Author : Penaz Parveen Sultana Mohammad
Publisher :
ISBN 13 :
Total Pages : 65 pages
Book Rating : 4.:/5 (119 download)
Book Synopsis Quantitative Measurement of Cerebral Hemodynamics During Activation of Auditory Cortex with Single- and Multi-distance Near Infrared Spectroscopy by : Penaz Parveen Sultana Mohammad
Download or read book Quantitative Measurement of Cerebral Hemodynamics During Activation of Auditory Cortex with Single- and Multi-distance Near Infrared Spectroscopy written by Penaz Parveen Sultana Mohammad and published by . This book was released on 2018 with total page 65 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functional Near Infrared Spectroscopy (fNIRS) is a safe, low-cost, non-invasive opti-cal technique to monitor focal changes in brain activity using neurovascular coupling and measurements of local tissue oxygenation, i.e., changes in concentrations of oxygenated hemoglobin (HbO) and deoxygenated hemoglobin (HbR)[42]. This thesis utilizes two fNIRS approaches to measure hemodynamic changes associated with functional stimulation of the human auditory cortex. The rst approach, single-distance continuous wave NIRS (CW-NIRS) utilizes relatively simple instrumentation and the Modied-Beer Lambert (MBL) law to estimate activation induced changes in tissue oxygenation (CHbO and CHbR)[17]. The second more complex approach, frequency domain NIRS (FD-NIRS), employs a photon diffusion model of light propagation through tissue to measure both baseline (CHbO and CHbR), and stimulus induced changes in oxygenated and deoxygenated hemoglobin[10]. FD-NIRS is more quantitative, but requires measurements at multiple light source-detector separations and thus its use in measuring focal changes in cerebral hemodynamics have been limited.