Prostacyclin And Hypertension

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Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension

Author : Toshio Nakanishi
Publisher : Springer Nature
ISBN 13 : 9811511853
Total Pages : 374 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension by : Toshio Nakanishi

Download or read book Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension written by Toshio Nakanishi and published by Springer Nature. This book was released on 2020-02-28 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book focuses on the molecular mechanism of congenital heart disease and pulmonary hypertension, offering new insights into the development of pulmonary circulation and the ductus arteriosus. It describes in detail the molecular mechanisms involved in the development and morphogenesis of the heart, lungs and ductus arteriosus, covering a range of topics such as gene functions, growth factors, transcription factors and cellular interactions, as well as stem cell engineering technologies. The book also presents recent advances in our understanding of the molecular mechanism of lung development, pulmonary hypertension and molecular regulation of the ductus arteriosus. As such, it is an ideal resource for physicians, scientists and investigators interested in the latest findings on the origins of congenital heart disease and potential future therapies involving pulmonary circulation/hypertension and the ductus arteriosus.

Hepatotoxicity

Author : Hyman J. Zimmerman
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9780781719520
Total Pages : 850 pages
Book Rating : 4.7/5 (195 download)

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Book Synopsis Hepatotoxicity by : Hyman J. Zimmerman

Download or read book Hepatotoxicity written by Hyman J. Zimmerman and published by Lippincott Williams & Wilkins. This book was released on 1999 with total page 850 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.

Cardiovascular Disability

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 030915698X
Total Pages : 304 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Cardiovascular Disability by : Institute of Medicine

Download or read book Cardiovascular Disability written by Institute of Medicine and published by National Academies Press. This book was released on 2010-12-04 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Social Security Administration (SSA) uses a screening tool called the Listing of Impairments to identify claimants who are so severely impaired that they cannot work at all and thus immediately qualify for benefits. In this report, the IOM makes several recommendations for improving SSA's capacity to determine disability benefits more quickly and efficiently using the Listings.

Introduction to Basics of Pharmacology and Toxicology

Author : Abialbon Paul
Publisher : Springer Nature
ISBN 13 : 9813360097
Total Pages : 1156 pages
Book Rating : 4.8/5 (133 download)

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Book Synopsis Introduction to Basics of Pharmacology and Toxicology by : Abialbon Paul

Download or read book Introduction to Basics of Pharmacology and Toxicology written by Abialbon Paul and published by Springer Nature. This book was released on 2021-03-13 with total page 1156 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explains the pharmacological relationships between the various systems in the human body. It offers a comprehensive overview of the pharmacology concerning the autonomic, central, and peripheral nervous systems. Presenting up-to-date information on chemical mediators and their significance, it highlights the therapeutic aspects of several diseases affecting the cardiovascular, renal, respiratory, gastrointestinal, endocrinal, and hematopoietic systems. The book also includes drug therapy for microbial and neoplastic diseases. It also comprises sections on immunopharmacology, dermatological, and ocular pharmacology providing valuable insights into these emerging and recent topics. Covering the diverse groups of drugs acting on different systems, the book reviews their actions, clinical uses, adverse effects, interactions, and subcellular mechanisms of action. It is divided into 11 parts, subdivided into several chapters that evaluate the basic pharmacological principles that govern the different types of body systems. This book is intended for academicians, researchers, and clinicians in industry and academic institutions in pharmaceutical, pharmacological sciences, pharmacy, medical sciences, physiology, neurosciences, biochemistry, molecular biology and other allied health sciences.

Primary Pulmonary Hypertension

Author : Lewis J. Rubin
Publisher : CRC Press
ISBN 13 : 9780824795054
Total Pages : 384 pages
Book Rating : 4.7/5 (95 download)

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Book Synopsis Primary Pulmonary Hypertension by : Lewis J. Rubin

Download or read book Primary Pulmonary Hypertension written by Lewis J. Rubin and published by CRC Press. This book was released on 1996-11-06 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Detailing state-of-the-art developments in the various aspects of primary pulmonary hypertension (PPH), this practical reference explores the history, most current scientific concepts, and treatments of this disease. Includes new advances not yet formally published! Written by nearly 30 of the top international experts in the field, Primary Pulmonary Hypertension addresses the general histological features of the normal and hypertensive pulmonary vasculature and the pathology of PPH discusses etiological possibilities of pathogenesis, common morphological features, and findings in experimental models examines risks factors for PPH and looks separately at familial PPH and PPH in children presents an approach to the differential diagnosis of pulmonary hypertension, emphasizing the recognition of PPH elucidates the invasive and noninvasive modalities available for obtaining qualitative and quantitative hemodynamic data for the diagnosis of PPH covers a variety of therapeutic options and much more!

Prostacyclin and Hypertension

Author : Gerd Bönner
Publisher : Springer Science & Business Media
ISBN 13 : 3642956084
Total Pages : 131 pages
Book Rating : 4.6/5 (429 download)

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Book Synopsis Prostacyclin and Hypertension by : Gerd Bönner

Download or read book Prostacyclin and Hypertension written by Gerd Bönner and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 131 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of present-day treatment of hypertension is no longer as the effective reduction of blood pressure, regarded merely but as the ever-increasing application of new therapeutic prin ciples to prevent such consequences of hypertension as left heart hypertrophy, medial hypertrophy of the vessels and ar teriosclerosis. In this context special attention has been di rected to stimulation of the endogenous vasocilator hormonal systems such as the prostaglandins. The great interest in our book, which has meanwhile appeared in a French edition, seems to confirm this trend and has encouraged us to include in the book the new findings published in the last twelve months. These changes and additions maintain the current status of the book and provide an even more complete survey of the available information about prostacyclin in hyperten sion. We wish to thank all those colleagues who have made useful suggestions for this second edition, as well as Springer Verlag and its associates, who ensured a uniformly smooth passage in the production of the book. Cologne and MUnster, January 1990 Gerd Bonner Karl-Heinz Rahn v Preface to the First Edition Diseases of the heart and circulation currently constitute the commonest causes of death in our population. Hypertension, as evidenced by a pathologic increase in blood pressure, is one of the most important risk factors. Primary hypertension can be established in about 15 % of adults. Patients with hyperten sion usually feel well subjectively and only rarely complain of symptoms.

Kendig and Chernick's Disorders of the Respiratory Tract in Children E-Book

Author : Robert W. Wilmott
Publisher : Elsevier Health Sciences
ISBN 13 : 1455740500
Total Pages : 1163 pages
Book Rating : 4.4/5 (557 download)

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Book Synopsis Kendig and Chernick's Disorders of the Respiratory Tract in Children E-Book by : Robert W. Wilmott

Download or read book Kendig and Chernick's Disorders of the Respiratory Tract in Children E-Book written by Robert W. Wilmott and published by Elsevier Health Sciences. This book was released on 2012-02-25 with total page 1163 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kendig, Chernick’s Disorders of the Respiratory Tract in Children is the definitive medical reference book to help you confront critical challenges using the latest knowledge and techniques. You’ll get the state-of-the-art answers you need to offer the best care to young patients. Tackle the toughest challenges and improve patient outcomes with coverage of all the common and rare respiratory problems found in newborns and children worldwide. Get a solid foundation of knowledge to better understand and treat your patients through coverage of the latest basic science and its relevance to clinical problems. Get comprehensive, authoritative coverage on today’s hot topics, such as interstitial lung disease, respiratory disorders in the newborn, congenital lung disease, swine flu, genetic testing for disease and the human genome, inflammatory cytokines in the lung, new radiologic techniques, diagnostic imaging of the respiratory tract, and pulmonary function tests. Learn from the experts with contributions from 100 world authorities in the fields of pediatrics, pulmonology, neurology, microbiology, cardiology, physiology, diagnostic imaging, anesthesiology, otolaryngology, allergy, and surgery.

The Endothelium

Author : Michel Félétou
Publisher : Morgan & Claypool Publishers
ISBN 13 : 1615041230
Total Pages : 309 pages
Book Rating : 4.6/5 (15 download)

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Book Synopsis The Endothelium by : Michel Félétou

Download or read book The Endothelium written by Michel Félétou and published by Morgan & Claypool Publishers. This book was released on 2011 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References

Handbook of Inpatient Cardiology

Author : Bryan J. Wells
Publisher : Springer Nature
ISBN 13 : 3030478688
Total Pages : 545 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Handbook of Inpatient Cardiology by : Bryan J. Wells

Download or read book Handbook of Inpatient Cardiology written by Bryan J. Wells and published by Springer Nature. This book was released on 2020-07-22 with total page 545 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book serves as a pocket-sized resource to aid with the diagnosis and management of cardiovascular disease in the inpatient setting. Containing up-to-date information from guidelines and clinical trials, this book is the only handbook-style reference on cardiac care designed specifically for the hospitalist. The first section of the book covers cardiac pathology with an emphasis on evidence-based and guideline-based approaches to patient care. Each chapter focuses on a specific cardiovascular disease state such as acute coronary syndrome, atrial fibrillation, pulmonary hypertension, and aortic disease. The second section examines the differential diagnoses and recommended workup for common cardiac chief complaints including chest pain, palpitations, syncope, and dyspnea. The third and final section discusses indications and interpretation of commonly used cardiac procedures and imaging modalities. This book provides a concise review over a broad range of cardiovascular disease states in an accessible handbook-style to aid with the care of these patients. The Handbook of Inpatient Cardiology is an essential resource for physician hospitalists caring for cardiac patients on the medical ward in addition to cardiology physicians and trainees, affiliate providers, and students.

Pulmonary Hypertension

Author : Bradley A. Maron
Publisher : Springer
ISBN 13 : 331923594X
Total Pages : 371 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Pulmonary Hypertension by : Bradley A. Maron

Download or read book Pulmonary Hypertension written by Bradley A. Maron and published by Springer. This book was released on 2015-11-02 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the framework for a singular reference in the field of pulmonary hypertension. Pulmonary vascular disease is a complex and heterogeneous condition characterized by remodeling of distal pulmonary arterioles that increases pulmonary vascular resistance to affect cardiopulmonary hemodynamic and right ventricular function adversely, resulting in a clinical syndrome of diminished exercise tolerance, shortness of breath, and heart failure-associated morbidity and mortality. Owing to the availability of novel pulmonary circulation-selective pharmacotherapies over the previous decade, the number of pulmonary hypertension patients eligible for treatment has increased substantially. Despite this progress, under-awareness persists within the practicing pulmonary, cardiovascular, and general internal medicine communities. This is due, in part, to the complex array of molecular mechanisms implicated in the pathobiology of PH, as well as cutting-edge discoveries from translational scientific works that provide a new framework by which to understand pulmonary vascular-right ventricular coupling. Taken together, a key educational opportunity is exposed to bridge this knowledge gap through the synthesis of a contemporary text that emphasizes basic science, translational and clinical principles, and treatment strategies for understanding pulmonary hypertension.

The ESC Textbook of Vascular Biology

Author : Rob Krams
Publisher : Oxford University Press
ISBN 13 : 0198755775
Total Pages : 347 pages
Book Rating : 4.1/5 (987 download)

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Book Synopsis The ESC Textbook of Vascular Biology by : Rob Krams

Download or read book The ESC Textbook of Vascular Biology written by Rob Krams and published by Oxford University Press. This book was released on 2017 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ESC Textbook of Vascular Biology is a rich and clearly laid-out guide by leading European scientists providing comprehensive information on vascular physiology, disease, and research.

Critical Care of Children with Heart Disease

Author : Ricardo Munoz
Publisher : Springer Science & Business Media
ISBN 13 : 1848822626
Total Pages : 1185 pages
Book Rating : 4.8/5 (488 download)

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Book Synopsis Critical Care of Children with Heart Disease by : Ricardo Munoz

Download or read book Critical Care of Children with Heart Disease written by Ricardo Munoz and published by Springer Science & Business Media. This book was released on 2010-06-21 with total page 1185 pages. Available in PDF, EPUB and Kindle. Book excerpt: Critical Care of Children with Heart Disease will summarize the comprehensive medical and surgical management of the acutely-ill patient with congenital and acquired cardiac disease. The aim of the book is to teach bedside physicians, nurses and other caregivers, basic and practical concepts of anatomy, pathophysiology, surgical techniques and peri-operative management of critically ill children and adults with congenital heart disease, allowing these professionals to anticipate, prevent or else treat such pathologies. The book will cover specific cardiac lesions, review their anatomy, pathophysiology, current preoperative, intraoperative and postoperative assessment and management; medical and surgical complications will be briefly described with each lesion further discussed in specific chapters. In addition, the book will have dedicated chapters to management of cardiac patients on extracorporeal membrane oxygenation, hemofiltration, hemo or peritoneal dialysis and plasma exchange. Practical guidelines for cardiovascular nursing care will be also included.

Diagnosis and Management of Adult Congenital Heart Disease E-Book

Author : Michael A. Gatzoulis
Publisher : Elsevier Health Sciences
ISBN 13 : 0702069310
Total Pages : 739 pages
Book Rating : 4.7/5 (2 download)

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Book Synopsis Diagnosis and Management of Adult Congenital Heart Disease E-Book by : Michael A. Gatzoulis

Download or read book Diagnosis and Management of Adult Congenital Heart Disease E-Book written by Michael A. Gatzoulis and published by Elsevier Health Sciences. This book was released on 2017-02-02 with total page 739 pages. Available in PDF, EPUB and Kindle. Book excerpt: Designed to meet the needs of clinicians working with adults with congenital heart disease, Diagnosis and Management of Adult Congenital Heart Disease , by Drs. Michael A. Gatzoulis, Gary D. Webb, and Piers E. F. Daubeney, offers essential guidance on the anatomical issues, clinical presentation, diagnosis, and treatment options available to practitioners today. This latest edition features completely updated content, including new information for nurses and nurse practitioners who, now more than ever, are playing an important role in the care of adults with CHD. You'll also access four new chapters, illustrated congenital defects, coverage of long-term outcomes, and much more. - Drs. Gatzoulis, Webb, and Daubeney lead a team of experts ideally positioned to provide state-of-the-art global coverage of this increasingly important topic. - Each disease-oriented chapter is written to a highly structured template and provides key information on incidence, genetics, morphology, presentation, investigation and imaging, and treatment and intervention. - Congenital defects are illustrated with full-color line drawings and by the appropriate imaging modality (for example, EKG, x-ray, echocardiogram, MRI, CT, ). - Provides coverage of long-term outcomes, including the management of pregnant patients and patients undergoing non-cardiac surgery. - Features the addition of four new chapters: A Historic Perspective; Quality of Life in Patients with Pulmonary Hypertension; Psychosocial Issues in ACHD; Supportive and Palliative Care for End-Stage ACHD.

Continuous Renal Replacement Therapy

Author : John A. Kellum
Publisher : Oxford University Press
ISBN 13 : 019022553X
Total Pages : 329 pages
Book Rating : 4.1/5 (92 download)

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Book Synopsis Continuous Renal Replacement Therapy by : John A. Kellum

Download or read book Continuous Renal Replacement Therapy written by John A. Kellum and published by Oxford University Press. This book was released on 2016 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: Continuous Renal Replacement Therapy provides concise, evidence-based, bedside guidance for the management of critically ill patients with acute renal failure, offering quick reference answers to clinicians' questions about treatments and situations encountered in daily practice.

Pharmacotherapy of Pulmonary Hypertension

Author : Marc Humbert
Publisher : Springer
ISBN 13 : 9783642386633
Total Pages : 0 pages
Book Rating : 4.3/5 (866 download)

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Book Synopsis Pharmacotherapy of Pulmonary Hypertension by : Marc Humbert

Download or read book Pharmacotherapy of Pulmonary Hypertension written by Marc Humbert and published by Springer. This book was released on 2013-10-16 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume focuses on current evidence-based pharmacological treatments of various forms of pulmonary hypertension and provides a comprehensive review of the latest developments in this area. The first part of the book covers the definition, classification, pathophysiology, pathology, biomarkers and animal models of the disease, thus laying the conceptual basis for what follows. The middle section provides an overview of the established therapies, such as calcium channel blockers, prostanoids, endothelin receptor antagonists, phosphodiesterase-5 inhibitors and inhaled nitric oxide. The last section explores novel pathways and emerging therapeutic approaches including soluble guanylate cyclase stimulators, Rho-kinase inhibitors, inhibitors of serotonin receptors and transporters, peptide growth factors, vasoactive peptides, modulators of redox equilibrium and cyclic nucleotide homeostasis, as well as immunosuppressive and anti-proliferative agents. Particular attention is given to the clinical applications of these experimental therapies, that are on the horizon. The book thus spans the continuum from basic science to clinical applications.

Pulmonary Circulation

Author : Andrew J. Peacock
Publisher : CRC Press
ISBN 13 : 1498719945
Total Pages : 773 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Pulmonary Circulation by : Andrew J. Peacock

Download or read book Pulmonary Circulation written by Andrew J. Peacock and published by CRC Press. This book was released on 2016-03-23 with total page 773 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pulmonary Circulation provides physicians with a better understanding of the structure, function and pathophysiology of the pulmonary circulation. It provides comprehensive coverage from diagnosis and clinical evaluation of patients with pulmonary hypertension to imaging techniques, disorders and treatment. This new edition incorporates the latest clinical, pathophysiological and pathological research on pulmonary circulatory disorders. In particular, it provides greater emphasis on the role of the right ventricle in pulmonary vascular disease, updated knowledge on pathobiology and genetics, and includes new material related to imaging and other diagnostic modalities. This edition also reflects new classifications and all the recommendations from the 2013 World Conference on Pulmonary Circulation as well as current guidelines from the European Society of Cardiology and the European Respiratory Society. Thoroughly updated to keep up with the brisk pace of discovery and emerging therapies, the book remains an essential resource by providing a balance between scientific review and clinically relevant guidelines for the busy practicing physician.

Eicosanoids in Reproduction

Author : Murray D. Mitchell
Publisher : CRC Press
ISBN 13 : 9780849364648
Total Pages : 318 pages
Book Rating : 4.3/5 (646 download)

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Book Synopsis Eicosanoids in Reproduction by : Murray D. Mitchell

Download or read book Eicosanoids in Reproduction written by Murray D. Mitchell and published by CRC Press. This book was released on 1990-05-31 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this book is to provide comprehensive coverage and an update of the major roles of eicosanoids in reproduction. It presents considerable evidence of the importance of lipoxygenase metabolites of arachidonic acid metabolism in reproductive processes. This interesting volume embraces a multidisciplinary approach to research in reproduction (biochemistry, endocrinology, physiology, pharmacology, etc.) at all levels, from whole animal studies through organ, cellular, and molecular approaches. This one-of-a-kind work provides several clinically relevant chapters and places emphasis on the relevance to human reproduction, when applicable. This text is an excellent update for researchers and clinicians on the current state of knowledge of the role of eicosanoids in mechanisms critical for successful reproductive function. This informative, easy-to-read resource is also useful to all those with a more specific interest in obstetrics, gynecology, clinical endocrinology, and the study of fertility.