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Regulation Of Gene Expression And Cell Growth By Transcriptional Proteins Of The Interferon System
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Book Synopsis Regulation of Gene Expression and Cell Growth by Transcriptional Proteins of the Interferon System by : Hannah Anh-Quan Nguyen
Download or read book Regulation of Gene Expression and Cell Growth by Transcriptional Proteins of the Interferon System written by Hannah Anh-Quan Nguyen and published by . This book was released on 1998 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The Interferon Regulatory Factors (IRFs) are a family of interferon-inducible proteins which play distinct roles in diverse processes such as pathogen response, cytokine signalling, cell growth regulation and hematopoietic development. The objective of this research was to investigate the mechanisms by which IRF-1 and IRF-2 regulate gene expression and cell growth. Structure-function analyses of the IRF-2 protein demonstrate that transcriptional repression by IRF-2 is contained within the first 125 N-terminal amino acids and correlates directly with IRF-2 DNA binding. Overexpression of functional IRF-2 deletion mutant proteins in NIH3T3 cells results in oncogenic transformation and tumorigenesis, suggesting that IRF-2 oncogenicity correlates directly with transcriptional repression. Similar structure-function analyses localize IRF-1 transactivation to the C-terminus. Like IRF-1, hybrid constructs which fuse the DNA binding domain of IRF-1 and IRF-2 to the transactivation domain of NF-kappaB RelA(p65) are transcriptional activators. Inducible expression of IRF-1 and IRF/RelA in NIH3T3 cells results in reduced cellular growth and induction of apoptosis. Furthermore, expression of the PKR, STAT1(p91), and WAF1 growth regulatory proteins are elevated following induction of IRF-1 or IRF/RelA, correlating transactivation function and tumor suppressor activity of IRF-1 or IRF/RelA. By RNA fingerprinting, the secretory leukocyte protease inhibitor (SLPI) was identified as the first gene whose expression is downregulated by IRF-1 or IRF-1/RelA. A region in the SLPI promoter was identified that bound IRF-1, suggesting a direct mechanism for IRF-1 regulation of SLPI expression." --
Book Synopsis Regulation of Gene Expression and Cell Growth by Transcriptional Proteins of the Interferon System by :
Download or read book Regulation of Gene Expression and Cell Growth by Transcriptional Proteins of the Interferon System written by and published by . This book was released on 1998 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Human Herpesviruses written by Ann Arvin and published by Cambridge University Press. This book was released on 2007-08-16 with total page 1325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.
Book Synopsis Interaction of Translational and Transcriptional Controls in the Regulation of Gene Expression by : Marianne Grunberg-Manago
Download or read book Interaction of Translational and Transcriptional Controls in the Regulation of Gene Expression written by Marianne Grunberg-Manago and published by Elsevier. This book was released on 2012-12-02 with total page 537 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interaction of Translational and Transcriptional Controls in the Regulation of Gene Expression presents the proceedings of the Fogarty International Conference on Translational/Transcriptional Regulation of Gene Expression, held at the National Institutes of Health in Bethesda, Maryland, on April 7-9, 1982. Speakers discussed the molecular strategies at work during the modulation of gene expression following transcriptional initiation. They also discussed recent developments in a number of key areas in which transcriptional and translational components interact. Organized into five sections encompassing 36 chapters, this volume explores both prokaryotic and eukaryotic systems, as well as structure-function correlations. It begins with an overview of translational/transcriptional controls in prokaryotes, the regulation of gene expression by transcription termination and RNA processing, and the structure and expression of initiation factor genes. It then examines the effect of the codon context on translational fidelity, including mistranslation of messenger RNA; protein synthesis for the construction of cell architecture; regulation of initiation factor activity; and translational regulation in cells. This book is a valuable resource for Fogarty International Scholars who want to broaden their knowledge and contribute their expertise to the National Institutes of Health community.
Book Synopsis Transcriptional Regulation in the Interferon System by : Ganes C. Sen
Download or read book Transcriptional Regulation in the Interferon System written by Ganes C. Sen and published by . This book was released on 1997 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides detailed information about the signal transduction pathways used by interferons to activate gene transcription. In addition, this book discusses how the same pathways are used by many other cytokines and thus provide a forum for cross-talk among these important biological response modifiers. Additionally, the book introduces the interferon system and describes the interferon-inducible genes whose products are responsible for the cellular actions of interferons. The nature of the interferon receptors and how the transcriptional signals are transmitted from the receptors on the cell surface to the genes in the nucleus are discussed in detail. Finally, the use of similar pathways of signal transduction by other cytokines is highlighted.
Book Synopsis Translational Regulation of Gene Expression 2 by : J. Ilan
Download or read book Translational Regulation of Gene Expression 2 written by J. Ilan and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, which results from the dramatic increase in interest in the control mechanism employed in gene expression and the importance of the regulated proteins, presents new information not covered in Translational Regulation of Gene Expression, which was published in 1987. It is not a revision of the earlier book but, rather, an extension of that volume witl, special emphasis on mecha nIsm. As the reader will discover, there is enormous diversity in the systems employing genes for translational regulation in order to regulate the appearance of the final product-the protein. Thus, we find that important proteins such as protooncogenes, growth factors, stress proteins, cytokines, lymphokines, iron storage and iron-uptake proteins, and a panorama of prokaryotic proteins, as well as eukaryotic viral proteins, are translationally regulated. Since for some gene products the degree of control is greater by a few orders of magnitude than their transcription, we can state that for these genes, at least, the expression is translationall y controlled. Translational regulation of gene expression in eukaryotes has emerged in the last few years as a major research field. The present book describes mechanisms of translational regulation in bacteria, yeast, and eukaryotic viruses, as well as in eukaryotic genes. In this book we try to provide in-depth coverage by including important examples from each group rather than systematically including all additional systems not described in the previous volume.
Book Synopsis Signaling and Gene Expression in the Immune System by :
Download or read book Signaling and Gene Expression in the Immune System written by and published by CSHL Press. This book was released on 1999 with total page 656 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a dialogue on the nature of the membrane signals and intracytoplasmic events that provoke immunity. The debate ranges over biochemistry, physiology, molecular genetics, as well as classical cellular immunology. Input came from over 70 of the world's leading investigators.
Book Synopsis Interferons as Cell Growth Inhibitors and Antitumor Factors by : Robert Morris Friedman
Download or read book Interferons as Cell Growth Inhibitors and Antitumor Factors written by Robert Morris Friedman and published by . This book was released on 1986 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Protein Phosphorylation in Cell Growth Regulation by : Michael J. Clemens
Download or read book Protein Phosphorylation in Cell Growth Regulation written by Michael J. Clemens and published by CRC Press. This book was released on 1996-12-03 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of this text is to integrate the processes of protein phosphorylation and dephosphorylation into the complex pathways by which cellular proliferation is driven, bringing together the many different systems of control implicated in the regulation of cell growth. Presents a survey of protein phosphorylation roles in the control of cellular proliferation and differentiation. A large number of protein kinases and phosphatases have been characterised in higher cells, and have been shown to be involved in signal transduction pathways by which growth factors, mitogens, and extracellular agents exert proliferative effects on cells. Important subjects covered include control of gene expression at the transcriptional and translational levels, and roles of the cdk kinases and cyclins in cell cycles regulation. Describes all major families of protein kinases of significance to growth regulation.
Book Synopsis Interferons and Other Regulatory Cytokines by : E. M. DeMaeyer
Download or read book Interferons and Other Regulatory Cytokines written by E. M. DeMaeyer and published by Wiley-Interscience. This book was released on 1988 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text provides a presentation of the state-of-knowledge of interferons (IFNs) providing a synthetic overview of the role and significance of IFNs in health and disease. Treatment is placed in a broad biological context including much up-to-date background information on the different systems (eg oncogenes or T cell function) that are under the influence of IFNs. This approach makes the book accessible to those not directly involved in IFN research. Coverage also includes other cytokines, such as tumor necrosis factor alpha and beta, and the various interleukins.
Book Synopsis The Epstein-Barr Virus by : M. A. Epstein
Download or read book The Epstein-Barr Virus written by M. A. Epstein and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Epstein-Barr virus was discovered 15 years ago. Since that time an immense body of information has been accumu lated on this agent which has come to assume great signifi cance in many different fields of biological science. Thus, the virus has very special relevance in human medicine and oncology, in tumor virology, in immunology, and in mole cular virology, since it is the cause of infectious mononu cleosis and also the first human cancer virus, etiologically related to endemic Burkitt's lymphoma and probably to nasopharyngeal carcinoma. In addition, continuous human lymphoid cell lines initiated and maintained by the transform ing function of the virus genome provide a laboratory tool with wide and ever-growing applications. Innumerable papers on the Epstein-Barr virus have ap peared over recent years and reports of work with this agent now constitute a veritable flood. The present book provides the first and only comprehensive, authoritative over-view of all aspects of the virus by authors who have been the original and major contributors in their particular disciplines. A complete and up-to-date survey of this unique and important agent is thus provided which should be of great interest to experts, teachers, and students engaged in cancer research, virology, immunology, molecular biology, epide miology, and cell culture. Where topics have been dealt with from more than one of these viewpoints, some inevitable overlap and duplication has resulted; although this has been kept to a minimum, it has been retained in some places because of positive usefulness.
Book Synopsis Interferons and Their Actions by : William E. Stewart
Download or read book Interferons and Their Actions written by William E. Stewart and published by . This book was released on 1977 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Measuring Immunity by : Michael T. Lotze
Download or read book Measuring Immunity written by Michael T. Lotze and published by Elsevier. This book was released on 2011-05-04 with total page 759 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most of the diseases of modern mankind involve either acute or chronic inflammation. Measuring Immunity integrates the current information available on biomarkers and surrogate assays into a single handbook. It highlights the principles behind various applications, gives a brief summary on how they are conducted and provides detailed and critical analyses of murine models of immunity, clinical trials, and tests to predict utility and benefit. Measuring Immunity is indispensable for scientists and clinicians interested in the clinical applications of modern immunobiology. * Defines which assays of immune function are helpful in the assessment of clinical disorders involving inflammation and immunity* Assesses the dynamics of cellular and soluble factors in the peripheral blood using modern techniques * Includes basic science foundations as well as the approaches currently applied
Author :Jacqueline M. Matthews Publisher :Springer Science & Business Media ISBN 13 :1461432294 Total Pages :184 pages Book Rating :4.4/5 (614 download)
Book Synopsis Protein Dimerization and Oligomerization in Biology by : Jacqueline M. Matthews
Download or read book Protein Dimerization and Oligomerization in Biology written by Jacqueline M. Matthews and published by Springer Science & Business Media. This book was released on 2012-09-04 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume has a strong focus on homo-oligomerization, which is surprisingly common. However, protein function is so often linked to both homo- and hetero-oligomerization and many heterologous interactions likely evolved from homologous interaction, so this volume also covers many aspects of hetero-oligomerization.
Book Synopsis Systems Biology of Cancer by : Sam Thiagalingam
Download or read book Systems Biology of Cancer written by Sam Thiagalingam and published by Cambridge University Press. This book was released on 2015-04-09 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.
Book Synopsis DNA-protein Interactions by : Andrew Arthur Travers
Download or read book DNA-protein Interactions written by Andrew Arthur Travers and published by Oxford University Press, USA. This book was released on 2000 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA-Protein Interactions is a novel compilation of methods for studying the interactions of proteins with DNA. It is a rapidly advancing research area in which multidisciplinary approaches are especially valuable for solving problems and obtaining a detailed understanding of the molecular regulatory interactions involved. This book covers all the major tools that are required for the study of the large macromolecular enzymatic machines that manipulate DNA, with particular emphasis on biophysical techniques applied to the analysis of transcription and its relation to chromatin structure. Knowledge of basic techniques is assumed, although advances in fundamental fields are covered.
Book Synopsis Biological DNA Sensor by : Ken Ishii
Download or read book Biological DNA Sensor written by Ken Ishii and published by Academic Press. This book was released on 2013-10-30 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological DNA Sensor defines the meaning of DNA sensing pathways and demonstrates the importance of the innate immune responses induced by double stranded DNA (dsDNA) through its influencing functions in disease pathology and immune activity of adjuvants for vaccines. Though discussed in specific subsections of existing books, dsDNA and its immunogenic properties has never received the complete treatment given in this book. Biological DNA Sensor approaches the impact of dsDNA's immunogenicity on disease and vaccinology holistically. It paints a complete and concise picture on the topic so you can understand this area of study and make more informed choices for your respective research needs. Chapters are authored by researchers who are renowned for their research focus, ensuring that this book provides the most complete views on the topics. Multi-authored by a distinguished panel of world-class experts Ideal source of information for those wanting to learn about DNA sensing Provides in-depth explanations of DNA sensing pathways and the innate immune system, bridging the gap between them
