Saliva Derived Microcosm Biofilm Models For Understanding Oral Microbial Ecology

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Oral Biofilms

Author : S. Eick
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318068527
Total Pages : 247 pages
Book Rating : 4.3/5 (18 download)

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Book Synopsis Oral Biofilms by : S. Eick

Download or read book Oral Biofilms written by S. Eick and published by Karger Medical and Scientific Publishers. This book was released on 2020-12-21 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biofilms are highly organized polymicrobial communities that are embedded in an extracellular matrix and formed on natural and artificial surfaces. In the oral cavity, biofilms are formed not only on natural teeth, but also on restorative materials, prosthetic constructions, and dental implants. Oral diseases like caries, gingivitis, periodontitis, and also pulp inflammation are associated with biofilms. This publication is an up-to-date overview on oral biofilms from different clinically relevant perspectives. Experts comprising basic researchers and clinicians report on recent research relating to biofilms - from general summaries to recommendations for daily clinical work. This book covers all aspects of oral biofilms, including models used in the laboratory, biofilms in dental water unit lines, periodontal and peri-implant biofilms, caries-related biofilms, halitosis, endodontic biofilms, and Candida infections, as well as biofilms on dental materials and on orthodontic appliances. Several chapters deal with anti-biofilm therapy, from the efficacy of mechanical methods and the use of antimicrobials, to alternative concepts. This publication is particularly recommended to dental medicine students, practitioners, other oral healthcare professionals, and scientists with an interest in translational research on biofilms.

Microbial Biofilms

Author : Dharumadurai Dhanasekaran
Publisher : BoD – Books on Demand
ISBN 13 : 9535124358
Total Pages : 526 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Microbial Biofilms by : Dharumadurai Dhanasekaran

Download or read book Microbial Biofilms written by Dharumadurai Dhanasekaran and published by BoD – Books on Demand. This book was released on 2016-07-13 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the book Microbial Biofilms: Importance and applications, eminent scientists provide an up-to-date review of the present and future trends on biofilm-related research. This book is divided with four subdivisions as biofilm fundamentals, applications, health aspects, and their control. Moreover, this book also provides a comprehensive account on microbial interactions in biofilms, pyocyanin, and extracellular DNA in facilitating Pseudomonas aeruginosa biofilm formation, atomic force microscopic studies of biofilms, and biofilms in beverage industry. The book comprises a total of 21 chapters from valued contributions from world leading experts in Australia, Bulgaria, Canada, China, Serbia, Germany, Italy, Japan, the United Kingdom, the Kingdom of Saudi Arabia, Republic of Korea, Mexico, Poland, Portugal, and Turkey. This book may be used as a text or reference for everyone interested in biofilms and their applications. It is also highly recommended for environmental microbiologists, soil scientists, medical microbiologists, bioremediation experts, and microbiologists working in biocorrosion, biofouling, biodegradation, water microbiology, quorum sensing, and many other related areas. Scientists in academia, research laboratories, and industry will also find it of interest.

Microbial Extracellular Polymeric Substances

Author : Jost Wingender
Publisher : Springer Science & Business Media
ISBN 13 : 3642601472
Total Pages : 266 pages
Book Rating : 4.6/5 (426 download)

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Book Synopsis Microbial Extracellular Polymeric Substances by : Jost Wingender

Download or read book Microbial Extracellular Polymeric Substances written by Jost Wingender and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microbial extracellular polymeric substances (EPS) are the key components for the aggregation of microorganisms in biofilms, flocs and sludge. They are composed of polysaccharides, proteins, nucleic acids, lipids and other biological macromolecules. EPS provide a highly hydrated gel matrix in which microbial cells can establish stable synergistic consortia. Cohesion and adhesion as well as morphology, structure, biological function and other properties such as mechanical stability, diffusion, sorption and optical properties of microbial aggregates are determined by the EPS matrix. Also, the protection of biofilm organisms against biocides is attributed to the EPS. Their matrix allows phase separation in biofiltration and is also important for the degradation of particulate material which is of great importance for the self purification processes in surface waters and for waste water treatment.

The Root Canal Biofilm

Author : Luis E. Chávez de Paz
Publisher : Springer
ISBN 13 : 3662474158
Total Pages : 369 pages
Book Rating : 4.6/5 (624 download)

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Book Synopsis The Root Canal Biofilm by : Luis E. Chávez de Paz

Download or read book The Root Canal Biofilm written by Luis E. Chávez de Paz and published by Springer. This book was released on 2015-10-20 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the current state of research on the basic scientific aspects of root canal biofilm biology within a clinically applicable context. Root canal biofilms are complex polymicrobial structures adhering to the root canal surface that are formed by microorganisms invading the pulpal space of teeth, and are associated with persistent root canal infections. Concerted efforts to study root canal biofilms have been made in the past decade, resulting in the publication of observational and experimental studies that detail the morphology and biology of these structures in infected root canals. In addition to confirming that bacteria in root canals do not exist in free-floating planktonic states as previously assumed, this new information on root canal biofilm infections has provided an opportunity to re-evaluate conventional clinical protocols and improve endodontic therapeutic measures.

Bioelectrochemical Systems

Author : Korneel Rabaey
Publisher : IWA Publishing
ISBN 13 : 184339233X
Total Pages : 525 pages
Book Rating : 4.8/5 (433 download)

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Book Synopsis Bioelectrochemical Systems by : Korneel Rabaey

Download or read book Bioelectrochemical Systems written by Korneel Rabaey and published by IWA Publishing. This book was released on 2009-12-01 with total page 525 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the context of wastewater treatment, Bioelectrochemical Systems (BESs) have gained considerable interest in the past few years, and several BES processes are on the brink of application to this area. This book, written by a large number of world experts in the different sub-topics, describes the different aspects and processes relevant to their development. Bioelectrochemical Systems (BESs) use micro-organisms to catalyze an oxidation and/or reduction reaction at an anodic and cathodic electrode respectively. Briefly, at an anode oxidation of organic and inorganic electron donors can occur. Prime examples of such electron donors are waste organics and sulfides. At the cathode, an electron acceptor such as oxygen or nitrate can be reduced. The anode and the cathode are connected through an electrical circuit. If electrical power is harvested from this circuit, the system is called a Microbial Fuel Cell; if electrical power is invested, the system is called a Microbial Electrolysis Cell. The overall framework of bio-energy and bio-fuels is discussed. A number of chapters discuss the basics – microbiology, microbial ecology, electrochemistry, technology and materials development. The book continues by highlighting the plurality of processes based on BES technology already in existence, going from wastewater based reactors to sediment based bio-batteries. The integration of BESs into existing water or process lines is discussed. Finally, an outlook is provided of how BES will fit within the emerging biorefinery area.

Bacterial Biofilms

Author : Tony Romeo
Publisher : Springer Science & Business Media
ISBN 13 : 3540754180
Total Pages : 302 pages
Book Rating : 4.5/5 (47 download)

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Book Synopsis Bacterial Biofilms by : Tony Romeo

Download or read book Bacterial Biofilms written by Tony Romeo and published by Springer Science & Business Media. This book was released on 2008-02-26 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: Throughout the biological world, bacteria thrive predominantly in surface-attached, matrix-enclosed, multicellular communities or biofilms, as opposed to isolated planktonic cells. This choice of lifestyle is not trivial, as it involves major shifts in the use of genetic information and cellular energy, and has profound consequences for bacterial physiology and survival. Growth within a biofilm can thwart immune function and antibiotic therapy and thereby complicate the treatment of infectious diseases, especially chronic and foreign device-associated infections. Modern studies of many important biofilms have advanced well beyond the descriptive stage, and have begun to provide molecular details of the structural, biochemical, and genetic processes that drive biofilm formation and its dispersion. There is much diversity in the details of biofilm development among various species, but there are also commonalities. In most species, environmental and nutritional conditions greatly influence biofilm development. Similar kinds of adhesive molecules often promote biofilm formation in diverse species. Signaling and regulatory processes that drive biofilm development are often conserved, especially among related bacteria. Knowledge of such processes holds great promise for efforts to control biofilm growth and combat biofilm-associated infections. This volume focuses on the biology of biofilms that affect human disease, although it is by no means comprehensive. It opens with chapters that provide the reader with current perspectives on biofilm development, physiology, environmental, and regulatory effects, the role of quorum sensing, and resistance/phenotypic persistence to antimicrobial agents during biofilm growth.

Dental Caries

Author : Zhou Xuedong
Publisher : Springer
ISBN 13 : 3662474506
Total Pages : 187 pages
Book Rating : 4.6/5 (624 download)

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Book Synopsis Dental Caries by : Zhou Xuedong

Download or read book Dental Caries written by Zhou Xuedong and published by Springer. This book was released on 2015-10-20 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a well-illustrated and comprehensive guide to the etiology, clinical manifestations, diagnosis, clinical management and prevention of dental caries. Current challenging problems in the field are analyzed and the latest research findings, presented. After an introductory chapter on tooth development, the relationships of biofilm and saliva to dental caries and the significance of the balance between demineralization and remineralization for the development of carious lesions are discussed. Subsequent chapters address the state of the art in diagnosis and treatment, the implications of disease burden for prevention and the association between systemic diseases and dental caries. Dental Caries: Principles and Management is intended for dental school students, practicing dentists and researchers in dentistry.

Oral Biofilms and Modern Dental Materials

Author : Andrei Cristian Ionescu
Publisher : Springer Nature
ISBN 13 : 303067388X
Total Pages : 146 pages
Book Rating : 4.0/5 (36 download)

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Book Synopsis Oral Biofilms and Modern Dental Materials by : Andrei Cristian Ionescu

Download or read book Oral Biofilms and Modern Dental Materials written by Andrei Cristian Ionescu and published by Springer Nature. This book was released on 2021-04-01 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an up-to-date perspective on oral biofilms and dental materials, equipping readers with a sound understanding of their mutual interactions. Experts from across the world comprehensively describe the main strategies that can be followed when designing modern bioactive and biomimetic dental materials, bearing in mind the goal of reducing the occurrence of pathological conditions such as secondary caries and peri-implantitis. The background to the book is the rapid expansion in the use of nanotechnologies and modern techniques to achieve levels of performance of dental materials that were unthinkable even a few years ago. Whereas conventionally dental materials have been regarded as inert, an important paradigm shift is underway: now, these materials are being conceived as bioactive and biomimetic. Modern dental materials can produce a response by interacting positively both with the host and with the biofilm permanently colonizing hard and soft tissues of the oral cavity. These materials increasingly mimic the behavior of the tissues that they are replacing. In documenting the latest knowledge in the field, this book will be of value for both scientists in the fields of nanotechnology, biofilms and dental materials and interested clinicians.

Salivary Diagnostics

Author : David T. Wong
Publisher : John Wiley & Sons
ISBN 13 : 081380664X
Total Pages : 321 pages
Book Rating : 4.8/5 (138 download)

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Book Synopsis Salivary Diagnostics by : David T. Wong

Download or read book Salivary Diagnostics written by David T. Wong and published by John Wiley & Sons. This book was released on 2009-03-16 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: Salivary Diagnostics surveys one of the most exciting areas of research in oral biology. Regarded as the mirror of the body, saliva has immense potential to yield real clinical improvements in our ability to diagnose, and hence treat, oral and systemic conditions. The composition of saliva and other oral fluids reflects the tissue fluid levels of therapeutic, hormonal, and immunological molecules, as well as the presence of markers for systemic and oral disease.

Newman and Carranza's Clinical Periodontology and Implantology E-Book

Author : Michael G. Newman
Publisher : Elsevier Health Sciences
ISBN 13 : 0323878881
Total Pages : 1877 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Newman and Carranza's Clinical Periodontology and Implantology E-Book by : Michael G. Newman

Download or read book Newman and Carranza's Clinical Periodontology and Implantology E-Book written by Michael G. Newman and published by Elsevier Health Sciences. This book was released on 2023-04-28 with total page 1877 pages. Available in PDF, EPUB and Kindle. Book excerpt: **Selected for Doody's Core Titles® 2024 in Dentistry** Learn and master a range of clinical techniques and achieve therapeutic goals with Newman and Carranza's Clinical Periodontology and Implantology, 14th Edition! Unmatched for its comprehensive approach, this resource provides detailed, up-to-date information on the etiology and pathogenesis of periodontal disease. Basic and advanced evidence-based information on the various treatment modalities employed in periodontics and implantology is presented in an easy-to-read format, with callout boxes throughout the text highlighting the clinical relevance of foundational basic science information. Full-color photos and radiographic images depict periodontal conditions and procedures, and the Atlas of Periodontal Pathology is one of the most comprehensive ever compiled in a periodontal textbook. Written by a team of leading experts led by Michael G. Newman, this text not only demonstrates how to perform periodontal procedures but explains the evidence supporting each treatment and provides knowledge on how to achieve the best possible outcomes of periodontal therapy and implant treatment. An eBook version is included with print purchase, providing access to all the text, figures, and references, plus the ability to search, customize content, make notes and highlights, and have content read aloud. The eBook version included with print purchase also includes Periopixel 3D color illustrations, a periodontal classification calculator and interactive learning tool, review questions, case studies, videos, 3D animations, and more! This edition features new chapters on Precision Medicine, Pocket Reduction Therapy, Periodontal Referral, and Digital Implant Workflows, as well as an updated glossary of terms linked to the eBook. It also features first-of-its-kind content on the effects of COVID-19 on treatment from key opinion leaders in this area. Case studies reflect the new format of the Integrated National Board Dental Exam (INBDE). - Full-color photos, illustrations, radiographs, animations, simulations, and videos demonstrate how to perform periodontal and implant procedures. - Current information on clinical techniques in periodontology and the latest advances in basic science. - Evidence-based treatment planning provides knowledge on how to achieve the best possible outcomes of periodontal therapy and implant treatment. - Extensive color atlas of periodontal pathology - Internationally known experts contribute chapters on their areas of specialty. - An eBook version is included with print purchase, providing access to all the text, figures, and references, plus the ability to search, customize content, make notes and highlights, and have content read aloud.

Implication of Quorum Sensing System in Biofilm Formation and Virulence

Author : Pallaval Veera Bramhachari
Publisher : Springer
ISBN 13 : 9811324298
Total Pages : 377 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Implication of Quorum Sensing System in Biofilm Formation and Virulence by : Pallaval Veera Bramhachari

Download or read book Implication of Quorum Sensing System in Biofilm Formation and Virulence written by Pallaval Veera Bramhachari and published by Springer. This book was released on 2019-01-28 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book illustrates the importance and significance of Quorum sensing (QS), it’s critical roles in regulating diverse cellular functions in microbes, including bioluminescence, virulence, pathogenesis, gene expression, biofilm formation and antibiotic resistance. Microbes can coordinate population behavior with small molecules called autoinducers (AHL) which serves as a signal of cellular population density, triggering new patterns of gene expression for mounting virulence and pathogenesis. Therefore, these microbes have the competence to coordinate and regulate explicit sets of genes by sensing and communicating amongst themselves utilizing variety of signals. This book descry emphasizes on how bacteria can coordinate an activity and synchronize their response to external signals and regulate gene expression. The chapters of the book provide the recent advancements on various functional aspects of QS systems in different gram positive and gram negative organisms. Finally, the book also elucidates a comprehensive yet a representative description of a large number of challenges associated with quorum sensing signal molecules viz. virulence, pathogenesis, antibiotic synthesis, biosurfactants production, persister cells, cell signaling and biofilms, intra and inter-species communications, host-pathogen interactions, social interactions & swarming migration in biofilms.

The Oral Microbiome in an Ecological Perspective

Author : Egija Zaura
Publisher : Frontiers Media SA
ISBN 13 : 2889195767
Total Pages : 118 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis The Oral Microbiome in an Ecological Perspective by : Egija Zaura

Download or read book The Oral Microbiome in an Ecological Perspective written by Egija Zaura and published by Frontiers Media SA. This book was released on 2015-07-27 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt: The oral cavity harbors an immense diversity of microorganisms, including bacteria, fungi, archaea, protozoa and viruses. At health, oral microbial community is thought to be in a state of homeostasis, even after numerous perturbations (e.g., toothbrushing, food intake) a day. The breach in this homeostasis can occur for instance if the perturbations become too excessive (e.g., frequent carbohydrate intake leading to acidification of the community) or the host is compromised (e.g., inadequate immune response resulting in persistent inflammation of periodontal tissue). Aggressive antimicrobial therapy (e.g., antibiotics in case of periodontal disease or preventive antibiotic therapy before and after dental extractions) is commonly applied with all the negative consequences of this approach. So far little is known on the interplay between the environmental, host and microbial factors in maintaining an ecological balance. What are the prerequisites for a healthy oral ecosystem? Can we restore an unbalanced oral microbiome? How stable is the oral microbiome through time and how robust it is to external perturbations? Gaining new insights in the ecological factors sustaining oral health will lead to conceptually new therapies and preventive programs. Recent advances in high throughput technologies have brought microbiology as a science to a new era, allowing an open-ended approach instead of focusing on few opportunistic pathogens. With this topic we would like to integrate the current high-throughput ‘omics’ tools such as metagenomics, metatranscriptomics, metaproteomics or metabolomics with biochemical, physiological, genetic or clinical parameters within the oral microbial ecosystem. We aim to address questions underlying the regulation of the ecological balance in the oral cavity by including the following areas: • Ecology of oral microbiome at health • Ecology of oral microbiome under oral diseases • Ecology of oral microbiome during non-oral diseases • Shifts in the oral microbiome by therapeutic approaches (e.g., antimicrobials, replacement therapy, pre- and probiotics) • Modeling of oral ecological shifts (e.g., animal models, in vitro microcosm models) • Complex inter- and intra-kingdom interactions (e.g., bacterial-fungal-host) related to oral ecology • Environmental (e.g., diet, tobacco), host-related (e.g., immune response, saliva composition and flow) and biotic (e.g., bacterial competition) factors influencing oral ecology • Geographic variation in oral microbial ecology and diversity

Odontogenesis

Author : Petros Papagerakis
Publisher : Humana Press
ISBN 13 : 9781493990115
Total Pages : 565 pages
Book Rating : 4.9/5 (91 download)

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Book Synopsis Odontogenesis by : Petros Papagerakis

Download or read book Odontogenesis written by Petros Papagerakis and published by Humana Press. This book was released on 2019-04-22 with total page 565 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides methods and approaches to study genetic and environmental regulatory controls on odontogenesis. Chapters guide readers through protocols for isolation and characterization of both epithelial and mesenchymal dental cells, methods on isolation, phenotypic characterization, expansion, differentiation, immunofluorescence, in situ hybridization, immunohistochemistry, imaging protocols, rodent dental fluorosis model, 3D assessment of crown size, dental diseases models, next generation sequencing, genetic and epigenetic studies, genome-wide association studies as well as clinical protocols for measurement of early childhood caries and saliva, and supragingival fluids and biofilm collection and subsequent analyses. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Odontogenesis: Methods and Protocols aims to guide researchers towards elucidating the secrets and mysteries of a fascinating and unique organ, the tooth.

Insights in Antimicrobials, Resistance & Chemotherapy: 2021

Author : Rustam Aminov
Publisher : Frontiers Media SA
ISBN 13 : 2832505961
Total Pages : 185 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Insights in Antimicrobials, Resistance & Chemotherapy: 2021 by : Rustam Aminov

Download or read book Insights in Antimicrobials, Resistance & Chemotherapy: 2021 written by Rustam Aminov and published by Frontiers Media SA. This book was released on 2022-11-16 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Newman and Carranza's Clinical Periodontology E-Book

Author : Michael G. Newman
Publisher : Elsevier Health Sciences
ISBN 13 : 032353323X
Total Pages : 1991 pages
Book Rating : 4.3/5 (235 download)

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Book Synopsis Newman and Carranza's Clinical Periodontology E-Book by : Michael G. Newman

Download or read book Newman and Carranza's Clinical Periodontology E-Book written by Michael G. Newman and published by Elsevier Health Sciences. This book was released on 2018-05-29 with total page 1991 pages. Available in PDF, EPUB and Kindle. Book excerpt: From basic science and fundamental procedures to the latest advanced techniques in reconstructive, esthetic, and implant therapy, Newman and Carranza's Clinical Periodontology, 13th Edition is the resource you can count on to help master the most current information and techniques in periodontology. Full color photos, illustrations, and radiographs show you how to perform periodontal procedures, while renowned experts from across the globe explain the evidence supporting each treatment and lend their knowledge on how to best manage the outcomes. - UNIQUE! Periodontal Pathology Atlas contains the most comprehensive collection of cases found anywhere. - Full-color photos and anatomical drawings clearly demonstrate core concepts and reinforce important principles. - UNIQUE! Chapter opener boxes in the print book alert readers when more comprehensive coverage of topics is available in the online version of the text. - NEW! Chapters updated to meet the current exam requirements for the essentials in periodontal education. - NEW! Case-based clinical scenarios incorporated throughout the book mimic the new patient case format used in credentialing exams. - NEW! Additional tables, boxes, and graphics highlight need-to-know information. - NEW! Virtual microscope on Expert Consult offers easy access to high-resolution views of select pathology images. - NEW! Two new chapters cover periimplantitis and resolving inflammation. - NEW! Section on evidence-based practice consists of two chapters covering evidence-based decision making and critical thinking.

Oral Microbial Communities

Author : Paul E. Kolenbrander
Publisher : American Society for Microbiology Press
ISBN 13 : 1555815030
Total Pages : 617 pages
Book Rating : 4.5/5 (558 download)

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Book Synopsis Oral Microbial Communities by : Paul E. Kolenbrander

Download or read book Oral Microbial Communities written by Paul E. Kolenbrander and published by American Society for Microbiology Press. This book was released on 2011-08-02 with total page 617 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understand how the intricacies of multispecies community life are related to human oral health. * Explores the immense opportunities presented by readily accessible, genetically tractable, genome-sequenced oral species that naturally form multispecies communities. * Highlights model systems that study oral bacterial interactions, including biofilm growth using saliva as the source of nutrition. * Emphasizes the use of genomic inquiry to probe the human oral microbiome.

Uncultivated Microorganisms

Author : Slava S. Epstein
Publisher : Springer Science & Business Media
ISBN 13 : 3540854657
Total Pages : 215 pages
Book Rating : 4.5/5 (48 download)

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Book Synopsis Uncultivated Microorganisms by : Slava S. Epstein

Download or read book Uncultivated Microorganisms written by Slava S. Epstein and published by Springer Science & Business Media. This book was released on 2009-09-01 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1898, an Austrian microbiologist Heinrich Winterberg made a curious observation: the number of microbial cells in his samples did not match the number of colonies formed on nutrient media (Winterberg 1898). About a decade later, J. Amann qu- tified this mismatch, which turned out to be surprisingly large, with non-growing cells outnumbering the cultivable ones almost 150 times (Amann 1911). These papers signify some of the earliest steps towards the discovery of an important phenomenon known today as the Great Plate Count Anomaly (Staley and Konopka 1985). Note how early in the history of microbiology these steps were taken. Detecting the Anomaly almost certainly required the Plate. If so, then the period from 1881 to 1887, the years when Robert Koch and Petri introduced their key inventions (Koch 1881; Petri 1887), sets the earliest boundary for the discovery, which is remarkably close to the 1898 observations by H. Winterberg. Celebrating its 111th anniversary, the Great Plate Count Anomaly today is arguably the oldest unresolved microbiological phenomenon. In the years to follow, the Anomaly was repeatedly confirmed by all microb- logists who cared to compare the cell count in the inoculum to the colony count in the Petri dish (cf., Cholodny 1929; Butkevich 1932; Butkevich and Butkevich 1936). By mid-century, the remarkable difference between the two counts became a universally recognized phenomenon, acknowledged by several classics of the time (Waksman and Hotchkiss 1937; ZoBell 1946; Jannasch and Jones 1959).