021-08-12 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: International Review of Cell and Molecular Biology reviews and details current advances in cell and molecular biology. The IRCMB series has a worldwide readership, maintaining a high standard by publishing invited articles on important and timely topics that are authored by prominent cell and molecular biologists. The articles published in IRCMB have a high impact and an average cited half-life of 9 years. This great resource ranks high amongst scientific journals dealing with cell biology. Publishes only invited review articles on selected topics Authored by established and active cell and molecular biologists and drawn from international sources Offers a wide range of perspectives on specific subjects
Download or read book Autophagy written by Daniel Klionsky and published by CRC Press. This book was released on 2003-12-15 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: Starting in the early 1970s, a type of programmed cell death called apoptosis began to receive attention. Over the next three decades, research in this area continued at an accelerated rate. In the early 1990s, a second type of programmed cell death, autophagy, came into focus. Autophagy has been studied in mammalian cells for many years. The recen
Book Synopsis Non-Canonical Autophagy by : Giulia Petroni
Download or read book Non-Canonical Autophagy written by Giulia Petroni and published by Academic Press. This book was released on 2021-04-21 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: Non-canonical Autophagy: Mechanisms and Pathophysiological Implications outlines the differences between ‘canonical’ and ‘non-canonical’ forms of autophagy, highlighting the discoveries concerning the molecular mechanisms underlying these unconventional forms of autophagy and the advancements in pathophysiological features of ‘non-canonical’ autophagy. The book discusses all forms of ‘non-canonical’ autophagy and the complexity of autophagy-dependent cell death. Readers will gain a better understanding of mechanisms underlying ‘non-canonical’ autophagy so that they can interpret the biological effects of autophagy correctly and identify reliable, novel and effective treatment strategies. Presents the most advanced information surrounding the molecular mechanisms underlying non-canonical autophagy Outlines the increasing evidence regarding the involvement of non-canonical autophagy in multiple physiological and pathological processes Discusses the therapeutic potential of autophagy modulators and the obstacles that have limited their development
Book Synopsis A Time for Metabolism and Hormones by : Paolo Sassone-Corsi
Download or read book A Time for Metabolism and Hormones written by Paolo Sassone-Corsi and published by Springer. This book was released on 2016-04-04 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent years have seen spectacular advances in the field of circadian biology. These have attracted the interest of researchers in many fields, including endocrinology, neurosciences, cancer, and behavior. By integrating a circadian view within the fields of endocrinology and metabolism, researchers will be able to reveal many, yet-unsuspected aspects of how organisms cope with changes in the environment and subsequent control of homeostasis. This field is opening new avenues in our understanding of metabolism and endocrinology. A panel of the most distinguished investigators in the field gathered together to discuss the present state and the future of the field. The editors trust that this volume will be of use to those colleagues who will be picking up the challenge to unravel how the circadian clock can be targeted for the future development of specific pharmacological strategies toward a number of pathologies.
Book Synopsis Parkinson's Disease by : Richard Nass
Download or read book Parkinson's Disease written by Richard Nass and published by Elsevier. This book was released on 2011-04-28 with total page 687 pages. Available in PDF, EPUB and Kindle. Book excerpt: Parkinson’s disease is the second most prevalent neurodegenerative disease and is characterized by the irreversible loss of dopamine neurons. Despite its high prevalence in society and many decades of research, the origin of the pathogenesis and the molecular determinants involved in the disorder has remained elusive. Confounding this issue is the lack of experimental models that completely recapitulate the disease state. The identification of a number of genes thought to play a role in the cell death, and development of both toxin and genetic models to explore the function of the genes both in unaffected and diseased cells are now providing new insights into the molecular basis of the neurodegeneration, as well as therapeutic approaches. In this reference, we will describe the advances and the advantages that various invertebrates, cell culture, rodents, and mammals provide in the identification of the molecular components and mechanisms involved in the cell death, and outline the opportunities that these systems provide in drug discovery. Comprehensive and critical assessment of the utility of various model systems to identify the molecular components and pathways involved in Parkinson’s disease Describes the power of toxin and genetic models to identify novel therapeutic targets and compounds that can be used in PD Current overviews of current status of PD research and discovery from bench-to-bedside Provides novel insights and views on where the future of PD research may lead Provides a powerful teaching tool and template to explore the utility of model systems to identify molecular pathways, molecular targets, and therapeutics that are applicable to a variety of neurological diseases
