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Probiotics In The Prevention And Management Of Human Diseases
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Book Synopsis Probiotics in The Prevention and Management of Human Diseases by : Mitesh Kumar Dwivedi
Download or read book Probiotics in The Prevention and Management of Human Diseases written by Mitesh Kumar Dwivedi and published by Academic Press. This book was released on 2021-12-02 with total page 531 pages. Available in PDF, EPUB and Kindle. Book excerpt: Probiotics in The Prevention and Management of Human Diseases: A Scientific Perspective addresses the use of probiotics and their mechanistic aspects in diverse human diseases. In particular, the mechanistic aspects of how these probiotics are involved in mitigating disease symptoms (novel approaches and immune-mechanisms induced by Probiotics), clinical trials of certain probiotics, and animal model studies will be presented through this book. In addition, the book covers the role of probiotics in prevention and management aspects of crucial human diseases, including multidrug resistant infections, hospital acquired infections, allergic conditions, autoimmune diseases, metabolic disorders, gastrointestinal diseases, neurological disorders, and cancers. Finally, the book addresses the use of probiotics as vaccine adjuvants and as a solution for nutritional health problems and describes the challenges of using probiotics in management of human disease conditions as well as their biosafety concerns. Intended for nutrition researchers, microbiologists, physiologists, and researchers in related disciplines as well as students studying these topics require a resource that addresses the specific role of probiotics in the prevention and management of human disease. Contains information on the use of probiotics in significant human diseases, including antibiotic resistant microbial infections Presents novel applications of probiotics, including their use in vaccine adjuvants and concept of pharmabiotics Includes case studies and human clinical trials for probiotics in diverse disease conditions and explores the role of probiotics in mitigation of the symptoms of disease
Book Synopsis Probiotics for Human Nutrition in Health and Disease by : Evandro Leite de Souza
Download or read book Probiotics for Human Nutrition in Health and Disease written by Evandro Leite de Souza and published by Academic Press. This book was released on 2022-06-15 with total page 614 pages. Available in PDF, EPUB and Kindle. Book excerpt: Probiotics for Human Nutrition in Health and Disease provides a comprehensive resource of information on traditional and emerging health concepts and the development and application evolution of probiotics and their role in prevention and treatment of human metabolic disorders and illnesses. Key issues related to the general aspects of probiotics, probiotics in human nutrition, and probiotics in human health promotion and disease treatment are described and discussed. Sections discuss general features of probiotics, such as relationships with prebiotics, probiotics in human nutrition, including pregnancy, lactation, in children, and in the elderly, and the role of probiotics in human health and disease treatment. This book provides the most significant knowledge, mechanistic bases, uses, clinical perceptions, case studies and perspectives about probiotics for humans, considering possibilities and limitations in light of the appropriate available reference materials. Written by highly qualified researchers and edited by a team of experts, each chapter summarizes the latest available information on probiotics in human health and critically interprets the most significant evidence by applying the author’s own practical experience from investigations with probiotics. Present traditional and emerging concepts, developments and the evolution of probiotics Provides key insights that characterize probiotics as promising and innovative options for human nutrition Discusses how probiotics can be used in a perspective of health promotion and prevention and treatment of human metabolic disorders and illnesses
Author :Alfredo Guarino Publisher :Karger Medical and Scientific Publishers ISBN 13 :3318023248 Total Pages :216 pages Book Rating :4.3/5 (18 download)
Book Synopsis Probiotic Bacteria and Their Effect on Human Health and Well-Being by : Alfredo Guarino
Download or read book Probiotic Bacteria and Their Effect on Human Health and Well-Being written by Alfredo Guarino and published by Karger Medical and Scientific Publishers. This book was released on 2013 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: An update on intestinal microbiota and probiotics Our microflora is an individual personal feature, providing a distinct tag to individuals. However, our intestinal microbiome is strongly affected by genetic, nutritional, and other external factors, and evolves with age. An effect of different microbial patterns on health appears very likely as there seem to be specific changes of intestinal microflora associated with various diseases. Specific microbial tags may thus be used as biomarkers of disease: to diagnose it, to monitor its evolution, and eventually to predict its response to treatment. This scenario opens the opportunity for targeting intestinal microflora using probiotics, both for prevention and treatment of an increasing number of conditions. Probiotic therapy is applied either as an adjunct to other treatments or as primary therapy, and evidence of efficacy is accumulating in several conditions, affecting either the intestine or nonintestinal organs. This publication provides an update on probiotics directed at physicians, biologists, biotechnologists, and researchers working in the food industry and agriculture, as well as in the environmental and basic sciences.
Book Synopsis Prebiotics and Probiotics in Disease Regulation and Management by : Rajesh Kumar Kesharwani
Download or read book Prebiotics and Probiotics in Disease Regulation and Management written by Rajesh Kumar Kesharwani and published by John Wiley & Sons. This book was released on 2022-09-02 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: PREBIOTICS AND PROBIOTICS IN DISEASE REGULATION AND MANAGEMENT The book covers all the emerging technologies and the challenges related to the synthesis and application of prebiotics and probiotics including the recent developments in the delivery of prebiotics, probiotics for the treatment of various diseases, the immune-boosting activity of the emerging prebiotics and probiotic ingredients, and the anti-cancer and anti-tumor potential The demand for biobased products is increasing enormously, among which are prebiotic oligosaccharides and probiotics, which occupy a major share of the food industry. Even though the majority of agro waste is currently being used for the production of 2G biofuels, agro waste such as citrus peel, sugar beet pulp, copra meal, and wheat husk can be considered for the production of prebiotic oligosaccharides. Prebiotics are dietary fibers that are selectively fermented by the microbes present in the gut and promote the growth of beneficial bacteria in the intestine and regulate the growth of harmful bacteria. The book highlights the importance of nutraceuticals (prebiotics, and probiotics) in maintaining gut homeostasis, prevention, and treatment of gut-related disorders, as anti-cancer agents, immune-modulatory agents, and treatment of metabolic disorders. It brings out the current challenges involved in the formulation and development of nutraceuticals, together with the application of nanotechnology and bioinformatics-based approaches to study the effect of nutraceuticals on oral health, and gut microflora in a very precise way. Audience The book will be read by food scientists and biotechnologists, as well as researchers in nutraceuticals and food processing research companies, nutraceutical/supplement product developers, and those in pharmaceutical companies.
Book Synopsis The Role of Probiotics for the Prevention and Treatment of Infectious Disease by : Nasia Safdar
Download or read book The Role of Probiotics for the Prevention and Treatment of Infectious Disease written by Nasia Safdar and published by . This book was released on 2009 with total page 64 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Probiotics, Prebiotics, and Synbiotics by : Ronald Ross Watson
Download or read book Probiotics, Prebiotics, and Synbiotics written by Ronald Ross Watson and published by Academic Press. This book was released on 2015-09-23 with total page 938 pages. Available in PDF, EPUB and Kindle. Book excerpt: Probiotics, Prebiotics, and Synbiotics: Bioactive Foods in Health Promotion reviews and presents new hypotheses and conclusions on the effects of different bioactive components of probiotics, prebiotics, and synbiotics to prevent disease and improve the health of various populations. Experts define and support the actions of bacteria; bacteria modified bioflavonoids and prebiotic fibrous materials and vegetable compounds. A major emphasis is placed on the health-promoting activities and bioactive components of probiotic bacteria. Offers a novel focus on synbiotics, carefully designed prebiotics probiotics combinations to help design functional food and nutraceutical products Discusses how prebiotics and probiotics are complementary and can be incorporated into food products and used as alternative medicines Defines the variety of applications of probiotics in health and disease resistance and provides key insights into how gut flora are modified by specific food materials Includes valuable information on how prebiotics are important sources of micro-and macronutrients that modify body functions
Book Synopsis The Role of Probiotics, Postbiotics, and Microbial Metabolites in Preventing and Treating Chronic Diseases by : Tingtao Chen
Download or read book The Role of Probiotics, Postbiotics, and Microbial Metabolites in Preventing and Treating Chronic Diseases written by Tingtao Chen and published by Frontiers Media SA. This book was released on 2023-07-31 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic conditions, such as cardiovascular diseases and diabetes, are now among the greatest threats to human health. As public concerns with complex causality and long development period, chronic diseases generally cannot be cured by medication or prevented by vaccines. Finding new strategies to prevent or treat chronic diseases has long been a challenge to science. Recently, a series of breakthrough studies in intestinal biology, especially in the fields of the gut microbiota, has made us pay close attention to the critical role of intestinal function in chronic disease treatment. Emerging evidence suggests that the gut microbiota could affect the occurrence, diagnosis, and treatment of human conditions, resulting in gut microbiota intervention as a new therapeutic strategy for chronic disorders. However, investigating the intrinsic relation between the gut microbiome and chronic conditions is still in development and requires intense concentration, although the wave of research on the gut microbiome has continued growing and the associated innovations are evolving rapidly. Moreover, translational research on the human microbiome is gaining attention nowadays. Probiotics and their engineered strains, postbiotics, microbial metabolites, prebiotics, microbiota transplantation, and microbiota-targeted interventions are practical approaches to modulating the microbiome. Probiotics, postbiotics, and microbial metabolites are one of the most important and effective interventions. As for disease prevention and treatment, some microbiota-associated live biotherapeutic products (e.g., Akkermansia muciniphila) have been demonstrated with respectable efficacy for human disorders, including diabetes. As for the food nutrition community, supplement with probiotics or prebiotics in diet shows health-promoting benefits for the human being. Collectively, these results inspire us to explore more effective strains to prevent or treat human conditions such as chronic diseases. Undoubtedly, exploring the human-associated microbiota provides a novel perspective for unlocking life’s mystery and unraveling the underlying basic pathogenesis of diseases such as chronic conditions. Targeting microbiota through probiotics, postbiotics, microbial metabolites, prebiotics, microbiota transplantation, and other interventions can generate new therapeutic strategies for chronic disorders in humans. Therefore, this research topic aims to explore the beneficial effects of novel probiotics, postbiotics, and microbial metabolites on chronic diseases, determine the critical role that the human microbiome and probiotics or postbiotics play in chronic conditions changes, determine the basic principles of translational research on probiotics or postbiotics or microbial metabolites and contribute to the prevention and treatment of chronic disorders. We welcome submissions including original research articles, clinical studies, and reviews that contribute innovative knowledge to the following but not limited to potential research topics: •Identification of functional probiotics, postbiotics, and microbial metabolites with human health-promoting, chronic disease prevention and therapeutic properties. •Probiotics/postbiotics or microbial metabolites supplements prevent and treat several most prevalent chronic conditions including cardiovascular diseases, diabetes mellitus, mental disorders, cancers, and pulmonary conditions. •Clinical and experimental studies using multi-omics to reveal the intrinsic relationship between human microbes/microbiota and chronic diseases. •Translational microbiome research on chronic diseases. •The engineered probiotics for the prevention and treatment of chronic diseases, especially related studies involved in exploring the potential molecular mechanisms of engineering microbes. •The key technologies involved in the industrialization process of probiotics, postbiotics, and microbial metabolites.
Book Synopsis Prebiotics, Probiotics and Nutraceuticals by : Kambaska Kumar Behera
Download or read book Prebiotics, Probiotics and Nutraceuticals written by Kambaska Kumar Behera and published by Springer Nature. This book was released on 2022-06-06 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book titled ‘Prebiotics, Probiotics and Nutraceuticals’ is expected to direct many emerging research pathwaysneed at local and global levels for nutrition and food supplements for developing immunity for healthy life. This volume incorporates sixteen seminal papers on issue based research and their practical applications covering latest information and progress on different area of nutritional supplement research fight against disease. The book highlights the frontier issues and applications in nutritional biotechnology with wide coverage of the themes like Potentiality of Probiotics in Inactivation of Tetrodotoxin, Therapeutic Strategy for the Deterrence of COVID-19 with Relevance to Probiotics and Prospectives of Prebiotics, Probiotics and Synbiotics for Sustainable Development in Aquaculture.Plant based Bioactive compounds in Cancer Therapeutics, Recent Trends in Natural Medicines and Nutraceuticals Research, Probiotics as efficacious therapeutic option for treating gut-related diseases: molecular and immune-biological perspectives, The progressive development of probiotics, prebiotics, synbiotics research, and its multipurpose use in the ornamental fishery, The commercial perspective of probiotics, and bioremediating components in aquaculture pond management: A Case Study andPrebiotics as promising therapeutics for treating gut-related disorders : Biochemical and Molecular Perspectives. Prebiotics and Probiotics as Functional Foods: Prospect and Promises in Metabolic Diseases, Implications of probiotics and prebiotics on immune functions. Recent Trends in Natural Medicines and Nutraceuticals Research, Nutraceuticals are alternative to modern medicines, Socio-Economic Study of Prospective of probiotic, prebiotic and synbiotic for sustainable development of aquaculture in Indian Sunderban. This book will be very useful for the scholars, biotechnologists, agricultural scientists, nutritionist, medical doctors, researchers, teachers and students in the emerging field of biotechnology.
Book Synopsis Probiotics and Child Gastrointestinal Health by : Stefano Guandalini
Download or read book Probiotics and Child Gastrointestinal Health written by Stefano Guandalini and published by Springer. This book was released on 2019-06-17 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book shows the huge impact the gut microbiota has on the gastrointestinal health of humans with a particular focus on children. It also highlights the potential use of probiotic microorganisms to protect or improve children’s gastrointestinal health. Humans are not single organisms: We are a multi-organism structure composed of ourselves and our microbiota, living in close symbiosis since birth and even before. The huge impact that the billons of microscopic cells living in our gut have on our gastrointestinal and systemic health cannot be overestimated. The enormous progress that has been made in the past decade in our still very incomplete understanding of the gut microbiota is opening the door to potential applications in human health that were simply unthinkable before. One of the most interesting aspects of this new scientific horizon is the fact that we may identify (or even create in the laboratory) and utilize many of these “friendly bacteria” to protect, or improve our health. Thus, strains of probiotic microorganisms are being identified and studied in a vast array of clinical scenarios. Among the most investigated areas for probiotics is the gastrointestinal health of children. The topics addressed in this book are spanning from the development of the gut microbiota in the fetus and newborn all the way to current and potential applications in disparate conditions such as necrotizing enterocolitis, or infectious, or inflammatory conditions affecting the child. The book is written in a rigorous, evidence based manner by an international group of outstanding experts in these fields and is aimed at pediatric gastroenterologists, pediatricians and physician scientists alike.
Download or read book Prebiotics and Probiotics written by and published by BoD – Books on Demand. This book was released on 2020-03-04 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Probiotic bacteria are found in the intestinal microbiota of the host and favor multiple metabolic reactions. Prebiotics provide food for probiotic bacteria and have an effect on their own performance in favor of host health. Numerous metabolic and immunological mechanisms are involved in its effects. Probiotics have been studied for several decades and their use for human consumption is still unclear. However, new types of molecules with prebiotic functions and components of probiotic bacteria with therapeutic potential are still being studied. The versatility of these molecules makes their incorporation into human food and animal diets feasible. This book is a compendium of recent scientific information on the use of probiotics and prebiotics for the benefit of human and animal health.
Book Synopsis Lactic Acid Bacteria: Genetics, Metabolism and Applications by : Roland J. Siezen
Download or read book Lactic Acid Bacteria: Genetics, Metabolism and Applications written by Roland J. Siezen and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: Foods fermented with lactic acid bacteria are an important part of the human diet. Lactic acid bacteria play an essential role in the preservation of food raw materials and contribute to the nutritional, organoleptic, and health properties of food products and animal feed. The importance of lactic acid bacteria in the production of foods throughout the world has resulted in a continued scientific interest in these micro-organisms over the last two decades by academic research groups as well as by industry. This research has resulted in a number of important scientific breakthroughs and has led to new applications. The most recent of these advances is the establishment of the complete genome sequences of a number of different lactic acid bacterial species. To communicate and stimulate the research on lactic acid bacteria and their applications, a series of tri-annual symposia on lactic acid bacteria was started in 1983 under the auspices of the Netherlands Society for Microbiology (NVVM), which was later also supported by the Federation of European Microbiological Societies (FEMS). The aim of these state-of-the-art symposia is to offer a unique platform for universities, institutes, and industry in this area of biotechnology, to present recent work, to obtain information on new developments, and to exchange views with colleagues from all over the world on scientific progress and applications. The growing number of participants at these symposia has been a clear demonstration of the interest of the international industrial and scientific community in this area of research. The 7th Symposium is based on a number of plenary lectures that review the scientific progress of the last years in the different areas of research on lactic acid bacteria, and which are documented in this special issue of Antonie van Leeuwenhoek.
Book Synopsis Probiotics and Their Role in Health and Disease by : Yusuf Olsen
Download or read book Probiotics and Their Role in Health and Disease written by Yusuf Olsen and published by Nova Science Publishers. This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Probiotics are live microorganisms that, when consumed, can provide health benefits, generally by improving or restoring the gut flora. As probiotics have become increasingly popular in recent years, it is important for consumers and clinicians to understand the details of the potential health effects of these supplements. Chapter 1 focuses on the relationship between different types of milk, the growth of probiotics, and relevant characteristics regarding viability, the quality of the dairy product, and the production of undesirable components. Chapter 2 summarizes studies on the probiotic impact of functional foods on the immune system and analyzes the future of the probiotic functional food market. Chapter 3 describes pathways and mechanisms through which probiotics may improve hypothyroidism and its complications. Chapter 4 presents a literature review of intestinal microbiota and bone health and discusses the effectiveness of probiotics in the treatment and prevention of osteoporosis. Chapter 5 presents an FTIR analysis of protein/peptide-based biopolymers used for probiotic encapsulation. Lastly, Chapter 6 collates experimental studies on probiotics with ameliorative effects on arsenic toxicity"--
Book Synopsis Bugs as Drugs by : Robert A. Britton
Download or read book Bugs as Drugs written by Robert A. Britton and published by John Wiley & Sons. This book was released on 2020-07-02 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: Examining the enormous potential of microbiome manipulation to improve health Associations between the composition of the intestinal microbiome and many human diseases, including inflammatory bowel disease, cardiovascular disease, metabolic disorders, and cancer, have been elegantly described in the past decade. Now, whole-genome sequencing, bioinformatics, and precision gene-editing techniques are being combined with centuries-old therapies, such as fecal microbiota transplantation, to translate current research into new diagnostics and therapeutics to treat complex diseases. Bugs as Drugs provides a much-needed overview of microbes in therapies and will serve as an excellent resource for scientists and clinicians as they carry out research and clinical studies on investigating the roles the microbiota plays in health and disease. In Bugs as Drugs, editors Robert A. Britton and Patrice D. Cani have assembled a fascinating collection of reviews that chart the history, current efforts, and future prospects of using microorganisms to fight disease and improve health. Sections cover traditional uses of probiotics, next-generation microbial therapeutics, controlling infectious diseases, and indirect strategies for manipulating the host microbiome. Topics presented include: How well-established probiotics support and improve host health by improving the composition of the intestinal microbiota of the host and by modulating the host immune response. The use of gene editing and recombinant DNA techniques to create tailored probiotics and to characterize next-generation beneficial microbes. For example, engineering that improves the anti-inflammatory profile of probiotics can reduce the number of colonic polyps formed, and lactobacilli can be transformed into targeted delivery systems carrying therapeutic proteins or bioengineered bacteriophage. The association of specific microbiota composition with colorectal cancer, liver diseases, osteoporosis, and inflammatory bowel disease. The gut microbiota has been proposed to serve as an organ involved in regulation of inflammation, immune function, and energy homeostasis. Fecal microbiota transplantation as a promising treatment for numerous diseases beyond C. difficile infection. Practical considerations for using fecal microbiota transplantation are provided, while it is acknowledged that more high-quality evidence is needed to ascertain the importance of strain specificity in positive treatment outcomes. Because systems biology approaches and synthetic engineering of microbes are now high-throughput and cost-effective, a much wider range of therapeutic possibilities can be explored and vetted.
Download or read book Probiotics written by Min-Tze Liong and published by Springer Science & Business Media. This book was released on 2011-07-28 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: Probiotic microorganisms have a long history of use, and their health benefits for hosts are well documented. This Microbiology Monographs volume provides an overview of the current knowledge and applications of probiotics. Reviews cover the biology and probiotic potential of the thoroughly studied prokaryotic genera Lactobacillus and Bifidobacterium, several eukaryotic microorganisms, probiotic strain characterization, and the analytical methods (such as FISH, microarray, and high throughput sequencing) required for their study. Further chapters describe the positive effects of probiotics on malabsorption disorders such as diarrhea and lactose intolerance, and document the clinical evidence of benefits in treating allergies and lung emphysema, and in dermatological applications. Also addresses are topics such as genetically engineered strains, new carriers for probiotics, protection techniques, challenges of health claims, safety aspects, and future market trends.
Book Synopsis Probiotic Bacteria and Enteric Infections by : J.J. Malago
Download or read book Probiotic Bacteria and Enteric Infections written by J.J. Malago and published by Springer Science & Business Media. This book was released on 2011-01-20 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: Every day many people suffer from intestinal diseases. These disorders can result from pathogens like bacteria, fungi, parasites and viruses, but the causes of non-infectious intestinal disorders and colorectal cancers remain to be elucidated. Disturbances to the normal gut flora (the microbiota) are central to the development of many, if not all, of these disorders. Disturbed gut microbiota is a prelude to public health issues like traveller’s-, antibiotic- and Clostridium difficile-associated diarrhoea, irritable bowel syndrome, inflammatory bowel disease, and colorectal cancers. This book discusses the way intestinal disorders affect the microbiota, how the disturbed microbiotal balance leads to enteric disorders and the ways to prevent these disorders. Further his book explores the potential of probiotics (live microorganisms that when ingested bring a health benefit) in treating enteric disorders by analysing the probiotic genome through proteomics, metabolomics and functional assays. Discussed is how the ingestion of specific microorganisms repairs the disturbed microbiota and subsequently ameliorates enteric disorders. Finally this book addresses how genetic engineering and biotechnology will contribute to the development of effective and safe designer probiotics.
Book Synopsis Probiotic Research in Therapeutics by : Sandip V. Pawar
Download or read book Probiotic Research in Therapeutics written by Sandip V. Pawar and published by Springer Nature. This book was released on 2021-02-01 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt: In a normal physiological state, several bacteria are present in the human gut that is essential to maintain the normal to healthy gastrointestinal function. Disturbances in this “normal flora” lead to gut inflammation and infection. This volume explores the potential of probiotics, the healthy bacteria, to manage gut-related diseases including gastrointestinal cancers, ulcerative colitis, H. pylori infections, and diarrhea; vaginosis; oral health; airway inflammation; and atopic dermatitis. The concept of designer probiotics, edible vaccines and future scope of research in the field is also presented. The animal models used for studying the benefits of probiotics in gut inflammation are described for beginners.
Book Synopsis Probiotic Bacteria and Postbiotic Metabolites: Role in Animal and Human Health by : Naheed Mojgani
Download or read book Probiotic Bacteria and Postbiotic Metabolites: Role in Animal and Human Health written by Naheed Mojgani and published by Springer Nature. This book was released on 2021-05-13 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers all aspects of probiotic bacteria and their metabolites, as well as their role and significance in human and animal health. Given the role of probiotic bacterial strains in the production of short chain fatty acids, butyrate etc probiotics may be considered as an alternative approach for the prevention or treatment of intestinal dysbiosis, cancers, cardiovascular diseases, hypertensions. Additionally, the significance of probiotics added in aquaculture systems for improving health, performance and growth of aquatic organisms has been highlighted. In this book, the multi-functional role of probiotics and their post-biotic metabolites in improving overall health status of man and animals, is discussed. It is a comprehensive compilation useful for researchers, academics, veterinarians and students in the field of microbiology, food technology and biotechnology.
