Review of the Styrene Assessment in the National Toxicology Program 12th Report on Carcinogens

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Publisher :
ISBN 13 : 9780309312165
Total Pages : 193 pages
Book Rating : 4.3/5 (121 download)

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Book Synopsis Review of the Styrene Assessment in the National Toxicology Program 12th Report on Carcinogens by : National Research Council

Download or read book Review of the Styrene Assessment in the National Toxicology Program 12th Report on Carcinogens written by National Research Council and published by . This book was released on 2014 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Review of the Styrene Assessment in the National Toxicology Program 12th Report on Carcinogens

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Publisher : National Academy Press
ISBN 13 : 9780309301787
Total Pages : 178 pages
Book Rating : 4.3/5 (17 download)

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Book Synopsis Review of the Styrene Assessment in the National Toxicology Program 12th Report on Carcinogens by : National Research Council (U.S.). Committee to Review the Styrene Assessment in the National Toxicology Program 12th Report on Carcinogens

Download or read book Review of the Styrene Assessment in the National Toxicology Program 12th Report on Carcinogens written by National Research Council (U.S.). Committee to Review the Styrene Assessment in the National Toxicology Program 12th Report on Carcinogens and published by National Academy Press. This book was released on 2014 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction -- Review of the styrene profile in the National Toxicology Program 12th report on carcinogens -- Independent assessment of styrene -- Biographic Information on the Committee to Review the Styrene Assessment in the National Toxicology Program 12th Report on Carcinogens -- Statement of task of the Committee to Review the Styrene Assessment in the National Toxicology Program 12th report on carcinogens -- Review of the literature search used in the National Toxicology Program 12th report on carcinogens -- Literature search strategies used in support of the committee's independent assessment of styrene.

Review of the Formaldehyde Assessment in the National Toxicology Program 12th Report on Carcinogens

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Publisher :
ISBN 13 : 9780309312271
Total Pages : 0 pages
Book Rating : 4.3/5 (122 download)

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Book Synopsis Review of the Formaldehyde Assessment in the National Toxicology Program 12th Report on Carcinogens by : National Research Council

Download or read book Review of the Formaldehyde Assessment in the National Toxicology Program 12th Report on Carcinogens written by National Research Council and published by . This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Review of: Report on carcinogens. 12th ed. 2011.

Review of the Formaldehyde Assessment in the National Toxicology Program 12th Report on Carcinogens

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Publisher :
ISBN 13 : 9780309312240
Total Pages : 232 pages
Book Rating : 4.3/5 (122 download)

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Book Synopsis Review of the Formaldehyde Assessment in the National Toxicology Program 12th Report on Carcinogens by :

Download or read book Review of the Formaldehyde Assessment in the National Toxicology Program 12th Report on Carcinogens written by and published by . This book was released on 2014 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Many people in the United States are exposed to formaldehyde. Exposure can occur from environmental sources (for example, combustion processes, building materials, and tobacco smoke) or in occupational settings (for example, the furniture, textile, and construction industries). Formaldehyde exposure also has endogenous sources--it is produced intracellularly as a component of the one carbon pool intermediary metabolism pathway. Scientists have studied formaldehyde for decades to determine whether exogenous formaldehyde exposure may be associated with cancer in humans. In 1981, The National Toxicology Program (NTP) first listed formaldehyde in the 2nd Report on Carcinogens as "reasonably anticipated to be a human carcinogen". In 2011, NTP upgraded the listing of formaldehyde to "known to be a human carcinogen". Following the new listing, Congress directed the Department of Health and Human Services to arrange for the National Academy of Sciences to independently review formaldehyde's substance profile and listing. This report presents the findings and conclusions of the committee formed in response to the congressional request. Review of the Formaldehyde Assessment in the National Toxicology Program 12th Report on Carcinogens concurs with NTP that there is sufficient evidence in studies that had adequate characterization of relevant exposure metrics to enable a strong conclusion about the association between formaldehyde exposure and cancer in humans. Additionally, the authoring committee independently reviewed the scientific evidence from studies in humans, experimental animals, and other studies relevant to the mechanisms of carcinogenesis and made level-of-evidence conclusions. This report finds clear and convincing epidemiologic evidence of an association between formaldehyde exposure and nasopharyngeal and sinonasal cancers in humans."--Publisher's description.

Report on Carcinogens (12th Ed. )

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Publisher : DIANE Publishing
ISBN 13 : 1437987362
Total Pages : 507 pages
Book Rating : 4.4/5 (379 download)

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Book Synopsis Report on Carcinogens (12th Ed. ) by : Nat. Toxicology Program (NTP) (NIH)

Download or read book Report on Carcinogens (12th Ed. ) written by Nat. Toxicology Program (NTP) (NIH) and published by DIANE Publishing. This book was released on 2011-10-08 with total page 507 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Report on Carcinogens (RoC) is a congressionally mandated, science-based, public health document that identifies and discusses agents, substances, mixtures, or exposure circumstances (hereinafter referred to as "substances") that may pose a hazard to human health by virtue of their carcinogenicity. For each listed substance, the report contains a substance profile which provides information on (1) the listing status, (2) cancer studies in humans and animals, (3) studies of genotoxicity (ability to damage genes) and biologic mechanisms, (4) the potential for human exposure to these substances, and (5) Federalregulations to limit exposures. Eight substances have been added to this 12th ed. of the report, which now includes 240 listings. The industrial chemical formaldehyde and a botanical known as aristolochic acids are listed as known human carcinogens. Six other substances captafol, cobalt-tungsten carbide (in powder or hard metal form), certain inhalable glass wool fibers, o-nitrotoluene, riddelliine, and styrene are added as substances that are reasonably anticipated to be human carcinogens. Figures. This is a print on demand report.

Household Hazardous Waste Management

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Publisher : BoD – Books on Demand
ISBN 13 : 9535129090
Total Pages : 94 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Household Hazardous Waste Management by : Daniel Mmereki

Download or read book Household Hazardous Waste Management written by Daniel Mmereki and published by BoD – Books on Demand. This book was released on 2017-02-01 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rapid global urbanization and increases in living standards in recent decades have led to changes in the household hazardous waste (HHW) generation characteristics due to increases in buying power and easier access to products that are convenient but not always safe. In recent years, the amount of diversified hazardous materials and/or potentially hazardous materials, such as cleaning products, medicines, personal care products, packaging and container products, phthalates, and antibacterial agents, poses a serious threat to the environment and public health. As a result developed countries have adopted well-functioning policy measures and innovative technologies to deal with HHW. On the other hand, developing countries have weak institutional structures and poor policy performance and have adopted ad hoc approaches to manage HHW. The book contains five chapters covering topics of household hazardous waste management and exposure assessment. This book will be useful to many research scientists, solid and hazardous waste managers, administrators, librarians, and students in the scope of development in solid and hazardous waste management program including sources of household hazardous waste, exposure assessment, and government policies on waste generation and treatment and processing of HHW.

Using 21st Century Science to Improve Risk-Related Evaluations

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Publisher : National Academies Press
ISBN 13 : 0309453518
Total Pages : 201 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Using 21st Century Science to Improve Risk-Related Evaluations by : National Academies of Sciences, Engineering, and Medicine

Download or read book Using 21st Century Science to Improve Risk-Related Evaluations written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-02-16 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last decade, several large-scale United States and international programs have been initiated to incorporate advances in molecular and cellular biology, -omics technologies, analytical methods, bioinformatics, and computational tools and methods into the field of toxicology. Similar efforts are being pursued in the field of exposure science with the goals of obtaining more accurate and complete exposure data on individuals and populations for thousands of chemicals over the lifespan; predicting exposures from use data and chemical-property information; and translating exposures between test systems and humans. Using 21st Century Science to Improve Risk-Related Evaluations makes recommendations for integrating new scientific approaches into risk-based evaluations. This study considers the scientific advances that have occurred following the publication of the NRC reports Toxicity Testing in the 21st Century: A Vision and a Strategy and Exposure Science in the 21st Century: A Vision and a Strategy. Given the various ongoing lines of investigation and new data streams that have emerged, this publication proposes how best to integrate and use the emerging results in evaluating chemical risk. Using 21st Century Science to Improve Risk-Related Evaluations considers whether a new paradigm is needed for data validation, how to integrate the divergent data streams, how uncertainty might need to be characterized, and how best to communicate the new approaches so that they are understandable to various stakeholders.

Controlled Human Inhalation-Exposure Studies at EPA

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Publisher : National Academies Press
ISBN 13 : 030945252X
Total Pages : 159 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Controlled Human Inhalation-Exposure Studies at EPA by : National Academies of Sciences, Engineering, and Medicine

Download or read book Controlled Human Inhalation-Exposure Studies at EPA written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-04-10 with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt: The U.S. Environmental Protection Agency (EPA) has a mission and regulatory responsibility to protect human health and the environment. EPA's pursuit of that goal includes a variety of research activities involving human subjects, such as epidemiologic studies and surveys. Those research activities also involve studies of individuals who volunteer to be exposed to air pollutants intentionally in controlled laboratory settings so that measurements can be made of transient and reversible biomarker or physiologic responses to those exposures that can indicate pathways of toxicity and mechanisms of air-pollution responses. The results of those controlled human inhalation exposure (CHIE) studies, also referred to as human clinical studies or human challenge studies, are used to inform policy decisions and help establish or revise standards to protect public health and improve air quality. Controlled Human Inhalation-Exposure Studies at EPA addresses scientific issues and provides guidance on the conduct of CHIE studies. This report assesses the utility of CHIE studies to inform and reduce uncertainties in setting air-pollution standards to protect public health and assess whether continuation of such studies is warranted. It also evaluates the potential health risks to test subjects who participated in recent studies of air pollutants at EPA's clinical research facility.

Report on Carcinogens

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ISBN 13 :
Total Pages : 368 pages
Book Rating : 4.:/5 (6 download)

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Book Synopsis Report on Carcinogens by :

Download or read book Report on Carcinogens written by and published by . This book was released on 2000 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Acute Exposure Guideline Levels for Selected Airborne Chemicals

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Publisher : National Academies Press
ISBN 13 : 0309449189
Total Pages : 195 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Acute Exposure Guideline Levels for Selected Airborne Chemicals by : National Academies of Sciences, Engineering, and Medicine

Download or read book Acute Exposure Guideline Levels for Selected Airborne Chemicals written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2016-09-26 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extremely hazardous substances can be released accidentally as a result of chemical spills, industrial explosions, fires, or accidents involving railroad cars and trucks transporting EHSs. Workers and residents in communities surrounding industrial facilities where these substances are manufactured, used, or stored and in communities along the nation's railways and highways are potentially at risk of being exposed to airborne EHSs during accidental releases or intentional releases by terrorists. Pursuant to the Superfund Amendments and Reauthorization Act of 1986, the U.S. Environmental Protection Agency (EPA) has identified approximately 400 EHSs on the basis of acute lethality data in rodents. Acute Exposure Guideline Levels for Selected Airborne Chemicals, Volume 20 reviews and updates the technical support document on acute exposure guideline levels (AEGLs) for selected chloroformates. This update focuses on establishing AEGL-3 values for n-propyl chloroformate and isopropyl chloroformate, but will also consider whether any new data are available that would affect the proposed values for the other 10 chloroformates. AEGLs represent threshold exposure limits (exposure levels below which adverse health effects are not likely to occur) for the general public and are applicable to emergency exposures ranging from 10 minutes (min) to 8 h. Three levels - AEGL-1, AEGL-2, and AEGL-3 - are developed for each of five exposure periods (10 min, 30 min, 1 h, 4 h, and 8 h) and are distinguished by varying degrees of severity of toxic effects. This report will inform planning, response, and prevention in the community, the workplace, transportation, the military, and the remediation of Superfund sites.

Application of Modern Toxicology Approaches for Predicting Acute Toxicity for Chemical Defense

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Publisher : National Academies Press
ISBN 13 : 0309376696
Total Pages : 134 pages
Book Rating : 4.3/5 (93 download)

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Book Synopsis Application of Modern Toxicology Approaches for Predicting Acute Toxicity for Chemical Defense by : National Academies of Sciences, Engineering, and Medicine

Download or read book Application of Modern Toxicology Approaches for Predicting Acute Toxicity for Chemical Defense written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2015-09-01 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt: The US Department of Defense (DOD) is faced with an overwhelming task in evaluating chemicals that could potentially pose a threat to its deployed personnel. There are over 84,000 registered chemicals, and testing them with traditional toxicity-testing methods is not feasible in terms of time or money. In recent years, there has been a concerted effort to develop new approaches to toxicity testing that incorporate advances in systems biology, toxicogenomics, bioinformatics, and computational toxicology. Given the advances, DOD asked the National Research Council to determine how DOD could use modern approaches for predicting chemical toxicity in its efforts to prevent debilitating, acute exposures to deployed personnel. This report provides an overall conceptual approach that DOD could use to develop a predictive toxicology system. Application of Modern Toxicology Approaches for Predicting Acute Toxicity for Chemical Defense reviews the current state of computational and high-throughput approaches for predicting acute toxicity and suggests methods for integrating data and predictions. This report concludes with lessons learned from current high-throughput screening programs and suggests some initial steps for DOD investment.

Refinements to the Methods for Developing Spacecraft Exposure Guidelines

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Publisher : National Academies Press
ISBN 13 : 0309390788
Total Pages : 65 pages
Book Rating : 4.3/5 (93 download)

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Book Synopsis Refinements to the Methods for Developing Spacecraft Exposure Guidelines by : National Academies of Sciences, Engineering, and Medicine

Download or read book Refinements to the Methods for Developing Spacecraft Exposure Guidelines written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2016-05-07 with total page 65 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human spaceflight is inherently risky, with numerous potential hazards posed at each phase of a mission. Potential health risks during spaceflights include short-term health consequences from being in microgravity, as well as long-term health consequences that arise, or continue, months or years after a flight. Additional health considerations are risks posed by exposure to environmental contaminants onboard spacecraft. Because the International Space Station and spacecraft are closed environments that require recirculation of air and water supplies, some contamination of the air and water will occur. Even with onboard air and water purification systems, chemicals will accumulate in the air and water as they recirculate or are recycled onboard. Therefore, it is necessary for the National Aeronautics and Space Administration (NASA) to identify hazardous contaminants and determine exposure levels that are not expected to pose a health risk to astronauts. NASA uses spacecraft maximum allowance concentrations (SMACs) and spacecraft water exposure guidelines (SWEGs) to provide guidance on acceptable exposures to air and water contaminants during normal operations and emergency situations. Refinements to the Methods for Developing Spacecraft Exposure Guidelines updates the methods for establishing SMACs and SWEGs and assists NASA with identifying chemicals that need updated SMACs or SWEGs and new chemicals for which these guidelines should be developed.

Acute Exposure Guideline Levels for Selected Airborne Chemicals

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Publisher : National Academies Press
ISBN 13 : 0309368979
Total Pages : 224 pages
Book Rating : 4.3/5 (93 download)

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Book Synopsis Acute Exposure Guideline Levels for Selected Airborne Chemicals by : National Research Council

Download or read book Acute Exposure Guideline Levels for Selected Airborne Chemicals written by National Research Council and published by National Academies Press. This book was released on 2015-04-09 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extremely hazardous substances can be released accidentally as a result of chemical spills, industrial explosions, fires, or accidents involving railroad cars and trucks transporting EHSs. Workers and residents in communities surrounding industrial facilities where these substances are manufactured, used, or stored and in communities along the nation's railways and highways are potentially at risk of being exposed to airborne EHSs during accidental releases or intentional releases by terrorists. Pursuant to the Superfund Amendments and Reauthorization Act of 1986, the U.S. Environmental Protection Agency (EPA) has identified approximately 400 EHSs on the basis of acute lethality data in rodents. Acute Exposure Guideline Levels for Selected Airborne Chemicals, Volume 19 identifies, reviews, and interprets relevant toxicologic and other scientific data for selected AEGL documents for cyanide salts, diketene, methacrylaldehyde, pentaborane, tellurium hexafluoride, and tetrafluoroethylene in order to develop acute exposure guideline levels (AEGLs) for these high-priority, acutely toxic chemicals. AEGLs represent threshold exposure limits (exposure levels below which adverse health effects are not likely to occur) for the general public and are applicable to emergency exposures ranging from 10 minutes (min) to 8 h. Three levels - AEGL-1, AEGL-2, and AEGL-3 - are developed for each of five exposure periods (10 min, 30 min, 1 h, 4 h, and 8 h) and are distinguished by varying degrees of severity of toxic effects. This report will inform planning, response, and prevention in the community, the workplace, transportation, the military, and the remediation of Superfund sites.

Review of the Draft NTP Monograph

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Publisher : National Academies Press
ISBN 13 : 0309673135
Total Pages : 61 pages
Book Rating : 4.3/5 (96 download)

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Book Synopsis Review of the Draft NTP Monograph by : National Academies of Sciences, Engineering, and Medicine

Download or read book Review of the Draft NTP Monograph written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2020-03-18 with total page 61 pages. Available in PDF, EPUB and Kindle. Book excerpt: The National Toxicology Program (NTP) conducted a systematic review of the evidence of adverse neurodevelopmental and cognitive effects of fluoride exposure. NTP's conclusions are summarized in the monograph Systematic Review of Fluoride Exposure and Neurodevelopmental and Cognitive Health Effects. At the request of NTP, a committee convened by the National Academies reviewed their monograph to ensure the integrity of that report. It is important to note that the committee was tasked with reviewing the monograph and focused its efforts on evaluating whether evidence as presented in the monograph supported NTP's conclusions. Thus, it did not conduct its own independent evaluation of the evidence, and it did not conduct a data audit. However, it did review some key literature to enable its review of the monograph. Review of the Draft NTP Monograph contains findings and suggestions for improvements and some overarching findings concerning methods, assessment of animal and human evidence, and NTP's hazard conclusion.

The Healing Power of Essential Oils

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Publisher : Harmony
ISBN 13 : 1524761362
Total Pages : 322 pages
Book Rating : 4.5/5 (247 download)

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Book Synopsis The Healing Power of Essential Oils by : Eric Zielinski, DC

Download or read book The Healing Power of Essential Oils written by Eric Zielinski, DC and published by Harmony. This book was released on 2018-03-13 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: NATIONAL BESTSELLER • Discover the life-changing benefit of essential oils and aromatherapy in this soup-to-nuts guide from the host of the Essential Oil Revolution summits “A powerful new approach that can help you safely reverse the effects of modern scourges, including depression, chronic stress, and mood disorders.”—Alan Christianson, N.M.D., New York Times bestselling author of The Adrenal Reset Diet Aromatic plants and their extracted oils have been used medicinally and in religious traditions for thousands of years; they represent nature in its most concentrated form. Through modern distillation processes, essential oils offer natural treatments for a host of health conditions, from anxiety and depression to hormonal imbalance, digestive distress, candida, sleep disorders, and even autoimmune disease. The Healing Power of Essential Oils includes DIY recipes and formulations for all of these health needs and more—all backed by extensive scientific research and the trusted guidance of public health researcher and aromatherapist Eric Zielinski, D.C. Some of the unique recipes you will master: • Morning Prayer or Meditation Body Oil • Sweet Slumber Diffuser Blend • Citrus-Powered Pain Relief Roll-On • Deet-Free Bug Spray • Essential Oil-Powered Mouthwash • Anti-aging Body Butter • Lemon Fresh Laundry Detergent • Hot Spot Spray for Pets • Perineum Healing Soap • Menopause Relief Ointment From lavender, peppermint, and frankincense to tea tree and ylang ylang, essential oils are God’s gift to those seeking to take control of their physical and mental health. Whether you’re new to essential oils or you’re ready for advanced techniques, Dr. Z’s thorough, evidence-based approach equips you with the knowledge to build daily rituals that fit your unique needs—and lead to amazing results!

Respiratory Health Effects of Airborne Hazards Exposures in the Southwest Asia Theater of Military Operations

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Author :
Publisher : National Academies Press
ISBN 13 : 0309679133
Total Pages : 271 pages
Book Rating : 4.3/5 (96 download)

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Book Synopsis Respiratory Health Effects of Airborne Hazards Exposures in the Southwest Asia Theater of Military Operations by : National Academies of Sciences, Engineering, and Medicine

Download or read book Respiratory Health Effects of Airborne Hazards Exposures in the Southwest Asia Theater of Military Operations written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2020-09-23 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: More than 3.7 million U.S. service members have participated in operations taking place in the Southwest Asia Theater of Military Operations since 1990. These operations include the 1990-1991 Persian Gulf War, a post-war stabilization period spanning 1992 through September 2001, and the campaigns undertaken in the wake of the September 11, 2001, attacks. Deployment to Iraq, Kuwait, Saudi Arabia, Bahrain, Gulf of Aden, Gulf of Oman, Oman, Qatar, the United Arab Emirates, and Afghanistan exposed service members to a number of airborne hazards, including oil-well fire smoke, emissions from open burn pits, dust and sand suspended in the air, and exhaust from diesel vehicles. The effects of these were compounded by stressors like excessive heat and noise that are inevitable attributes of service in a combat environment. Respiratory Health Effects of Airborne Hazards Exposures in the Southwest Asia Theater of Military Operations reviews the scientific evidence regarding respiratory health outcomes in veterans of the Southwest Asia conflicts and identifies research that could feasibly be conducted to address outstanding questions and generate answers, newly emerging technologies that could aid in these efforts, and organizations that the Veterans Administration might partner with to accomplish this work.

World Trade Center Chemicals of Potential Concern and Selected Other Chemical Agents

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Publisher :
ISBN 13 :
Total Pages : 93 pages
Book Rating : 4.:/5 (781 download)

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Book Synopsis World Trade Center Chemicals of Potential Concern and Selected Other Chemical Agents by : Robert E. McCleery

Download or read book World Trade Center Chemicals of Potential Concern and Selected Other Chemical Agents written by Robert E. McCleery and published by . This book was released on 2012 with total page 93 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The James Zadroga 9/11 Health and Compensation Act of 2010, Public Law 111-347, Title XXXIII of the Public Health Service Act, 124 Stat. 3623 (codified at 42 United States Code section 300mm-300mm-61), requires the Administrator of the World Trade Center (WTC) Health Program to "periodically conduct a review of all available scientific and medical evidence, including findings and recommendations of Clinical Centers of Excellence, published in peer-reviewed journals to determine if, based on such evidence, cancer or a certain type of cancer should be added to the applicable list of WTC-related health conditions." 42 U.S.C. sec. 300mm-22(a)(5)(A). The National Institute for Occupational Safety and Health (NIOSH) presented the first periodic review of cancer for the WTC Health Program in July 2011. This review included findings from the peer-reviewed scientific and medical literature about exposures and cancer resulting from the September 11, 2001, terrorist attacks [NIOSH 2011]. The Exposure section of the first periodic review provided an initial list of agents detected in the area around the World Trade Center (WTC) during the disaster response and recovery periods. The Contaminants of Potential Concern (COPC) Committee of the World Trade Center Indoor Air Task Force Working Group developed the initial list from the chemicals identified in air sample testing results included in four databases [COPC Committee 2003]. The committee used this list to select COPCs and set health-based benchmarks for indoor environments. The four data sources were the: 1. Environmental Protection Agency (EPA) Region 2 database of environmental sampling results, which contains more than 200,000 records on sampling results for 137 agents; 2. New York City Department of Health and Mental Hygiene (NYCDOHMH)/Agency for Toxic Substances and Disease Registry (ATSDR) public health investigation database, which includes results from Lower Manhattan samples of six minerals, 354 air samples from residential buildings, and 32 samples of fibers collected outdoors and analyzed by phase contrast microscopy; 3. New York City Department of Education findings from sampling in schools, which involved samples collected both indoors and outdoors from six schools between September 2001 and June 2002 and includes more than 30,000 records of air sampling results for more than 70 agents; and 4. Chatfield and Kominsky's survey of indoor air quality. A total of 287 chemicals or chemical groups were identified from the report [COPC Committee 2003], and each of them was checked against (1) the United States National Toxicology Program (NTP) 12th Report on Carcinogens (RoC) [NTP 2011] and (2) the United Nations International Agency on Research on Cancer (IARC) list of agents and documented in the IARC monographs, Volumes 1-102 [IARC 2006]. The list and cancer designations of these chemicals were provided in Appendix E of the First Periodic Review of Scientific and Medical Evidence Related to Cancer for the World Trade Center Health Program [NIOSH 2011]. In addition to the agents identified by the COPC Committee [COPC 2003], several other agents of potential concern have been included because of the potential for widespread exposure. In particular, the fires at the WTC site produced over an extended period of time substantial amounts of combustion products from building materials, including wood and plastics. Also, a large number of trucks, many of which run on diesel fuels, were used at the WTC site. These trucks likely produced large quantities of diesel particulates, which were discharged into the air at and around the WTC site. Because of the potential exposure of rescue and recovery workers, as well as workers and residents in area buildings, to soot, biomass fuel, and diesel particulates, these are included with the COPC agents identified by EPA. Tables 1, 2, and 3 (Section IV) provide the cancer classifications of NTP and IARC and expand upon the information provided in the first periodic report by providing a summary of the basis for the IARC classification. NTP and IARC do not address decomposition products from plastics as a group; they are addressed only as individual compounds. Therefore, the individual compounds from thermal decomposition of plastics that were identified by the COPC Committee are included in the tables. A summary of the studies cited in the IARC monographs is provided in Section IV. Hyperlinks to the NTP Report on Carcinogens and the IARC monographs are provided as well. The agents identified as COPC and other select agents are grouped according to their IARC designation as Group 1, 2A, or 2B. Agents categorized by IARC as Group 3 or Group 4 are not summarized because they are not expected to contribute to potential cancer outcomes among the rescue and recovery workers and the survivors. Descriptions of uncategorized agents are not available in the IARC Monographs. A total of 63 agents are included from the original list of 287 COPCs, and the additional three agents (soot, biomass fuel, and diesel) have been added." - NIOSHTIC-2