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Retinal Pharmacotherapeutics
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Book Synopsis Retinal Pharmacotherapeutics by : Q.D. Nguyen
Download or read book Retinal Pharmacotherapeutics written by Q.D. Nguyen and published by Karger Medical and Scientific Publishers. This book was released on 2015-10-27 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of pharmacotherapeutics in the management of retinal diseases is rapidly evolving, and a favorable therapy for the patient. Today anti-VEGF agents are used for a range of indications from inflammation-related choroidal neovascularization to macular edema secondary to retinal vein occlusion or diabetic retinopathy. Beyond VEGF, there is an array of target areas under investigation – not only for vascular pathologies such as age-related macular degeneration and diabetic eye disease, but also for degenerative, infectious and inflammatory retinal conditions. This publication discusses many aspects from basic research on the retina, to animal models for retinal drug delivery, retinal diseases that are amenable to pharmacotherapy and also drugs and mechanisms in retinal diseases. Anyone concerned with the management of retinal diseases - the general ophthalmologist and the retina specialist alike – will find this book indispensable reading.
Book Synopsis Retinal Pharmacotherapy E-Book by : Quan Dong Nguyen
Download or read book Retinal Pharmacotherapy E-Book written by Quan Dong Nguyen and published by Elsevier Health Sciences. This book was released on 2010-02-26 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: Retinal Pharmacotherapy is the first comprehensive book devoted to pharmacologic agents and their rationale and mechanisms of action in selected retinal and uveitic diseases. Drs. Quan Dong Nguyen, Eduardo Buchele Rodrigues, Michel Eid Farah, and William F. Mieler lead an international team of expert contributors to present up-to-date knowledge of new drugs on the market, the science behind the drugs, evidence of how the drugs work, and the reasons why they are effective or not. This user-friendly, all-in-one reference provides you with easy access to practical information on the effective and appropriate use of pharmacologic agents in the management of retinal diseases. Covers all new and existing retinal drugs to keep you current in this expanding area of the treatment of retinal diseases. Discusses the background behind retinal drugs and the various pathways of how they work so you can make thoroughly informed clinical decisions. Presents 400 color photographs and line drawings that illustrate disease appearance before and after treatment and clarify difficult key concepts. Features contributors from Europe, North America, South America, the Middle East, Asia, and Australia for an international approach. Identifies and emphasizes key points clearly in each chapter to improve comprehension and make finding information easier.
Book Synopsis Drug Delivery for the Retina and Posterior Segment Disease by : Jayvadan K. Patel
Download or read book Drug Delivery for the Retina and Posterior Segment Disease written by Jayvadan K. Patel and published by Springer. This book was released on 2018-10-08 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses the issues relating to a wide variety of ocular diseases from which millions of people suffer. Long-term challenges include visual impairment and ocular blindness. Certain ocular diseases are quite rare, whereas others, such as cataracts, age-related macular degeneration (AMD), and glaucoma, are very common, especially in the aging population. A rapid expansion of new technologies in ocular drug delivery and new drug candidates, including biologics, to treat these challenging diseases in the retina and posterior segments of the eye have recently emerged. These approaches are necessary because the eye has many unique barriers to drug delivery. Thus, this timely reference Drug Delivery for the Retina and Posterior Segment Disease compiles and analyzes recent advances in the research and development of drug delivery systems for retina and posterior segment diseases of the eye, with an emphasis on the use of implantable devices, iontophoresis as well as micro- and nanoparticles.
Book Synopsis Drug Delivery Challenges and Novel Therapeutic Approaches for Retinal Diseases by : Christopher L. Cioffi
Download or read book Drug Delivery Challenges and Novel Therapeutic Approaches for Retinal Diseases written by Christopher L. Cioffi and published by Springer Nature. This book was released on 2020-09-23 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the current state of ocular drug therapy and future therapeutic opportunities for a wide variety of conditions, including Age-related Macular Degeneration, Diabetic Retinopathy and Macular Edema, Glaucoma, and Inherited Retinal Diseases. Retinal diseases are major contributors to moderate or severe vision impairment in adults aged 50 years and older. The respective patient populations for many of these indications is expected to significantly increase as the world population continues to grow older. An improved understanding of the etiological underpinnings of ocular degenerative diseases over the past decade has significantly bolstered ophthalmic drug discovery. In this volume, contributions from leading experts explore the unique challenges faced for ocular drug discovery and delivery providing the reader with detailed information on ocular pharmacokinetics, in vitro, ex vivo and in vivo models for retinal disease pathology and emerging gene therapy treatments. The book is intended for all researchers and clinicians who wish to increase their knowledge on the latest findings in ocular drug therapy.
Book Synopsis Drug Product Development for the Back of the Eye by : Uday B. Kompella
Download or read book Drug Product Development for the Back of the Eye written by Uday B. Kompella and published by Springer Science & Business Media. This book was released on 2011-08-03 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive volume discusses approaches for a systematic selection of delivery systems for various classes of therapeutic agents including small molecule, protein, and nucleic acid drugs. Specific topics covered in this book include: Solution, suspension, gel, nanoparticle, microparticle, and implant dosage forms Refillable and microneedle devices Intravitreal, suprachoroidal, intrascleral, transscleral, systemic, and topical routes of delivery Physical methods including iontophoresis for drug delivery Rational selection of routes of administration and delivery systems Noninvasive and continuous drug monitoring Regulatory path to drug product development Clinical endpoints for drug product development Emerging and existing drugs and drug targets Drug Product Development for the Back of the Eye is authored by renowned ocular drug delivery experts, representing academic, clinical, and industrial organizations and serves as indispensable resource for ophthalmic researchers, drug formulation scientists, drug delivery and drug disposition scientists, as well as clinicians involved in designing and developing novel therapeutics for the back of the eye diseases. This book is also relevant for students in various disciplines including ophthalmology, pharmaceutical sciences, drug delivery, and biomedical engineering. Refillable and microneedle devices Intravitreal, suprachoroidal, intrascleral, transscleral, systemic, and topical routes of delivery Physical methods including iontophoresis for drug delivery Rational selection of routes of administration and delivery systems Noninvasive and continuous drug monitoring Regulatory path to drug product development Clinical endpoints for drug product development Emerging and existing drugs and drug targets Drug Product Development for the Back of the Eye is authored by renowned ocular drug delivery experts, representing academic, clinical, and industrial organizations and serves as indispensable resource for ophthalmic researchers, drug formulation scientists, drug delivery and drug disposition scientists, as well as clinicians involved in designing and developing novel therapeutics for the back of the eye diseases. This book is also relevant for students in various disciplines including ophthalmology, pharmaceutical sciences, drug delivery, and biomedical engineering. Refillable and microneedle devices Intravitreal, suprachoroidal, intrascleral, transscleral, systemic, and topical routes of delivery Physical methods including iontophoresis for drug delivery Rational selection of routes of administration and delivery systems Noninvasive and continuous drug monitoring Regulatory path to drug product development Clinical endpoints for drug product development Emerging and existing drugs and drug targets Drug Product Development for the Back of the Eye is authored by renowned ocular drug delivery experts, representing academic, clinical, and industrial organizations and serves as indispensable resource for ophthalmic researchers, drug formulation scientists, drug delivery and drug disposition scientists, as well as clinicians involved in designing and developing novel therapeutics for the back of the eye diseases. This book is also relevant for students in various disciplines including ophthalmology, pharmaceutical sciences, drug delivery, and biomedical engineering.
Book Synopsis Pharmacologic Therapy of Ocular Disease by : Scott M. Whitcup
Download or read book Pharmacologic Therapy of Ocular Disease written by Scott M. Whitcup and published by Springer. This book was released on 2017-06-05 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: There have been major advancements in the pharmacologic treatment of eye diseases over the past decade. With newly discovered disease targets and novel approaches to deliver therapeutic compounds to the eye, patients are seeing improved outcomes. Not only are there better treatments for diseases where treatments existed, we now have effective therapy for previously untreatable and blinding eye disorders. This volume will cover the pharmacologic treatment of eye diseases from the front of the eye including eyelids, conjunctiva and cornea all the way back to the retina and optic nerve. The first section of the volume reviews general principles of ocular pharmacology, pharmacokinetics, pharmaceutical sciences, and drug delivery. In addition, the volume provides an up to date guide to the pharmacologic approach to the key eye diseases that threaten sight or ocular function.
Book Synopsis Intraocular Drug Delivery by : Glenn J. Jaffe
Download or read book Intraocular Drug Delivery written by Glenn J. Jaffe and published by CRC Press. This book was released on 2006-03-13 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference studies the most recent advances in the development of ocular drug delivery systems. Covering methods to treat or prevent ocular inflammation, retinal vascular disease, retinal degeneration, and proliferative eye disease, this source covers breakthroughs in the management of endophthalmitis, uveitis, diabetic macular edema, and age-r
Book Synopsis Therapies for Retinal Degeneration by : de la Rosa (Enrique J.)
Download or read book Therapies for Retinal Degeneration written by de la Rosa (Enrique J.) and published by Royal Society of Chemistry. This book was released on 2018 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses approaches to the treatment of retinal diseases, targeting common processes and components.
Book Synopsis Pharmacology of Ocular Therapeutics by : Thirumurthy Velpandian
Download or read book Pharmacology of Ocular Therapeutics written by Thirumurthy Velpandian and published by Springer. This book was released on 2016-02-29 with total page 541 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book comprises an integrated review of ocular therapeutics across all relevant fields. It addresses the real-world requirements of ophthalmologists, pharmacists and optometrists, as observed through working alongside these practitioners for two decades. Knowledge surrounding agents used in ophthalmic practice has, historically, been scattered. The book facilitates understanding of ocular drug therapy by compiling all key aspects of the pharmacology, toxicology, pharmaceutical science, ocular biochemistry and cell biology of these agents. Chapters detail drug transfer across barriers, systemic toxicity of topically applied drugs, autonomic drugs used for diagnostics, as well as anti-inflammatory, antiallergic, glaucoma and antimicrobial therapies, and avenues for the development of new ocular drugs. Applications of extemporaneously prepared formulations are described to inform day-to-day clinical practice. The use of mucoadhesive polymers in tear substitutes, ocular drug delivery systems, stem cell therapy, pharmacogenomics and antiangiogenic ocular chemotherapy are also explored. The book also provides insights from drugs of herbal origin, and a historical perspective on drugs for ocular use. Practicing and resident ophthalmologists, optometrists, pharmacists, nursing professionals, scholars in ocular drug research and students will equally benefit from this comprehensive guide.
Book Synopsis Handbook of Basic and Clinical Ocular Pharmacology and Therapeutics by : Sunny Ohia
Download or read book Handbook of Basic and Clinical Ocular Pharmacology and Therapeutics written by Sunny Ohia and published by Academic Press. This book was released on 2022-07-26 with total page 673 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Basic and Clinical Ocular Pharmacology and Therapeutics provides a review of the basic anatomy, physiology, biochemistry and pathology of the eye with a focus drug therapy, drug delivery and use of therapeutic medical miniature devices. An understanding of the pharmacological actions of drugs acting on the eye requires the student and health care practitioner to learn additional principles in basic and clinical sciences that are unique to this organ. As a sensory organ, the eye is relatively inaccessible to the systemic circulation due to the blood-vitreous, blood-aqueous and blood-retinal barriers. Consequently, the administration of drugs for therapeutic effects in the eye necessitates an understanding of physico-chemical properties of the molecules and pharmacokinetic principles involved in the access to its site of action via topical, intracameral and intravitreal administration. This book includes information on the general principles of pharmacokinetics and pharmacodynamics of drugs as it pertains to the eye and in combating ocular disorders and diseases. Using a disease-themed approach, the book discusses basic and clinical pharmacological principles involved in the therapy of these diseases including the ocular side effect of systemically-administered drugs, drugs used in ophthalmic surgery and miscellaneous agents, the therapeutic utility of biologics, drug conjugates, combination products, gene and cellular therapy are also covered. Handbook of Basic and Clinical Ocular Pharmacology and Therapeutics is useful as a primary and secondary source of reference for up-to-date information about the pharmacological mechanisms of action, pharmacokinetics, side effects, drug-drug interactions and therapeutic indications of drugs for pharmacologists, pharmaceutical scientists, students in the health care disciplines (nursing, pharmacy, optometry, medical), and practitioners in optometry and ophthalmology. Explains the mechanisms of action, side-effects and therapeutic uses of drugs, biologics, miniature devices, gene and cellular therapies for the eye Provides a comprehensive review of the anatomy, physiology, biochemistry, pharmacology, microbiology, genetics and pathology of parts of the eye involved in drug therapy to combat eye disorders and diseases Explores the pharmacological and clinical basis of drugs, drug conjugates, combination products used in the treatment of anterior and posterior segment diseases
Book Synopsis Introduction to Basics of Pharmacology and Toxicology by : Abialbon Paul
Download or read book Introduction to Basics of Pharmacology and Toxicology written by Abialbon Paul and published by Springer Nature. This book was released on 2021-03-13 with total page 1156 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explains the pharmacological relationships between the various systems in the human body. It offers a comprehensive overview of the pharmacology concerning the autonomic, central, and peripheral nervous systems. Presenting up-to-date information on chemical mediators and their significance, it highlights the therapeutic aspects of several diseases affecting the cardiovascular, renal, respiratory, gastrointestinal, endocrinal, and hematopoietic systems. The book also includes drug therapy for microbial and neoplastic diseases. It also comprises sections on immunopharmacology, dermatological, and ocular pharmacology providing valuable insights into these emerging and recent topics. Covering the diverse groups of drugs acting on different systems, the book reviews their actions, clinical uses, adverse effects, interactions, and subcellular mechanisms of action. It is divided into 11 parts, subdivided into several chapters that evaluate the basic pharmacological principles that govern the different types of body systems. This book is intended for academicians, researchers, and clinicians in industry and academic institutions in pharmaceutical, pharmacological sciences, pharmacy, medical sciences, physiology, neurosciences, biochemistry, molecular biology and other allied health sciences.
Book Synopsis Diabetic Retinopathy by : Michael W. Stewart
Download or read book Diabetic Retinopathy written by Michael W. Stewart and published by Springer. This book was released on 2017-04-07 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: A well-illustrated and comprehensive analysis of the treatment of diabetic retinopathy, this book covers current treatment options and guidelines, whilst also providing a detailed discussion of emerging therapeutic targets. Existing therapeutic options are covered in depth, with a major focus on anti-vascular endothelial growth factor drugs and sustained release corticosteroids, including a review of trial results supporting current treatment guidelines. The use of agents off-label is also discussed. Controversial topics are discussed in detail with an emphasis on helping the reader make informed decisions, particularly when treating patients for which several treatment approaches may be appropriate because trial data does not clearly define the best option. Emerging therapeutic areas are evaluated, as work continues to identify agents that produce superior morphologic responses and visual acuity gains by targeting other molecules that contribute to diabetic retinopathy. Promising new drugs, targets and delivery systems are identified, and their development analysed.
Book Synopsis Ocular Therapeutics by : Thomas Yorio
Download or read book Ocular Therapeutics written by Thomas Yorio and published by Academic Press. This book was released on 2011-04-28 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ocular Therapeutics: Eye on New Discovery focuses on emerging areas in ocular research, from new approaches to dry eye to gene therapy in the management of retinal diseases. This comprehensive book features more than 25 chapters of information that will be vital for ocular investigators and ophthalmologists bringing them new information on promising therapeutics. It is the intent of this book to provide not only information on current approaches to treatment, but also in giving the reader a greater understanding as to what may become available for treating a number of important eye diseases. Each chapter features some new aspect of treatment that holds great promise for the future. The approach has been to concentrate on those areas of ocular diseases that are more prevalent. It also features new insight for drug delivery and for managing devasting diseases, such as macula edema and glaucoma, two of the leading causes of blindness in the United States. This book will serve as an important resource as it contains a number of relevant references highlighted for their importance to the field. New investigators will be able to obtain an historical perspective for each of the topics and to develop an understanding of the new research directions that are underway. Ocular Therapeutics: Eye on New Discovery is more than a reference book, as it also provides an important glimpse into the near future. * Contains information that is vital for ocular investigators and ophthalmologists bringing them new information on promising therapeutics. * Provides not only information on current approaches to treatment, but also gives the reader a greater understanding as to what may become available for treating a number of important eye diseases. * Historical perspective for each of the topics as well as an important glimpse into the near future to develop an understanding of the new research directions underway. * New insight for drug delivery and for managing devastating diseases, such as macula edema and glaucoma, two of the leading causes of blindness in the United States
Book Synopsis Ophthalmologic Drug Guide by : Douglas J. Rhee
Download or read book Ophthalmologic Drug Guide written by Douglas J. Rhee and published by Springer Science & Business Media. This book was released on 2010-11-25 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: to follow
Book Synopsis Ocular Drug Delivery Systems by : Deepak Thassu
Download or read book Ocular Drug Delivery Systems written by Deepak Thassu and published by CRC Press. This book was released on 2012-10-02 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug discovery for ocular diseases has taken great strides in the last two decades. From cornea to choroid, new drugs have been formulated to address a great variety of ocular diseases. Yet without good drug delivery systems, these drugs are less effective than they might be or could even cause serious side effects. Ocular Drug Delivery Systems: Ba
Book Synopsis Focal Controlled Drug Delivery by : Abraham J. Domb
Download or read book Focal Controlled Drug Delivery written by Abraham J. Domb and published by Springer Science & Business Media. This book was released on 2014-02-17 with total page 700 pages. Available in PDF, EPUB and Kindle. Book excerpt: The concept of focal controlled drug delivery has been applied for treating illnesses that are localized to a certain tissue or organ. These delivery systems are applied directly to the diseased site and deliver a desired dose for an extended time period while minimizing systemic distribution of toxic drug. Controlled drug delivery systems have been focused on oral extended release formulations and on systemic delivery of small drugs and peptides. Despite the upsurge of interest in focal targeted drug delivery, there is currently no single reference text on the subject. By comparison, there are numerous authored and edited books on oral, systemic and transdermal drug delivery or books on biodegradable polymers as drug carriers. Thus, the aim of Focal Drug Delivery is to bring together leading experts and researchers in the field to provide an authoritative account of the essential pharmaceutical, technological, physiological and biological sciences underpinning the topic. In addition, the book will review advances in treatment options for diseases localized at a certain tissue or organ.
Book Synopsis Ocular Transporters in Ophthalmic Diseases and Drug Delivery by : Joyce Tombran-Tink
Download or read book Ocular Transporters in Ophthalmic Diseases and Drug Delivery written by Joyce Tombran-Tink and published by Springer Science & Business Media. This book was released on 2008-04-09 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this exceptionally important new work, a panel of distinguished authors discusses all the latest developments in the study of ocular transporters. Focusing on the molecular characteristics, localization, and substrate specificities in various compartments of the eye, this volume discusses how transporters regulate the clarity of the cornea and lens, the movements of fluids across the ciliary epithelium and nutrients across the retinal pigment epithelium.
