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Prostate Cancer Metabolism
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Book Synopsis The Heterogeneity of Cancer Metabolism by : Anne Le
Download or read book The Heterogeneity of Cancer Metabolism written by Anne Le and published by Springer. This book was released on 2018-06-26 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.
Book Synopsis Prostate Cancer Metabolism by : Tomas Koltai
Download or read book Prostate Cancer Metabolism written by Tomas Koltai and published by Academic Press. This book was released on 2021-06-25 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prostate Cancer Metabolism: From Biochemistry to Therapeutics shows the peculiarities of prostate cancer metabolism, emphasizing the targetable aspects – that have not been considered in conventional treatment protocols. The book specifically addresses treatment of the castration-resistant stage of prostate cancer proposing many repurposed drugs and nutraceuticals to complement, not replace, standard therapies. The large body of evidence supporting these concepts makes them deserving of further research and well-designed clinical trials. It discusses lipid, cholesterol, glutamine, and glucose metabolisms and their impact on prostate cancer. Additionally, it explains how current established drugs can be repurposed to improve treatment outcomes. The concepts set out in the book, that deal with cancer at the cellular/molecular level, help identify new avenues of research and treatments to pursue that do not affect well-being whilst offer consistent benefits. Since most practicing physicians have not studied basic biochemistry since medical school, each chapter begins with a brief review of the topic to facilitate an understanding of the metabolically-oriented approach to targeting prostate cancer. Conventional treatments are not discussed here since they are covered in textbooks and specialized updates that abound in the medical literature. It is a valuable resource for cancer researchers, oncologists, clinicians and members of biomedical field who want to learn more about prostate cancer metabolism and how to apply recent findings in the field to bedside. - Explains the basic aspects of prostate cancer metabolism, including its biochemistry which has a pivotal role in clinical practice - Discusses new drugs and nutraceuticals with a metabolism-centered approach - Offers practical bedside approach in combination with molecular and biochemical fundamentals to help readers identify and provide the best treatment to their patients
Book Synopsis Cancer as a Metabolic Disease by : Thomas Seyfried
Download or read book Cancer as a Metabolic Disease written by Thomas Seyfried and published by John Wiley & Sons. This book was released on 2012-05-18 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg's well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the "hallmarks of cancer" and thus his theory was discredited. This book aims to provide evidence, through case studies, that cancer is primarily a metabolic disease requring metabolic solutions for its management and prevention. Support for this position is derived from critical assessment of current cancer theories. Brain cancer case studies are presented as a proof of principle for metabolic solutions to disease management, but similarities are drawn to other types of cancer, including breast and colon, due to the same cellular mutations that they demonstrate.
Book Synopsis Quantification of of Prostate Cancer Metabolism Using 3D Multiecho BSSFP and Hyperpolarized [1-13C] Pyruvate: Metabolism Differs Between Tumors of the Same Gleason Grade by : Rafat Chowdhury
Download or read book Quantification of of Prostate Cancer Metabolism Using 3D Multiecho BSSFP and Hyperpolarized [1-13C] Pyruvate: Metabolism Differs Between Tumors of the Same Gleason Grade written by Rafat Chowdhury and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: Background Three-dimensional (3D) multiecho balanced steady-state free precession (ME-bSSFP) has previously been demonstrated in preclinical hyperpolarized (HP) 13C-MRI in vivo experiments, and it may be suitable for clinical metabolic imaging of prostate cancer (PCa). Purpose To validate a signal simulation framework for the use of sequence parameter optimization. To demonstrate the feasibility of ME-bSSFP for HP 13C-MRI in patients. To evaluate the metabolism in PCa measured by ME-bSSFP. Study Type Retrospective single-center cohort study. Phantoms/Population Phantoms containing aqueous solutions of [1-13C] lactate (2.3 M) and [13C] urea (8 M). Eight patients (mean age 67 ± 6 years) with biopsy-confirmed Gleason 3 + 4 (n = 7) and 4 + 3 (n = 1) PCa. Field Strength/Sequences 1H MRI at 3 T with T2-weighted turbo spin-echo sequence used for spatial localization and spoiled dual gradient-echo sequence used for B0-field measurement. ME-bSSFP sequence for 13C MR spectroscopic imaging with retrospective multipoint IDEAL metabolite separation. Assessment The primary endpoint was the analysis of pyruvate-to-lactate conversion in PCa and healthy prostate regions of interest (ROIs) using model-free area under the curve (AUC) ratios and a one-directional kinetic model (kP). The secondary objectives were to investigate the correlation between simulated and experimental ME-bSSFP metabolite signals for HP 13C-MRI parameter optimization. Statistical Tests Pearson correlation coefficients with 95% confidence intervals and paired t-tests. The level of statistical significance was set at P 0.05.brResultsbrbrStrong correlations between simulated and empirical ME-bSSFP signals were found (r 0.96). Therefore, the simulation framework was used for sequence optimization. Whole prostate metabolic HP 13C-MRI, observing the conversion of pyruvate into lactate, with a temporal resolution of 6 seconds was demonstrated using ME-bSSFP. Both assessed metrics resulted in significant differences between PCa (mean ± SD) (AUC = 0.33 ± 012, kP = 0.038 ± 0.014) and healthy (AUC = 0.15 ± 0.10, kP = 0.011 ± 0.007) ROIs. Data Conclusion Metabolic HP 13C-MRI in the prostate using ME-bSSFP allows for differentiation between aggressive PCa and healthy tissue. Evidence Level 2 Technical Efficacy Stage 1
Book Synopsis Metabolism in Cancer by : Thorsten Cramer
Download or read book Metabolism in Cancer written by Thorsten Cramer and published by Springer. This book was released on 2016-08-24 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook presents concise chapters written by internationally respected experts on various important aspects of cancer-associated metabolism, offering a comprehensive overview of the central features of this exciting research field. The discovery that tumor cells display characteristic alterations of metabolic pathways has significantly changed our understanding of cancer: while the first description of tumor-specific changes in cellular energetics was published more than 90 years ago, the causal significance of this observation for the pathogenesis of cancer was only discovered in the post-genome era. The first 10 years of the twenty-first century were characterized by rapid advances in our grasp of the functional role of cancer-specific metabolism as well as the underlying molecular pathways. Various unanticipated interrelations between metabolic alterations and cancer-driving pathways were identified and currently await translation into diagnostic and therapeutic applications. Yet the speed, quantity, and complexity of these new discoveries make it difficult for researchers to keep up to date with the latest developments, an issue this book helps to remedy.
Author :Shanmugasundaram Ganapathy-Kanniappan Publisher :Frontiers Media SA ISBN 13 :2889453227 Total Pages :116 pages Book Rating :4.8/5 (894 download)
Book Synopsis Cancer Metabolism: Molecular Targeting and Implications for Therapy by : Shanmugasundaram Ganapathy-Kanniappan
Download or read book Cancer Metabolism: Molecular Targeting and Implications for Therapy written by Shanmugasundaram Ganapathy-Kanniappan and published by Frontiers Media SA. This book was released on 2017-11-03 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: Development of an effective anticancer therapeutic necessitates the selection of cancer-related or cancer-specific pathways or molecules that are sensitive to intervention. Several such critical yet sensitive molecular targets have been recognized, and their specific antagonists or inhibitors validated as potential therapeutics in preclinical models. Yet, majority of anticancer principles or therapeutics show limited success in the clinical translation. Thus, the need for the development of an effective therapeutic strategy persists.
“Altered energy metabolism” in cancer is one of the earliest known biochemical phenotypes which dates back to the early 20th century. The German scientist, Otto Warburg and his team (Warburg, Wind, Negelein 1926; Warburg, Wind, Negelein 1927) provided the first evidence that the glucose metabolism of cancer cells diverge from normal cells. This phenomenal discovery on deregulated glucose metabolism or cellular bioenergetics is frequently witnessed in majority of solid malignancies. Currently, the altered glucose metabolism is used in the clinical diagnosis of cancer through positron emission tomography (PET) imaging. Thus, the “deregulated bioenergetics” is a clinically relevant metabolic signature of cancer cells, hence recognized as one of the hallmarks of cancer (Hanahan and Weinberg 2011). Accumulating data unequivocally demonstrate that, besides cellular bioenergetics, cancer metabolism facilitates several cancer-related processes including metastasis, therapeutic resistance and so on. Recent reports also demonstrate the oncogenic regulation of glucose metabolism (e.g. glycolysis) indicating a functional link between neoplastic growth and cancer metabolism. Thus, cancer metabolism, which is already exploited in cancer diagnosis, remains an attractive target for therapeutic intervention as well. The Frontiers in Oncology Research Topic “Cancer Metabolism: Molecular Targeting and Implications for Therapy” emphases on recent advances in our understanding of metabolic reprogramming in cancer, and the recognition of key molecules for therapeutic targeting. Besides, the topic also deliberates the implications of metabolic targeting beyond the energy metabolism of cancer. The research topic integrates a series of reviews, mini-reviews and original research articles to share current perspectives on cancer metabolism, and to stimulate an open forum to discuss potential challenges and future directions of research necessary to develop effective anticancer strategies. Acknowledgment I sincerely thank the Frontiers for providing the opportunity and constant support throughout the process of this research topic and eBook production. I gratefully acknowledge all the authors for their valuable contributions. Finally, I would like to thank my brother, Saravana Kumar, G.K., whose personal sacrifices and unflinching encouragement made my career in science possible. References: Hanahan D, Weinberg RA. 2011. Hallmarks of cancer: The next generation. Cell. 144(5):646-74. Warburg O, Wind F, Negelein E. 1926. Über den stoffwechsel der tumoren in körper. Klinische Wochenschrift. 5:829-32. Warburg O, Wind F, Negelein E. 1927. The metabolism of tumors in the body. J Gen Physiol. 8(6):519-30.
Book Synopsis Personalized Medicine for Urological Cancers: Targeting Cancer Metabolism by : Eugenio Zoni
Download or read book Personalized Medicine for Urological Cancers: Targeting Cancer Metabolism written by Eugenio Zoni and published by Frontiers Media SA. This book was released on 2022-03-28 with total page 129 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Genetic Alteration of Metabolism and Tumorigenicity of Prostate Cancer Cells by :
Download or read book Genetic Alteration of Metabolism and Tumorigenicity of Prostate Cancer Cells written by and published by . This book was released on 2003 with total page 57 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the prostate, overwhelming evidence now exists that zinc and citrate metabolism are important factors in the pathogenesis and progression of prostate cancer (Pca). This proposal is aiming to establish that the pro static tumor cells obtained from PC-3 and LNCaP-derived tumors are citrate oxidizing cells; and to demonstrate that the genetic alteration of zinc accumulation and expression of m-aconitase will alter citrate oxidation and will correspondingly alter the tumorigenic capabilities of LNCaP and PC-3 cells. The second year study was focused on: 1) to study the zinc effect on the prostate tumorigenicity in vivo; 2) to establish and characterize ZIP1 over-expressed PC-3 cells; 3) To determine the tumorigenic capacity of ZIP1 over-expressed PC-3 cells; 4) To establish ZIP1 over-expressed LNCaP cells using stable transfection technique. At the present time the progress of this study is very promising, and we anticipate continuation of significant outcomes from this project. With this grant support, two abstracts were published and presented in international and local meetings, one paper was published and two manuscripts have been submitted.
Book Synopsis Cancer Cell Metabolism: A Potential Target for Cancer Therapy by : Dhruv Kumar
Download or read book Cancer Cell Metabolism: A Potential Target for Cancer Therapy written by Dhruv Kumar and published by Springer Nature. This book was released on 2020-02-13 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book illustrates various aspects of cancer cell metabolism, including metabolic regulation in solid tumours vs. non-solid tumours, the molecular pathways involved in its metabolism, and the role of the tumour microenvironment in the regulation of cancer cell metabolism. It summarizes the complexity of cancer cell metabolism in terms of the switch from anaerobic to aerobic glycolysis and how mitochondrial damage promotes aerobic glycolysis in cancer cells. The respective chapters provide the latest information on the metabolic remodelling of cancer cells and elucidate the important role of the signalling pathways in reprogramming of cancer cell metabolism. In addition, the book highlights the role of autophagy in cancer cell metabolism, and how metabolic crosstalk between cancer cells and cancer-associated fibroblasts promotes cancer cell progression. In closing, it summarizes recent advancements in drug development through targeting cancer metabolism.
Download or read book Prostate Cancer written by Scott M. Dehm and published by Springer Nature. This book was released on 2020-01-03 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this book is to provide a contemporary overview of the causes and consequences of prostate cancer from a cellular and genetic perspective. Written by experts in the fields of epidemiology, toxicology, cell biology, genetics, genomics, cell-cell interactions, cell signaling, hormone signaling, and transcriptional regulation, the text covers aspects of prostate cancer from disease initiation to metastasis. Chapters explore in depth the cells of origin for prostate cancer, its genomic subtypes, neural transcription factors in disease progression, epigenetic regulation of chromatin, and many other topics. This book distinguishes itself from other texts on prostate cancer by its focus on cellular and genetic mechanisms, as opposed to clinical diagnosis and management. As a result, this book will be of broad interest to basic and translational scientists with familiarity of these topics, as well as to trainees at earlier stages of their research careers.
Book Synopsis Androgen Action in Prostate Cancer by : Donald Tindall
Download or read book Androgen Action in Prostate Cancer written by Donald Tindall and published by Springer Science & Business Media. This book was released on 2009-04-20 with total page 782 pages. Available in PDF, EPUB and Kindle. Book excerpt: Androgens are critical regulators of prostate differentiation and function, as well as prostate cancer growth and survival. Therefore, androgen ablation is the preferred systemic treatment for disseminated prostate cancer. Androgen action is exerted in target tissues via binding the androgen receptor (AR), a nuclear receptor transcription factor. Historically, the gene expression program mediated by the AR has been poorly understood. However, recent gene expression profiling and more traditional single-gene characterization studies have revealed many androgen-regulated genes that are important mediators of androgen action in both normal and malignant prostate tissue. This book will focus on the androgen-regulated gene expression program, and examine how recently identified androgen-regulated genes are likely to contribute to the development and progression of prostate cancer. Recent studies that have attempted to unravel how these genes are deregulated in androgen depletion independent prostate cancer will be included
Book Synopsis Approaches to Prostate Cancer Imaging and Therapy by : Jun Yang
Download or read book Approaches to Prostate Cancer Imaging and Therapy written by Jun Yang and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: Prostate cancer is one of the most common cancers and remains the second leading cause of death from cancer in men. Metastatic prostate tumors express the androgen receptor (AR) regardless of their sensitivity to hormonal therapy. This offers a cellular target for receptor-mediated imaging or treatment of prostate cancer. We first identified a series of novel agents that can be used to image and treat advanced prostate cancer via high affinity interaction with the AR. One of the most promising compounds, S-26, demonstrated a favorable receptor specificity profile, pharmacokinetic properties, and nonsteroidal structure, making it amenable to further optimization for AR mediated imaging. In vivo biodistribution studies showed that radiolabeled S-26 does not accumulate in AR-rich tissues. In vivo metabolism studies were performed to further understand the factors governing disposition of this ligand. The extensive plasma clearance of S-26 and unstable iodine substituent in the A ring likely contributed to its lack of AR tissue selectivity in vivo. During studies to elaborate new pharmacophores for the human AR, we discovered a series of bis-indole analogs that do not bind the AR, but exhibit potent cytotoxic activity in a variety of human tumor cell lines. One lead compound, bis-indole I-13, inhibited the growth of a number of human cancer cell lines, including the high P-glycoprotein expressing cell line, with IC50 in the range of 0.034 to 0.162 uM. Studies of in vivo pharmacokinetics, toxicity, antitumor activity in PC-3 xenograft, and metabolism demonstrated that bis-indole analogs represent a novel class of anticancer drugs for prostate cancer and offer hope for achievable pharmacologic activity in the clinic.
Book Synopsis Cancer Metabolomics 2018 by : Paula Guedes De Pinho
Download or read book Cancer Metabolomics 2018 written by Paula Guedes De Pinho and published by MDPI. This book was released on 2019-09-03 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: The metabolomics approach, defined as the study of all endogenously-produced low-molecular-weight compounds, appeared as a promising strategy to define new cancer biomarkers. Information obtained from metabolomic data can help to highlight disrupted cellular pathways and, consequently, contribute to the development of new-targeted therapies and the optimization of therapeutics. Therefore, metabolomic research may be more clinically translatable than other omics approaches, since metabolites are closely related to the phenotype and the metabolome is sensitive to many factors. Metabolomics seems promising to identify key metabolic pathways characterizing features of pathological and physiological states. Thus, knowing that tumor metabolism markedly differs from the metabolism of normal cells, the use of metabolomics is ideally suited for biomarker research. Some works have already focused on the application of metabolomic approaches to different cancers, namely lung, breast and liver, using urine, exhaled breath and blood. In this Special Issue we contribute to a more complete understanding of cancer disease using metabolomics approaches.
Book Synopsis Prostate Cancer As a Metabolic Disease by : Algeciras Algeciras Press
Download or read book Prostate Cancer As a Metabolic Disease written by Algeciras Algeciras Press and published by . This book was released on 2016-08-08 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emerging evidence indicates that altered cellular metabolism is the defining characteristic of nearly all diseases regardless of cellular or tissue origin. In contrast to normal cells, most diseased cells become heavily dependent on alternative metabolic pathways to meet cellular functions. A view of prostate cancer as primarily a metabolic disease will impact approaches to prostate cancer management and prevention. Proceeds from the sale of this book go to the support of an elderly disabled person.
Book Synopsis Recent Advances in Prostate Cancer by : Donald J. Tindall
Download or read book Recent Advances in Prostate Cancer written by Donald J. Tindall and published by World Scientific. This book was released on 2011 with total page 698 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book effectively summarizes our knowledge of recent advances in prostate cancer. It focuses on our state-of-the-art understanding of risk factors, prevention, detection, prognosis and treatment of prostate cancer and identifies basic science findings that are being translated into clinical practice. In addition, the book singles out key areas of research that have potential for clinical translation. Both basic scientists and clinicians will be invited to provide up-to-date reviews in each area of prostate cancer. During the last decade the pace of clinical discovery and the scientific advances in prostate cancer have been very rapid. For instance, currently there are more than 100 drugs in the pharmaceutical pipeline that have the potential for clinical management of prostate cancer. Therefore, it has been very difficult for clinicians and basic scientists to keep pace with the field as a whole. Recently, some of these discoveries are already having an impact on clinical practice. For example, the discovery of the androgen receptor gene amplification in prostate cancer has led to the development of a OC super-antiandrogenOCO, which is being tested in clinical trials. Also, recent knowledge of androgen synthesis in prostate cancer cells has led to clinical trials with steroid-metabolism inhibitors. Finally, robotic surgery has also dramatically changed clinical practice. Thus, this important book serves to provide readers with a one-stop overview of the field of prostate cancer research and its translation into the clinical arena."
Book Synopsis Investigating Different Metabolic Pathways of Highly Metastatic and Poorly Metastatic Prostate Cancer Cells by : Lei Yan
Download or read book Investigating Different Metabolic Pathways of Highly Metastatic and Poorly Metastatic Prostate Cancer Cells written by Lei Yan and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Hypoxia and the Metabolic Phenotype of Prostate Cancer Cells by :
Download or read book Hypoxia and the Metabolic Phenotype of Prostate Cancer Cells written by and published by . This book was released on 2008 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer cells have the ability to survive when oxygen is limiting, and upregulate the pathway of fatty acid synthesis, owing in part to alterations in their metabolism. I compared the metabolic phenotypes of the prostate cancer cell lines LNCaP, DU145, and PC3 assessing energy metabolism, and metabolic gene expression. I also explored the plasticity of the metabolic phenotype following passage, selection and in vivo growth. Finally, I explored the sensitivity of the fatty acid synthesis pathway to low oxygen. LNCaP cells had a more oxidative phenotype based on oxygen consumption, lactate production, enzyme assays, and mRNA levels. While DU145 and PC3 cells were more glycolytic, they were unresponsive to dichloroacetate (DCA), and dinitrophenol (DNP), stimulators of oxygen consumption. Mitochondrial dysfunction in the PC3 and DU145 cells may explain this phenomenon, for they possessed normal cardiolipin levels but lower mitochondrial enzyme activities (cytochrome oxidase (COX), citrate synthase (CS)). When LNCaP cells were subjected to high passage, with and without clonal selection, the derived lines acquired a dysfunctional oxidative phenotype, becoming more glycolytic. Clonal selection appeared to have the most dramatic effect on cellular metabolism. This finding is supported by decreased oxygen consumption, increased lactate production, and a reduction in the activity of the oxidative enzymes CS and COX in the clonally selected LNCaP-luc cell line. Similar to the DU145 and PC3 cells, NAO fluorescence indicates that the oxidative impairment in these LNCaP-derived lines may be due to a reduction in mitochondrial activity. The pattern of metabolic gene expression iii seen in vitro was unaffected when LNCaP cells were grown as subcaspular and muscle xenografts in immunodeficient mice, though xenografts did exhibit indications of an hypoxic response (elevated VEGF mRNA). Oxygen deprivation in vitro increased mRNA for HIF and responsive genes but not SREBP responsive ge.
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