Translational Research In Breast Cancer

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Translational Research in Breast Cancer

Author : Dong-Young Noh
Publisher : Springer Nature
ISBN 13 : 9813296208
Total Pages : 630 pages
Book Rating : 4.8/5 (132 download)

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Book Synopsis Translational Research in Breast Cancer by : Dong-Young Noh

Download or read book Translational Research in Breast Cancer written by Dong-Young Noh and published by Springer Nature. This book was released on 2021-05-13 with total page 630 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes recent advances in translational research in breast cancer and presents emerging applications of this research that promise to have meaningful impacts on diagnosis and treatment. It introduces ideas and materials derived from the clinic that have been brought to "the bench" for basic research, as well as findings that have been applied back to "the bedside". Detailed attention is devoted to breast cancer biology and cell signaling pathways and to cancer stem cell and tumor heterogeneity in breast cancer. Various patient-derived research models are discussed, and a further focus is the role of biomarkers in precision medicine for breast cancer patients. Next-generation clinical research receives detailed attention, addressing the increasingly important role of big data in breast cancer research and a wide range of other emerging developments. An entire section is also devoted to the management of women with high-risk breast cancer. Translational Research in Breast Cancer will help clinicians and scientists to optimize their collaboration in order to achieve the common goal of conquering breast cancer.

Translational Research in Breast Cancer

Author : Erwei Song
Publisher : Springer
ISBN 13 : 9811060207
Total Pages : 418 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis Translational Research in Breast Cancer by : Erwei Song

Download or read book Translational Research in Breast Cancer written by Erwei Song and published by Springer. This book was released on 2017-12-28 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a comprehensive introduction to translational efforts in breast cancer, addressing the latest approaches to precision medicine based on the current state of understanding of breast cancer. With the latest developments in breast cancer research, our understanding of the genomic changes and the oncogenic signaling cascade of breast cancer has made considerable strides. Further, the immuno-environment has been demonstrated as the barrier to clinical cancer. In addition, major advances in cancer biology, immunology, genomics and metabolism have broken new ground for designing therapeutic approaches and selecting appropriate treatments on the basis of more precise information on the individual patient. As a result of these two trends, a clearer picture of the molecular landscape of breast cancers has facilitated the development of diagnostic, prognostic and predictive biomarkers for clinical oncology. All these aspects are addressed in this volume, which offers a comprehensive resource for researchers, graduate students and oncologists in cancer research.

Translational Research in Cancer

Author : Sivapatham Sundaresan
Publisher : BoD – Books on Demand
ISBN 13 : 1838805346
Total Pages : 212 pages
Book Rating : 4.8/5 (388 download)

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Book Synopsis Translational Research in Cancer by : Sivapatham Sundaresan

Download or read book Translational Research in Cancer written by Sivapatham Sundaresan and published by BoD – Books on Demand. This book was released on 2021-02-03 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translational research in oncology benefits from an abundance of knowledge resulting from genome-scale studies concerning the molecular pathways involved in tumorigenesis. Translational oncology represents a bridge between basic research and clinical practice in cancer medicine. The vast majority of cancer cases are due to environmental risk factors. Many of these environmental factors are controllable lifestyle choices. Experimental cancer treatments are studied in clinical trials to compare the proposed treatment to the best existing treatment through translational research. The key features of the book include: 1) New screening for the development of radioprotectors: radioprotection and anti-cancer effect of β-Glucan (Enterococcus faecalis) 2) Translational perspective on hepatocellular carcinoma 3) Brachytherapy for endometrial cancer 4) Discovery of small molecule inhibitors for histone methyltransferases in cancer

Targeted Therapy in Translational Cancer Research

Author : Apostolia-Maria Tsimberidou
Publisher : John Wiley & Sons
ISBN 13 : 1118468570
Total Pages : 396 pages
Book Rating : 4.1/5 (184 download)

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Book Synopsis Targeted Therapy in Translational Cancer Research by : Apostolia-Maria Tsimberidou

Download or read book Targeted Therapy in Translational Cancer Research written by Apostolia-Maria Tsimberidou and published by John Wiley & Sons. This book was released on 2015-12-21 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: Targeted Therapy in Translational Cancer Research for the Translational Oncology series provides a comprehensive overview of recent developments in our understanding of tumor biology, elucidates the roles of targets and pathways involved in carcinogenesis, and describes current state-of-the-art anticancer therapy, as well as the most promising areas of translational research and targeted therapy. Introduces cutting-edge ‘bench to bedside and back’ breakthroughs which have transformed the diagnosis, prognosis, and treatment of cancer Covers basic principles of targeted therapy, including immunotherapy and the roles of cancer stem cells, the microenvironment, angiogenesis, epigenetics, microRNAs, and functional imaging in precision medicine Summarises major advances in therapeutic management of hematologic malignancies and solid tumors using conventional therapy, targeted therapy, immunotherapy, or novel treatment modalities

Lost in Translation

Author : Rakesh K. Srivastava
Publisher : World Scientific
ISBN 13 : 9814489077
Total Pages : 766 pages
Book Rating : 4.8/5 (144 download)

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Book Synopsis Lost in Translation by : Rakesh K. Srivastava

Download or read book Lost in Translation written by Rakesh K. Srivastava and published by World Scientific. This book was released on 2014 with total page 766 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is all about the definition and finding ways to prioritize and accelerate translation research in biomedical sciences and rapidly turning new knowledge into first-in-human studies. It represents an effort to bring together scientists active in various areas of translational research to share science and, hopefully, generate new ideas and potential collaborations. The book provides a comprehensive overview of translational work that includes significant discoveries and pioneering contributions, e.g., in immunology, gene therapy, stem cells and population sciences. It may be used as an advanced textbook by graduate students and even ambitious undergraduates in biomedical sciences. It is also suitable for non-experts, i.e. medical doctors, who wish to have an overview of some of the fundamental models in translational research. Managing the translational enterprise remains a work in progress. The world is changing rapidly, and the scientific world needs to seek new ways to ensure that discoveries get translated for patients efficiently and as quickly as possible. In addition, everyone expects the investment in biomedical research should pay dividends through effective therapeutic solutions. This unique project provides a broad collaborative approach of the international scientific team to present its view and opinion how to cross barriers to incentives for translational research in medical sciences. Contributing to the book is an international team of prominent co-authors. The book consists of unique and widely treated topics, and includes new hypotheses, data and analyses. Sample Chapter(s). Foreword (41 KB). Chapter 1: Translational Research: Lost in Complexity (305 KB). Contents: Barriers to Incentives for Translational Research; Integrating Emerging Science into Clinical Practice; Organization, Prioritization, Review and Funding for the Translational Research; Translational Sciences in Cancer Research; Translational Science in Infectious Diseases; Translation Research in Endocrinology and Nutrition; Translation Research and Neuroscience; Stem Cells and Translation Research; The Role of Translational Research in Public Health and Behavioral Sciences; Translational Epidemiology, Biostatistics and Informatics; Translational Research Outcomes and Resources. Readership: Graduate students and researchers in cancer research, pharmacology/drug discovery/pharmaceuticals, immunology, infectious diseases and public health.

Translational Cancer Research for Surgeons, An Issue of Surgical Oncology Clinics,

Author : William G. Cance
Publisher : Elsevier Health Sciences
ISBN 13 : 0323227457
Total Pages : 311 pages
Book Rating : 4.3/5 (232 download)

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Book Synopsis Translational Cancer Research for Surgeons, An Issue of Surgical Oncology Clinics, by : William G. Cance

Download or read book Translational Cancer Research for Surgeons, An Issue of Surgical Oncology Clinics, written by William G. Cance and published by Elsevier Health Sciences. This book was released on 2013-09-11 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of the Surgical Oncology Clinics of North America, Guest Edited by Dr. William G. Cance, is devoted to Translational Cancer Research for Surgeons. Translational Cancer research aims to move bench research to the bedside by applying basic science toward potential therapies. This issue will present the concepts of translational research and development of targeted therapeutics, and its implications for surgeons. It will show clinical applications for surgeons regarding sarcoma/GIST, melanoma, colorectal cancer, breast cancer, and endocrine cancer.

Combinatorial Approaches for Cancer Treatment: from Basic to Translational Research

Author : Daniela Spano
Publisher : Frontiers Media SA
ISBN 13 : 2889745708
Total Pages : 206 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Combinatorial Approaches for Cancer Treatment: from Basic to Translational Research by : Daniela Spano

Download or read book Combinatorial Approaches for Cancer Treatment: from Basic to Translational Research written by Daniela Spano and published by Frontiers Media SA. This book was released on 2022-03-03 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Translational Research and Onco-Omics Applications in the Era of Cancer Personal Genomics

Author : Erika Ruiz-Garcia
Publisher : Springer Nature
ISBN 13 : 3030241009
Total Pages : 171 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Translational Research and Onco-Omics Applications in the Era of Cancer Personal Genomics by : Erika Ruiz-Garcia

Download or read book Translational Research and Onco-Omics Applications in the Era of Cancer Personal Genomics written by Erika Ruiz-Garcia and published by Springer Nature. This book was released on 2019-11-11 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: Being a complex disease that affects millions of people world over, cancer research has assumed great significance. Translational cancer research transforms scientific discoveries in the laboratory into clinical application to reduce incidence of cancer, morbidity and mortality. On the other hand, personalized medicine in cancer is the concept that selection of a treatment should be tailored according to the individual patient’s specific genomic characteristics, including mutations, chromosomal aberrations, protein interactions, and SNPs, and even more, taking into account the inmume system, the metabolism and maybe in the next future also the microbiome.

Current Advances in Breast Cancer Research: A Molecular Approach

Author : Shankar Suman
Publisher : Bentham Science Publishers
ISBN 13 : 9811451427
Total Pages : 401 pages
Book Rating : 4.8/5 (114 download)

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Book Synopsis Current Advances in Breast Cancer Research: A Molecular Approach by : Shankar Suman

Download or read book Current Advances in Breast Cancer Research: A Molecular Approach written by Shankar Suman and published by Bentham Science Publishers. This book was released on 2020-04-30 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: Breast cancer is a recognized disease around the world with varying patient outcomes based on the type of breast cancer, access to healthcare and other factors. Survival rates for breast cancer are significantly lower in metastatic cases than localized cases. Early diagnosis and effective treatments for the efficient management of breast cancer are now in demand , as they help to prolong patient life. There have been many breakthrough developments in the molecular biology of breast cancer research in recent times. Advancements in diagnostic techniques (imaging and biomarker detection) for breast cancer have improved the screening of the disease and have improved patient outcomes. Despite these enhancements, the disease is still lethal for patients and the search for a cure requires a complete understanding of the disease. Current Advances in Breast Cancer Research: A Molecular Approach presents a comprehensive overview of current basic and translational research on the subject. The 14 chapters of the book give emphasis to current knowledge about breast cancer, ongoing challenges, and innovative research findings by different research groups. Readers will find detailed information about breast cancer biology, genetics, clinical diagnostics and treatments. Additional information for advanced readers in life sciences, such as techniques relevant to genomics (including genetic fingerprinting), proteomics, metabolomics and medicine (such as imaging and molecular diagnostics) is also provided. The combination of both basic and advanced information makes this book a useful reference to the student and researcher, alike, seeking an understanding about breast cancer at a molecular level.

Integrating Clinical and Translational Research Networks—Building Team Medicine

Author : Ravi Salgia
Publisher : MDPI
ISBN 13 : 303650396X
Total Pages : 250 pages
Book Rating : 4.0/5 (365 download)

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Book Synopsis Integrating Clinical and Translational Research Networks—Building Team Medicine by : Ravi Salgia

Download or read book Integrating Clinical and Translational Research Networks—Building Team Medicine written by Ravi Salgia and published by MDPI. This book was released on 2021-01-29 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medical centers are widely recognized as vital components of the healthcare system. However, academic medical centers are differentiated from their community counterparts by their mission, which typically focuses on clinical care, education, and research. Nonetheless, community clinics/hospitals fill a critical need and play a complementary role serving as the primary sites for health care in most communities. Furthermore, it is now increasingly recognized that in addition to physicians, physician-scientists, and other healthcare-related professionals, basic research scientists also contribute significantly to the emerging inter- and cross-disciplinary, team-oriented culture of translational science. Therefore, approaches that combine the knowledge, skills, experience, expertise, and visions of clinicians in academic medical centers and their affiliated community centers and hospitals, together with basic research scientists, are critical in shaping the emerging culture of translational research so that patients from the urban as well as suburban settings can avail the benefits of the latest developments in science and medicine. ‘Integrating Clinical and Translational Research Networks—Building Team Medicine’ is an embodiment of this ethos at the City of Hope National Medical Center in Duarte, California. It includes a series of papers authored by teams of leading clinicians, basic research scientists, and translational researchers. The authors discuss how engaging and collaborating with community-based practices, where the majority of older patients with cancer receive their care, can ensure that these patients receive the highest-quality, evidence-based care. Based on our collective experience at City of Hope, we would like to stress that the success of academic-community collaborative programs not only depends on the goodwill and vision of the participants but also on the medical administration, academic leadership, and policymakers who define the principles and rules by which cooperation within the health care industry occurs. We trust that our experience embodied in this singular compendium will serve as a ‘Rosetta Stone’ for other institutions and practitioners.

Translational Radiation Oncology

Author : Adam Eltorai
Publisher : Elsevier
ISBN 13 : 0323884245
Total Pages : 736 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Translational Radiation Oncology by : Adam Eltorai

Download or read book Translational Radiation Oncology written by Adam Eltorai and published by Elsevier. This book was released on 2023-08-01 with total page 736 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translational Radiation Oncology covers the principles of evidence-based medicine and applies them to the design of translational research. The book provides valuable discussions on the critical appraisal of published studies and recent developments in radiation oncology, allowing readers to learn how to evaluate the quality of such studies with respect to measuring outcomes and make effective use of all types of evidence. By reading this book, researchers have access to a practical approach to help them navigate challenging considerations in study design and implementation. It is a valuable resource for researchers, oncologists and members of biomedical field who want to understand more about translational research applied to the field of radiation oncology. Translational medicine serves as an indispensable tool in grant writing and funding efforts, so understanding how to apply its principles to research is necessary to guarantee that results will be impactful to patients. Provides a clear process for understanding, designing, executing and analyzing clinical and translational research Presents practical, step-by-step guidance to help readers take ideas from the lab to the bedside Written by a team of oncologists, radiologists and clinical research experts that fully cover translational research in radiation oncology

Breast Translational Research

Author : Abeer M. Shaaban
Publisher :
ISBN 13 : 9783318055870
Total Pages : 0 pages
Book Rating : 4.0/5 (558 download)

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Book Synopsis Breast Translational Research by : Abeer M. Shaaban

Download or read book Breast Translational Research written by Abeer M. Shaaban and published by . This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Breast translational research has markedly evolved over the past few decades and the emerging knowledge has revolutionized our understanding of breast neoplasms. Novel techniques and concepts in studying breast cancer have been developed. These have contributed to the understanding and recognition of this complex disease. This special topic issue on Breast Translational Research provides pertinent and succinct reviews on tumor microenvironment, metabolomics, the role of the calpain family of enzymes, the molecular mechanisms of lymphovascular invasion, and predictors of response to neoadjuvant therapy. It proposes and illustrates a new terminology for the practising pathologist who needs to describe a diagnostically challenging group of breast neoplasms showing dermal analogue differentiation. It also evaluates the role of p40 immunohistochemistry in diagnostic breast pathology. This publication is of special interest to pathologists as well as scientists and members of the breast multidisciplinary team, since it provides a useful overview of pertinent markers and techniques in the field of breast cancer translational research and diagnostic histopathology.

Immunotherapy in Translational Cancer Research

Author : Laurence J. N. Cooper
Publisher : John Wiley & Sons
ISBN 13 : 1118123220
Total Pages : 306 pages
Book Rating : 4.1/5 (181 download)

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Book Synopsis Immunotherapy in Translational Cancer Research by : Laurence J. N. Cooper

Download or read book Immunotherapy in Translational Cancer Research written by Laurence J. N. Cooper and published by John Wiley & Sons. This book was released on 2018-05-01 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: A guide to state-of-the-art cancer immunotherapy in translational cancer research A volume in the Translational Oncology series, Immunotherapy in Translational Cancer Research explores the recent developments in the role that immunotherapy plays in the treatment of a wide range of cancers. The editors present key concepts, illustrative examples, and suggest alternative strategies in order to achieve individualized targeted therapy. Comprehensive in scope, Immunotherapy in Translational Cancer Research reviews the relevant history, current state, and the future of burgeoning cancer-fighting therapies. The book also includes critical information on drug development, clinical trials, and governmental resources and regulatory issues. Each chapter is created to feature: development of the immunotherapy; challenges that have been overcome in order to scale up and undertake clinical trials; and clinical experience and application of research. This authoritative volume is edited by a team of noted experts from MD Anderson Cancer Center, the world’s foremost cancer research and care center and: Offers a comprehensive presentation of state-of-the-art cancer immunotherapy research that accelerates the pace of clinical cancer care Filled with the concepts, examples, and approaches for developing individualized therapy Explores the breath of treatments that reflect the complexity of the immune system itself Includes contributions from a panel international experts in the field of immunotherapy Designed for physicians, medical students, scientists, pharmaceutical executives, public health and public policy government leaders and community oncologists, this essential resource offers a guide to the bidirectional interaction between laboratory and clinic immunotherapy cancer research.

The Pathobiology of Breast Cancer

Author : Jose Russo
Publisher : Springer
ISBN 13 : 3319408151
Total Pages : 235 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis The Pathobiology of Breast Cancer by : Jose Russo

Download or read book The Pathobiology of Breast Cancer written by Jose Russo and published by Springer. This book was released on 2016-08-10 with total page 235 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph, written by well renowned breast cancer expect, Dr. Jose Russo, provides new insight on the pathobiology of breast cancer from the most current advances in the field, translational research, initiation and progression of the disease, the mechanism of invasion and metastasis and the concept of stem cells in treatment and drug resistance. The role of personalized medicine and genomic testing are also explored, which will provide a window to the future progress of cancer care.

ESMO Handbook on Principles of Translational Research

Author : Håkan Mellstedt
Publisher : CRC Press
ISBN 13 : 0203092422
Total Pages : 192 pages
Book Rating : 4.2/5 (3 download)

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Book Synopsis ESMO Handbook on Principles of Translational Research by : Håkan Mellstedt

Download or read book ESMO Handbook on Principles of Translational Research written by Håkan Mellstedt and published by CRC Press. This book was released on 2007-05-21 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using state-of-the-art and evidence-based literature references and reviews, the authors present an overview of translational research that is both reliable and easily understood. The book begins with principles of normal cell biology and normal immunology. It examines tumor biology and basic tumor immunology. It then discusses limitless replicativ

Personalized Treatment of Breast Cancer

Author : Masakazu Toi
Publisher : Springer
ISBN 13 : 4431555528
Total Pages : 388 pages
Book Rating : 4.4/5 (315 download)

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Book Synopsis Personalized Treatment of Breast Cancer by : Masakazu Toi

Download or read book Personalized Treatment of Breast Cancer written by Masakazu Toi and published by Springer. This book was released on 2016-05-24 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book deals with the essential factors in the personalization of treatment for primary breast cancer. These include host issues, lymph node surgery, radiation therapy, and preoperative systemic treatment requiring specialized knowledge, multidisciplinary care experience, techniques, and research. Locoregional treatment in conjunction with systemic treatments is another important factor, with options for local therapy significantly affected by genetic BRCA mutation. Axillary treatment issues have become top priorities in recent primary breast cancer care, and these are highlighted in the book’s presentation of technological advances in lymph node mapping and diagnosis, axillary clearance in patients with nodal metastasis, and the role of axillary surgery. Attention is also given to locoregional treatment after preoperative systemic therapy. Because therapeutic impact differs depending upon biological characteristics such as tumor subtype, local therapy should be based both on tumor biology and on therapeutic response in parallel. Associated translational research and mathematical prediction tools such as nomograms also are introduced. This book provides the essence of primary breast cancer care, particularly its individualization with novel therapeutic concepts and strategies, and will greatly benefit physicians and clinical investigators in breast cancer institutions.

Translational Cancer Research for Surgeons, An Issue of Surgical Oncology Clinics

Author : William G. Cance
Publisher : Elsevier Health Sciences
ISBN 13 : 0323227449
Total Pages : 311 pages
Book Rating : 4.3/5 (232 download)

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Book Synopsis Translational Cancer Research for Surgeons, An Issue of Surgical Oncology Clinics by : William G. Cance

Download or read book Translational Cancer Research for Surgeons, An Issue of Surgical Oncology Clinics written by William G. Cance and published by Elsevier Health Sciences. This book was released on 2013-09-19 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of the Surgical Oncology Clinics of North America, Guest Edited by Dr. William G. Cance, is devoted to Translational Cancer Research for Surgeons. Translational Cancer research aims to move bench research to the bedside by applying basic science toward potential therapies. This issue will present the concepts of translational research and development of targeted therapeutics, and its implications for surgeons. It will show clinical applications for surgeons regarding sarcoma/GIST, melanoma, colorectal cancer, breast cancer, and endocrine cancer.