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Regulation Of Telomerase By Genistein In Human Prostate Cancer Cells
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Book Synopsis Regulation of Telomerase by Genistein in Human Prostate Cancer Cells by : My N. Chau
Download or read book Regulation of Telomerase by Genistein in Human Prostate Cancer Cells written by My N. Chau and published by . This book was released on 2008 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mechanism for genistein-induced activation of STAT3 was then determined. A physiological concentration of genistein activated signaling proteins upstream of STAT3 including JAK2, Akt, Src, and MAPK p44/42 in human prostate cancer cells. Specific shRNA inhibition of these signaling proteins in stable STAT3 reporter prostate cancer cells reduced STAT3 reporter activity and cancer cell proliferation. Genistein treatment of cells with the signaling proteins inhibited did not increase STAT3 reporter activity and cancer cell proliferation to the level observed in genistein treated control cells, indicating that JAK2, Akt, Src, and MAPK p44/42 are necessary for genistein-induced activation of STAT3. The data collectively suggests that physiologically achievable concentrations of genistein enhance cancer cell proliferation by increasing telomerase activity via STAT3 activation mediated by upstream signaling proteins. The result that physiological concentrations of genistein promote prostate cancer cell growth indicates that prudence should be exercised when genistein is considered for chemotherapeutic purposes as unfavorable effects in individuals with prostate cancer is possible.
Book Synopsis Novel Molecular Targets for Genistein in Prostate Cancer Cells by : Kendra Merchant PhD
Download or read book Novel Molecular Targets for Genistein in Prostate Cancer Cells written by Kendra Merchant PhD and published by LAP Lambert Academic Publishing. This book was released on 2010-03 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genistein is a major isoflavone constituent of soy that has been shown to inhibit growth proliferation and induce apoptosis in cancer cells. The mechanism of genistein-induced cell death and potential molecular targets for genistein in LNCaP prostate cancer cells was investigated using several techniques. The chemosensitivity of genistein towards prostate cancer cells was investigated using the ATP and MTS assays and apoptosis induction was determined using apoptosis and caspase assays. Several molecular targets were also identified using cDNA microarray and RT-PCR analysis.
Book Synopsis Indole Regulation of Telomerase Gene Expression in Human Breast Cancer Cells by : Min Zeng
Download or read book Indole Regulation of Telomerase Gene Expression in Human Breast Cancer Cells written by Min Zeng and published by . This book was released on 2008 with total page 110 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Polyphenols and Health by : Neville Vassallo
Download or read book Polyphenols and Health written by Neville Vassallo and published by Nova Publishers. This book was released on 2008 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book touches upon the subject of diet and health interest to a wide audience. It is a very topical subject and one which is at the forefront of scientific research, not only in universities but also in industry. The exponential increase in the number of scientific reports is a strong indicator of the need for this book that provides an exciting, up-to-date guide to the mechanisms and themes that underlie the applications of polyphenols in health.
Book Synopsis Epigenetics and Cancer by : Fazlul H. Sarkar
Download or read book Epigenetics and Cancer written by Fazlul H. Sarkar and published by Springer Science & Business Media. This book was released on 2013-05-29 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: Overall, this book illustrates the complexities of the regulation and deregulation of genes mediated through epigenetics in the development and progression of human malignancies. All the articles have been carefully chosen to represent several cancer systems with state of our knowledge on the role of epigenetic deregulation of microRNAs (miRNAs) and their target mRNAs along with epigenetic deregulation of mRNAs. This book also illustrates the role of several dietary agents, collectively called nutraceuticals or natural agents in modulating the epigenetic reprogramming of miRNAs and mRNAs for the prevention and/or treatment of human malignancies. It is well known that genetic aberrations, especially inherited through parents (somatic genetic alterations) contribute to the development of less than 10% of all cancer yet epigenetic alterations in genes especially through selective methylation and acetylation appears to be responsible for the development and progression of the vast majority of all cancers. Therefore, understanding the role of epigenetics in the regulation of genes especially through deregulated expression of miRNAs as presented in this book will allow scientists to devise targeted therapeutic strategies for re-expression of the lost genes or down-regulate the genes that are over-expressed in order to eradicate cancer. It is hoped that targeting epigenetics will not only target cancer cells but it will also target the tumor microenvironment (more like the entire tumor environment such as the entire host) for achieving better treatment outcomes for patients diagnosed with cancer which will lead to achieve the long-term objective for complete eradication of cancer. This book contains fifteen chapters which begins with the concept of systems and network biology for investigating the epigenetics of cancer followed by a series of articles on the role of miRNAs and their target genes in the biology of pancreatic cancer and other cancers such as breast, kidney, prostate and and colon. Since it is becoming increasingly clear that cancer stem cells (CSCs) are important in the development and progression of cancer, and CSCs are important in therapeutic resistance, treatment failure and tumor recurrence, thus the importance of CSCs and epigenetics has been highlighted by a very timely article on epigenetic variations of stem cell markers in cancer including miRNAs. Moreover, just targeting heterogeneous cancer cell populations may not be optimal to eradicate tumors and for which one must take a holistic approach for developing drugs that could also target the tumor microenvironment and tumor dormancy that are regulated through epigenetics. Keeping abreast with this thought process the concluding chapter provides a concept towards curative cancer therapy with maspin, which could be a unique window of opportunity to target tumor dormancy. Therefore, it suggest that targeting the tumor dormancy and the tumor microenvironment using novel therapeutics specifically by targeting epigenetics would become the future of medicine.
Book Synopsis Evidence-based Anticancer Materia Medica by : William C.S. Cho
Download or read book Evidence-based Anticancer Materia Medica written by William C.S. Cho and published by Springer Science & Business Media. This book was released on 2011-03-29 with total page 443 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer is one of the leading killers in the world and the incidence is increasing, but most cancer patients and cancer survivors suffer much from the disease and its conventional treatments’ side effects. In the past, clinical data showed that some complementary and alternative medicine (CAM) possessed anticancer abilities, but some clinicians and scientists have queried about the scientific validity of CAM due to the lack of scientific evidence. There is great demand in the knowledge gap to explore the scientific and evidence-based knowledge of CAM in the anticancer field. With this aim, a book series is needed to structurally deliver the knowledge to readers. Recently there have been encouraging results from both laboratory experiments and clinical trials demonstrating the anticancer effects of herbal medicine. There is considerable interest among oncologists and cancer researchers to find anticancer agents in herbal medicine. This volume is a specialised book presenting the up-to-date scientific evidence for anticancer herbal medicine. This unique book provides an overview of the anticancer herbal medicines and remedies, as well as a detailed evidence-based evaluation of 18 common anticancer herbal medicines covering their biological and pharmacological properties, efficacies, herb-drug interactions, adverse effects, pre-clinical studies, and clinical applications. Gathering international opinion leaders’ views, this volume will contribute great to the cancer, academic, and clinical community by providing evidence-based information on the anticancer efficacy of herbal medicine. Readership Oncologists, cancer researchers, pharmacologists, pharmaceutical specialists, Chinese medicine practitioners, medical educators, postgraduates and advanced undergraduates in biomedical disciplines, cancer caregivers, cancer patients.
Book Synopsis Nutrition in Epigenetics by : Mihai D. Niculescu
Download or read book Nutrition in Epigenetics written by Mihai D. Niculescu and published by John Wiley & Sons. This book was released on 2011-03-25 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: The study of epigenetics, or how heritable changes in gene expression are regulated without modifying the coding DNA sequence, has become an increasingly important field of study in recent years. Rapid developments in our understanding of the way in which gene function is modulated by the environment has revolutionized the way we think about human development and health. Nutrition in Epigenetics reviews the latest research looking at the interaction between genes and nutrients and the role they play together in maintaining human health. Nutrition in Epigenetics is divided into two primary parts. The first part provides key principles such as epigenetic mechanisms, developmental epigenetics, and the role of epigenetics in disease. The second part looks specifically at the application of epigenetics to the field of human nutrition. Chapters review the role of specific nutrients in modulating epigenetic status and the effect on health and disease. Nutrition in Epigenetics is an indispensable resource for researchers, professionals and advanced students with an interest in human nutrition, epigenetics, and biomedical research.
Book Synopsis Telomeres and Telomerase in Cancer by : Keiko Hiyama
Download or read book Telomeres and Telomerase in Cancer written by Keiko Hiyama and published by Springer Science & Business Media. This book was released on 2009-03-18 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: Telomerase, an enzyme that maintains telomeres and endows eukaryotic cells with immortality, was first discovered in tetrahymena in 1985. In 1990s, it was proven that this enzyme also plays a key role in the infinite proliferation of human cancer cells. Now telomere and telomerase are widely accepted as important factors involved in cancer biology, and as promising diagnostic tools and therapeutic targets. Recently, role of telomerase in “cancer stem cells” has become another attractive story. Until now, there are several good books on telomere and telomerase focusing on biology in ciliates, yeasts, and mouse or basic sciences in human, providing basic scientists or students with updated knowledge.
Book Synopsis Genetic and Epigenetic Control on Immune Responses Regulating Molecules in Cancer Development, Progression, and Treatment by : Katherine Chiappinelli
Download or read book Genetic and Epigenetic Control on Immune Responses Regulating Molecules in Cancer Development, Progression, and Treatment written by Katherine Chiappinelli and published by Frontiers Media SA. This book was released on 2021-11-30 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Epigenetic and Transcriptional Dysregulations in Cancer and Therapeutic Opportunities by : Ata Abbas
Download or read book Epigenetic and Transcriptional Dysregulations in Cancer and Therapeutic Opportunities written by Ata Abbas and published by Frontiers Media SA. This book was released on 2022-07-29 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nutritional Epigenomics written by and published by Academic Press. This book was released on 2019-07-20 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nutritional Epigenomics offers a comprehensive overview of nutritional epigenomics as a mode of study, along with nutrition’s role in the epigenomic regulation of disease, health and developmental processes. Here, an expert team of international contributors introduces readers to nutritional epigenomic regulators of gene expression, our diet’s role in epigenomic regulation of disease and disease inheritance, caloric restriction and exercise as they relate to recent epigenomic findings, and the influence of nutritional epigenomics over circadian rhythms, aging and longevity, and fetal health and development, among other processes. Disease specific chapters address metabolic disease (obesity and diabetes), cancer, and neurodegeneration, among other disorders. Diet-gut microbiome interactions in the epigenomic regulation of disease are also discussed, as is the role of micronutrients and milk miRNAs in epigenetic regulation. Finally, chapter authors examine ongoing discussions of race and ethnicity in the social-epigenomic regulation of health and disease. Empowers the reader to employ nutritional epigenomics approaches in their own research Discusses the latest topics in nutritional epigenomics in the regulation of aging, circadian rhythm, inheritance and fetal development, as well as metabolism and disease Offers a full grounding in epigenetic reprogramming and nutritional intervention in the treatment and prevention of disease, as informed by population-based studies
Book Synopsis Nutraceuticals and Functional Foods in Human Health and Disease Prevention by : Debasis Bagchi
Download or read book Nutraceuticals and Functional Foods in Human Health and Disease Prevention written by Debasis Bagchi and published by CRC Press. This book was released on 2015-10-15 with total page 716 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functional foods and nutraceuticals, dietary supplements, and natural antioxidants have established their potential roles in the protection of human health against disease. Nutraceuticals and Functional Foods in Human Health and Disease Prevention examines the benefits, efficacy, and success of properly designed nutraceuticals and functional foods
Download or read book Anticancer Research written by and published by . This book was released on 2008 with total page 918 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Current Aspects of Flavonoids: Their Role in Cancer Treatment by : Hardeep Singh Tuli
Download or read book Current Aspects of Flavonoids: Their Role in Cancer Treatment written by Hardeep Singh Tuli and published by Springer. This book was released on 2019-05-21 with total page 181 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book comprehensively introduces readers to various aspects of flavonoids, a category of natural metabolites that exhibits various pharmacological effects. It discusses their chemistry, absorption and metabolism, mechanisms of action and toxicology as well as future perspectives for clinical applications, and also provides detailed insights into their anti-cancer properties, since flavonoids are known to modulate tumor-associated intracellular as well as extracellular signaling pathways. The book also highlights the current research on the health effects of selected flavonoids, and their various roles in cancer prevention and treatment. Lastly, the book elucidates nanotechnology-mediated tools to enhance the bioavailability and solubility of flavonoids to improve their bioactivity and pharmacokinetic parameters.
Book Synopsis Textbook of Aging Skin by : Miranda A. Farage
Download or read book Textbook of Aging Skin written by Miranda A. Farage and published by Springer Science & Business Media. This book was released on 2009-12-02 with total page 1255 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive ‘Major Reference Book’ compiles all current and latest information on aging skin in a two-volume set. Highly structured with a reader-friendly format, it covers a wide range of areas such as basic sciences, the different diseases and conditions which occur with aging (from malignant to non-malignant), the latest techniques and methods being used such as bioengineering methods and biometrics as well as toxicological and safety considerations for the elderly population. It also illustrates the global consumers’ sociological and psychological implications, ethnicity and gender differences and includes marketing considerations for this elderly group. This unique and comprehensive guide will become the main reference textbook on this topic.
Download or read book Vitamin D written by David Feldman and published by Academic Press. This book was released on 2011-05-12 with total page 2190 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vitamin D, a steroid hormone, has mainly been known for its effects on bone and osteoporosis. The current therapeutic practices expand into such markets as cancer research, pediatrics, nephrology, dermatology, immunology, and genetics. This 3e includes over 100 chapters covering everything from chemistry and metabolism to mechanisms of action, diagnosis and management, new analogs, and emerging therapies. This complete reference works is a must-have resource for anyone working in endocrinology, osteology, bone biology, or cancer research.
Book Synopsis Journal of the National Cancer Institute by :
Download or read book Journal of the National Cancer Institute written by and published by . This book was released on 1998 with total page 986 pages. Available in PDF, EPUB and Kindle. Book excerpt:
