Principles And Applications Of Clinical Mass Spectrometry

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Principles and Applications of Clinical Mass Spectrometry

Author : Nader Rifai
Publisher : Elsevier
ISBN 13 : 0128160640
Total Pages : 216 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Principles and Applications of Clinical Mass Spectrometry by : Nader Rifai

Download or read book Principles and Applications of Clinical Mass Spectrometry written by Nader Rifai and published by Elsevier. This book was released on 2018-06-26 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles and Applications of Clinical Mass Spectrometry: Small Molecules, Peptides, and Pathogens is a concise resource for quick implementation of mass spectrometry methods in clinical laboratory work. Focusing on the practical use of these techniques, the first half of the book covers principles of chromatographic separations, principles and types of mass spectrometers, and sample preparation for analysis; the second half outlines the main applications of this technology within clinical laboratory settings, including determination of small molecules and peptides, as well as pathogen identification. A thorough yet succinct guide to using mass spectrometry technology in the clinical laboratory, Principles and Applications of Clinical Mass Spectrometry: Small Molecules, Peptides, and Pathogens is an essential resource for chemists, pharmaceutical and biotech researchers, certain government agencies, and standardization groups. Provides concrete examples of the main applications of mass spectrometry technology Describes current capabilities of the LC- and MS-based analytical methods Details methods for successful analytical work in the field

Medical Applications of Mass Spectrometry

Author : Karoly Vekey
Publisher : Elsevier
ISBN 13 : 0080554652
Total Pages : 606 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Medical Applications of Mass Spectrometry by : Karoly Vekey

Download or read book Medical Applications of Mass Spectrometry written by Karoly Vekey and published by Elsevier. This book was released on 2011-08-11 with total page 606 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mass spectrometry is fast becoming an indispensable field for medical professionals. The mass spectrometric analysis of metabolites and proteins promises to revolutionize medical research and clinical diagnostics. As this technology rapidly enters the medical field, practicing professionals and students need to prepare to take full advantage of its capabilities. Medical Applications of Mass Spectrometry addresses the key issues in the medical applications of mass spectrometry at the level appropriate for the intended readership. It will go a long way to help the utilization of mass spectrometry in medicine. The book comprises five parts. A general overview is followed by a description of the basic sampling and separation methods in analytical chemistry. In the second part a solid foundation in mass spectrometry and modern techniques of data analysis is presented. The third part explains how mass spectrometry is used in exploring various classes of biomolecules, including proteins and lipids. In the fourth section mass spectrometry is introduced as a diagnostic tool in clinical treatment, infectious pathogen research, neonatal diagnostics, cancer, brain and allergy research, as well as in various fields of medicine: cardiology, pulmonology, neurology, psychiatric diseases, hemato-oncology, urologic diseases, gastrointestinal diseases, gynecology and pediatrics. The fifth part covers emerging applications in biomarker discovery and in mass spectrometric imaging. * Provides a broad look at how the medical field is benefiting from advances in mass spectrometry. * Guides the reader from basic principles and methods to cutting edge applications. * There is NO comparable book on the market to fill this fast growing field.

Mass Spectrometry for the Clinical Laboratory

Author : Hari Nair
Publisher : Academic Press
ISBN 13 : 0128009926
Total Pages : 304 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Mass Spectrometry for the Clinical Laboratory by : Hari Nair

Download or read book Mass Spectrometry for the Clinical Laboratory written by Hari Nair and published by Academic Press. This book was released on 2016-11-02 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mass Spectrometry for the Clinical Laboratory is an accessible guide to mass spectrometry and the development, validation, and implementation of the most common assays seen in clinical labs. It provides readers with practical examples for assay development, and experimental design for validation to meet CLIA requirements, appropriate interference testing, measuring, validation of ion suppression/matrix effects, and quality control. These tools offer guidance on what type of instrumentation is optimal for each assay, what options are available, and the pros and cons of each. Readers will find a full set of tools that are either directly related to the assay they want to adopt or for an analogous assay they could use as an example. Written by expert users of the most common assays found in a clinical laboratory (clinical chemists, toxicologists, and clinical pathologists practicing mass spectrometry), the book lays out how experts in the field have chosen their mass spectrometers, purchased, installed, validated, and brought them on line for routine testing. The early chapters of the book covers what the practitioners have learned from years of experience, the challenges they have faced, and their recommendations on how to build and validate assays to avoid problems. These chapters also include recommendations for maintaining continuity of quality in testing. The later parts of the book focuses on specific types of assays (therapeutic drugs, Vitamin D, hormones, etc.). Each chapter in this section has been written by an expert practitioner of an assay that is currently running in his or her clinical lab. Provides readers with the keys to choosing, installing, and validating a mass spectrometry platform Offers tools to evaluate, validate, and troubleshoot the most common assays seen in clinical pathology labs Explains validation, ion suppression, interference testing, and quality control design to the detail that is required for implementation in the lab

Mass Spectrometry, An Issue of Clinics in Laboratory Medicine - E-Book

Author : Nigel Clarke
Publisher : Elsevier Health Sciences
ISBN 13 : 1455712019
Total Pages : 104 pages
Book Rating : 4.4/5 (557 download)

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Book Synopsis Mass Spectrometry, An Issue of Clinics in Laboratory Medicine - E-Book by : Nigel Clarke

Download or read book Mass Spectrometry, An Issue of Clinics in Laboratory Medicine - E-Book written by Nigel Clarke and published by Elsevier Health Sciences. This book was released on 2011-10-03 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Clinics in Laboratory Medicine, Guest Edited by Nigel Clarke, MD, and Andrew Hoofnagle, MD, will focus on Mass Spectrometry, with topics including: Proteins; Peptides; Small Molecules: Toxicology; Small Molecules: Diagnostics; and Regulatory Considerations.

Direct Analysis in Real Time Mass Spectrometry

Author : Yiyang Dong
Publisher : John Wiley & Sons
ISBN 13 : 3527341846
Total Pages : 370 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Direct Analysis in Real Time Mass Spectrometry by : Yiyang Dong

Download or read book Direct Analysis in Real Time Mass Spectrometry written by Yiyang Dong and published by John Wiley & Sons. This book was released on 2018-04-09 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clear, comprehensive, and state of the art, the groundbreaking book on the emerging technology of direct analysis in real time mass spectrometry Written by a noted expert in the field, Direct Analysis in Real Time Mass Spectrometry offers a review of the background and the most recent developments in DART-MS. Invented in 2005, DART-MS offers a wide range of applications for solving numerous analytical problems in various environments, including food science, forensics, and clinical analysis. The text presents an introduction to the history of the technology and includes information on the theoretical background, for exampleon the ionization mechanism. Chapters on sampling and coupling to different types of mass spectrometers are followed by a comprehensive discussion of a broad range of applications. Unlike most other ionization methods, DART does not require laborious sample preparation, as ionization takes place directly on the sample surface. This makes the technique especially attractive for applications in forensics and food science. Comprehensive in scope, this vital text: -Sets the standard on an important and emerging ionization technique -Thoroughly discusses all the relevant aspects from instrumentation to applications -Helps in solving numerous analytical problems in various applications, for example food science, forensics, environmental and clinical analysis -Covers mechanisms, coupling to mass spectrometers, and includes information on challenges and disadvantages of the technique Academics, analytical chemists, pharmaceutical chemists, clinical chemists, forensic scientists, and others will find this illuminating text a must-have resource for understanding the most recent developments in the field.

Clinical Applications of Mass Spectrometry

Author : Uttam Garg
Publisher : Humana Press
ISBN 13 : 9781607614586
Total Pages : 0 pages
Book Rating : 4.6/5 (145 download)

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Book Synopsis Clinical Applications of Mass Spectrometry by : Uttam Garg

Download or read book Clinical Applications of Mass Spectrometry written by Uttam Garg and published by Humana Press. This book was released on 2009-12-14 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: As mass spectrometric methods now offer a level of specificity and sensitivity unrealized by spectrophotometric- and immunoassay-based methods, mass spectrometry has entered the clinical laboratory where it is being used for a wide range of applications. In Clinical Applications of Mass Spectrometry: Methods and Protocols, expert researchers provide detailed step-by-step procedures for the analysis of number of analytes of clinical importance. This versatile and expansive volume covers mass spectrometry methods for analytes including a variety of drugs, hormones, and metabolic compounds spanning the disciplines of toxicology, therapeutic drug monitoring, endocrinology, and pediatric metabolism. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include brief introductions to the analytes, lists of the necessary materials and reagents, readily reproducible analytical protocols, and detailed notes on troubleshooting and avoiding known pitfalls. Comprehensive and dependable, Clinical Applications of Mass Spectrometry: Methods and Protocols offers its readers a wide array of valuable methods for experienced mass spectrometric labs that are looking to introduce new analyses as well as for those laboratories currently considering the addition of this resourceful and vital technology.

Introduction to Mass Spectrometry

Author : J. Throck Watson
Publisher : John Wiley & Sons
ISBN 13 : 1118681584
Total Pages : 972 pages
Book Rating : 4.1/5 (186 download)

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Book Synopsis Introduction to Mass Spectrometry by : J. Throck Watson

Download or read book Introduction to Mass Spectrometry written by J. Throck Watson and published by John Wiley & Sons. This book was released on 2013-07-09 with total page 972 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completely revised and updated, this text provides an easy-to-read guide to the concept of mass spectrometry and demonstrates its potential and limitations. Written by internationally recognised experts and utilising "real life" examples of analyses and applications, the book presents real cases of qualitative and quantitative applications of mass spectrometry. Unlike other mass spectrometry texts, this comprehensive reference provides systematic descriptions of the various types of mass analysers and ionisation, along with corresponding strategies for interpretation of data. The book concludes with a comprehensive 3000 references. This multi-disciplined text covers the fundamentals as well as recent advance in this topic, providing need-to-know information for researchers in many disciplines including pharmaceutical, environmental and biomedical analysis who are utilizing mass spectrometry

Mass spectrometry in the clinical laboratory : general principles and guidance ; approved guideline

Author : Donald H. Chace
Publisher :
ISBN 13 : 9781562386481
Total Pages : 97 pages
Book Rating : 4.3/5 (864 download)

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Book Synopsis Mass spectrometry in the clinical laboratory : general principles and guidance ; approved guideline by : Donald H. Chace

Download or read book Mass spectrometry in the clinical laboratory : general principles and guidance ; approved guideline written by Donald H. Chace and published by . This book was released on 2007 with total page 97 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Mass Spectrometry

Author : Edmond de Hoffmann
Publisher : Wiley
ISBN 13 : 9780471485650
Total Pages : 420 pages
Book Rating : 4.4/5 (856 download)

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Book Synopsis Mass Spectrometry by : Edmond de Hoffmann

Download or read book Mass Spectrometry written by Edmond de Hoffmann and published by Wiley. This book was released on 2001-10-10 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offers a complete overview of the principles, theories and key applications of modern mass spectrometry in this introductory textbook. Following on from the highly successful first edition, this edition is extensively updated including new techniques and applications. All instrumental aspects of mass spectrometry are clearly and concisely described; sources, analysers and detectors. * Revised and updated * Numerous examples and illustrations are combined with a series of exercises to help encourage student understanding * Includes biological applications, which have been significantly expanded and updated * Also includes coverage of ESI and MALDI

Handbook of GC-MS

Author : Hans-Joachim Hubschmann
Publisher : John Wiley & Sons
ISBN 13 : 3527334742
Total Pages : 884 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Handbook of GC-MS by : Hans-Joachim Hubschmann

Download or read book Handbook of GC-MS written by Hans-Joachim Hubschmann and published by John Wiley & Sons. This book was released on 2015-07-27 with total page 884 pages. Available in PDF, EPUB and Kindle. Book excerpt: The only comprehensive reference on this popular and rapidly developing technique provides a detailed overview, ranging from fundamentals to applications, including a section on the evaluation of GC-MS analyses. As such, it covers all aspects, including the theory and principles, as well as a broad range of real-life examples taken from laboratories in environmental, food, pharmaceutical and clinical analysis. It also features a glossary of approximately 300 terms and a substance index that facilitates finding a specific application. The first two editions were very well received, making this handbook a must-have in all analytical laboratories using GC-MS.

The Use of Mass Spectrometry Technology (MALDI-TOF) in Clinical Microbiology

Author : Fernando Cobo
Publisher : Academic Press
ISBN 13 : 0128144521
Total Pages : 298 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis The Use of Mass Spectrometry Technology (MALDI-TOF) in Clinical Microbiology by : Fernando Cobo

Download or read book The Use of Mass Spectrometry Technology (MALDI-TOF) in Clinical Microbiology written by Fernando Cobo and published by Academic Press. This book was released on 2018-08-03 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Use of Mass Spectrometry Technology (MALDI-TOF) in Clinical Microbiology presents the state-of the-art for MALDI-TOF mass spectrometry. It is a key reference defining how MALDI-TOF mass spectrometry is used in clinical settings as a diagnostic tool of microbial identification and characterization that is based on the detection of a mass of molecules. The book provides updated applications of MALDI-TOF techniques in clinical microbiology, presenting the latest information available on a technology that is now used for rapid microbial identification at relatively low cost, thus offering an alternative to conventional laboratory diagnosis and proteomic identification systems. Although the main use of the technology has, until now, been identification or typing of bacteria from a positive culture, applications in the field of virology, mycology, microbacteriology and resistances are opening up new opportunities. Presents updated applications of MALDI-TOF techniques in clinical microbiology Describes the use of mass spectrometry in the lab, the principles of the technology, preparation of samples, device calibration and maintenance, treatment of microorganisms, and quality control Presents key information for researchers, including possible uses of the technology, differences between devices, how to interpret results, and future applications Covers the topic in a systematic and comprehensive manner that is useful to both clinicians and researchers

Liquid Chromatography

Author : Salvatore Fanali
Publisher : Elsevier
ISBN 13 : 0128093447
Total Pages : 838 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Liquid Chromatography by : Salvatore Fanali

Download or read book Liquid Chromatography written by Salvatore Fanali and published by Elsevier. This book was released on 2017-06-23 with total page 838 pages. Available in PDF, EPUB and Kindle. Book excerpt: Liquid Chromatography: Applications, Second Edition,is a single source of authoritative information on all aspects of the practice of modern liquid chromatography. It gives those working in both academia and industry the opportunity to learn, refresh, and deepen their knowledge of the wide variety of applications in the field. In the years since the first edition was published, thousands of papers have been released on new achievements in liquid chromatography, including the development of new stationary phases, improvement of instrumentation, development of theory, and new applications in biomedicine, metabolomics, proteomics, foodomics, pharmaceuticals, and more. This second edition addresses these new developments with updated chapters from the most expert researchers in the field. Emphasizes the integration of chromatographic methods and sample preparation Explains how liquid chromatography is used in different industrial sectors Covers the most interesting and valuable applications in different fields, e.g., proteomic, metabolomics, foodomics, pollutants and contaminants, and drug analysis (forensic, toxicological, pharmaceutical, biomedical) Includes references and tables with commonly used data to facilitate research, practical work, comparison of results, and decision-making

Liquid Chromatography - Mass Spectrometry

Author : Robert E. Ardrey
Publisher : John Wiley & Sons
ISBN 13 : 0470862173
Total Pages : 296 pages
Book Rating : 4.4/5 (78 download)

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Book Synopsis Liquid Chromatography - Mass Spectrometry by : Robert E. Ardrey

Download or read book Liquid Chromatography - Mass Spectrometry written by Robert E. Ardrey and published by John Wiley & Sons. This book was released on 2003-07-25 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: First explaining the basic principles of liquid chromatography and mass spectrometry and then discussing the current applications and practical benefits of LC-MS, along with descriptions of the basic instrumentation, this title will prove to be the indispensable reference source for everyone wishing to use this increasingly important tandem technique. * First book to concentrate on principles of LC-MS * Explains principles of mass spectrometry and chromatography before moving on to LC-MS * Describes instrumental aspects of LC-MS * Discusses current applications of LC-MS and shows benefits of using this technique in practice

Current Practice of Gas Chromatography-Mass Spectrometry

Author : Wilfried M.A. Niessen
Publisher : CRC Press
ISBN 13 : 9781420029512
Total Pages : 530 pages
Book Rating : 4.0/5 (295 download)

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Book Synopsis Current Practice of Gas Chromatography-Mass Spectrometry by : Wilfried M.A. Niessen

Download or read book Current Practice of Gas Chromatography-Mass Spectrometry written by Wilfried M.A. Niessen and published by CRC Press. This book was released on 2001-04-04 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume details the principles and instrumentation of gas chromatography-mass spectrometry (CG-MS), and outlines industrial, environmental, pharmaceutical, clinical, toxicological, forensic and food-related applications, revealing findings from the laboratories of 40 contributing scientists around the world using GC-MS in practice. It describes upstream and downstream applications of GC-MS in the petroleum industry and identifies chlorinated compounds in the environment with quadrupole ion-trap technology and high-resolution sector instruments.

Liquid Chromatography-Mass Spectrometry

Author : Wilfried M.A. Niessen
Publisher : CRC Press
ISBN 13 : 1420014544
Total Pages : 629 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Liquid Chromatography-Mass Spectrometry by : Wilfried M.A. Niessen

Download or read book Liquid Chromatography-Mass Spectrometry written by Wilfried M.A. Niessen and published by CRC Press. This book was released on 2006-08-09 with total page 629 pages. Available in PDF, EPUB and Kindle. Book excerpt: A constructive evaluation of the most significant developments in liquid chromatography-mass spectrometry (LC-MS) and its uses for quantitative bioanalysis and characterization for a diverse range of disciplines, Liquid Chromatography-Mass Spectrometry, Third Edition offers a well-rounded coverage of the latest technological developments and

Mass Spectrometry

Author : Marek Smoluch
Publisher : John Wiley & Sons
ISBN 13 : 1119377307
Total Pages : 450 pages
Book Rating : 4.1/5 (193 download)

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Book Synopsis Mass Spectrometry by : Marek Smoluch

Download or read book Mass Spectrometry written by Marek Smoluch and published by John Wiley & Sons. This book was released on 2019-07-11 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a comprehensive description of mass spectrometry basics, applications, and perspectives Mass spectrometry is a modern analytical technique, allowing for fast and ultrasensitive detection and identification of chemical species. It can serve for analysis of narcotics, counterfeit medicines, components of explosives, but also in clinical chemistry, forensic research and anti-doping analysis, for identification of clinically relevant molecules as biomarkers of various diseases. This book describes everything readers need to know about mass spectrometry—from the instrumentation to the theory and applications. It looks at all aspects of mass spectrometry, including inorganic, organic, forensic, and biological MS (paying special attention to various methodologies and data interpretation). It also contains a list of key terms for easier and faster understanding of the material by newcomers to the subject and test questions to assist lecturers. Knowing how crucial it is for young researchers to fully understand both the power of mass spectrometry and the importance of other complementary methodologies, Mass Spectrometry: An Applied Approach teaches that it should be used in conjunction with other techniques such as NMR, pharmacological tests, structural identification, molecular biology, in order to reveal the true function(s) of the identified molecule. Provides a description of mass spectrometry basics, applications and perspectives of the technique Oriented to a broad audience with limited or basic knowledge in mass spectrometry instrumentation, theory, and its applications in order to enhance their competence in this field Covers all aspects of mass spectrometry, including inorganic, organic, forensic, and biological MS with special attention to application of various methodologies and data interpretation Includes a list of key terms, and test questions, for easier and faster understanding of the material Mass Spectrometry: An Applied Approach is highly recommended for advanced students, young scientists, and anyone involved in a field that utilizes the technique.

Mass Spectrometry in Biophysics

Author : Igor A. Kaltashov
Publisher : John Wiley & Sons
ISBN 13 : 0471705160
Total Pages : 320 pages
Book Rating : 4.4/5 (717 download)

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Book Synopsis Mass Spectrometry in Biophysics by : Igor A. Kaltashov

Download or read book Mass Spectrometry in Biophysics written by Igor A. Kaltashov and published by John Wiley & Sons. This book was released on 2005-05-06 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first systematic summary of biophysical mass spectrometrytechniques Recent advances in mass spectrometry (MS) have pushed the frontiersof analytical chemistry into the biophysical laboratory. As aresult, the biophysical community's acceptance of MS-based methods,used to study protein higher-order structure and dynamics, hasaccelerated the expansion of biophysical MS. Despite this growing trend, until now no single text has presentedthe full array of MS-based experimental techniques and strategiesfor biophysics. Mass Spectrometry in Biophysics expertly closesthis gap in the literature. Covering the theoretical background and technical aspects of eachmethod, this much-needed reference offers an unparalleled overviewof the current state of biophysical MS. Mass Spectrometry inBiophysics begins with a helpful discussion of general biophysicalconcepts and MS-related techniques. Subsequent chaptersaddress: * Modern spectrometric hardware * High-order structure and dynamics as probed by various MS-basedmethods * Techniques used to study structure and behavior of non-nativeprotein states that become populated under denaturingconditions * Kinetic aspects of protein folding and enzyme catalysis * MS-based methods used to extract quantitative information onprotein-ligand interactions * Relation of MS-based techniques to other experimental tools * Biomolecular properties in the gas phase Fully referenced and containing a helpful appendix on the physicsof electrospray mass spectrometry, Mass Spectrometry in Biophysicsalso offers a compelling look at the current challenges facingbiomolecular MS and the potential applications that will likelyshape its future.