Controlled Human Inhalation-Exposure Studies at EPA

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Author :
Publisher : National Academies Press
ISBN 13 : 030945249X
Total Pages : 159 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Controlled Human Inhalation-Exposure Studies at EPA by : National Academies of Sciences, Engineering, and Medicine

Download or read book Controlled Human Inhalation-Exposure Studies at EPA written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-05-10 with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt: The U.S. Environmental Protection Agency (EPA) has a mission and regulatory responsibility to protect human health and the environment. EPA's pursuit of that goal includes a variety of research activities involving human subjects, such as epidemiologic studies and surveys. Those research activities also involve studies of individuals who volunteer to be exposed to air pollutants intentionally in controlled laboratory settings so that measurements can be made of transient and reversible biomarker or physiologic responses to those exposures that can indicate pathways of toxicity and mechanisms of air-pollution responses. The results of those controlled human inhalation exposure (CHIE) studies, also referred to as human clinical studies or human challenge studies, are used to inform policy decisions and help establish or revise standards to protect public health and improve air quality. Controlled Human Inhalation-Exposure Studies at EPA addresses scientific issues and provides guidance on the conduct of CHIE studies. This report assesses the utility of CHIE studies to inform and reduce uncertainties in setting air-pollution standards to protect public health and assess whether continuation of such studies is warranted. It also evaluates the potential health risks to test subjects who participated in recent studies of air pollutants at EPA's clinical research facility.

Review of the Environmental Protection Agency's Draft IRIS Assessment of Tetrachloroethylene

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Publisher : National Academies Press
ISBN 13 : 0309152356
Total Pages : 187 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Review of the Environmental Protection Agency's Draft IRIS Assessment of Tetrachloroethylene by : National Research Council

Download or read book Review of the Environmental Protection Agency's Draft IRIS Assessment of Tetrachloroethylene written by National Research Council and published by National Academies Press. This book was released on 2010-03-18 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tetrachloroethylene is a volatile, chlorinated organic hydrocarbon that is widely used as a solvent in the dry-cleaning and textile-processing industries and as an agent for degreasing metal parts. It is an environmental contaminant that has been detected in the air, groundwater, surface waters, and soil. In June 2008, the U.S. Environmental Protection Agency released its draft Toxicological Review of Tetrachloroethylene (Perchloroethylene) (CAS No. 127-18-4) in Support of Summary Information on the Integrated Risk Information System (IRIS). The draft IRIS assessment provides quantitative estimates of cancer and noncancer effects of exposure to tetrachloreothylene, which will be used to establish airquality and water-quality standards to protect public health and to set cleanup standards for hazardous waste sites. At the request of EPA, the National Research Council conducted an independent scientific review of the draft IRIS assessment of tetrachloroethylene from toxicologic, epidemiologic, and human clinical perspectives. The resulting book evaluates the adequacy of the EPA assessment, the data and methods used for deriving the noncancer values for inhalation and oral exposures and the oral and inhalation cancer unit risks posed by tetrachloroethylene; evaluates whether the key studies underlying the draft IRIS assessment are of requisite quality, reliability, and relevance to support the derivation of the reference values and cancer risks; evaluates whether the uncertainties in EPA's risk assessment were adequately described and, where possible, quantified; and identifies research that could reduce the uncertainty in the current understanding of human health effects associated with tetrachloroethylene exposure.

Intentional Human Dosing Studies for EPA Regulatory Purposes

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Publisher : National Academies Press
ISBN 13 : 0309166411
Total Pages : 226 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Intentional Human Dosing Studies for EPA Regulatory Purposes by : National Research Council

Download or read book Intentional Human Dosing Studies for EPA Regulatory Purposes written by National Research Council and published by National Academies Press. This book was released on 2004-06-04 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: The EPA commissioned The National Academies to provide advice on the vexing question of whether and, if so, under what circumstances EPA should accept and consider intentional human dosing studies conducted by companies or other sources outside the agency (so-called third parties) to gather evidence relating to the risks of a chemical or the conditions under which exposure to it could be judged safe. This report recommends that such studies be conducted and used for regulatory purposes only if all of several strict conditions are met, including the following: The study is necessary and scientifically valid, meaning that it addresses an important regulatory question that can't be answered with animal studies or nondosing human studies; The societal benefits of the study outweigh any anticipated risks to participants. At no time, even when benefits beyond improved regulation exist, can a human dosing study be justified that is anticipated to cause lasting harm to study participants; and All recognized ethical standards and procedures for protecting the interests of study participants are observed. In addition, EPA should establish a Human Studies Review Board (HSRB) to evaluate all human dosing studiesâ€"both at the beginning and upon completion of the experimentsâ€"if they are carried out with the intent of affecting the agency's policy-making.

Review of the national ambient air quality standards for particulate matter policy assessment of scientific and technical information.

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Author :
Publisher : DIANE Publishing
ISBN 13 : 1428904697
Total Pages : 525 pages
Book Rating : 4.4/5 (289 download)

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Book Synopsis Review of the national ambient air quality standards for particulate matter policy assessment of scientific and technical information. by :

Download or read book Review of the national ambient air quality standards for particulate matter policy assessment of scientific and technical information. written by and published by DIANE Publishing. This book was released on 1996 with total page 525 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Inside Story

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Publisher :
ISBN 13 :
Total Pages : 38 pages
Book Rating : 4.3/5 (121 download)

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Book Synopsis The Inside Story by : United States. Environmental Protection Agency. Office of Air and Radiation

Download or read book The Inside Story written by United States. Environmental Protection Agency. Office of Air and Radiation and published by . This book was released on 1995 with total page 38 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Human exposure assessment : a guide to risk ranking, risk reduction, and research planning

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Publisher : DIANE Publishing
ISBN 13 : 1428904026
Total Pages : 72 pages
Book Rating : 4.4/5 (289 download)

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Book Synopsis Human exposure assessment : a guide to risk ranking, risk reduction, and research planning by :

Download or read book Human exposure assessment : a guide to risk ranking, risk reduction, and research planning written by and published by DIANE Publishing. This book was released on with total page 72 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Air Quality Criteria for Particulate Matter

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Publisher :
ISBN 13 :
Total Pages : 1100 pages
Book Rating : 4.3/5 ( download)

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Book Synopsis Air Quality Criteria for Particulate Matter by : National Center for Environmental Assessment (Research Triangle Park, N.C.)

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Air Quality Criteria for Carbon Monoxide

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Publisher :
ISBN 13 :
Total Pages : 188 pages
Book Rating : 4.:/5 (25 download)

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Book Synopsis Air Quality Criteria for Carbon Monoxide by : United States. National Air Pollution Control Administration

Download or read book Air Quality Criteria for Carbon Monoxide written by United States. National Air Pollution Control Administration and published by . This book was released on 1970 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Relationship between concentration of carbon monoxide in the air and its adverse effects on man and the environment.

Health Effects Assessment Summary Tables

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Publisher :
ISBN 13 :
Total Pages : 414 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Health Effects Assessment Summary Tables by :

Download or read book Health Effects Assessment Summary Tables written by and published by . This book was released on 1997 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt:

EPA 630/R

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Publisher :
ISBN 13 :
Total Pages : 94 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis EPA 630/R by :

Download or read book EPA 630/R written by and published by . This book was released on 1998 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Air Pollution, the Automobile, and Public Health

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Publisher : National Academies Press
ISBN 13 : 0309037263
Total Pages : 703 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Air Pollution, the Automobile, and Public Health by : Sponsored by The Health Effects Institute

Download or read book Air Pollution, the Automobile, and Public Health written by Sponsored by The Health Effects Institute and published by National Academies Press. This book was released on 1988-01-01 with total page 703 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The combination of scientific and institutional integrity represented by this book is unusual. It should be a model for future endeavors to help quantify environmental risk as a basis for good decisionmaking." â€"William D. Ruckelshaus, from the foreword. This volume, prepared under the auspices of the Health Effects Institute, an independent research organization created and funded jointly by the Environmental Protection Agency and the automobile industry, brings together experts on atmospheric exposure and on the biological effects of toxic substances to examine what is knownâ€"and not knownâ€"about the human health risks of automotive emissions.

Indoor Pollutants

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Publisher : National Academies Press
ISBN 13 :
Total Pages : 553 pages
Book Rating : 4./5 ( download)

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Book Synopsis Indoor Pollutants by : National Research Council

Download or read book Indoor Pollutants written by National Research Council and published by National Academies Press. This book was released on 1981-01-01 with total page 553 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discusses pollution from tobacco smoke, radon and radon progeny, asbestos and other fibers, formaldehyde, indoor combustion, aeropathogens and allergens, consumer products, moisture, microwave radiation, ultraviolet radiation, odors, radioactivity, and dirt and discusses means of controlling or eliminating them.

WHO Guidelines for Indoor Air Quality

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Publisher : World Health Organization
ISBN 13 :
Total Pages : 488 pages
Book Rating : 4.:/5 (1 download)

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Book Synopsis WHO Guidelines for Indoor Air Quality by :

Download or read book WHO Guidelines for Indoor Air Quality written by and published by World Health Organization. This book was released on 2010 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents WHO guidelines for the protection of public health from risks due to a number of chemicals commonly present in indoor air. The substances considered in this review, i.e. benzene, carbon monoxide, formaldehyde, naphthalene, nitrogen dioxide, polycyclic aromatic hydrocarbons (especially benzo[a]pyrene), radon, trichloroethylene and tetrachloroethylene, have indoor sources, are known in respect of their hazardousness to health and are often found indoors in concentrations of health concern. The guidelines are targeted at public health professionals involved in preventing health risks of environmental exposures, as well as specialists and authorities involved in the design and use of buildings, indoor materials and products. They provide a scientific basis for legally enforceable standards.

Risk Assessment Guidance for Superfund: pt. A. Human health evaluation manual

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Author :
Publisher :
ISBN 13 :
Total Pages : 300 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Risk Assessment Guidance for Superfund: pt. A. Human health evaluation manual by :

Download or read book Risk Assessment Guidance for Superfund: pt. A. Human health evaluation manual written by and published by . This book was released on 1989 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Technical Support Document for Water Quality-based Toxics Control

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Publisher :
ISBN 13 :
Total Pages : 284 pages
Book Rating : 4.3/5 (121 download)

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Book Synopsis Technical Support Document for Water Quality-based Toxics Control by :

Download or read book Technical Support Document for Water Quality-based Toxics Control written by and published by . This book was released on 1984 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Particulate Air Pollution Controversy

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Publisher : Springer Science & Business Media
ISBN 13 : 0306482088
Total Pages : 128 pages
Book Rating : 4.3/5 (64 download)

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Book Synopsis The Particulate Air Pollution Controversy by : Robert F. Phalen

Download or read book The Particulate Air Pollution Controversy written by Robert F. Phalen and published by Springer Science & Business Media. This book was released on 2007-05-08 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: Small invisible particles in the urban air, especially those produced by human activities, have recently stimulated intense scrutiny, debate, regulation, and legal proceedings. The stakes are high, both with respect to health impacts and economic costs, and the methods used previously to resolve similar issues are no longer adequate. Everyone on earth inhales thousands to millions of particles in each breath, so if urban particulate air pollution—particulate matter (PM)—is significantly hazardous, the negative impact on health could be staggering. Yet the activities that generate PM, such as farming, manufacturing, mining, transportation, and generating electricity, are themselves essential to human health and welfare. Scientists, regulators, legislators, activists, judges, lawyers, journalists, and representatives of the business community are actively involved in addressing the question of what should be done. This complex issue presents opportunities for critically assessing the relevant knowledge and for adopting more rigorous approaches to this and similar problems. What is the PM controversy, and why is it a good case study for how science and public policy might better interface? The PM controversy is the sum of the frequently heated debates related to the potential health risks from urban PM.

Child-specific Exposure Factors Handbook

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Publisher :
ISBN 13 :
Total Pages : 452 pages
Book Rating : 4.:/5 (31 download)

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Book Synopsis Child-specific Exposure Factors Handbook by :

Download or read book Child-specific Exposure Factors Handbook written by and published by . This book was released on 2002 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: