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Author : L. Selmeci
Publisher :
ISBN 13 : 9780785562931
Total Pages : 634 pages
Book Rating : 4.5/5 (629 download)
Download or read book Recent Progress in Polyamine Research written by L. Selmeci and published by . This book was released on 1985-01-01 with total page 634 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : V. Zappia
Publisher : Springer Science & Business Media
ISBN 13 : 1468456377
Total Pages : 755 pages
Book Rating : 4.4/5 (684 download)
Download or read book Progress in Polyamine Research written by V. Zappia and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 755 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains the scientific contributions presented at an International Symposium held in Sorrento, Italy, in June 1988 under the auspices of the University of Naples, the Italian Society of Biochemistry, and the National Research Council. The modern history of polyamines dates back to 1958 when the Tabors and Rosenthal first described the outlines of their biological synthesis. From then on, and particularly in the last ten years, a veri table explosion of Literature, characterized by thousands of papers, has witnessed the interest of the scientific community toward these molecules. Perhaps the old statement that "polyamines are molecules in search of a function" is no longer true today. A large number of effects exerted by these simple molecules are well known, and in many cases the mechanisms underlying these effects have been elucidated. The first section of the volume is entirely devoted to the enzymology and molecular biology of ornithine decarboxylase. Since its discovery by Gale more than forty years ago, this can be considered among the most widely studied enzymes in biology, and one of the most complex models in enzyme regulation. The mechanism of control of the enzyme activity at the transcriptional, post-transcriptional and post-translational levels, as well as the fine regulation by antizyme, are discussed in detail. The second group of contributions deals wi th AdoMet decarboxylase, propylamine transferase, polyamine oxidase and the other enzymes related to polyamine interconversion and regeneration.
Author : Advances in Polyamine Research Staff
Publisher :
ISBN 13 : 9780783772745
Total Pages : 395 pages
Book Rating : 4.7/5 (727 download)
Download or read book Advances in Polyamine Research written by Advances in Polyamine Research Staff and published by . This book was released on with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Robert A. Campbell
Publisher :
ISBN 13 : 9780890041949
Total Pages : 395 pages
Book Rating : 4.0/5 (419 download)
Download or read book Advances in Polyamine Research written by Robert A. Campbell and published by . This book was released on 1978 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Tracy Murray-Stewart
Publisher : MDPI
ISBN 13 : 3039211528
Total Pages : 240 pages
Book Rating : 4.0/5 (392 download)
Download or read book Polyamine Metabolism in Disease and Polyamine-Targeted Therapies written by Tracy Murray-Stewart and published by MDPI. This book was released on 2019-10-01 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polyamines are ubiquitous polycations essential for all cellular life. The most common polyamines in eukaryotes, spermine, spermidine, and putrescine, exist in millimolar intracellular concentrations that are tightly regulated through biosynthesis, catabolism, and transport. Polyamines interact with, and regulate, negatively charged macromolecules, including nucleic acids, proteins, and ion channels. Accordingly, alterations in polyamine metabolism affect cellular proliferation and survival through changes in gene expression and transcription, translation, autophagy, oxidative stress, and apoptosis. Dysregulation of these multifaceted polyamine functions contribute to multiple disease processes, thus their metabolism and function have been targeted for preventive or therapeutic intervention. The correlation between elevated polyamine levels and cancer is well established, and ornithine decarboxylase, the rate-limiting biosynthetic enzyme in the production of putrescine, is a bona fide transcriptional target of the Myc oncogene. Furthermore, induced polyamine catabolism contributes to carcinogenesis that is associated with certain forms of chronic infection and/or inflammation through the production of reactive oxygen species. These and other characteristics specific to cancer cells have led to the development of polyamine-based agents and inhibitors aimed at exploiting the polyamine metabolic pathway for chemotherapeutic and chemopreventive benefit. In addition to cancer, polyamines are involved in the pathologies of neurodegenerative diseases including Alzheimer’s and Parkinson’s, parasitic and infectious diseases, wound healing, ischemia/reperfusion injuries, and certain age-related conditions, as polyamines are known to decrease with age. As in cancer, polyamine-based therapies for these conditions are an area of active investigation. With recent advances in immunotherapy, interest has increased regarding polyamine-associated modulation of immune responses, as well as potential immunoregulation of polyamine metabolism, the results of which could have relevance to multiple disease processes. The goal of this Special Issue of Medical Sciences is to present the most recent advances in polyamine research as it relates to health, disease, and/or therapy.
Author : C.M. Karssen
Publisher : Springer Science & Business Media
ISBN 13 : 9401124582
Total Pages : 984 pages
Book Rating : 4.4/5 (11 download)
Download or read book Progress in Plant Growth Regulation written by C.M. Karssen and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 984 pages. Available in PDF, EPUB and Kindle. Book excerpt: The current growing interest of molecular biologists in plant hormone research is undoubtedly the most promising development of recent times. Many papers were presented during the 14th International Conference on Plant Growth Substances illustrating the impact of this new approach on our understanding of hormone-controlled processes. The specific character is the integrated study of plant growth regulation at all levels ranging from single molecules to the entire plant and its functioning in the environment. Hormones play an essential role in the regulation, but not an exclusive one. Other compounds and factors, such as Ca2+, for instance are often of equal relevance, because they may take part in the signal transduction pathway. Moreover, regulation of the regulator by non-hormonal factors is an essential part of any control mechanism. The present volume reflects the change in interest from plant growth substances to plant growth regulation.
Author :
Publisher :
ISBN 13 : 9788391007600
Total Pages : 808 pages
Book Rating : 4.0/5 (76 download)
Download or read book Advances in polyamine research written by and published by . This book was released on 1983 with total page 808 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Vincenzo Zappia
Publisher :
ISBN 13 :
Total Pages : 779 pages
Book Rating : 4.:/5 (246 download)
Download or read book Progress in Polyamine Research written by Vincenzo Zappia and published by . This book was released on 1988 with total page 779 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jian-Ying Wang
Publisher : Springer Science & Business Media
ISBN 13 : 1597451452
Total Pages : 490 pages
Book Rating : 4.5/5 (974 download)
Download or read book Polyamine Cell Signaling written by Jian-Ying Wang and published by Springer Science & Business Media. This book was released on 2007-11-19 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polyamines are organic cations found in all eukaryotic cells and intimately involved in, and required for, distinct biological functions. An increasing body of evidence indicates that the regulation of cellular polyamines is a central convergence point for the multiple signaling pathways driving various cellular functions. Over the last decade, considerable progress has been made in und- standing the molecular functions of cellular polyamines. These significant findings provide a fundamental basis to not only define the exact role of polyamines in physiology, but also to develop new therapeutic approaches for cancers and other diseases. The major objective of this book is to provide a timely and long lasting guide for investigators in the fields of polyamines, physiology, pharmacology, and cancer research. It will provide a foundation based on research and address the potential for subsequent applications in clinical practice. Polyamine Cell Signaling: Physiology, Pharmacology, and Cancer Research is divided into four main parts: Part I: Polyamines in Signal Transduction of Cell Proliferation Part II: Polyamines in Cellular Signaling of Apoptosis, Carcinogenesis, and Cancer Therapy Part III: Polyamines in Cell Motility and Cell–Cell Interactions Part IV: Polyamine Homeostasis and Transport This book not only covers the current state-of-the-art findings relevant to cellular and molecular functions of polyamines, but also provides the underlying conceptual basis and knowledge regarding potential therapeutic targeting of polyamines and polyamine metabolism. These points are addressed by int- nationally recognized experts in their contributions to this book.
Author : Uriel Bachrach
Publisher : CRC Press
ISBN 13 : 9780849368097
Total Pages : 328 pages
Book Rating : 4.3/5 (68 download)
Download or read book The Physiology of Polyamines written by Uriel Bachrach and published by CRC Press. This book was released on 1989-03-31 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: The state of the art in the area of polyamines is presented in this useful, two-volume publication. Basic information describing the role of polyamines in the processes of growth and differentiation is given. Also included are data on the regulation of polyamine biosynthesis and metabolism and their interactions with nucleic acids. Several chapters are devoted to the role of polyamines in various aspects of plant biology, with a special emphasis on their participation in the response of plants to extreme environments. Special attention is given to the use of inhibitors of polyamine biosynthesis as potential antitumor and antiproliferative agents. Additionally, recent progress in the molecular biology and genetic engineering of genes coding for polyamine biosynthetic enzymes is described. Cancer researchers, biologists, geneticists, biochemists, physiologists, and clinicians will find this volume indispensible. Contents VOLUME II: POLYAMINES IN MICROBES. Polyamines and the Growth of Bacteria and Viruses. Polyamines in Thermophiles. Propylamine Transfer Reactions in Thermophilic Archaebacteria: Enzymological Aspects and Comparative Biochemistry. Microbial Mutants Deficient in Polyamine Synthesis. Regulation of the Putrescine Biosynthetic Genes (SpeA, speB, and speC) in Escherichia coli. Utilization of L-Arginine, L-Ornithine, Agmatine, and Putrescine as the Major Source of Nitrogen and Its Control in Escherichia coli. POLYAMINES AND PLANTS. Polyamines and Plant Response to Stress. Polyamines and Plant Growth and Development. Polyamines and Plant Hormones. Polyamines in Plant Mutants. POLYAMINES AND DISEASES. Polyamines in Health and Disease. Polyamine Metabolism and Neoplastic Growth: A Programmed Deregulation? Polyamines as Markers of Malignancy. Polyamines as Indicators of Disease Activity and Response to Therapy in Cancer Patients. Inhibitors of Polyamine Biosynthesis as Therapeutic Agents. Clinical Studies of a- Difluoromethylornithine and a-Interferon in Cancer Patients. Changes in Polyamine Metabolism in Tumor-Bearing Hosts with Total Parenteral Nutrition and Intravenous Infusion of a-Difluoromethylornithine. Index. c. 328 pp., 7x10, due February 1989, ISBN-0-8493-6809-X.
Author : Robert A. Campbell
Publisher :
ISBN 13 : 9780783772752
Total Pages : 300 pages
Book Rating : 4.7/5 (727 download)
Download or read book Advances in Polyamine Research written by Robert A. Campbell and published by . This book was released on 1978 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Anthony E. Pegg
Publisher : Humana Press
ISBN 13 : 9781493958399
Total Pages : 523 pages
Book Rating : 4.9/5 (583 download)
Download or read book Polyamines written by Anthony E. Pegg and published by Humana Press. This book was released on 2016-08-23 with total page 523 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recently, important new findings in the polyamine field and a variety of new experimental systems have revolutionized the study of these ubiquitous cellular components, essential for normal growth and development. In Polyamines: Methods and Protocols, leading researchers contribute an extensive collection of up-to-date laboratory techniques for the further pursuit of polyamine study. The volume delves into vital subjects such as neoplasia studies with animal models and human patients, therapeutic roles for polyamine inhibitors and analogs, polyamine metabolism and oxidative damage, polyamines as regulators of critical ion channels, as well as polyamine transport systems and polyamine-responsive genes. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and expert notes on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Polyamines: Methods and Protocols provides a key resource for all scientists pursuing the study of this dynamic and significant aspect of cellular biology.
Author : Patrick M. Woster
Publisher : Royal Society of Chemistry
ISBN 13 : 184973190X
Total Pages : 303 pages
Book Rating : 4.8/5 (497 download)
Download or read book Polyamine Drug Discovery written by Patrick M. Woster and published by Royal Society of Chemistry. This book was released on 2012 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first comprehensive description of the discovery and therapeutic potential of polyamine drugs.
Author : Ralph Chayen
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9780890048900
Total Pages : 808 pages
Book Rating : 4.0/5 (489 download)
Download or read book Advances in Polyamine Research written by Ralph Chayen and published by Lippincott Williams & Wilkins. This book was released on 1982-12 with total page 808 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : L. Selmeci
Publisher :
ISBN 13 :
Total Pages : 658 pages
Book Rating : 4.3/5 (91 download)
Download or read book Recent Progress in Polyamine Research written by L. Selmeci and published by . This book was released on 1985 with total page 658 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Tracy Murray-Stewart
Publisher :
ISBN 13 : 9783039211531
Total Pages : 1 pages
Book Rating : 4.2/5 (115 download)
Download or read book Polyamine Metabolism in Disease and Polyamine-Targeted Therapies written by Tracy Murray-Stewart and published by . This book was released on 2019 with total page 1 pages. Available in PDF, EPUB and Kindle. Book excerpt: Spermine, spermidine, and putrescine constitute the mammalian polyamines, abundant polycations with essential roles in critical cell functions. As such, intracellular polyamine concentrations are tightly regulated through biosynthesis, catabolism, and transport. The multifaceted effects of polyamine dysregulation have contributed to its role in multiple disease processes but have also implicated it as target for preventive or therapeutic intervention. The correlation between oncogene-mediated elevation of polyamine biosynthesis and cancer is well established, and induced polyamine catabolism contributes to carcinogenesis that is associated with certain forms of chronic infection and/or inflammation. In addition to cancer, polyamines are involved in the pathologies of neurodegenerative diseases, parasitic and infectious diseases, wound healing, ischemia/reperfusion injuries, and certain age-related conditions, as polyamines concentrations are reported to decrease with age. As in cancer, polyamine-based therapies for these conditions are an area of active investigation. With recent advances in immunotherapy, interest has increased regarding polyamine-associated modulation of immune responses as well as potential immunoregulation of polyamine metabolism, the results of which could have relevance to multiple disease processes. The goal of this Special Issue of Medical Sciences is to present the most recent advances in polyamine research as it relates to health, disease, and/or therapy.
Author : Rubén Alcázar
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (21 download)
Download or read book Polyamines written by Rubén Alcázar and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides readers with a collection of the latest protocols used by researchers to study polyamines (PA). The chapters in this book cover various topics, such as quantification of different polyamines and conjugates, subcellular localization studies, transport, DNA methylation, ODC regulation, genetic and phenotyping analyses, genome-wide association mapping, polyamine applications and cancer. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Polyamines: Methods and Protocols is a useful reference for researchers looking to advance and stimulate their knowledge of polyamines.
