Radioactive Pharmaceuticals

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Fundamentals of Nuclear Pharmacy

Author : Gopal B. Saha
Publisher : Springer
ISBN 13 : 3319575805
Total Pages : 428 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Fundamentals of Nuclear Pharmacy by : Gopal B. Saha

Download or read book Fundamentals of Nuclear Pharmacy written by Gopal B. Saha and published by Springer. This book was released on 2017-11-11 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: Currently an estimated 17 million nuclear medicine procedures are performed each year in the US and constantly evolving, as new radiopharmaceuticals and imaging techniques are introduced for better diagnosis and treatment of human diseases. In keeping up with new developments, the Seventh Edition of Fundamentals of Nuclear Pharmacy chronicles the advancements in radiopharmaceuticals and their use in clinical applications. It discusses basic concepts such as the atom, radioactive decay, instrumentation and production of radionuclides, and explores the design, labeling, characteristics and quality control of radiopharmaceuticals. Radiation regulations and diagnostic and therapeutic applications of radiopharmaceuticals are detailed. Thoroughly updated, the Seventh Edition includes new topics such as alternative productions of 99Mo; production of 64Cu, 86Y, 89Zr, 177Lu, 223Ra; synthesis and clinical uses of new radiopharmaceuticals such as DaTscan, Xofigo, Amyvid, Neuraceq, Vizamyl, Axumin and 68Ga-DOTATATE; dosimetry of new radiopharmaceuticals; theranostic agents and translational medicine. It features numerous examples, diagrams, and images to further clarify the information and offers end- of-chapter questions to help readers assess their comprehension of the material. Recognized as a classic text on nuclear chemistry and pharmacy and acclaimed for its concise and easy-to-understand presentation, Fundamentals of Nuclear Pharmacy is an authoritative resource for nuclear medicine physicians, residents, students, and technologists.

Technetium-99m Pharmaceuticals

Author : Ilse Zolle
Publisher : Springer Science & Business Media
ISBN 13 : 3540339906
Total Pages : 354 pages
Book Rating : 4.5/5 (43 download)

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Book Synopsis Technetium-99m Pharmaceuticals by : Ilse Zolle

Download or read book Technetium-99m Pharmaceuticals written by Ilse Zolle and published by Springer Science & Business Media. This book was released on 2007-01-28 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radioactive drug development is a multi-disciplinary task. Therefore, dedicated scientists and experts from different fields of specialisation have contributed to this book. The text reviews forty years of advances in radiopharmaceutical development based on Technetium. The first section reviews basic principles and analytic methods, and information on chemical makeup of radiopharmaceuticals. Part 2 reviews 99mTc-radiopharmaceuticals used in nuclear medicine, thoroughly outlining their chemistry, formulation, pharmacokinetics and clinical applications.

Radiopharmaceutical Chemistry

Author : Jason S. Lewis
Publisher : Springer
ISBN 13 : 3319989472
Total Pages : 648 pages
Book Rating : 4.3/5 (199 download)

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Book Synopsis Radiopharmaceutical Chemistry by : Jason S. Lewis

Download or read book Radiopharmaceutical Chemistry written by Jason S. Lewis and published by Springer. This book was released on 2019-04-02 with total page 648 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive guide to radiopharmaceutical chemistry. The stunning clinical successes of nuclear imaging and targeted radiotherapy have resulted in rapid growth in the field of radiopharmaceutical chemistry, an essential component of nuclear medicine and radiology. However, at this point, interest in the field outpaces the academic and educational infrastructure needed to train radiopharmaceutical chemists. For example, the vast majority of texts that address radiopharmaceutical chemistry do so only peripherally, focusing instead on nuclear chemistry (i.e. nuclear reactions in reactors), heavy element radiochemistry (i.e. the decomposition of radioactive waste), or solely on the clinical applications of radiopharmaceuticals (e.g. the use of PET tracers in oncology). This text fills that gap by focusing on the chemistry of radiopharmaceuticals, with key coverage of how that knowledge translates to the development of diagnostic and therapeutic radiopharmaceuticals for the clinic. The text is divided into three overarching sections: First Principles, Radiochemistry, and Special Topics. The first is a general overview covering fundamental and broad issues like “The Production of Radionuclides” and “Basics of Radiochemistry”. The second section is the main focus of the book. In this section, each chapter’s author will delve much deeper into the subject matter, covering both well established and state-of-the-art techniques in radiopharmaceutical chemistry. This section will be divided according to radionuclide and will include chapters on radiolabeling methods using all of the common nuclides employed in radiopharmaceuticals, including four chapters on the ubiquitously used fluorine-18 and a “Best of the Rest” chapter to cover emerging radionuclides. Finally, the third section of the book is dedicated to special topics with important information for radiochemists, including “Bioconjugation Methods,” “Click Chemistry in Radiochemistry”, and “Radiochemical Instrumentation.” This is an ideal educational guide for nuclear medicine physicians, radiologists, and radiopharmaceutical chemists, as well as residents and trainees in all of these areas.

Safety and efficacy of radiopharmaceuticals

Author : Knud Kristensen
Publisher : Springer Science & Business Media
ISBN 13 : 9400967535
Total Pages : 392 pages
Book Rating : 4.4/5 (9 download)

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Book Synopsis Safety and efficacy of radiopharmaceuticals by : Knud Kristensen

Download or read book Safety and efficacy of radiopharmaceuticals written by Knud Kristensen and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Safety and efficacy of radiopharmaceuticals are elements of great importance in nuclear medicine. Since the first meeting in 1965 in Oak Ridge with the title Radiopharmaceuticals tremendous developments have taken place. In 1965 the whole technetium-99m area was just in its very beginning. Safety and efficacy of the non-radioactive pharmaceuticals have attracted great attention during the last 10 years and so have similar aspects of radiopharmaceuticals during the later years. Regulatory agencies are extending their work also to the preparation of radiopharmaceuticals at hospitals and to requirements for registration of radiopharmaceuticals. In a fast developing field there might be tendencies to confrontation between interests and there have certainly been some tendencies to put undue restrictions on the use of radio pharmaceuticals due to the lack of understanding between the industry and the regulatory authorities and between regulatory authorities and hospitals. Much of this may have been due to lack of information and certainly is due to the lack of fundamental scientific knowledge in many radiopharmaceutical aspects. A fast and safe introduction of new radio pharmaceuticals and the proper handling of these requires a lot of development work, but also an understanding of how general principles from the non-radioactive drug field may be sensibly transformed into the radiopharmaceutical area. It may even require compromises between requirements for safety in different areas such as radiation protection and pharmaceutical aspects.

Therapeutic Nuclear Medicine

Author : Richard P. Baum
Publisher : Springer
ISBN 13 : 3540367195
Total Pages : 922 pages
Book Rating : 4.5/5 (43 download)

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Book Synopsis Therapeutic Nuclear Medicine by : Richard P. Baum

Download or read book Therapeutic Nuclear Medicine written by Richard P. Baum and published by Springer. This book was released on 2014-08-16 with total page 922 pages. Available in PDF, EPUB and Kindle. Book excerpt: The recent revolution in molecular biology offers exciting new opportunities for targeted radionuclide therapy. This up-to-date, comprehensive book, written by world-renowned experts, discusses the basic principles of radionuclide therapy, explores in detail the available treatments, explains the regulatory requirements, and examines likely future developments. The full range of clinical applications is considered, including thyroid cancer, hematological malignancies, brain tumors, liver cancer, bone and joint disease, and neuroendocrine tumors. The combination of theoretical background and practical information will provide the reader with all the knowledge required to administer radionuclide therapy safely and effectively in the individual patient. Careful attention is also paid to the role of the therapeutic nuclear physician in coordinating a diverse multidisciplinary team, which is central to the safe provision of treatment.

Advancing Nuclear Medicine Through Innovation

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309134153
Total Pages : 173 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Advancing Nuclear Medicine Through Innovation by : National Research Council

Download or read book Advancing Nuclear Medicine Through Innovation written by National Research Council and published by National Academies Press. This book was released on 2007-09-11 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nearly 20 million nuclear medicine procedures are carried out each year in the United States alone to diagnose and treat cancers, cardiovascular disease, and certain neurological disorders. Many of the advancements in nuclear medicine have been the result of research investments made during the past 50 years where these procedures are now a routine part of clinical care. Although nuclear medicine plays an important role in biomedical research and disease management, its promise is only beginning to be realized. Advancing Nuclear Medicine Through Innovation highlights the exciting emerging opportunities in nuclear medicine, which include assessing the efficacy of new drugs in development, individualizing treatment to the patient, and understanding the biology of human diseases. Health care and pharmaceutical professionals will be most interested in this book's examination of the challenges the field faces and its recommendations for ways to reduce these impediments.

Radioactive Pharmaceuticals

Author : Gould A. Andrews
Publisher :
ISBN 13 :
Total Pages : 384 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Radioactive Pharmaceuticals by : Gould A. Andrews

Download or read book Radioactive Pharmaceuticals written by Gould A. Andrews and published by . This book was released on 1966 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Regulating Clinical Applications of Radioactive Drugs

Author : Atomic Industrial Forum. Ad Hoc Committee on Regulation of Radioactive Pharmaceuticals
Publisher :
ISBN 13 :
Total Pages : 56 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Regulating Clinical Applications of Radioactive Drugs by : Atomic Industrial Forum. Ad Hoc Committee on Regulation of Radioactive Pharmaceuticals

Download or read book Regulating Clinical Applications of Radioactive Drugs written by Atomic Industrial Forum. Ad Hoc Committee on Regulation of Radioactive Pharmaceuticals and published by . This book was released on 1964 with total page 56 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Handbook of Radiopharmaceuticals

Author : Azuwuike Owunwanne
Publisher : Springer
ISBN 13 : 1475704143
Total Pages : 242 pages
Book Rating : 4.4/5 (757 download)

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Book Synopsis The Handbook of Radiopharmaceuticals by : Azuwuike Owunwanne

Download or read book The Handbook of Radiopharmaceuticals written by Azuwuike Owunwanne and published by Springer. This book was released on 2012-12-06 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: One Radiobiopharmaceutics.- 1 Preparation of radiopharmaceuticals.- Production of radionuclides.- Synthesis of the non-radioactive compound.- Reaction of the radionuclide with the non-radioactive compound.- References.- 2 Ideal characteristics of radiopharmaceuticals.- Availability and cost.- Preparation.- Biologic behavior.- Radionuclidic characteristics.- Hematology.- 3 Quality control of radiopharmaceuticals.- Biologic tests.- Physicochemical tests.- References.- 4 Design of radiopharmaceuticals.- Radionuclide.- Chemistry.- Biology.- Human studies.- Registration.- References.- 5 The fate of.

Fundamentals of Nuclear Pharmacy

Author : Gopal B. Saha
Publisher : Springer Science & Business Media
ISBN 13 : 1475740271
Total Pages : 318 pages
Book Rating : 4.4/5 (757 download)

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Book Synopsis Fundamentals of Nuclear Pharmacy by : Gopal B. Saha

Download or read book Fundamentals of Nuclear Pharmacy written by Gopal B. Saha and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: A new edition of a book is warranted when the book is successful and there are many new developments in the related discipline. Both have occurred for this book during the past 7 years since its second edition. The growth and development in nuclear pharmacy and radiopharmaceutical chemistry along with the continued success of the book have convinced us to update the book; hence this third edition. This book is a ramification of my nuclear pharmacy courses offered to pharmacy students specializing in nuclear pharmacy, nuclear medicine resi dents, and nuclear medicine technology students. The book is written in an integrated form from the basic concept of atomic structure to the practical clinical uses of radiopharmaceuticals. It serves both as a textbook on nu clear pharmacy for pharmacy students and nuclear medicine technologists, and as a useful reference book for many professionals related to nuclear medicine, such as nuclear medicine physicians and radiologists. The book contains 12 chapters. Each chapter is written as comprehen sively as possible based on my personal experience and understanding. At the end of each chapter, a section of pertinent questions and problems and so me suggested reading materials are included. I have made justifiably many additions and deletions as weIl as some reorganization in this edition. Chapter 3 is entirely dedicated to instru ments for radiation detection and measurement, including brief description of gas detectors, gamma-detecting instruments, and tomographic scanners.

Radiopharmaceuticals in Nuclear Medicine Practice

Author : Richard J. Kowalsky
Publisher :
ISBN 13 :
Total Pages : 536 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Radiopharmaceuticals in Nuclear Medicine Practice by : Richard J. Kowalsky

Download or read book Radiopharmaceuticals in Nuclear Medicine Practice written by Richard J. Kowalsky and published by . This book was released on 1987 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Radiopharmaceuticals in Nuclear Pharmacy and Nuclear Medicine,

Author : RICHARD J. KOWALSKY
Publisher : American Pharmacists Association (APhA)
ISBN 13 : 9781582122830
Total Pages : 800 pages
Book Rating : 4.1/5 (228 download)

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Book Synopsis Radiopharmaceuticals in Nuclear Pharmacy and Nuclear Medicine, by : RICHARD J. KOWALSKY

Download or read book Radiopharmaceuticals in Nuclear Pharmacy and Nuclear Medicine, written by RICHARD J. KOWALSKY and published by American Pharmacists Association (APhA). This book was released on 2020-03-10 with total page 800 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completed revised and updated, Radiopharmaceuticals in Nuclear Pharmacy and Nuclear Medicine, 4th Edition is the radiopharmaceutical bible for nuclear pharmacists, nuclear medicine physicians, and nuclear medicine technologists. Useful in educational programs across these disciplines, it also serves as a key reference in preparation for specialty board examination in nuclear medicine and nuclear pharmacy. The book contains essential information required by state and federal radiation licensing organization for specialty practitioners preparing to become authorized nuclear pharmacists or authorized nuclear medicine physicians. Key Features: - All chapters are entirely reorganized and revised to reflect the latest developments in the field - Chapters new to the fourth edition cover of range of topics including Adverse Reactions to Radiopharmaceuticals, Pregnancy and Pediatrics, Localization Mechanisms of Radiopharmaceuticals, Non-Radioactive Pharmaceuticals, PET Manufacturing, and Radiopharmaceutical Distribution. - Over 500 figures and 200 tables--many in full-color--underscore key concepts

Targeted Radionuclide Therapy

Author : Tod W. Speer
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1451153260
Total Pages : 564 pages
Book Rating : 4.4/5 (511 download)

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Book Synopsis Targeted Radionuclide Therapy by : Tod W. Speer

Download or read book Targeted Radionuclide Therapy written by Tod W. Speer and published by Lippincott Williams & Wilkins. This book was released on 2012-03-28 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radioimmunotherapy, also known as systemic targeted radiation therapy, uses antibodies, antibody fragments, or compounds as carriers to guide radiation to the targets. It is a topic rapidly increasing in importance and success in treatment of cancer patients. This book represents a comprehensive amalgamation of the radiation physics, chemistry, radiobiology, tumor models, and clinical data for targeted radionuclide therapy. It outlines the current challenges and provides a glimpse at future directions. With significant advances in cell biology and molecular engineering, many targeting constructs are now available that will safely deliver these highly cytotoxic radionuclides in a targeted fashion. A companion website includes the full text and an image bank.

Radiopharmaceuticals

Author : AdrainD. Nunn
Publisher : Routledge
ISBN 13 : 1351419900
Total Pages : 460 pages
Book Rating : 4.3/5 (514 download)

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Book Synopsis Radiopharmaceuticals by : AdrainD. Nunn

Download or read book Radiopharmaceuticals written by AdrainD. Nunn and published by Routledge. This book was released on 2018-04-27 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: This timely resource compares single-photon emission tomography (SPECT), used mainly withTechnetium and iodine for routine clinical examinations, and positron emission tomography(PET) , employing short-lived radionuclides of carbon, oxygen, nitrogen, and fluorine in researchinvestigations.Presenting the logic behind why one approach is better than another in various circumstances,Radio pharmaceuticals details the use of radiolabelled substrates in measuring the effect of diseaseand drugs on regional metabolism and receptor concentration/occupancy .. . discusses factorsaffecting the selective retention of small metal complexes by various tissues .. . analyzes the interactionof small exogenous metal complexes with enzymes in vivo and the critical role of stereochemistry. . . explores the use of radio labelled compounds in the study of neuroactive compounds,neurotransmitters, enzyme inhibitors, and substrates in vivo .. . covers the design and pharmacologyof radiolabelled drugs as probes of site of action , selectivity and specificity, and pharmacokineticsin vivo .. . and more.Extensively referenced with over l 050 bibliographic citations, Radiopharmaceuticals is a state-ofthe-art guide for pharmacists; organic, medicinal , and radiopharmaceutical chemists; pharmacokineticists;nuclear medicine physicians and technologists; neurochemists; and governmentregulatory personnel .

Molecular Imaging

Author : Shankar Vallabhajosula
Publisher : Springer Science & Business Media
ISBN 13 : 3540767355
Total Pages : 379 pages
Book Rating : 4.5/5 (47 download)

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Book Synopsis Molecular Imaging by : Shankar Vallabhajosula

Download or read book Molecular Imaging written by Shankar Vallabhajosula and published by Springer Science & Business Media. This book was released on 2009-07-13 with total page 379 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radioisotope-based molecular imaging probes provide unprecedented insight into biochemistry and function involved in both normal and disease states of living systems, with unbiased in vivo measurement of regional radiotracer activities offering very high specificity and sensitivity. No other molecular imaging technology including functional magnetic resonance imaging (fMRI) can provide such high sensitivity and specificity at a tracer level. The applications of this technology can be very broad ranging from drug development, pharmacokinetics, clinical investigations, and finally to routine diagnostics in radiology. The design and the development of radiopharmaceuticals for molecular imaging studies using PET/MicroPET or SPECT/MicroSPECT are a unique challenge. This book is intended for a broad audience and written with the main purpose of educating the reader on various aspects including potential clinical utility, limitations of drug development, and regulatory compliance and approvals.

Molybdenum-99 for Medical Imaging

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309445310
Total Pages : 264 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Molybdenum-99 for Medical Imaging by : National Academies of Sciences, Engineering, and Medicine

Download or read book Molybdenum-99 for Medical Imaging written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2016-11-28 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: The decay product of the medical isotope molybdenum-99 (Mo-99), technetium-99m (Tc-99m), and associated medical isotopes iodine-131 (I-131) and xenon-133 (Xe-133) are used worldwide for medical diagnostic imaging or therapy. The United States consumes about half of the world's supply of Mo-99, but there has been no domestic (i.e., U.S.-based) production of this isotope since the late 1980s. The United States imports Mo-99 for domestic use from Australia, Canada, Europe, and South Africa. Mo-99 and Tc-99m cannot be stockpiled for use because of their short half-lives. Consequently, they must be routinely produced and delivered to medical imaging centers. Almost all Mo-99 for medical use is produced by irradiating highly enriched uranium (HEU) targets in research reactors, several of which are over 50 years old and are approaching the end of their operating lives. Unanticipated and extended shutdowns of some of these old reactors have resulted in severe Mo-99 supply shortages in the United States and other countries. Some of these shortages have disrupted the delivery of medical care. Molybdenum-99 for Medical Imaging examines the production and utilization of Mo-99 and associated medical isotopes, and provides recommendations for medical use.

Radiopharmaceutical Chemistry between Imaging and Endoradiotherapy

Author : Klaus Kopka
Publisher : MDPI
ISBN 13 : 3038420840
Total Pages : 257 pages
Book Rating : 4.0/5 (384 download)

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Book Synopsis Radiopharmaceutical Chemistry between Imaging and Endoradiotherapy by : Klaus Kopka

Download or read book Radiopharmaceutical Chemistry between Imaging and Endoradiotherapy written by Klaus Kopka and published by MDPI. This book was released on 2018-10-04 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Radiopharmaceutical Chemistry between Imaging and Radioendotherapy" that was published in Pharmaceuticals