Receptor Receptor Interactions In The Central Nervous System

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Receptor-Receptor Interactions in the Central Nervous System

Author : KJELL FUXE
Publisher : Humana
ISBN 13 : 9781493993314
Total Pages : 346 pages
Book Rating : 4.9/5 (933 download)

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Book Synopsis Receptor-Receptor Interactions in the Central Nervous System by : KJELL FUXE

Download or read book Receptor-Receptor Interactions in the Central Nervous System written by KJELL FUXE and published by Humana. This book was released on 2019-08-16 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers methodologies, ranging from the molecular level to the network level, used to study receptor-receptor interactions in heteroreceptor complexes inside the central nervous system. The chapters in this book cover topics such as biochemical binding techniques; receptor autoradiography; superfused synaptosome techniques; RTK-GPCR interaction; fluorescence and bioluminiscence energy transfer methods, Co-IP cytometry-based FRET; and novel bioinformatic approaches to understand membrane heteroreceptor complexes and the global panorama of their receptor-receptor interactions. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and thorough, Receptor-Receptor Interactions in the Central Nervous System is a valuable resource for any scientist or researcher interested in this field of study.

Receptors in the Human Nervous System

Author : F. A. O. Mendelsohn
Publisher : Academic Press
ISBN 13 : 1483258629
Total Pages : 272 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Receptors in the Human Nervous System by : F. A. O. Mendelsohn

Download or read book Receptors in the Human Nervous System written by F. A. O. Mendelsohn and published by Academic Press. This book was released on 2013-10-22 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: Receptors in the Human Nervous System is a synthesis of the results of receptor mapping by leaders in the field. In addition to a comprehensive discussion of the distribution and possible interactions of the receptors of different neuroactive substances, this book also contains an abundance of pictorial representations of receptor distributions. High-quality photographs of one receptor are often juxtaposed with photographs of the distribution of a different receptor or receptor subtype for the consideration of possible interactions between different systems. The book surveys the distribution of receptor subtypes for the classical monoamine transmitters (acetylcholine, adrenaline, noradrenaline and serotonin) as well as the distribution of receptors for the excitatory and inhibitory amino acids, (glutamate, GABA and benzodiazepines) as well as the opioid peptides, angiotensen and other neuropeptides. The distribution of multiple types of serotonin receptors is given in detail, and the codistribution of receptors in the cortex is discussed. The book is directed toward researchers in the field of chemical neuroanatomy, as well as pharmacologists, neurophysiologists, and neuroscientists.

Biology of the NMDA Receptor

Author : Antonius M. VanDongen
Publisher : CRC Press
ISBN 13 : 9781420044157
Total Pages : 350 pages
Book Rating : 4.0/5 (441 download)

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Book Synopsis Biology of the NMDA Receptor by : Antonius M. VanDongen

Download or read book Biology of the NMDA Receptor written by Antonius M. VanDongen and published by CRC Press. This book was released on 2008-10-29 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: The NMDA receptor plays a critical role in the development of the central nervous system and in adult neuroplasticity, learning, and memory. Therefore, it is not surprising that this receptor has been widely studied. However, despite the importance of rhythms for the sustenance of life, this aspect of NMDAR function remains poorly studied. Written by one of the world’s leading authorities on NMDA receptors, Biology of the NMDA Receptor brings together virtually all the players in this important field.

Neurotransmitter Receptors

Author : Sam J. Enna
Publisher : Springer Science & Business Media
ISBN 13 : 9400959281
Total Pages : 282 pages
Book Rating : 4.4/5 (9 download)

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Book Synopsis Neurotransmitter Receptors by : Sam J. Enna

Download or read book Neurotransmitter Receptors written by Sam J. Enna and published by Springer Science & Business Media. This book was released on 2013-12-12 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the discovery that neuronal transmission can be chemically mediated, a large number of compounds have been found in the mammalian central nervous system which appear to function as neurotransmitter agents. Recently, electro physiological and biochemical methods have been developed which have enabled neuroscientists to classify better the myriad of neurotransmitter receptor sites in brain and to study their properties in finer detail. As a result of these investigations, a significant number of new discoveries have been made about the mechanisms involved in neurotransmitter receptor interactions, the role neurotransmitters play in the actions of pharmacological agents and in the pathogenesis of various neuropsychiatric disorders. The present two volume text was compiled to summarize the information relating to the physiological, biochemical, pharmacological and functional characteristics of neurotransmitter receptor sites. While emphasis is placed on neurotransmitter receptors in the mammalian central nervous system, the characteristics of these receptors in other species, both vertebrate and invertebrate, are also discussed where appropriate. While these books cover the major classes of putative neurotransmitters - amino acids, peptides and biogenic amines - and are therefore broad in scope, each is discussed in a concise fashion to highlight the major points of historical and contemporary interest. In addition to outlining data, each chapter addresses current theories relating to the various aspects of receptor properties and function in an attempt to reveal the directions of future research and as a stimulus for other workers in the field.

5-HT2A Receptors in the Central Nervous System

Author : Bruno P. Guiard
Publisher : Springer
ISBN 13 : 3319704745
Total Pages : 446 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis 5-HT2A Receptors in the Central Nervous System by : Bruno P. Guiard

Download or read book 5-HT2A Receptors in the Central Nervous System written by Bruno P. Guiard and published by Springer. This book was released on 2018-02-14 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt: 5-HT2A receptors are G-protein coupled receptors that are widely distributed throughout the brain, most notably on neuronal and glial cells. 5-HT2A receptors have been implicated in various central physiological functions including mood regulation, memory, sleep, nociception, eating, and reward behaviors, and they are also believed to control the cardiovascular system. This book provides a comprehensive overview of these receptors including sections on their properties and distribution, approaches for their study, their role in a number of brain functions and diseases, and their role as therapeutic targets.

CNS Neurotransmitters and Neuromodulators

Author : Trevor W. Stone
Publisher : CRC Press
ISBN 13 : 9780849376320
Total Pages : 280 pages
Book Rating : 4.3/5 (763 download)

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Book Synopsis CNS Neurotransmitters and Neuromodulators by : Trevor W. Stone

Download or read book CNS Neurotransmitters and Neuromodulators written by Trevor W. Stone and published by CRC Press. This book was released on 1996-05-09 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: CNS Neurotransmitters and Neuromodulators: Dopamine is an indispensable single-volume resource for any researcher involved with dopamine in the central nervous system (CNS). Part of the CNS Neurotransmitters and Neuromodulators Series, it is destined to be the definitive reference work on this topic. This book is comprised of independently authored chapters dealing with biochemistry, molecular biology and localization of dopamine receptors and transporters, receptor interactions, growth factors, new antipsychotic drugs, and the neuroendocrinal and retinal functions of dopamine. The authors, an international group of well-known researchers from varied disciplines, have utilized the most up-to-date material in preparing their reviews. CNS Neurotransmitters and Neuromodulators: Dopamine is the perfect source for established researchers seeking the latest information or for students requiring an in-depth one-step introduction.

Molecular and Functional Characterizations of Protein-protein Interactions in Central Nervous System

Author : Min Wang
Publisher :
ISBN 13 : 9780494776711
Total Pages : 406 pages
Book Rating : 4.7/5 (767 download)

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Book Synopsis Molecular and Functional Characterizations of Protein-protein Interactions in Central Nervous System by : Min Wang

Download or read book Molecular and Functional Characterizations of Protein-protein Interactions in Central Nervous System written by Min Wang and published by . This book was released on 2011 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many pathological processes are associated with excessive neurotransmitter release that leads to the over-stimulation of post-synaptic neurotransmitter receptors. Examples include excessive activation of glutamate receptors in ischemic stroke and hyper-dopaminergic state in schizophrenia and drug addiction. Thus, it would seem that simply antagonizing the involved receptors should be able to correct the pathological condition. In some instances, this strategy has been somewhat effective, such as with the use of dopamine D2 receptor antagonists as antipsychotics in the treatment of positive symptoms of schizophrenia despite severe side effect. However, clinical application of drugs antagonizing glutamate receptor in the treatment of stoke, although attracting intensive research effort, has been restricted by serious side effects caused by suppressing postsynaptic responses that are needed for normal brain function. As a consequence, it is important to develop novel therapeutics aiming at specific targets with minimized side effects. Numerous studies have suggested that the pathophysiology of neuropsychiatric disorders, drug addictions and stroke involves multiple neurotransmitter receptor systems such as the dopamine and glutamate systems. The activation or inhibition of one receptor can have cross-functional effect that will be better understood by investigating the functional and structural relationship between receptor systems. Thus, the present study has focused on characterizing receptor-receptor interactions associated with dopamine receptors and glutamate receptors, and to elucidate the physiological and pathological consequence of altered receptor interactions in schizophrenia, depression and ischemic stroke.

Receptors in the Developing Nervous System

Author : Ian S. Zagon
Publisher : Springer Science & Business Media
ISBN 13 : 9401115443
Total Pages : 268 pages
Book Rating : 4.4/5 (11 download)

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Book Synopsis Receptors in the Developing Nervous System by : Ian S. Zagon

Download or read book Receptors in the Developing Nervous System written by Ian S. Zagon and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Receptors for cell hormones, growth factors, Fourth, alterations in the development of neu and neurotransmitters are involved in the ral receptors may have profound implications control and modulation of an enormous array for the structure and function of the of biological processes. The development of organism. As much as possible, the reper these receptors has distinct spatial and tem cussions of disrupting the orchestration of poral arrangements, and alterations in this receptor development in the nervous system pattern during embryogenesis can have signi are discussed. In many instances, however, ficant consequences for the well-being of the we are just beginning to learn about some fetus, infant, child and adult. The developing receptors and the authors may not be in a nervous system is particularly dependent on position to discuss the consequences of recep receptors because its period of structural and tor dysfunction. functional organization extends through both In designing these two volumes, we have prenatal and postnatal phases. Moreover, asked major figures in each field to review the receptors are a key element in neural com literature, to apprise the audience of their munication in both the developing and adult latest findings, and to provide a perspective on organism, so that the ontogeny of receptors is the role of receptors in the developing nervous crucial in determining the myriad connections system. These books are intended to sum forming the circuitry of the nervous system.

Neurotransmitter Receptors

Author : Sam J. Enna
Publisher : Springer Science & Business Media
ISBN 13 : 9401095477
Total Pages : 212 pages
Book Rating : 4.4/5 (1 download)

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Book Synopsis Neurotransmitter Receptors by : Sam J. Enna

Download or read book Neurotransmitter Receptors written by Sam J. Enna and published by Springer Science & Business Media. This book was released on 2013-12-11 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the discovery that neuronal transmission can be chemically mediated, a large number of compounds have been found in the mammalian central nervous system which appear to function as neurotransmitter agents. Recently, electrophysiological and biochemical methods have been developed which have enabled neuroscientists to classify better the myriad of neurotransmitter receptor sites in brain and to study their properties in finer detail. As a result of these investigations, a significant number of new discoveries have been made about the mechanisms involved in neurotransmitter receptor interactions, the role neurotransmitters play in the actions of pharmacological agents and in the pathogenesis of various neuropsychiatric disorders. The present two volume text was compiled to summarize the information relating to the physiological, biochemical, pharmacological and functional characteristics of neurotransmitter receptor sites. While emphasis is placed on neurotransmitter receptors in the mammalian central nervous system, the characteristics of these receptors in other species, both vertebrate and invertebrate, are also discussed where appropriate. While these books cover the major classes of putative neurotransmitters - amino acids, peptides and biogenic amines - and are therefore broad in scope, each is discussed in a concise fashion to highlight the major points of historical and contemporary interest. In addition to outlining data, each chapter addresses current theories relating to the various aspects of receptor properties and function in an attempt to reveal the directions of future research and as a stimulus for other workers in the field.

Ensemble Co-Interactions in the Central Nervous System

Author :
Publisher : Voronova Nadezda
ISBN 13 :
Total Pages : 163 pages
Book Rating : 4./5 ( download)

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Book Synopsis Ensemble Co-Interactions in the Central Nervous System by :

Download or read book Ensemble Co-Interactions in the Central Nervous System written by and published by Voronova Nadezda. This book was released on with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt:

5-HT2C Receptors in the Pathophysiology of CNS Disease

Author : Giuseppe Di Giovanni
Publisher : Springer Science & Business Media
ISBN 13 : 1607619415
Total Pages : 560 pages
Book Rating : 4.6/5 (76 download)

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Book Synopsis 5-HT2C Receptors in the Pathophysiology of CNS Disease by : Giuseppe Di Giovanni

Download or read book 5-HT2C Receptors in the Pathophysiology of CNS Disease written by Giuseppe Di Giovanni and published by Springer Science & Business Media. This book was released on 2010-11-30 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: Part of Springer’s “The Receptors,” series, this text is the first ever overview on the research of 5-HT2c receptors. 5-HT2c receptor research has been productive for twenty-five years, but recent years have seen an extraordinary increase in both amount produced and insight gained. 5-HT2c is a prominent central serotonin receptor subtype widely expressed within the central and the peripheral nervous system and is thought to play a key role in the regulation of numerous behaviors. This text covers the molecular, cellular, anatomical, biochemical and behavioral aspects of this receptor, highlighting its distinctive regulatory properties and the emerging functional significance of constitutive activity and RNA-editing in vivo. It also investigates the receptors’ therapeutic potential in many diseases, treated individually in separate chapters, including depression, drug abuse, schizophrenia, eating disorders, Parkinson’s disease, Prader-Willi Syndrome, Alzheimer’s disease and epilepsy.

Biochemical Studies of CNS Receptors

Author : Leslie Iversen
Publisher : Springer Science & Business Media
ISBN 13 : 1468443615
Total Pages : 448 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Biochemical Studies of CNS Receptors by : Leslie Iversen

Download or read book Biochemical Studies of CNS Receptors written by Leslie Iversen and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is now eight years since the first Handbook volumes on Basic Neuro pharmacology were published, and there have been many important advances. As in many other areas in science, progress in this field has depended to a considerable extent on the availability of new experimental methods, and Volume 15 reviews some major recent developments, including new autoradiographic techniques that allow direct visualization of drug and transmitter receptors in the nervous system, and the pin pointing of the precise locations of the changes in brain metabolism elicited by various drug treatments. Volume 16 and 17 cover two of the most active areas for basic research in psychopharmacology at the moment: the characterization of drug and transmitter receptors in brain by radioligand binding techniques, and studies of the role of small peptides in brain function. The latter area, in particular, illustrates how rapidly progress continues to be made in basic research on the mechanisms of chemical communication within the nervous system. Eight years ago when the Handbook first appeared none of the opioid peptides (enkephalins and endorphins) had yet been identified. Since then a whole new area of basic biological research has focused on these substances, and in addition we know of more than thirty other neuropeptides with putative eNS trans mitter functions.

Central Cholinergic Synaptic Transmission

Author : Frotscher
Publisher : Birkhäuser
ISBN 13 : 9783034899222
Total Pages : 324 pages
Book Rating : 4.8/5 (992 download)

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Book Synopsis Central Cholinergic Synaptic Transmission by : Frotscher

Download or read book Central Cholinergic Synaptic Transmission written by Frotscher and published by Birkhäuser. This book was released on 2011-09-27 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our knowledge of cholinergic synaptic transmission in the peripheral nervous system (PNS) has expanded enormously since the early 1930's, at which time O. Loewi discovered chemical neurotransmission through acetylcholine (ACh) and the pharmacological actions of ACh were described by H. Dale and his colleagues. Description of ACh's actions and receptors in various parts of the brain was followed by a detailed analysis of ACh's synthesis, release mechanism, removal from the synaptic cleft, modes of agonist-receptor interactions, properties of regulated conductances and of the pre-and postsynaptic modulation of cholinergic synapses. Our knowledge has been increasingly consolidat ing, leading us to the recent clarification of the structure of the periph eral nicotinic receptor-ion channel and its functional properties. It is appropriate to maintain the claim that the fundamentals of our under standing of synaptic transmission come from studies on cholinergic synapses in the PNS. Contrastingly, views held on the role of cholinergic synapses in the mammalian central nervous system (CNS) are extremely controversial, although it has been clear for some time that ACh is present in the brain. Illustrating this, no unanimous view is held on the role of nicotinic receptors in the CNS. There is one notable exception to this confusion: Studies begun by J. C. Eccles and associates in the 1960's and completed by D. R. Curtis and R. W.

Caffeine in Food and Dietary Supplements

Author : Leslie A. Pray
Publisher :
ISBN 13 : 9780309297493
Total Pages : 0 pages
Book Rating : 4.2/5 (974 download)

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Book Synopsis Caffeine in Food and Dietary Supplements by : Leslie A. Pray

Download or read book Caffeine in Food and Dietary Supplements written by Leslie A. Pray and published by . This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Caffeine in Food and Dietary Supplements is the summary of a workshop convened by the Institute of Medicine in August 2013 to review the available science on safe levels of caffeine consumption in foods, beverages, and dietary supplements and to identify data gaps. Scientists with expertise in food safety, nutrition, pharmacology, psychology, toxicology, and related disciplines; medical professionals with pediatric and adult patient experience in cardiology, neurology, and psychiatry; public health professionals; food industry representatives; regulatory experts; and consumer advocates discussed the safety of caffeine in food and dietary supplements, including, but not limited to, caffeinated beverage products, and identified data gaps. Caffeine, a central nervous stimulant, is arguably the most frequently ingested pharmacologically active substance in the world. Occurring naturally in more than 60 plants, including coffee beans, tea leaves, cola nuts and cocoa pods, caffeine has been part of innumerable cultures for centuries. But the caffeine-in-food landscape is changing. There are an array of new caffeine-containing energy products, from waffles to sunflower seeds, jelly beans to syrup, even bottled water, entering the marketplace. Years of scientific research have shown that moderate consumption by healthy adults of products containing naturally-occurring caffeine is not associated with adverse health effects. The changing caffeine landscape raises concerns about safety and whether any of these new products might be targeting populations not normally associated with caffeine consumption, namely children and adolescents, and whether caffeine poses a greater health risk to those populations than it does for healthy adults. This report delineates vulnerable populations who may be at risk from caffeine exposure; describes caffeine exposure and risk of cardiovascular and other health effects on vulnerable populations, including additive effects with other ingredients and effects related to pre-existing conditions; explores safe caffeine exposure levels for general and vulnerable populations; and identifies data gaps on caffeine stimulant effects.

Advances in CNS Drug-receptor Interactions

Author :
Publisher :
ISBN 13 :
Total Pages : 200 pages
Book Rating : 4.0/5 ( download)

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Book Synopsis Advances in CNS Drug-receptor Interactions by :

Download or read book Advances in CNS Drug-receptor Interactions written by and published by . This book was released on 1991 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Advances in CNS Drug-receptor Interactions

Author : Joseph G. Cannon
Publisher :
ISBN 13 : 9781559381635
Total Pages : 0 pages
Book Rating : 4.3/5 (816 download)

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Book Synopsis Advances in CNS Drug-receptor Interactions by : Joseph G. Cannon

Download or read book Advances in CNS Drug-receptor Interactions written by Joseph G. Cannon and published by . This book was released on 1991 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Adenosine Receptors in Health and Disease

Author : Constance N. Wilson
Publisher : Springer Science & Business Media
ISBN 13 : 3540896155
Total Pages : 656 pages
Book Rating : 4.5/5 (48 download)

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Book Synopsis Adenosine Receptors in Health and Disease by : Constance N. Wilson

Download or read book Adenosine Receptors in Health and Disease written by Constance N. Wilson and published by Springer Science & Business Media. This book was released on 2009-07-28 with total page 656 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since their discovery approximately 25 years ago, adenosine receptors have now emerged as important novel molecular targets in disease and drug discovery. These proteins play important roles in the entire spectrum of disease from inflammation to immune suppression. Because of their expression on a number of different cell types and in a number of different organ systems they play important roles in specific diseases, including asthma, rheumatoid arthritis, Parkinson’s disease, multiple sclerosis, Alzheimer’s disease, heart disease, stroke, cancer, sepsis, and obesity. As a result of intense investigations into understanding the molecular structures and pharmacology of these proteins, new molecules have been synthesized that have high specificity for these proteins and are now entering clinical trials. These molecules will define the next new classes of drugs for a number of diseases with unmet medical needs.