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Quantitative Targeting And Radiation Therapy Of Breast Cancer Using A Dedicated Breast Computed Tomography Platform
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Book Synopsis Quantitative Targeting and Radiation Therapy of Breast Cancer Using a Dedicated Breast Computed Tomography Platform by : Nicolas Demetrios Prionas
Download or read book Quantitative Targeting and Radiation Therapy of Breast Cancer Using a Dedicated Breast Computed Tomography Platform written by Nicolas Demetrios Prionas and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Dedicated breast computed tomography (bCT) is a fully tomographic cone beam x-ray based imaging modality that generates three-dimensional images of the breast. During a bCT scan, the patient lies prone and each breast is imaged, one at a time, in a pendant geometry without compression. While most research has focused on the potential of bCT for diagnostic imaging of the breast, the bCT platform may play a role in other phases of breast cancer management including the delivery of image-guided therapies. Image-guidance is particularly useful in verifying treatment accuracy and monitoring response to therapy. Currently, quantification of tumor size and response to therapy are given by linear measurements; however, there is a push towards three-dimensional evaluation of tumor volume. The accuracy and precision of tumor volumetry using computed tomography were established. The potential of bCT as a quantitative imaging modality was demonstrated through an initial evaluation of contrast-enhanced bCT (CE-bCT), using injected iodine-based contrast medium. Lesion enhancement at CE-bCT was quantified and the differential enhancement observed between benign and malignant lesions was supported as a metric to aid in the detection and diagnosis of breast cancer. Upon identifying the location and extent of disease, image-guided radiation therapy (IGRT) can be delivered on the bCT platform. The feasibility of external beam radiation therapy using kilovoltage x-rays (kV-EBRT) and rotational therapy within the geometric constraints of the bCT platform was demonstrated through Monte Carlo simulation. Dose distributions were generated for whole breast irradiation (WBI), partial breast irradiation (PBI), and dose painting. A preliminary treatment planning algorithm was developed to determine the optimal beam intensities and collimation widths for WBI through kV-EBRT on a bCT platform. As a high-resolution tomographic imaging system, the bCT platform is ideally suited for quantitative tumor targeting and delivery of IGRT. The use of the same platform for both tumor targeting and therapy may provide more accurate treatment delivery and shorter treatment times. Overall, the breast CT platform may be best commissioned in women's health clinics as a multimodality system aiming to increase access to procedures needed for early detection, diagnosis, and treatment of breast cancer.
Book Synopsis Advancing Nuclear Medicine Through Innovation by : National Research Council
Download or read book Advancing Nuclear Medicine Through Innovation written by National Research Council and published by National Academies Press. This book was released on 2007-09-11 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nearly 20 million nuclear medicine procedures are carried out each year in the United States alone to diagnose and treat cancers, cardiovascular disease, and certain neurological disorders. Many of the advancements in nuclear medicine have been the result of research investments made during the past 50 years where these procedures are now a routine part of clinical care. Although nuclear medicine plays an important role in biomedical research and disease management, its promise is only beginning to be realized. Advancing Nuclear Medicine Through Innovation highlights the exciting emerging opportunities in nuclear medicine, which include assessing the efficacy of new drugs in development, individualizing treatment to the patient, and understanding the biology of human diseases. Health care and pharmaceutical professionals will be most interested in this book's examination of the challenges the field faces and its recommendations for ways to reduce these impediments.
Book Synopsis Translational Research in Breast Cancer by : Dong-Young Noh
Download or read book Translational Research in Breast Cancer written by Dong-Young Noh and published by Springer Nature. This book was released on 2021-05-13 with total page 630 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes recent advances in translational research in breast cancer and presents emerging applications of this research that promise to have meaningful impacts on diagnosis and treatment. It introduces ideas and materials derived from the clinic that have been brought to "the bench" for basic research, as well as findings that have been applied back to "the bedside". Detailed attention is devoted to breast cancer biology and cell signaling pathways and to cancer stem cell and tumor heterogeneity in breast cancer. Various patient-derived research models are discussed, and a further focus is the role of biomarkers in precision medicine for breast cancer patients. Next-generation clinical research receives detailed attention, addressing the increasingly important role of big data in breast cancer research and a wide range of other emerging developments. An entire section is also devoted to the management of women with high-risk breast cancer. Translational Research in Breast Cancer will help clinicians and scientists to optimize their collaboration in order to achieve the common goal of conquering breast cancer.
Book Synopsis Adaptive Radiation Therapy by : X. Allen Li
Download or read book Adaptive Radiation Therapy written by X. Allen Li and published by CRC Press. This book was released on 2011-01-27 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modern medical imaging and radiation therapy technologies are so complex and computer driven that it is difficult for physicians and technologists to know exactly what is happening at the point-of-care. Medical physicists responsible for filling this gap in knowledge must stay abreast of the latest advances at the intersection of medical imaging an
Author :European Commission. Directorate-General for Health and Consumer Protection Publisher : ISBN 13 : Total Pages :436 pages Book Rating :4.3/5 (91 download)
Book Synopsis European Guidelines for Quality Assurance in Breast Cancer Screening and Diagnosis by : European Commission. Directorate-General for Health and Consumer Protection
Download or read book European Guidelines for Quality Assurance in Breast Cancer Screening and Diagnosis written by European Commission. Directorate-General for Health and Consumer Protection and published by . This book was released on 2006 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: Breast cancer is the most frequent cause of cancer-related deaths in women in Europe, and demographic trends indicate a continuing increase in this substantial public health problem. Systematic early detection through screening, effective diagnostic pathways and optimal treatment have the ability to substantially lower current breast cancer mortality rates and reduce the burden of this disease in the population. This is the fourth edition of these guidelines which contains information on recommended standards and procedures for breast cancer screening and diagnostic services, including chapters on multi-disciplinary aspects of quality assurance, data collection and monitoring, effective communication of information, requirements of a specialist unit, and a certification protocol.
Book Synopsis Deep Learning in Medical Image Analysis by : Gobert Lee
Download or read book Deep Learning in Medical Image Analysis written by Gobert Lee and published by Springer Nature. This book was released on 2020-02-06 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents cutting-edge research and applications of deep learning in a broad range of medical imaging scenarios, such as computer-aided diagnosis, image segmentation, tissue recognition and classification, and other areas of medical and healthcare problems. Each of its chapters covers a topic in depth, ranging from medical image synthesis and techniques for muskuloskeletal analysis to diagnostic tools for breast lesions on digital mammograms and glaucoma on retinal fundus images. It also provides an overview of deep learning in medical image analysis and highlights issues and challenges encountered by researchers and clinicians, surveying and discussing practical approaches in general and in the context of specific problems. Academics, clinical and industry researchers, as well as young researchers and graduate students in medical imaging, computer-aided-diagnosis, biomedical engineering and computer vision will find this book a great reference and very useful learning resource.
Book Synopsis Clinical Applications of SPECT/CT by : International Atomic Energy Agency
Download or read book Clinical Applications of SPECT/CT written by International Atomic Energy Agency and published by . This book was released on 2008 with total page 55 pages. Available in PDF, EPUB and Kindle. Book excerpt: Integrated single photon emission computed tomography and computed tomography (SPECT/CT) has emerged as an important diagnostic tool in medical imaging, where morphological markers are superimposed on anatomical images to allow a more thorough examination and higher levels of diagnostic accuracy. This TECDOC presents an overview of the SPECT/CT technology for use by nuclear medicine physicians, radiologists and clinical practitioners. The publication also covers the current medical status of SPECT/CT imaging, the role of this technology in the clinical management of patients and possible trends for future development.
Author :National Academies of Sciences, Engineering, and Medicine Publisher :National Academies Press ISBN 13 :0309670950 Total Pages :319 pages Book Rating :4.3/5 (96 download)
Book Synopsis Selected Health Conditions and Likelihood of Improvement with Treatment by : National Academies of Sciences, Engineering, and Medicine
Download or read book Selected Health Conditions and Likelihood of Improvement with Treatment written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2020-07-12 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Social Security Administration (SSA) administers two programs that provide disability benefits: the Social Security Disability Insurance (SSDI) program and the Supplemental Security Income (SSI) program. SSDI provides disability benefits to people (under the full retirement age) who are no longer able to work because of a disabling medical condition. SSI provides income assistance for disabled, blind, and aged people who have limited income and resources regardless of their prior participation in the labor force. Both programs share a common disability determination process administered by SSA and state agencies as well as a common definition of disability for adults: "the inability to engage in any substantial gainful activity by reason of any medically determinable physical or mental impairment which can be expected to result in death or which has lasted or can be expected to last for a continuous period of not less than 12 months." Disabled workers might receive either SSDI benefits or SSI payments, or both, depending on their recent work history and current income and assets. Disabled workers might also receive benefits from other public programs such as workers' compensation, which insures against work-related illness or injuries occurring on the job, but those other programs have their own definitions and eligibility criteria. Selected Health Conditions and Likelihood of Improvement with Treatment identifies and defines the professionally accepted, standard measurements of outcomes improvement for medical conditions. This report also identifies specific, long-lasting medical conditions for adults in the categories of mental health disorders, cancers, and musculoskeletal disorders. Specifically, these conditions are disabling for a length of time, but typically don't result in permanently disabling limitations; are responsive to treatment; and after a specific length of time of treatment, improve to the point at which the conditions are no longer disabling.
Book Synopsis Quality Assurance Programme for Computed Tomography by : International Atomic Energy Agency
Download or read book Quality Assurance Programme for Computed Tomography written by International Atomic Energy Agency and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This publication presents a harmonized approach to quality assurance in the field of computed tomography applied to both diagnostics and therapy. It gives a careful analysis of the principles and specific instructions that can be used for a quality assurance programme for optimal performance and reduced patient dose in diagnostic radiology. In some cases, radiotherapy programmes are making a transition from 2-D to 3-D radiotherapy, a complex process which critically depends on accurate treatment planning. In this respect, the authors also provide detailed information about the elements needed for quality assurance testing, including those relating to accurate patient characterization as needed for radiotherapy treatment planning.
Book Synopsis Accuracy Requirements and Uncertainties in Radiotherapy by : International Atomic Energy Agency
Download or read book Accuracy Requirements and Uncertainties in Radiotherapy written by International Atomic Energy Agency and published by . This book was released on 2017-04-12 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: Accuracy requirements in radiation oncology have been defined in multiple publications; however, these have been based on differing radiation technologies. In the meantime, the uncertainties in radiation dosimetry reference standards have been reduced and more detailed patient outcome data are available. No comprehensive literature on accuracy and uncertainties in radiotherapy has been published so far. The IAEA has therefore developed a new international consensus document on accuracy requirements and uncertainties in radiation therapy, to promote safer and more effective patient treatments. This publication addresses accuracy and uncertainty issues related to the vast majority of radiotherapy departments including both external beam radiotherapy and brachytherapy. It covers clinical, radiobiological, dosimetric, technical and physical aspects.
Download or read book Teleradiology written by Sajeesh Kumar and published by Springer Science & Business Media. This book was released on 2008-07-25 with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developments in teleradiology are progressing at great speed. As a consequence, there is a need for a broad overview of the field. This first-ever book on teleradiology is presented in such a way that it should make it accessible to anyone, independent of their knowledge of technology. The text is designed to be used by all professionals, including radiologists, surgeons, nurses and allied health professionals, and computer scientists. In a very short time, driven by technical developments, the field of teleradiology has become too extensive to be covered by only a small number of experts. Therefore, Teleradiology has been written with chapter contributions from a host of renowned international authorities in teleradiology (see the Contents and the Contributors). This ensures that the subject matter focusing on recent advances in teleradiology is truly up to date. Our guiding hope during this task was that as editors of multiple chapters we could still write with a single voice and keep the content coherent and simple. We hope that the clarity of this book makes up for any limitations in its comp- hensiveness.
Book Synopsis Machine Learning for Subsurface Characterization by : Siddharth Misra
Download or read book Machine Learning for Subsurface Characterization written by Siddharth Misra and published by Gulf Professional Publishing. This book was released on 2019-10-12 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: Machine Learning for Subsurface Characterization develops and applies neural networks, random forests, deep learning, unsupervised learning, Bayesian frameworks, and clustering methods for subsurface characterization. Machine learning (ML) focusses on developing computational methods/algorithms that learn to recognize patterns and quantify functional relationships by processing large data sets, also referred to as the "big data." Deep learning (DL) is a subset of machine learning that processes "big data" to construct numerous layers of abstraction to accomplish the learning task. DL methods do not require the manual step of extracting/engineering features; however, it requires us to provide large amounts of data along with high-performance computing to obtain reliable results in a timely manner. This reference helps the engineers, geophysicists, and geoscientists get familiar with data science and analytics terminology relevant to subsurface characterization and demonstrates the use of data-driven methods for outlier detection, geomechanical/electromagnetic characterization, image analysis, fluid saturation estimation, and pore-scale characterization in the subsurface. Learn from 13 practical case studies using field, laboratory, and simulation data Become knowledgeable with data science and analytics terminology relevant to subsurface characterization Learn frameworks, concepts, and methods important for the engineer’s and geoscientist’s toolbox needed to support
Book Synopsis Craniofacial Growth and Development: Novel Insights by : Erika Kuchler
Download or read book Craniofacial Growth and Development: Novel Insights written by Erika Kuchler and published by Frontiers Media SA. This book was released on 2021-10-13 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Evolution of Ionizing Radiation Research by : Mitsuru Nenoi
Download or read book Evolution of Ionizing Radiation Research written by Mitsuru Nenoi and published by BoD – Books on Demand. This book was released on 2015-09-17 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: The industrial and medical applications of radiation have been augmented and scientific insight into mechanisms for radiation action notably progressed. In addition, the public concern about radiation risk has also grown extensively. Today the importance of risk communication among stakeholders involved in radiation-related issues is emphasized much more than any time in the past. Thus, the circumstances of radiation research have drastically changed, and the demand for a novel approach to radiation-related issues is increasing. It is thought that the publication of the book Evolution of Ionizing Radiation Research at this time would have enormous impacts on the society. The editor believes that technical experts would find a variety of new ideas and hints in this book that would be helpful to them to tackle ionizing radiation.
Book Synopsis Moments and Moment Invariants in Pattern Recognition by : Jan Flusser
Download or read book Moments and Moment Invariants in Pattern Recognition written by Jan Flusser and published by John Wiley & Sons. This book was released on 2009-11-04 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Moments as projections of an image’s intensity onto a proper polynomial basis can be applied to many different aspects of image processing. These include invariant pattern recognition, image normalization, image registration, focus/ defocus measurement, and watermarking. This book presents a survey of both recent and traditional image analysis and pattern recognition methods, based on image moments, and offers new concepts of invariants to linear filtering and implicit invariants. In addition to the theory, attention is paid to efficient algorithms for moment computation in a discrete domain, and to computational aspects of orthogonal moments. The authors also illustrate the theory through practical examples, demonstrating moment invariants in real applications across computer vision, remote sensing and medical imaging. Key features: Presents a systematic review of the basic definitions and properties of moments covering geometric moments and complex moments. Considers invariants to traditional transforms – translation, rotation, scaling, and affine transform - from a new point of view, which offers new possibilities of designing optimal sets of invariants. Reviews and extends a recent field of invariants with respect to convolution/blurring. Introduces implicit moment invariants as a tool for recognizing elastically deformed objects. Compares various classes of orthogonal moments (Legendre, Zernike, Fourier-Mellin, Chebyshev, among others) and demonstrates their application to image reconstruction from moments. Offers comprehensive advice on the construction of various invariants illustrated with practical examples. Includes an accompanying website providing efficient numerical algorithms for moment computation and for constructing invariants of various kinds, with about 250 slides suitable for a graduate university course. Moments and Moment Invariants in Pattern Recognition is ideal for researchers and engineers involved in pattern recognition in medical imaging, remote sensing, robotics and computer vision. Post graduate students in image processing and pattern recognition will also find the book of interest.
Author :National Academies of Sciences, Engineering, and Medicine Publisher :National Academies Press ISBN 13 :0309457971 Total Pages :145 pages Book Rating :4.3/5 (94 download)
Book Synopsis The Drug Development Paradigm in Oncology by : National Academies of Sciences, Engineering, and Medicine
Download or read book The Drug Development Paradigm in Oncology written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2018-02-12 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in cancer research have led to an improved understanding of the molecular mechanisms underpinning the development of cancer and how the immune system responds to cancer. This influx of research has led to an increasing number and variety of therapies in the drug development pipeline, including targeted therapies and associated biomarker tests that can select which patients are most likely to respond, and immunotherapies that harness the body's immune system to destroy cancer cells. Compared with standard chemotherapies, these new cancer therapies may demonstrate evidence of benefit and clearer distinctions between efficacy and toxicity at an earlier stage of development. However, there is a concern that the traditional processes for cancer drug development, evaluation, and regulatory approval could impede or delay the use of these promising cancer treatments in clinical practice. This has led to a number of effortsâ€"by patient advocates, the pharmaceutical industry, and the Food and Drug Administration (FDA)â€"to accelerate the review of promising new cancer therapies, especially for cancers that currently lack effective treatments. However, generating the necessary data to confirm safety and efficacy during expedited drug development programs can present a unique set of challenges and opportunities. To explore this new landscape in cancer drug development, the National Academies of Sciences, Engineering, and Medicine developed a workshop held in December 2016. This workshop convened cancer researchers, patient advocates, and representatives from industry, academia, and government to discuss challenges with traditional approaches to drug development, opportunities to improve the efficiency of drug development, and strategies to enhance the information available about a cancer therapy throughout its life cycle in order to improve its use in clinical practice. This publication summarizes the presentations and discussions from the workshop.
Book Synopsis Systems Biology of Cancer by : Sam Thiagalingam
Download or read book Systems Biology of Cancer written by Sam Thiagalingam and published by Cambridge University Press. This book was released on 2015-04-09 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.
