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Regulation Of The Activity Of Aib1 An Estrogen Receptor Coactivator By Growth Factor Signals
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Book Synopsis Regulation of the Activity of AIB1 an Estrogen Receptor Coactivator by Growth Factor Signals by :
Download or read book Regulation of the Activity of AIB1 an Estrogen Receptor Coactivator by Growth Factor Signals written by and published by . This book was released on 2003 with total page 13 pages. Available in PDF, EPUB and Kindle. Book excerpt: The AIB1 protein is a member of a coactivator family that potentiates the transcriptional activity of the nuclear hormone receptors. AIB1, is amplified in certain breast and ovarian cancers and has been suggested that AIB1 plays a causative role in breast cancer development. Our lab recently identified AIB1 as a target of the MAPK signaling pathway (Font de Mora and Brown, Mol Cell Biol 20:5041, 2000). Based on these findings, we propose that the phosphorylation of AIB1 by MAPK may represent part of the molecular mechanism that integrates signals from steroid hormones and growth factors. In order to identify the sites of AIB1 that are phosphorylated by MAPK, seven potential phosphorylation sites were targeted for point mutations and or deletions. Previously we showed by an In vitro phosphorylation assay by (Erk2) that three out of the seven putative phosphorylation sites tested were most likely to be the specific MAPK phosphorylation sites. In order to investigate the physiological relevance of the AIB1 phosphorylation sites, we subcloned all mutants into GAL4DBD vector. We found that those mutants that showed low phosphorytation in vitro, gave the lowest transactivation levels when tested in vivo. In addition we were able to differentiate the sub-cellular localization of AIB1 after phosphorylation by performing transient transfection in COS cells using a constitutively active MAPK vector and a kinase inhibitor vector and further on performing immunofluorescence.
Book Synopsis Regulation of the Activity of AIB1, an Estrogen Coactivator, by Growth Factor Signals by :
Download or read book Regulation of the Activity of AIB1, an Estrogen Coactivator, by Growth Factor Signals written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: AIB1 is a member of a coactivator family that potentiates the transcriptional activity of nuclear hormone receptors. The AIB1 gene is amplified in certain breast and ovarian cancers. AIB1 amplification is preferentially found in ER and progesterone receptor-positive breast cancers. These findings suggest that AIB1 plays a causative role in breast cancer development. Our lab recently identified AIB1 as a target of the MAPK signaling pathway (Font de Mora and Brown, Mol Cell Biol 20:5041, 2000). This signaling pathway is triggered by growth factors of the insulin-like growth factor (IGF) and epidermal growth factor (EGF) family. These growth factors and their receptors have also been implicated in the development and progression of breast tumors. Based on these findings, we propose that the phosphorylation of AIB1 by MAPK may represent part of the molecular mechanism that integrates signals from steroid hormones and growth factors. Furthermore, we hypothesize that AIB1 phosphorylation may contribute to the role that AIB1 plays in the development of breast cancer. In order to identify the sites of AIB1 that are phosphorylated by MAPK, seven potential MAPK phosphorylation sites were targeted for deletion and mutations. In vitro phosphorylation of the point mutations and internal deletions by Erk2 revealed 4 major sites of phosphorylation. In the future we plan to test these mutants for their ability to function as coactivators. Our study will help to understand how AIB1 activity is modulated by MAPK. This may help to determine how AIB1 is involved in the development of breast cancer.
Book Synopsis Regulation of the Estrogen Receptor and Its Coactivator, AIB1, by Growth Factor Signaling by : Jamie Nicole Holloway
Download or read book Regulation of the Estrogen Receptor and Its Coactivator, AIB1, by Growth Factor Signaling written by Jamie Nicole Holloway and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis EGF Regulation of Nuclear Co-Activator AIB1 Function in Breast Cancer by :
Download or read book EGF Regulation of Nuclear Co-Activator AIB1 Function in Breast Cancer written by and published by . This book was released on 2002 with total page 16 pages. Available in PDF, EPUB and Kindle. Book excerpt: Various growth factor receptor pathways promote human breast tumorigenesis of hormone-independent tumors. The nuclear receptor coactivator AIBi (amplified in breast cancer 1) can be phosphorylated and regulated by growth factor-induced signaling pathways such as MAP kinase and IkB kinase. Our lab has found a splice variant of AIBl, called delta exon3 AIBl, which has a higher co-activating ability than the full-length protein. This study determined the ability of delta exon3 splice variant compared with AIBi in potentiating growth factor signaling and to determine the mechanism of this potentiation using a growth factor responsive promoter.
Book Synopsis Regulation and Role of Nuclear Receptor Coactivator AIB1 in Breast Cancer by :
Download or read book Regulation and Role of Nuclear Receptor Coactivator AIB1 in Breast Cancer written by and published by . This book was released on 2002 with total page 51 pages. Available in PDF, EPUB and Kindle. Book excerpt: AIB1 (Amplified In Breast cancer 1) is a nuclear receptor coactivator found amplified and overexpressed in a subset of breast cancers. AIBl potentiates the transcriptional activity of the estrogen, progesterone, thyroid hormone, and retinoid receptors. It is necessary for normal female reproductive function and mammary gland development and is rate-limiting for tumor growth in nude mice. It is hypothesized that the amplification and overexpression of AIBl contribute to the promotion and/or progression of breast cancer. An understanding of the regulation of expression of AIB1 will give insight into the role of AIB1 in breast cancer. This work has shown that antiestrogens, retinoids, and TGF-beta contribute to the overexpression of AIB1 in MCK-7 breast cancer cells. The putative promoter for the AIB1 gene has been identified. Regulatory elements involved in the regulation of AIB1 by antiestrogens, retinoids, and TGF-beta were not found in the cloned promoter regions and may be upstream or intronic enhancer elements. Further studies will explore the consequences of overexpression of AIB1 through stable transfection into a cell line with low endogenous levels of AIB1.
Book Synopsis Steroid Hormone Action by : Malcolm G. Parker
Download or read book Steroid Hormone Action written by Malcolm G. Parker and published by IRL Press. This book was released on 1993 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a detailed overview of the mechanisms by which steroid hormones regulate gene activity in target cells. It should be of interest to molecular biologists, endocrinologists, pharmacologists and clinicians interested in gene regulation hormones and steroid antagonists.
Book Synopsis Regulatory Mechanisms in Transcriptional Signaling by :
Download or read book Regulatory Mechanisms in Transcriptional Signaling written by and published by Academic Press. This book was released on 2009-07-25 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regulatory Mechanisms in Transcriptional Signaling, volume of Progress in Molecular Biology and Translational Science, includes in-depth discussion on roles of Chromatin remodeling proteins in nuclear receptor signaling, and the ANCCA regulator in cancer. This important resource, edited by Dr. Debabrata (Debu) Chakravarti, offers research on the progesterone receptor action in leiomyoma and endometrial cancer and emerging roles of the ubiquitin protein system in nuclear hormone receptor signaling to provide the reader with expert discussions of up-to-date research.
Book Synopsis Gene Regulation, Epigenetics and Hormone Signaling by : Subhrangsu S. Mandal
Download or read book Gene Regulation, Epigenetics and Hormone Signaling written by Subhrangsu S. Mandal and published by John Wiley & Sons. This book was released on 2017-10-23 with total page 678 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first of its kind, this reference gives a comprehensive but concise introduction to epigenetics before covering the many interactions between hormone regulation and epigenetics at all levels. The contents are very well structured with no overlaps between chapters, and each one features supplementary material for use in presentations. Throughout, major emphasis is placed on pathological conditions, aiming at the many physiologists and developmental biologists who are familiar with the importance and mechanisms of hormone regulation but have a limited background in epigenetics.
Book Synopsis Journal of the National Cancer Institute by :
Download or read book Journal of the National Cancer Institute written by and published by . This book was released on 2007 with total page 1026 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Endocrine Disruption and Human Health by : Philippa D. Darbre
Download or read book Endocrine Disruption and Human Health written by Philippa D. Darbre and published by Academic Press. This book was released on 2015-03-21 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endocrine Disruption and Human Health starts with an overview of what endocrine disruptors are, the issues surrounding them, and the source of these chemicals in the ecosystem. This is followed by an overview of the mechanisms of action and assay systems. The third section includes chapters written by specialists on different aspects of concern for the effects of endocrine disruption on human health. Finally, the authors consider the risk assessment of endocrine disruptors and the pertinent regulation developed by the EU, the US FDA, as well as REACH and NGOs. The book has been written for researchers and research clinicians interested in learning about the actions of endocrine disruptors and current evidence justifying concerns for human health but is useful for those approaching the subject for the first time, graduate students, and advanced undergraduate students. - Provides readers with access to a range of information from the basic mechanisms and assays to cutting-edge research investigating concerns for human health - Presents a comprehensive, translational look at all aspects of endocrine disruption and its effects on human health - Offers guidance on the risk assessment of endocrine disruptors and current relevant regulatory considerations
Book Synopsis Nuclear Hormone Receptors by : Malcolm G. Parker
Download or read book Nuclear Hormone Receptors written by Malcolm G. Parker and published by . This book was released on 1991 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: An overview of the supergene family made up of those nuclear hormone receptors which recognize thyroid and steroid hormones, vitamen D and retinoic acid and which are characterized by their ability to bind both ligands and the genes which respond to them.
Book Synopsis Steroid Hormones and Cell Cycle Regulation by : Kerry L. Burnstein
Download or read book Steroid Hormones and Cell Cycle Regulation written by Kerry L. Burnstein and published by Springer Science & Business Media. This book was released on 2002-05-31 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the tissue culture dish to genetically modified mice, this volume explores the long recognized role of steroid hormones in regulating cell proliferation and differentiation. Many striking effects of steroid hormones are apparent during development and neoplasia and these topics are covered extensively. Several chapters address the pharmacological uses of steroid and related hormones, their analogs and antagonists in controlling growth of endocrine cancers. This book also highlights the complex role of cross talk between steroid hormones and signals initiated at the cell surface in the regulation of cell cycle in hormone responsive tissues.
Book Synopsis Estrogen Receptor and Breast Cancer by : Xiaoting Zhang
Download or read book Estrogen Receptor and Breast Cancer written by Xiaoting Zhang and published by Humana Press. This book was released on 2019-11-08 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery of ER by Dr. Elwood Jensen exactly 60 years ago has not only led to the birth of a whole new vital nuclear receptor research field but also made a rapid, direct and lasting impact on the treatment and prevention of breast cancer. Since that landmark discovery, tremendous progress has been made in our understanding of the molecular functions of ER and development of targeted therapies against ER pathways for breast cancer treatment. However, there is currently no book available addressing these discoveries and recent advancement in a historical and systematic fashion. This book is intended to provide comprehensive, most up-to-date information on the history and recent advancement of ER and breast cancer by world renowned leaders in the field. These chapters include the history of the discovery of ER; physiological and pathological roles of ER; recent discovery of ER cistrome, transcriptome and its regulation of noncoding RNAs such as microRNAs and enhancer RNAs in breast cancer; development and clinical practices of the first targeted therapy Tamoxifen and other antiestrogens for breast cancer treatment; structural basis of ER and antiestrogen actions; molecular insights into endocrine resistance; the role of ER mutants, ER-beta and environmental estrogens in breast cancer; and emerging state-of-the-art therapeutic approaches currently in development to overcome treatment resistance and future perspectives. The book will provide undergraduate and graduate students, basic scientists and clinical cancer researchers, residents, fellows, as well as clinicians, oncology educators and the general public a thorough and authoritative review of these exciting topics.
Book Synopsis Gene Regulation and Therapeutics for Cancer by : Surinder K. Batra
Download or read book Gene Regulation and Therapeutics for Cancer written by Surinder K. Batra and published by CRC Press. This book was released on 2021-03-22 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: Differential gene regulation and targeted therapy are the critical aspects of several cancers. This book covers specific gene regulation and targeted therapies in different malignancies. It offers a comprehensive assessment of the transcriptional dysregulation in cancer, and considers some examples of transcriptional regulators as definitive oncogenic drivers in solid tumors, followed by a brief discussion of transcriptional effectors of the programs they drive, and discusses its specific targets. Most targeted therapeutics developed to date have been directed against a limited set of oncogenic drivers, exemplified by those encoding cell surface or cytoplasmic kinases that function in intracellular signaling cascades.
Book Synopsis Cellular Signal Transduction in Toxicology and Pharmacology by : Jonathan W. Boyd
Download or read book Cellular Signal Transduction in Toxicology and Pharmacology written by Jonathan W. Boyd and published by John Wiley & Sons. This book was released on 2019-04-16 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering a key topic due to growing research into the role of signaling mechanisms in toxicology, this book focuses on practical approaches for informatics, big data, and complex data sets. Combines fundamentals / basics with experimental applications that can help those involved in preclinical drug studies and translational research Includes detailed presentations of study methodology and data collection, analysis, and interpretation Discusses tools like experimental design, sample handling, analytical measurement techniques
Book Synopsis The Fish Oocyte by : Patrick J. Babin
Download or read book The Fish Oocyte written by Patrick J. Babin and published by Springer Science & Business Media. This book was released on 2007-08-17 with total page 513 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a comprehensive overview on egg production in fish, from the standpoint of the oocyte. It covers oocyte development, maturation, hydration and fertilization. The book places special emphasis on using state-of-the-art tools for discerning the ultra-structure of the follicle and genomic/proteomic tools to fully understand biological basis of fish reproduction.
Book Synopsis Estrogens and Antiestrogens by : Robert Lindsay
Download or read book Estrogens and Antiestrogens written by Robert Lindsay and published by Lippincott Williams & Wilkins. This book was released on 1997 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt:
