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Author : Li-How Chen
Publisher :
ISBN 13 :
Total Pages : 256 pages
Book Rating : 4.:/5 (7 download)
Download or read book Regulation of Milk Protein Gene Expression by Extracellular Matrix written by Li-How Chen and published by . This book was released on 1989 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Qiao Lin
Publisher :
ISBN 13 :
Total Pages : 276 pages
Book Rating : 4.:/5 (33 download)
Download or read book Regulation of Whey Acidic Protein Gene Expression by Extracellular Matrix and Cell Microenvironment written by Qiao Lin and published by . This book was released on 1994 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : JOANNE LORRAINE BLUM
Publisher :
ISBN 13 :
Total Pages : 140 pages
Book Rating : 4.:/5 (682 download)
Download or read book ROLE OF EXTRACELLULAR MATRIX IN MAMMARY DIFFERENTIATION. written by JOANNE LORRAINE BLUM and published by . This book was released on 1987 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: components affect milk protein gene expression at multiple levels of regulation.
Author : C.H. Knight
Publisher : Springer Science & Business Media
ISBN 13 : 146151973X
Total Pages : 296 pages
Book Rating : 4.4/5 (615 download)
Download or read book Intercellular Signalling in the Mammary Gland written by C.H. Knight and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: All being done, we went to Mrs Shipmans, who is a great butter-woman; and I did see there the most of milke and cream, and the cleanest, that I ever saw in my life (29 May 1661). Among others, Sir Wm. Petty did tell me that in good earnest, he hath in his will left such parts of his estate to him that could invent such and such things -as among others, that could discover truly the way of milk coming into the breasts of a woman ... (22 March 1665). My wife tells me that she hears that my poor aunt James hath had her breast cut off here in tow- her breast having long been out of order (5 May 1665). From the Diary of Samuel Pepys, published as The Shorter Pepys (edited by R. Latham), Penguin Books (1987) The long-standing ultimate importance of research on the mammary gland is illustrated by the importance attached to cows' milk for human consumption, to human lactation and to breast cancer by Samuel Pepys and his contemporaries in the middle of the 17th century. Research has tended to develop in isolation in these three areas of continuing contemporary importance largely because in most countries, the underlying science of agricultural productivity is funded separately from the underlying science of human health and welfare.
Author : John A. Mol
Publisher : Springer Science & Business Media
ISBN 13 : 0306468328
Total Pages : 309 pages
Book Rating : 4.3/5 (64 download)
Download or read book Biology of the Mammary Gland written by John A. Mol and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the European Cooperation in the Field of Scientific and Technical Research (COST 825) Symposium on Mammary Gland Biology, held September 16-18, 1999, in Tours, France. It is difficult to overstate the evolutionary and functional significance of mammary tissue in biology. Substantial progress has been made by researchers in various disciplines, particularly over the last fifteen years, towards realizing the potential of this tissue to yield powerful experimental models for morphogenesis and tissue development; for cellular differentiation; for the biosynthesis and secretion of proteins, lipids, small molecules and inorganic salts; and for the coordination and regulation of these processes. More recently, the possibility of exploiting the secretory epithelial cells of mammary tissue as `cell factories' has become a reality and the recombinant production by lactating animals of an increasing number of proteins, valuable both in the pharmaceutical and `nutraceutical' fields, is in progress or under development. Also in this sphere of agricultural production, genetic as well as nutritional technologies are under investigation and exploitation to optimize milk composition for various end-uses - for instance in food process and manufacture. The possibilities of deriving health benefit from the bioactive properties of some of the minor constituents of milk are emerging to counter the highly-publicized negative health impact of excessive consumption of saturated animal fats. In human nutrition and medicine, the mammary gland is both a source of nutrition to the neonate and a potential health threat to the adult female - breast cancer remains the major single cause of female mortality in most developed countries. This volume provides a unique glimpse into our understanding, at the cutting edge of a variety of disciplines, of this versatile and extraordinary tissue, at the birth of the twenty-first century.
Author : Frank Chiahung Mao
Publisher :
ISBN 13 :
Total Pages : 346 pages
Book Rating : 4.:/5 (89 download)
Download or read book Regulation of the Milk Proteins Α-lactalbumin and Β-lactoglobulin written by Frank Chiahung Mao and published by . This book was released on 1991 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Leslie MacKenzie Blackie
Publisher :
ISBN 13 :
Total Pages : 312 pages
Book Rating : 4.:/5 (33 download)
Download or read book The Heterogeneity of Expression of Basement Membrane Componets and Milk Proteins in the Mouse Mammary Gland During Pregnancy written by Leslie MacKenzie Blackie and published by . This book was released on 1992 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 13 pages
Book Rating : 4.:/5 (227 download)
Download or read book Chromatin Regulation of EGFR Locus in Human Mammary Epithelial Cells written by and published by . This book was released on 2005 with total page 13 pages. Available in PDF, EPUB and Kindle. Book excerpt: Relationship between chromatin remodeling and mammary tissue-specific gene transcription is not well understood. Using milk protein beta-casein as a marker, we investigate how extracellular matrix (ECM) and lactogenic hormone control transcription factors activity, and elucidate the role of histone acetylation and A P-dependent chromatin remodeling in the transcriptional regulation. By ChIP assays, we show that ECM cooperates with prolactin to induce binding of Stat5 and C/EBPBeta in the Beta-casein promoter. We also show that the levels of acetylated histones increase in the Beta-casein promoter. However, increasing acetylated histone levels in the promoter region by TSA treatment failed to induce Beta-casein expression, suggesting histone acetylation is not sufficient for the gene transcription. Introduction of the ATPase-deficient SWI/SNF complex significantly blocked Beta-casein expression, indicating that ATP-dependent chromatin remodeling is required for the transcriptional activation of this gene. Taken together, these observations indicate that Beta-casein expression requires the concerted action of both transcription and chromatin remodeling factors.
Author :
Publisher :
ISBN 13 :
Total Pages : 681 pages
Book Rating : 4.:/5 (727 download)
Download or read book Targeted Expression of Stromelysin-1 in Mammary Gland Provides Evidence for a Role of Proteinases in Branching Morphogenesis and the Requirement for an Intact Basement Membrane for Tissue-specific Gene Expression written by and published by . This book was released on 1994 with total page 681 pages. Available in PDF, EPUB and Kindle. Book excerpt: The extracellular matrix (ECM) is an important regulator of the differentiated phenotype of mammary epithelial cells in culture. Despite the fact that ECM-degrading enzymes have been implicated in morphogenesis and tissue remodeling, there is little evidence for a direct role for such regulation in vivo. We generated transgenic mice that express autoactivated isoforms of the matrix metalloproteinase stromelysin-1, under the control of the whey acidic protein gene promoter, to examine the effect of inappropriate expression of this enzyme. Stromelysin-1 is implicated as the primary player in the loss of basement membrane and loss of function in the mammary gland during involution. The transgene was expressed at low levels in mammary glands of virgin female mice, leading to an unexpected phenotype: The primary ducts had supernumerary branches and showed precocious development of alveoli that expressed beta-casein at levels similar to that of an early- to mid-pregnant gland. Lactating glands showed high levels of transgene expression, with accumulation at the basement membrane, and a decrease in laminin and collagen IV, resulting in a loss of basement membrane integrity; this was accompanied by a dramatic alteration of alveolar morphology, with decreased size and shrunken lumina containing little beta-casein. During pregnancy, expression of endogenous whey acidic protein and beta-casein was reduced in transgenic glands, confirming the observed dependence of milk protein transcription of ECM in mammary epithelial cells in culture. These data provide direct evidence that stromelysin-1 activity can be morphogenic for mammary epithelial cells, inducing hyperproliferation and differentiation in virgin animals, and that its lytic activity can, indeed, disrupt membrane integrity and reduce mammary-specific function. We conclude that the balance of ECM-degrading enzymes with their inhibitors, and the associated regulation of ECM structure, is crucial for tissue-specific gene expression and morphogenesis in vivo.
Author : Douglas W. DeSimone
Publisher : Springer Science & Business Media
ISBN 13 : 3642359353
Total Pages : 260 pages
Book Rating : 4.6/5 (423 download)
Download or read book Extracellular Matrix in Development written by Douglas W. DeSimone and published by Springer Science & Business Media. This book was released on 2013-03-15 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cells in the developing embryo depend on signals from the extracellular environment to help guide their differentiation. An important mediator in this process is the extracellular matrix – secreted macromolecules that interact to form large protein networks outside the cell. During development, the extracellular matrix serves to separate adjacent cell groups, participates in establishing morphogenic gradients, and, through its ability to interact directly will cell-surface receptors, provides developmental clocks and positional information. This volume discusses how the extracellular matrix influences fundamental developmental processes and how model systems can be used to elucidate ECM function. The topics addressed range from how ECM influences early development as well as repair processes in the adult that recapitulate developmental pathways.
Author : W.D. Comper
Publisher : CRC Press
ISBN 13 : 9783718658435
Total Pages : 406 pages
Book Rating : 4.6/5 (584 download)
Download or read book Extracellular Matrix written by W.D. Comper and published by CRC Press. This book was released on 1996-09-15 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jack Martinet
Publisher : Editions Quae
ISBN 13 : 2738008615
Total Pages : 692 pages
Book Rating : 4.7/5 (38 download)
Download or read book Biology of Lactation written by Jack Martinet and published by Editions Quae. This book was released on 1999 with total page 692 pages. Available in PDF, EPUB and Kindle. Book excerpt: A presentation of the most fundamental features of the biology of the mammary gland, a unique model of an organ capable of an abundant synthesis of proteins: endocrinology of lactation, role of prolactin, genetics and protein synthesis, immunology and the mammary gland, nutrition and dairy products. Readership: students, teachers, researchers, health and agriculture professionals. Lactation Biology was first published in French in 1993. The English version is not merely a translation: it has been updated by the author.
Author :
Publisher :
ISBN 13 :
Total Pages : 272 pages
Book Rating : 4.:/5 (3 download)
Download or read book Environmental Health Perspectives written by and published by . This book was released on 1993 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : George F. Vande Woude
Publisher : Elsevier
ISBN 13 : 008048820X
Total Pages : 364 pages
Book Rating : 4.0/5 (84 download)
Download or read book Advances in Cancer Research written by George F. Vande Woude and published by Elsevier. This book was released on 2011-07-29 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. A very special event the Nobel Minisymposium, “Molecular Oncology – From Bench to Bedside, held at the Karolinska Instituet, in Stockholm, Sweden, was marked the celebration of George and Eva Klein’s combined 160th birthday. To honor this occasion, this volume brings together contributions by their former students, colleagues and collaborators of the past fifty years into a volume of Advances in Cancer Research dedicated to George and Eva. Over a decade ago, a subdivision of ACR called “Foundations in Cancer Research was initiated and the tributes honoring the Kleins’ bodies of work presented at the minisymposium are especially appropriate for the series.
Author :
Publisher :
ISBN 13 :
Total Pages : 20 pages
Book Rating : 4.:/5 (227 download)
Download or read book Chromatin Regulation of the EGFR Locus in Human Mammary Epithelial Cells written by and published by . This book was released on 2006 with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell-Extracellularmatrix (ECM) adhesions structurally alter the cells as well as provide signals critical for the cell differentiation and tissue-specific gene transcription. We show showed that the ECM induce global deacetylation of his tones H3 and H4 in human breast epithelial cells and that this deacetylation correlated with a global reduction in gene expression. To determine how chromatin structure regulates differentiated gene expression in 3D culture we used mammary-specific case in genes as models. We identified that transcription factors Stat5 and CIEBP beta were regulated by ECM. Chromatinimmunoprecipitation(ChlP) assays demonstrated that levels of acetylated histones as well as binding of Stat5 and CIEBP betain the case inpromoters increased in response to ECM and prolactin treatment. However trichostatin A(TSA)-induced histoneacetylation failed to activate-case in expression suggesting that histoneacetylationis not sufficient for the gene transcription. Introduction of adominantnegative Brg 1 significantly reduced both beta-andgamma-casein expression indicating that ATP-depend entchromatinremodeling is required for transcription of these two milk proteingenes. Thus ECM-and prolactin-regulated transcription of the mammary-specific case in genes requires the concertedaction of histoneacetylation ATP-depend entchromatinre modeling and activation of transcription factors.
Author :
Publisher :
ISBN 13 :
Total Pages : 312 pages
Book Rating : 4.:/5 (6 download)
Download or read book LBL Research Review written by and published by . This book was released on 1991 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Marvin A. Rich
Publisher :
ISBN 13 :
Total Pages : 424 pages
Book Rating : 4.3/5 (91 download)
Download or read book Understanding Breast Cancer written by Marvin A. Rich and published by . This book was released on 1983 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt:
