Neurotransmitter Receptors

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Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309212243
Total Pages : 74 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System by : Institute of Medicine

Download or read book Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System written by Institute of Medicine and published by National Academies Press. This book was released on 2011-07-05 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glutamate is the most pervasive neurotransmitter in the central nervous system (CNS). Despite this fact, no validated biological markers, or biomarkers, currently exist for measuring glutamate pathology in CNS disorders or injuries. Glutamate dysfunction has been associated with an extensive range of nervous system diseases and disorders. Problems with how the neurotransmitter glutamate functions in the brain have been linked to a wide variety of disorders, including schizophrenia, Alzheimer's, substance abuse, and traumatic brain injury. These conditions are widespread, affecting a large portion of the United States population, and remain difficult to treat. Efforts to understand, treat, and prevent glutamate-related disorders can be aided by the identification of valid biomarkers. The Institute of Medicine's Forum on Neuroscience and Nervous System Disorders held a workshop on June 21-22, 2010, to explore ways to accelerate the development, validation, and implementation of such biomarkers. Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System: Workshop Summary investigates promising current and emerging technologies, and outlines strategies to procure resources and tools to advance drug development for associated nervous system disorders. Moreover, this report highlights presentations by expert panelists, and the open panel discussions that occurred during the workshop.

Neurotransmitter Release

Author : Hugo J. Bellen
Publisher :
ISBN 13 :
Total Pages : 466 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Neurotransmitter Release by : Hugo J. Bellen

Download or read book Neurotransmitter Release written by Hugo J. Bellen and published by . This book was released on 1999 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding the mechanisms that underlie brain activity and function remains one of the major frontiers of biology. All the processes of how we co-ordinate our movements, sense our surroundings, react to stimuli and learn and retain information rely on complicated networks of neurons thatcommunicate with each other and their targets. This fast and accurate intercellular signalling most occurs at synapses, specialized processes of neurons that release chemical signals, called neurotransmitters. Neurotransmitters: Frontiers in Molecular Biology will provide the reader withextensive background information on neurotransmitter release. It takes a multidisciplinary approach, but does not assume previous knowledge having basic introductions to most topics. Topics however are covered in enough detail to be of interest to experts in the field. Throughout, emphasis is placedon the rationale by which proteins are assigned specific functions rather than just providing facts about function. The first chapter provides an introduction to the basic features and properties of the synapse and is followed by a chapter detailing several important techniques used to elucidatevarious aspects of release. Chapters 3 describes many of the biochemical approaches used to identify proteins involved in neurotransmitter release and then chapters 4 and 5 focus on more specific aspects of synaptic transmission: the proteins that transport neurotransmitters and the role ofphosphlipids in the process. The next five chapters concentrate on approaches to unravel the function of many proteins in vivo by using toxins, giant squid axons, C. elegans, Drosophila, and mice. The final chapter summarizes current knowledge on endocytosis and recycling. Knowledge of themolecular mechanisms underlying neurotransmitter release has expanded tremendously over the last 10 years. Many of the proteins involved have been isolated, but their roles have yet to be determined. These discoveries will be a major challenge and it is therefore the major aim of this book not onlyto provide information but also to generate excitement.

Pharmacology of Neurotransmitter Release

Author : Thomas C. Südhof
Publisher : Springer Science & Business Media
ISBN 13 : 3540748059
Total Pages : 582 pages
Book Rating : 4.5/5 (47 download)

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Book Synopsis Pharmacology of Neurotransmitter Release by : Thomas C. Südhof

Download or read book Pharmacology of Neurotransmitter Release written by Thomas C. Südhof and published by Springer Science & Business Media. This book was released on 2007-12-07 with total page 582 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has been known for half a century that neurotransmitters are released in preformed quanta, that the quanta represent transmitter-storing vesicles, and that release occurs by exocytosis. The focus of this book is twofold. In the first part, the molecular events of exocytosis are analysed. In the second part of the book, the presynaptic receptors for endogenous chemical signals are presented that make neurotransmitter release a highly regulated process.

Neurotransmitters and Neuromodulators

Author : Oliver von Bohlen und Halbach
Publisher : John Wiley & Sons
ISBN 13 : 3527609075
Total Pages : 402 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Neurotransmitters and Neuromodulators by : Oliver von Bohlen und Halbach

Download or read book Neurotransmitters and Neuromodulators written by Oliver von Bohlen und Halbach and published by John Wiley & Sons. This book was released on 2006-12-13 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: A complete update of the highly acclaimed handbook with data on all neurotransmitters and the majority of neuromodulators. The coverage is now even more comprehensive, with 15% more entries on neuropeptides, "classic" neurotransmitters and related substances in a clear, alphabetical format. The methodological section has been expanded by 50% and now includes color figures, plus new chapters on genomics, proteomics, databases, microarrays, MALDI-TOF, neutrophins, FGF, endocannabinoids and neuroimaging. The text provides clearly structured information on the biosynthesis and degradation, localization, receptors, signal transduction pathways, and biological effects in the central nervous system, with all substances uniformly treated for an easy comparison of data. Furthermore, introductory chapters on receptors, transporters, and the blood-brain barrier make this an indispensable tool for researchers, teachers, and advanced students, as well as a must-have for every neuroscientist.

Neurotransmitter Receptors

Author : Sam J. Enna
Publisher : Springer Science & Business Media
ISBN 13 : 9400959281
Total Pages : 282 pages
Book Rating : 4.4/5 (9 download)

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Book Synopsis Neurotransmitter Receptors by : Sam J. Enna

Download or read book Neurotransmitter Receptors written by Sam J. Enna and published by Springer Science & Business Media. This book was released on 2013-12-12 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the discovery that neuronal transmission can be chemically mediated, a large number of compounds have been found in the mammalian central nervous system which appear to function as neurotransmitter agents. Recently, electro physiological and biochemical methods have been developed which have enabled neuroscientists to classify better the myriad of neurotransmitter receptor sites in brain and to study their properties in finer detail. As a result of these investigations, a significant number of new discoveries have been made about the mechanisms involved in neurotransmitter receptor interactions, the role neurotransmitters play in the actions of pharmacological agents and in the pathogenesis of various neuropsychiatric disorders. The present two volume text was compiled to summarize the information relating to the physiological, biochemical, pharmacological and functional characteristics of neurotransmitter receptor sites. While emphasis is placed on neurotransmitter receptors in the mammalian central nervous system, the characteristics of these receptors in other species, both vertebrate and invertebrate, are also discussed where appropriate. While these books cover the major classes of putative neurotransmitters - amino acids, peptides and biogenic amines - and are therefore broad in scope, each is discussed in a concise fashion to highlight the major points of historical and contemporary interest. In addition to outlining data, each chapter addresses current theories relating to the various aspects of receptor properties and function in an attempt to reveal the directions of future research and as a stimulus for other workers in the field.

Neurotransmitters, Drugs and Brain Function

Author : Roy Webster
Publisher : John Wiley & Sons
ISBN 13 : 9780471978190
Total Pages : 550 pages
Book Rating : 4.9/5 (781 download)

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Book Synopsis Neurotransmitters, Drugs and Brain Function by : Roy Webster

Download or read book Neurotransmitters, Drugs and Brain Function written by Roy Webster and published by John Wiley & Sons. This book was released on 2001-11-28 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurotransmitters, Drugs and Brain Function aims to link basic aspects of the activity of neurotransmitters at the receptor and synaptic level with their role in normal brain function, disease states, and drug action. Thus, the material considers to what extent our knowledge of the central synaptic action of certain drugs can explain their possible roles in the cause of diseases and in the modes of action of drugs effective in those conditions. It offers a working explanation of drug and neurotransmitter action in CNS function, with a clear, comprehensive, and challenging style of writing. The authors review the chemical basis for drugs and the conditions they treat. It also, includes numerous illustrations and schematic diagrams.

An Introduction to Neuroendocrinology

Author : Richard E. Brown
Publisher : Cambridge University Press
ISBN 13 : 9780521426657
Total Pages : 434 pages
Book Rating : 4.4/5 (266 download)

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Book Synopsis An Introduction to Neuroendocrinology by : Richard E. Brown

Download or read book An Introduction to Neuroendocrinology written by Richard E. Brown and published by Cambridge University Press. This book was released on 1994-01-27 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is designed as an introductory text in neuroendocrinology; the study of the interaction between the brain and endocrine system and the influence of this on behaviour. The endocrine glands, pituitary gland and hypothalamus and their interactions and hormones are discussed. The action of steroid and thyroid hormone receptors and the regulation of target cell response to hormones is examined. The function of neuropeptides is discussed with respect to the neuroendocrine system and behaviour. The neuroimmune system and lymphokines are described and the interaction between the neuroendocrine and neuroimmune systems discussed. Finally, methods for studying hormonal influences on behaviour are outlined. Each chapter has review and essay questions designed for advanced students and honours or graduate students with a background in neuroscience, respectively.

Basic Neurochemistry

Author : Scott Brady
Publisher : Academic Press
ISBN 13 : 0080959016
Total Pages : 1120 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Basic Neurochemistry by : Scott Brady

Download or read book Basic Neurochemistry written by Scott Brady and published by Academic Press. This book was released on 2011-11-02 with total page 1120 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basic Neurochemistry: Principles of Molecular, Cellular, and Medical Neurobiology, the outstanding and comprehensive classic text on neurochemistry, is now newly updated and revised in its Eighth Edition. For more than forty years, this text has been the worldwide standard for information on the biochemistry of the nervous system, serving as a resource for postgraduate trainees and teachers in neurology, psychiatry, and basic neuroscience, as well as for medical, graduate, and postgraduate students and instructors in the neurosciences. The text has evolved, as intended, with the science. It is also an excellent source of current information on basic biochemical and cellular processes in brain function and neurological diseases for continuing medical education and qualifying examinations. This text continues to be the standard reference and textbook for exploring the translational nature of neuroscience, bringing basic and clinical neuroscience together in one authoritative volume. Our book title reflects the expanded attention to these links between neurochemistry and neurologic disease. This new edition continues to cover the basics of neurochemistry as in the earlier editions, along with expanded and additional coverage of new research from: Intracellular trafficking; Stem cells, adult neurogenesis, regeneration; Lipid messengers; Expanded coverage of all major neurodegenerative and psychiatric disorders; Neurochemistry of addiction; Neurochemistry of pain; Neurochemistry of hearing and balance; Neurobiology of learning and memory; Sleep; Myelin structure, development, and disease; Autism; and Neuroimmunology. Completely updated text with new authors and material, and many entirely new chapters Over 400 fully revised figures in splendid color 61 chapters covering the range of cellular, molecular and medical neuroscience Translational science boxes emphasizing the connections between basic and clinical neuroscience Companion website at http://elsevierdirect.com/companions/9780123749475

Neurotransmitter Receptors

Author : Sam J. Enna
Publisher : Springer Science & Business Media
ISBN 13 : 9401095477
Total Pages : 212 pages
Book Rating : 4.4/5 (1 download)

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Book Synopsis Neurotransmitter Receptors by : Sam J. Enna

Download or read book Neurotransmitter Receptors written by Sam J. Enna and published by Springer Science & Business Media. This book was released on 2013-12-11 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the discovery that neuronal transmission can be chemically mediated, a large number of compounds have been found in the mammalian central nervous system which appear to function as neurotransmitter agents. Recently, electrophysiological and biochemical methods have been developed which have enabled neuroscientists to classify better the myriad of neurotransmitter receptor sites in brain and to study their properties in finer detail. As a result of these investigations, a significant number of new discoveries have been made about the mechanisms involved in neurotransmitter receptor interactions, the role neurotransmitters play in the actions of pharmacological agents and in the pathogenesis of various neuropsychiatric disorders. The present two volume text was compiled to summarize the information relating to the physiological, biochemical, pharmacological and functional characteristics of neurotransmitter receptor sites. While emphasis is placed on neurotransmitter receptors in the mammalian central nervous system, the characteristics of these receptors in other species, both vertebrate and invertebrate, are also discussed where appropriate. While these books cover the major classes of putative neurotransmitters - amino acids, peptides and biogenic amines - and are therefore broad in scope, each is discussed in a concise fashion to highlight the major points of historical and contemporary interest. In addition to outlining data, each chapter addresses current theories relating to the various aspects of receptor properties and function in an attempt to reveal the directions of future research and as a stimulus for other workers in the field.

Frontiers in Pharmacology of Neurotransmitters

Author : Puneet Kumar
Publisher : Springer Nature
ISBN 13 : 9811535566
Total Pages : 729 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Frontiers in Pharmacology of Neurotransmitters by : Puneet Kumar

Download or read book Frontiers in Pharmacology of Neurotransmitters written by Puneet Kumar and published by Springer Nature. This book was released on 2020-10-29 with total page 729 pages. Available in PDF, EPUB and Kindle. Book excerpt: Numerous phenomenal advances have been made towards understanding the role of neurotransmitters in the pathophysiology of neurological disorders, and these have resulted in a large number of novel molecules with the potential to revolutionize the treatment and prevention of such disorders. This book provides a comprehensive and detailed explanation of brain neurotransmitters and their receptors and associated channels. It includes a basic introduction, and also discusses the functions and recent advances and their pharmacology, highlighting the role of various computer aided drug design (CADD) strategies for the development of therapeutic ligands to modulate these receptors/ion channels. Written in an easy-to-read style, it is intended for neuroscience and pharmaceutical students and researchers working in the area of brain neurotransmitters.

The Central Nervous System

Author : Per Brodal
Publisher : Oxford University Press, USA
ISBN 13 :
Total Pages : 696 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The Central Nervous System by : Per Brodal

Download or read book The Central Nervous System written by Per Brodal and published by Oxford University Press, USA. This book was released on 1998 with total page 696 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is also new material throughout the text on such topics as cortical processing and its imaging, consciousness and sleep, cognitive functions of the cerebellum, the functional organization of the basal forebrain, pain, clinical disturbances of the somatosensory system, color vision, and cerebral lateralization. In addition, the text has been reorganized to improve its clarity in places, including the chapters on the hypothalamus, the peripheral autonomic nervous system, and the cerebral cortex.

Neurotransmitter Receptors

Author : F. Hucho
Publisher : Elsevier
ISBN 13 : 9780080860848
Total Pages : 366 pages
Book Rating : 4.8/5 (68 download)

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Book Synopsis Neurotransmitter Receptors by : F. Hucho

Download or read book Neurotransmitter Receptors written by F. Hucho and published by Elsevier. This book was released on 1994-03-17 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive compilation provides a wealth of information on receptor sequences produced by recombinant DNA techniques used in combination with classical biochemistry. To minimize redundancies in this wealth of information, only a few receptors (some of which are typical for a whole group of similar receptors, others which are presently of special interest) are dealt with in a full-size chapter. Others are represented in the TIPS Receptor Nomenclature Supplement which is included as a special feature in this book, making this volume more useful as a receptor handbook.

Histamine in the brain

Author : Jian-Sheng Lin
Publisher : Frontiers Media SA
ISBN 13 : 2889194345
Total Pages : 100 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Histamine in the brain by : Jian-Sheng Lin

Download or read book Histamine in the brain written by Jian-Sheng Lin and published by Frontiers Media SA. This book was released on 2015-03-18 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brain aminergic pathways are organized in parallel and interacting systems, which support a range of functions, from homoeostatic regulations to cognitive, and motivational processes. Despite overlapping functional influences, dopamine, serotonin, noradrenaline and histamine systems provide different contributions to these processes. The histaminergic system, long ignored as a major regulator of the sleep-wake cycle, has now been fully acknowledged also as a major coordinator of attention, learning and memory, decision making. Although histaminergic neurons project widely to the whole brain, they are functionally heterogeneous, a feature which may provide the substrate for differential regulation, in a region-specific manner, of other neurotransmitter systems. Neurochemical preclinical studies have clearly shown that histamine interacts and modulates the release of neurotransmitters that are recognized as major modulators of cognitive processing and motivated behaviours. As a consequence, the histamine system has been proposed as a therapeutic target to treat sleep-wake disorders and cognitive dysfunctions that accompany neurodegenerative and neuroinflammatory pathologies. Last decades have witnessed an unexpected explosion of interest in brain histamine system, as new receptors have been discovered and selective ligands synthesised. Nevertheless, the complete picture of the histamine systems fine-tuning and its orchestration with other pathways remains rather elusive. This Research Topic is intended to offer an inter-disciplinary forum that will improve our current understanding of the role of brain histamine and provide the fundamentals necessary to drive innovation in clinical practice and to improve the management and treatment of neurological disorders.

Neuroreceptor Mechanisms in Brain

Author : Shozo Kito
Publisher : Springer Science & Business Media
ISBN 13 : 1468459074
Total Pages : 489 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Neuroreceptor Mechanisms in Brain by : Shozo Kito

Download or read book Neuroreceptor Mechanisms in Brain written by Shozo Kito and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Third International Symposium on Neurotransmitter Receptors was held in Hiroshima at a time when the entire field of neurotransmitter receptors in the brain is progressing at an unprecedented pace. The sym posium also marked my retirement as Professor and Chairman of the Third Department of Internal Medicine, Hiroshima University School of Medicine, and a new beginning as a Professor of the University of the Air. The symposium was remarkably successful, and there were enthusiastic responses from scientists allover the world, proving that the meeting was timely. The selected papers contained in this volume constitute a state of-the-art survey of the most advanced aspects of neurotransmitter recep tor mechanisms in the brain. lowe thanks for the great success of the symposium to Prof. Richard Olsen of UCLA, Prof. Tomio Segawa of Hiroshima University, Prof. Kinya Kuriyama of Kyoto Prefectural University of Medicine, and Prof. Masaya Tohyama of Osaka University. I express my sincere gratitude to many friends for making this publication possible. I especially thank Dr. Rie Miyoshi, whose devoted efforts as secretary-general were vital to the success of the symposium. Dr. Miyoshi is currently an instructor in the Department of Pharmacology at Tokyo Women's Medical College. I would also like to acknowledge the excellent secretarial work of Misses Ritsuko Sato and Yuko Wakita.

Medical Biochemistry

Author : Antonio Blanco
Publisher : Academic Press
ISBN 13 : 0323916007
Total Pages : 910 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Medical Biochemistry by : Antonio Blanco

Download or read book Medical Biochemistry written by Antonio Blanco and published by Academic Press. This book was released on 2022-03-23 with total page 910 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition of Medical Biochemistry is supported by more than 45 years of teaching experience, providing coverage of basic biochemical topics, including the structural, physical, and chemical properties of water, carbohydrates, lipids, proteins, and nucleic acids. In addition, the general aspects of thermodynamics, enzymes, bioenergetics, and metabolism are presented in straightforward and easy-to-comprehend language. This book ties these concepts into more complex aspects of biochemistry using a systems approach, dedicating chapters to the integral study of biological phenomena, including cell membrane structure and function, gene expression and regulation, protein synthesis and post-translational modifications, metabolism in specific organs and tissues, autophagy, cell receptors, signal transduction pathways, biochemical bases of endocrinology, immunity, vitamins and minerals, and hemostasis. The field of biochemistry is continuing to grow at a fast pace. This edition has been revised and expanded with all-new sections on the cell plasma membrane, the human microbiome, autophagy, noncoding, small and long RNAs, epigenetics, genetic diseases, virology and vaccines, cell signaling, and different modes of programmed cell death. The book has also been updated with full-color figures, new tables, chapter summaries, and further medical examples to improve learning and better illustrate the concepts described and their clinical significance. Integrates basic biochemistry principles with molecular biology and molecular physiology Illustrates basic biochemical concepts through medical and physiological examples Utilizes a systems approach to understanding biological phenomena Fully updated for recent studies and expanded to include clinically relevant examples and succinct chapter summaries

The Role of the Nucleus of the Solitary Tract in Gustatory Processing

Author : Robert M. Bradley
Publisher : CRC Press
ISBN 13 : 9780849342004
Total Pages : 0 pages
Book Rating : 4.3/5 (42 download)

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Book Synopsis The Role of the Nucleus of the Solitary Tract in Gustatory Processing by : Robert M. Bradley

Download or read book The Role of the Nucleus of the Solitary Tract in Gustatory Processing written by Robert M. Bradley and published by CRC Press. This book was released on 2006-10-04 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing an essential brainstem relay for three cranial nerves, the NST coordinates highly complex sensory information. While other functions of the NST have received attention, its role in gustatory processing has received little. The first reference devoted exclusively to gustatory processing, The Role of the Nucleus of the Solitary Tract in Gustatory Processing offers an in-depth review of one of the most important central relay stations in the brain. Combining widely dispersed research into a comprehensive single volume, it presents a thorough historical background, documents the anatomy of the rostral nucleus of the solitary tract (rNST), and explores the properties of synaptic transmitters and neurons within that tract. The book examines the role of reflex activities and considers factors that influence how gustatory rNST neurons respond to taste stimuli. It describes the development and maturational changes the rNST undergoes and considers the challenge involved with identifying rNST neural circuits. The Role of the Nucleus of the Solitary Tract in Gustatory Processing brings together expert investigators who have contributed substantially to the current knowledge of the anatomy, physiology, and developmental biology of the solitary nucleus. This pertinent work serves as a standard reference for those involved in the field, providing ready access to past investigations and inviting practitioners to create new approaches that will advance knowledge about the central processing of gustatory information.

The Serotonin Receptors

Author : Bryan L. Roth
Publisher : Springer Science & Business Media
ISBN 13 : 1597450804
Total Pages : 628 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis The Serotonin Receptors by : Bryan L. Roth

Download or read book The Serotonin Receptors written by Bryan L. Roth and published by Springer Science & Business Media. This book was released on 2008-08-17 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive, state-of-the-art review of our current understanding of the molecular and structural biology of 5-HT receptors and their potential use for drug discovery. The authors describe the anatomical, cellular, and subcellular distribution of 5-HT receptors and demonstrate a powerful approach to elucidating their physiological role using knockout mice in which the 5-HT receptors were deleted. They also review our understanding of the physiological role(s) of 5-HT receptors based mainly on studies performed in genetically engineered mice. Highlights include discussions of the behavioral phenotypes of 5-HT receptor knockout animals, the molecular biology and pharmacology of 5-HT receptors, and insights into the complexity of 5-HT receptor signal transduction.