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Progress Towards The Synthesis Of N Methylwelwitindolinone C Isothiocyanate
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Book Synopsis Progress Towards the Total Synthesis of N-methylwelwitindolinone C Isothiocyanate by : Cynthia Béatrice Julie Paulin
Download or read book Progress Towards the Total Synthesis of N-methylwelwitindolinone C Isothiocyanate written by Cynthia Béatrice Julie Paulin and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis focuses on our progress towards the total synthesis of N-methylwelwitindolinone C isothiocyanate 7, commonly called welwistatin. This major alkaloid of the welwitindolinone family, which was isolated from Hapalosiphon welwitschii in 1994, represents a particularly attractive target due to its interesting biological activities (MDR reversing agent) and its challenging structure. Welwistatin possesses a complex bicyclo[4.3.1]decane ring system consisting of four stereogenic centres, three quaternary carbons and two unusual reactive functionalities: the isothiocyanate bridgehead and a vinyl chloride group. Inspired by the synthetic challenge of this complex architecture, the Simpkins group reported an expedient four-step synthesis of its core structure in 2005. Three years later, our group had investigated the reactivity at the bridgehead enolate positions. Taking inspiration from this previous work, we successfully synthesised bridgehead alkene 126. The other features present on welwistatin 7 were then investigated and enone 198 was obtained. Facing some difficulties on the model system 88, we turned our attention towards the synthesis of tetracycle 170, possessing the gem-dimethyl at the position C\(_{16}\), and its subsequent functionalisation.
Book Synopsis Progress towards the total synthesis of n-methylwelwitindolinone c isothiocyanate by : Valerie Beatrice Sylvie Boissel
Download or read book Progress towards the total synthesis of n-methylwelwitindolinone c isothiocyanate written by Valerie Beatrice Sylvie Boissel and published by . This book was released on 2009 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Progress Towards the Synthesis of N-methylwelwitindolinone C Isothiocyanate by : Sheng-Tung Huang
Download or read book Progress Towards the Synthesis of N-methylwelwitindolinone C Isothiocyanate written by Sheng-Tung Huang and published by . This book was released on 1999 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Progress Toward the Total Synthesis of N-methylwelwitindolinone C Isothiocyanate by : Hongbo Deng
Download or read book Progress Toward the Total Synthesis of N-methylwelwitindolinone C Isothiocyanate written by Hongbo Deng and published by . This book was released on 2001 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Progress Toward the Total Synthesis of N-Methylwelwitindolinone C Isothiocyanate by : Jibo Xia
Download or read book Progress Toward the Total Synthesis of N-Methylwelwitindolinone C Isothiocyanate written by Jibo Xia and published by . This book was released on 2007 with total page 680 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Strategies Towards the Synthesis of Welwitindolinone C by : Jennifer Pitzen
Download or read book Strategies Towards the Synthesis of Welwitindolinone C written by Jennifer Pitzen and published by . This book was released on 2015 with total page 207 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progress towards the total synthesis of N-methylwelwitindolinone C isothiocyanate is reported. The tetracyclic core is established by a key alkylation--type 2 intramolecular Diels--Alder cascade reaction, forming three new carbon-carbon bonds and five stereocenters in one step. Mechanistic studies suggest that alkylation proceeds via a zinc enolate intermediate instead of a silyl ketene aminal, shortening the synthesis by one step. Elaboration of the welwitindolinone core was accomplished with novel use of chlorinating agent MoCl5 to selectively convert a ketone to the vinyl chloride found in the natural product. To circumvent the problematic differentiation of two esters and install a bridgehead amine at an early stage in the synthesis, a series of new dienophiles were prepared. Ultimately selective protection of a diol intermediate allowed for differentiation, but methylation to install the final quaternary center proved to be challenging and remains one of the last hurdles in completing the synthesis.
Book Synopsis Progress Toward the Total Synthesis of N-methylwelwitindolinone C Isothiocyanate by : Hongbo Deng
Download or read book Progress Toward the Total Synthesis of N-methylwelwitindolinone C Isothiocyanate written by Hongbo Deng and published by . This book was released on 2001 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Facile Synthesis of Cis-2-alkyl-3-trialkylsilyloxycycloalkanones Via the Non-aldol Aldol Rearrangement of 2,3-epoxycycloalkanols ; And, Use of 4-cyanocoumarins as Dienophiles in a Facile Synthesis of Highly Substituted Dibenzopyranones ; And, Progress Toward the Total Synthesis of N-methylwelwitindolinone C Isothiocyanate by : Damian Arthur Allen
Download or read book Facile Synthesis of Cis-2-alkyl-3-trialkylsilyloxycycloalkanones Via the Non-aldol Aldol Rearrangement of 2,3-epoxycycloalkanols ; And, Use of 4-cyanocoumarins as Dienophiles in a Facile Synthesis of Highly Substituted Dibenzopyranones ; And, Progress Toward the Total Synthesis of N-methylwelwitindolinone C Isothiocyanate written by Damian Arthur Allen and published by . This book was released on 2009 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products by :
Download or read book Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products written by and published by Springer Science & Business Media. This book was released on 2000-08-23 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glycosmis is a clearly defined genus within the tribe Clauseneae of the Aurantioideae subfamily of the family Rutaceae comprising about 40 species (1). Its range of distribution is centered in south and southeast Asia (India, Sri Lanka, Myanmar, Thailand, Malaysia, Indonesia) and extends to south China and Taiwan as well as to New Guinea and north Australia. Exceptions are only cultivated species like the Chinese G. parvijiora (Sims) Little, formerly called G. citrifolia (Willd. ) Lindley, which became naturalized in tropical America and Africa (Angola) (1). The shrubs or small trees are unarmed and possess pinnate or simple leaves with translucent punctate glands emitting an aromatic odor when crushed. The axillary inflorescences are usually dispersed closed panicles with small white flowers. The fruits are mostly pink, reddish or white berries of about I cm in diameter with only one or two seeds. The genus name Glycosmis originates from the sweet smell of the flowers and the sweet taste of the fleshy pericarp of the fruits. A good field and herbarium character of the genus is that the buds of new leaves are usually covered with short rusty-red hairs. In spite of the good delimitation of Glycosmis from the other closely related Clauseneae genera Clausena, Micromelum, Murraya, and Merrillia and the already existing subrevisionary treatment by Stone (1), there are still many unresolved taxonomic problems at the species level.
Book Synopsis Retrosynthetic Analysis and Synthesis of Natural Products 1 by : Olivier Piva
Download or read book Retrosynthetic Analysis and Synthesis of Natural Products 1 written by Olivier Piva and published by John Wiley & Sons. This book was released on 2019-09-19 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: For chemists, attempting to mimic nature by synthesizing complex natural products from raw material is a challenge that is fraught with pitfalls. To tackle this unique but potentially rewarding task, researchers can rely on well-established reactions and methods of practice, or apply their own synthesis methods to verify their potential. Whatever the goal and its complexity, there are multiple ways of achieving it. We must now establish a strategic and effective plan that requires the minimum number of steps, but lends itself to widespread use. This book is structured around the study of a dozen target products (butyrolactone, macrolide, indole compound, cyclobutanic terpene, spiro- and polycyclic derivatives, etc.). For each product, the different disconnections are presented and the associated syntheses are analyzed step by step. The key reactions are described explicitly, followed by diagrams showing the range of impact of certain transformations. This set of data alone is conducive to understanding syntheses and indulging in this difficult, but worthwhile activity.
Book Synopsis Dissertation Abstracts International by :
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2002 with total page 684 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis American Doctoral Dissertations by :
Download or read book American Doctoral Dissertations written by and published by . This book was released on 2001 with total page 776 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Spirooxindole written by Gautam Patel and published by Elsevier. This book was released on 2024-06-12 with total page 660 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modern advances in organic synthesis require compouds having attractive properties with high percentage of yield. Spirooxindole examines the current state of the art, recent progress and new challenges associated with the development of spirooxindole derivatives for various medicinal applications. Owing to their exceptional properties, these compounds can be used in vaious fields, including chemical and pharma industries, and in clinical research. This book has chapters written by experts in several different areas. It serves as a useful reference book for scientists, industrial practitioners, graduate students, and other professionals in the field of hetrocyclic chemistry, medicinal chemistry, organic synthesis clinical research and chemical sciences.The growing interest among the academics and industrial researchers in the field of organic chemistry and medicinal chemistry is the driving force for the presentation of this edited book. - Consolidates information on each aspect of this novel compound and its applications in various fields, covering the entire spectrum of up-to-date literature citations, current market, and patents - Provides a comprehensive, in-depth description of spirooxindole derivatives as well as multipurpose scaffolds - Highlights green synthesis and nanocatalysis - Describes in-depth various medicinal applications - Covers both synthesis and applications
Book Synopsis The Formation of Quaternary, Aromatic SP2-Sp3 Carbon Centers and Tertiary Nitrogen Centers Mediated by Organolead Reagents by : Gregory Ian Elliott
Download or read book The Formation of Quaternary, Aromatic SP2-Sp3 Carbon Centers and Tertiary Nitrogen Centers Mediated by Organolead Reagents written by Gregory Ian Elliott and published by . This book was released on 2001 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Development of a Method for Rhodium-catalyzed Olefin Aziridination and Its Application to Synthesis of the Welwitindolinones by : Kiran Guthikonda
Download or read book The Development of a Method for Rhodium-catalyzed Olefin Aziridination and Its Application to Synthesis of the Welwitindolinones written by Kiran Guthikonda and published by . This book was released on 2008 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cancer Research Program Annual Report to the California State Legislature ... by : Cancer Research Program (Calif.)
Download or read book Cancer Research Program Annual Report to the California State Legislature ... written by Cancer Research Program (Calif.) and published by . This book was released on 2000 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cascade Biocatalysis by : Sergio Riva
Download or read book Cascade Biocatalysis written by Sergio Riva and published by John Wiley & Sons. This book was released on 2014-06-23 with total page 587 pages. Available in PDF, EPUB and Kindle. Book excerpt: This ready reference presents environmentally friendly and stereoselective methods of modern biocatalysis. The experienced and renowned team of editors have gathered top international authors for this book. They cover such emerging topics as chemoenzymatic methods and multistep enzymatic reactions, while showing how these novel methods and concepts can be used for practical applications. Multidisciplinary topics, including directed evolution, dynamic kinetic resolution, and continuous-flow methodology are also discussed. From the contents: * Directed Evolution of Ligninolytic Oxidoreductases: from Functional Expression to Stabilization and Beyond * New Trends in the In Situ Enzymatic Recycling of NAD(P)(H) Cofactors * Monooxygenase-Catalyzed Redox Cascade Biotransformations * Biocatalytic Redox Cascades Involving w-Transaminases * Multi-Enzyme Systems and Cascade Reactions Involving Cytochrome P450 Monooxygenases * Chemo-Enzymatic Cascade Reactions for the Synthesis of Glycoconjugates * Synergies of Chemistry and Biochemistry for the Production of Beta-Amino Acids * Racemizable Acyl Donors for Enzymatic Dynamic Kinetic Resolution * Stereoselective Hydrolase-Catalyzed Processes in Continuous-Flow Mode * Perspectives on Multienzyme Process Technology * Nitrile Converting Enzymes Involved in Natural and Synthetic Cascade Reactions * Mining Genomes for Nitrilases * Key-Study on the Kinetic Aspects of the In-Situ NHase/AMase Cascade System of M. imperiale Resting Cells for Nitrile Bioconversion * Enzymatic Stereoselective Synthesis of Beta-Amino Acids * New Applications of Transketolase: Cascade Reactions for Assay Development * Aldolases as Catalyst for the Synthesis of Carbohydrates and Analogs * Enzymatic Generation of Sialoconjugate Diversity * Methyltransferases in Biocatalysis * Chemoenzymatic Multistep One-Pot Processes
