Principles Of Animal Extrapolation 1991

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Principles of Animal Extrapolation (1991)

Author : Edward J. Calabrese
Publisher : CRC Press
ISBN 13 : 1351359037
Total Pages : 522 pages
Book Rating : 4.3/5 (513 download)

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Book Synopsis Principles of Animal Extrapolation (1991) by : Edward J. Calabrese

Download or read book Principles of Animal Extrapolation (1991) written by Edward J. Calabrese and published by CRC Press. This book was released on 2017-11-22 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles of Animal Extrapolation addresses the conceptual basis for animal extrapolation and provides an abundance of documentation that illustrates how these principles may be applied in the selection of the more appropriate models and in the interpretation of toxicological studies. The book analyzes and documents each specific biological cause of interspecies differences in susceptibility to toxic agents, including differences in absorption, gut flora, tissue distribution, metabolism, mechanisms and efficiencies of repair, and excretion. The problem of the heterogenicity of the human population is addressed through several chapters that assess the availability and prospects of developing predictive animal models for normal humans, as well as selected potential high-risk groups. Other topics presented in this book include the biological basis of regulatory actions involving attempts to extrapolate from exceptionally high exposure levels to realistic values, especially carcinogens; an assessment of genotoxicity tests, their ability to predict carcinogenicity in whole animals, and the manner in which they should be used by regulatory agencies; birth defects; and predicting the risk of human teratogenesis. Principle of Animal Extrapolation is essential for environmental toxicologists. It also provides valuable information to biomedical scientists (especially those involved in drug development and testing) and regulatory personnel in agencies such as the EPA, the OSHA, the NIOSH, and the FDA.

Specious Science

Author : C. Ray Greek
Publisher : A&C Black
ISBN 13 : 9780826413987
Total Pages : 308 pages
Book Rating : 4.4/5 (139 download)

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Book Synopsis Specious Science by : C. Ray Greek

Download or read book Specious Science written by C. Ray Greek and published by A&C Black. This book was released on 2002-01-01 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: Builds on the message of Sacred Cows and Golden Geese to understand why medical research on animals really harms humans.

Biologic Markers in Urinary Toxicology

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309052289
Total Pages : 322 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Biologic Markers in Urinary Toxicology by : National Research Council

Download or read book Biologic Markers in Urinary Toxicology written by National Research Council and published by National Academies Press. This book was released on 1995-08-28 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diseases of the kidney, bladder, and prostate exact an enormous human and economic toll on the population of the United States. This book examines prevention of these diseases through the development of reliable markers of susceptibility, exposure, and effect and the promise that new technologies in molecular biology and sophisticated understanding of metabolic pathways, along with classical approaches to the study of nephrotoxicants and carcinogens, can be developed and prevention of the diseases achieved. The specific recommendations included in this book complement those made in the previous three volumes on biomarkers, Biologic Markers in Reproductive Toxicology (1989), Biologic Markers in Pulmonary Toxicology (1989), and Biologic Markers in Immunotoxicology (1991).

Intentional Human Dosing Studies for EPA Regulatory Purposes

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309166411
Total Pages : 226 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Intentional Human Dosing Studies for EPA Regulatory Purposes by : National Research Council

Download or read book Intentional Human Dosing Studies for EPA Regulatory Purposes written by National Research Council and published by National Academies Press. This book was released on 2004-06-04 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: The EPA commissioned The National Academies to provide advice on the vexing question of whether and, if so, under what circumstances EPA should accept and consider intentional human dosing studies conducted by companies or other sources outside the agency (so-called third parties) to gather evidence relating to the risks of a chemical or the conditions under which exposure to it could be judged safe. This report recommends that such studies be conducted and used for regulatory purposes only if all of several strict conditions are met, including the following: The study is necessary and scientifically valid, meaning that it addresses an important regulatory question that can't be answered with animal studies or nondosing human studies; The societal benefits of the study outweigh any anticipated risks to participants. At no time, even when benefits beyond improved regulation exist, can a human dosing study be justified that is anticipated to cause lasting harm to study participants; and All recognized ethical standards and procedures for protecting the interests of study participants are observed. In addition, EPA should establish a Human Studies Review Board (HSRB) to evaluate all human dosing studiesâ€"both at the beginning and upon completion of the experimentsâ€"if they are carried out with the intent of affecting the agency's policy-making.

Philosophy of Medicine

Author : Fred Gifford
Publisher : Elsevier
ISBN 13 : 0444517871
Total Pages : 601 pages
Book Rating : 4.4/5 (445 download)

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Book Synopsis Philosophy of Medicine by : Fred Gifford

Download or read book Philosophy of Medicine written by Fred Gifford and published by Elsevier. This book was released on 2011-08-23 with total page 601 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers a wide range of conceptual, epistemological and methodological issues in the philosophy of science raised by reflection upon medical science and practice. Several chapters examine such general meta-scientific concepts as discovery, reduction, theories and models, causal inference and scientific realism as they apply to medicine or medical science in particular. Some discuss important concepts specific to medicine (diagnosis, health, disease, brain death). A topic such as evidence, for instance, is examined at a variety of levels, from social mechanisms for guiding evidence-based reasoning such as evidence-based medicine, consensus conferences, and clinical trials, to the more abstract analysis of experimentation, inference and uncertainty. Some chapters reflect on particular domains of medicine, including psychiatry, public health, and nursing. The contributions span a broad range of detailed cases from the science and practice of medicine, as well as a broad range of intellectual approaches, from conceptual analysis to detailed examinations of particular scientific papers or historical episodes. Chapters view philosophy of medicine from quite different angles Considers substantive cases from both medical science and practice Chapters from a distinguished array of contributors

Reference Manual on Scientific Evidence

Author :
Publisher :
ISBN 13 :
Total Pages : 652 pages
Book Rating : 4.:/5 (327 download)

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Book Synopsis Reference Manual on Scientific Evidence by :

Download or read book Reference Manual on Scientific Evidence written by and published by . This book was released on 1994 with total page 652 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Handbook of Laboratory Animal Science, Volume II

Author : Jann Hau
Publisher : CRC Press
ISBN 13 : 1420084585
Total Pages : 469 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Handbook of Laboratory Animal Science, Volume II by : Jann Hau

Download or read book Handbook of Laboratory Animal Science, Volume II written by Jann Hau and published by CRC Press. This book was released on 2011-04-22 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomedical research involving animals remains essential for the advancement of the medical, veterinary, agricultural, and biological sciences. Following in the footsteps of its predecessors, the Handbook of Laboratory Animal Science, Volume II, Third Edition: Animal Models explains in great detail the comparative considerations underlying the choic

Handbook of Laboratory Animal Science

Author : Jann Hau
Publisher : CRC Press
ISBN 13 : 1420040928
Total Pages : 280 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Handbook of Laboratory Animal Science by : Jann Hau

Download or read book Handbook of Laboratory Animal Science written by Jann Hau and published by CRC Press. This book was released on 2002-12-26 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: The conservative nature of animal evolution makes animal models the ideal tool for learning about human biology. The Handbook of Laboratory Animal Science, Second Edition: Animal Models, Volume II addresses the development and application of models in different areas of biomedical research and details the criteria used to choose animal species and

Encyclopedia of Animal Rights and Animal Welfare

Author : Marc Bekoff
Publisher : Routledge
ISBN 13 : 1135930023
Total Pages : 470 pages
Book Rating : 4.1/5 (359 download)

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Book Synopsis Encyclopedia of Animal Rights and Animal Welfare by : Marc Bekoff

Download or read book Encyclopedia of Animal Rights and Animal Welfare written by Marc Bekoff and published by Routledge. This book was released on 2013-12-16 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human beings' responsibility to and for their fellow animals has become an increasingly controversial subject. This book provides a provocative overview of the many different perspectives on the issues of animal rights and animal welfare in an easy-to-use encyclopedic format. Original contributions, from over 125 well-known philosophers, biologists, and psychologists in this field, create a well-balanced and multi-disciplinary work. Users will be able to examine critically the varied angles and arguments and gain a better understanding of the history and development of animal rights and animal protectionist movements around the world. Outstanding Reference Source Best Reference Source

Resources and References

Author : Donna S. Kocurek
Publisher : Elsevier
ISBN 13 : 0815518889
Total Pages : 303 pages
Book Rating : 4.8/5 (155 download)

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Book Synopsis Resources and References by : Donna S. Kocurek

Download or read book Resources and References written by Donna S. Kocurek and published by Elsevier. This book was released on 1995-12-31 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: This guide book provides references and resources for the complex field of hazardous waste and hazardous materials management. The book is divided into general topics such as air quality, industrial wastewater, pollution prevention, and risk assessment under hazardous waste management and chemical hazards, emergency planning, and hazard communication under hazardous materials management. Each individual section includes a list of annotated bibliographies of the most recent books by major publishers as well as established, standard references. Following the annotated titles, are additional references of books and documents by publishers, technical associations, and governmental agencies (primarily the U.S. Environmental Protection Agency). In general, only references from 1986 onward are included since the technology and regulations affecting hazardous waste and materials are constantly evolving. Additional resources included in the book are video tapes for training and instruction, information services and databases, libraries, agency contacts, technical journals, and a list of publishers and ordering information. This book will be a useful reference to professionals in the environmental field who need an extensive, but concise source of technical information and contacts. The book will be a valuable addition to individual libraries and will fill a current reference void in university libraries, and technical libraries in industry and government. At present there are very few technical bibliographies in the field, and none has covered topics related to hazardous materials and hazardous waste as extensively as this book.

Basic Concepts of Industrial Hygiene

Author : RonaldM. Scott
Publisher : Routledge
ISBN 13 : 1351464698
Total Pages : 496 pages
Book Rating : 4.3/5 (514 download)

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Book Synopsis Basic Concepts of Industrial Hygiene by : RonaldM. Scott

Download or read book Basic Concepts of Industrial Hygiene written by RonaldM. Scott and published by Routledge. This book was released on 2018-05-03 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basic Concepts of Industrial Hygiene covers the latest and most important topics in industrial hygiene today. The textbook begins with a look at the history and basis for industrial hygiene, which provides students with a foundation for understanding later developments. The book contains an in-depth discussion of new OSHA regulations, such as HAZWOPER and Process Safety, which deal with high hazard situations. It also features a chapter on biological hazards of current concern in health care, including tuberculosis, AIDS, and hepatitis B.

Preclinical Development Handbook

Author : Shayne Cox Gad
Publisher : John Wiley & Sons
ISBN 13 : 0470248475
Total Pages : 1346 pages
Book Rating : 4.4/5 (72 download)

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Book Synopsis Preclinical Development Handbook by : Shayne Cox Gad

Download or read book Preclinical Development Handbook written by Shayne Cox Gad and published by John Wiley & Sons. This book was released on 2008-03-14 with total page 1346 pages. Available in PDF, EPUB and Kindle. Book excerpt: A clear, straightforward resource to guide you through preclinical drug development Following this book's step-by-step guidance, you can successfully initiate and complete critical phases of preclinical drug development. The book serves as a basic, comprehensive reference to prioritizing and optimizing leads, dose formulation, ADME, pharmacokinetics, modeling, and regulations. This authoritative, easy-to-use resource covers all the issues that need to be considered and provides detailed instructions for current methods and techniques. Each chapter is written by one or more leading experts in the field. These authors, representing the many disciplines involved in preclinical toxicology screening and testing, give you the tools needed to apply an effective multidisciplinary approach. The editor has carefully reviewed all the chapters to ensure that each one is thorough, accurate, and clear. Among the key topics covered are: * Modeling and informatics in drug design * Bioanalytical chemistry * Absorption of drugs after oral administration * Transporter interactions in the ADME pathway of drugs * Metabolism kinetics * Mechanisms and consequences of drug-drug interactions Each chapter offers a full exploration of problems that may be encountered and their solutions. The authors also set forth the limitations of various methods and techniques used in determining the safety and efficacy of a drug during the preclinical stage. This publication should be readily accessible to all pharmaceutical scientists involved in preclinical testing, enabling them to perform and document preclinical safety tests to meet all FDA requirements before clinical trials may begin.

Veterinary Epidemiology

Author : Michael Thrusfield
Publisher : John Wiley & Sons
ISBN 13 : 1118280261
Total Pages : 888 pages
Book Rating : 4.1/5 (182 download)

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Book Synopsis Veterinary Epidemiology by : Michael Thrusfield

Download or read book Veterinary Epidemiology written by Michael Thrusfield and published by John Wiley & Sons. This book was released on 2018-02-15 with total page 888 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive introduction to the role of epidemiology in veterinary medicine This fully revised and expanded edition of Veterinary Epidemiology introduces readers to the field of veterinary epidemiology. The new edition also adds new chapters on the design of observational studies, validity in epidemiological studies, systematic reviews, and statistical modelling, to deliver more advanced material. This updated edition begins by offering an historical perspective on the development of veterinary medicine. It then addresses the full scope of epidemiology, with chapters covering causality, disease occurrence, determinants, disease patterns, disease ecology, and much more. Veterinary Epidemiology, Fourth Edition: ● Features updates of all chapters to provide a current resource on the subject of veterinary epidemiology ● Presents new chapters essential to the continued advancement of the field ● Includes examples from companion animal, livestock, and avian medicine, as well as aquatic animal diseases ● Focuses on the principles and concepts of epidemiology, surveillance, and diagnostic-test validation and performance ● Includes access to a companion website providing multiple choice questions Veterinary Epidemiology is an invaluable reference for veterinary general practitioners, government veterinarians, agricultural economists, and members of other disciplines interested in animal disease. It is also essential reading for epidemiology students at both the undergraduate and postgraduate levels.

Handbook of Toxicology, Third Edition

Author : Michael J. Derelanko
Publisher : CRC Press
ISBN 13 : 1439890137
Total Pages : 1027 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Handbook of Toxicology, Third Edition by : Michael J. Derelanko

Download or read book Handbook of Toxicology, Third Edition written by Michael J. Derelanko and published by CRC Press. This book was released on 2014-03-07 with total page 1027 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Handbook of Toxicology, Third Edition provides an updated practical reference source for practicing toxicologists in the pharmaceutical and chemical industries, contract laboratories, regulatory agencies, and academia. Written by experts in their specific toxicology fields, the chapters provide both fundamental and applied information. Topics range from General Toxicology, to Genetic Toxicology, Human Clinical Toxicology, Histopathology, Clinical Pathology, Metabolism and Toxicokinetics, Risk Assessment, and more. New to this edition: Completely rewritten chapters covering immunotoxicology, endocrine toxicology, and reproductive and developmental toxicology, providing a fresh perspective on these topics Addition of new chapters on Chemical Toxicology, Pharmaceutical Toxicology, Juvenile Toxicology, and Safety Pharmacology Updated information dealing with Inhalation Toxicology, Neurotoxicology, and Regulatory Toxicology, which has been consolidated into single chapters for each specialty A separate glossary with toxicological terms presented both alphabetically and by toxicological subspecialty For nearly 20 years, this handbook has remained the only reference book of its kind, designed to facilitate easy access to information related to the various toxicology specialties. This updated edition of a popular reference book reflects current practices and the state of the science of toxicology.

Animal Experimentation

Author : Kathrin Herrmann
Publisher :
ISBN 13 : 9789004356184
Total Pages : 0 pages
Book Rating : 4.3/5 (561 download)

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Book Synopsis Animal Experimentation by : Kathrin Herrmann

Download or read book Animal Experimentation written by Kathrin Herrmann and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Animal Experimentation: Working Towards a Paradigm Change critically appraises current animal use in science and discusses ways in which we can contribute to a paradigm change towards human-biology based approaches.

Xenobiotics in Fish

Author : D.J. Smith
Publisher : Springer Science & Business Media
ISBN 13 : 1461547032
Total Pages : 226 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Xenobiotics in Fish by : D.J. Smith

Download or read book Xenobiotics in Fish written by D.J. Smith and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aquaculture is rapidly becoming a major source of fish protein used to meet the nutritional needs of humans. As the aquaculture industry grows, exposure of farmed fish to environmental contaminants, and the need for chemical therapeutic agents for fish, will increase. This book is designed to bring together authorities worldwide on the regulation of environmental contaminants and food chemicals and researchers investigating the metabolism and disposition of foreign chemicals (xenobiotics) in fish species.

Veterinary Pharmacology and Therapeutics

Author : Jim E. Riviere
Publisher : John Wiley & Sons
ISBN 13 : 1118685903
Total Pages : 1541 pages
Book Rating : 4.1/5 (186 download)

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Book Synopsis Veterinary Pharmacology and Therapeutics by : Jim E. Riviere

Download or read book Veterinary Pharmacology and Therapeutics written by Jim E. Riviere and published by John Wiley & Sons. This book was released on 2013-05-13 with total page 1541 pages. Available in PDF, EPUB and Kindle. Book excerpt: Veterinary Pharmacology and Therapeutics, Ninth Edition is the long awaited update of the gold-standard reference on veterinary pharmacology and therapeutics. The field of veterinary pharmacology continues to evolve and expand and this new edition has been revised to reflect changes in the field. Veterinary Pharmacology and Therapeutics, Ninth Edition is thoroughly revised, updated, and expanded to meet the needs of today’s veterinarians, veterinary students, and animal health researchers.