Mass Spectrometry For The Clinical Laboratory

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Mass Spectrometry for the Clinical Laboratory

Author : Hari Nair
Publisher : Academic Press
ISBN 13 : 0128009926
Total Pages : 304 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Mass Spectrometry for the Clinical Laboratory by : Hari Nair

Download or read book Mass Spectrometry for the Clinical Laboratory written by Hari Nair and published by Academic Press. This book was released on 2016-11-02 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mass Spectrometry for the Clinical Laboratory is an accessible guide to mass spectrometry and the development, validation, and implementation of the most common assays seen in clinical labs. It provides readers with practical examples for assay development, and experimental design for validation to meet CLIA requirements, appropriate interference testing, measuring, validation of ion suppression/matrix effects, and quality control. These tools offer guidance on what type of instrumentation is optimal for each assay, what options are available, and the pros and cons of each. Readers will find a full set of tools that are either directly related to the assay they want to adopt or for an analogous assay they could use as an example. Written by expert users of the most common assays found in a clinical laboratory (clinical chemists, toxicologists, and clinical pathologists practicing mass spectrometry), the book lays out how experts in the field have chosen their mass spectrometers, purchased, installed, validated, and brought them on line for routine testing. The early chapters of the book covers what the practitioners have learned from years of experience, the challenges they have faced, and their recommendations on how to build and validate assays to avoid problems. These chapters also include recommendations for maintaining continuity of quality in testing. The later parts of the book focuses on specific types of assays (therapeutic drugs, Vitamin D, hormones, etc.). Each chapter in this section has been written by an expert practitioner of an assay that is currently running in his or her clinical lab. Provides readers with the keys to choosing, installing, and validating a mass spectrometry platform Offers tools to evaluate, validate, and troubleshoot the most common assays seen in clinical pathology labs Explains validation, ion suppression, interference testing, and quality control design to the detail that is required for implementation in the lab

Mass Spectrometry for the Clinical Laboratory

Author : Hari Nair
Publisher : Academic Press
ISBN 13 : 9780128008713
Total Pages : 0 pages
Book Rating : 4.0/5 (87 download)

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Book Synopsis Mass Spectrometry for the Clinical Laboratory by : Hari Nair

Download or read book Mass Spectrometry for the Clinical Laboratory written by Hari Nair and published by Academic Press. This book was released on 2016-11-17 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mass Spectrometry for the Clinical Laboratory is an accessible guide to mass spectrometry and the development, validation, and implementation of the most common assays seen in clinical labs. It provides readers with practical examples for assay development, and experimental design for validation to meet CLIA requirements, appropriate interference testing, measuring, validation of ion suppression/matrix effects, and quality control. These tools offer guidance on what type of instrumentation is optimal for each assay, what options are available, and the pros and cons of each. Readers will find a full set of tools that are either directly related to the assay they want to adopt or for an analogous assay they could use as an example. Written by expert users of the most common assays found in a clinical laboratory (clinical chemists, toxicologists, and clinical pathologists practicing mass spectrometry), the book lays out how experts in the field have chosen their mass spectrometers, purchased, installed, validated, and brought them on line for routine testing. The early chapters of the book covers what the practitioners have learned from years of experience, the challenges they have faced, and their recommendations on how to build and validate assays to avoid problems. These chapters also include recommendations for maintaining continuity of quality in testing. The later parts of the book focuses on specific types of assays (therapeutic drugs, Vitamin D, hormones, etc.). Each chapter in this section has been written by an expert practitioner of an assay that is currently running in his or her clinical lab.

Principles and Applications of Clinical Mass Spectrometry

Author : Nader Rifai
Publisher : Elsevier
ISBN 13 : 0128160640
Total Pages : 216 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Principles and Applications of Clinical Mass Spectrometry by : Nader Rifai

Download or read book Principles and Applications of Clinical Mass Spectrometry written by Nader Rifai and published by Elsevier. This book was released on 2018-06-26 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles and Applications of Clinical Mass Spectrometry: Small Molecules, Peptides, and Pathogens is a concise resource for quick implementation of mass spectrometry methods in clinical laboratory work. Focusing on the practical use of these techniques, the first half of the book covers principles of chromatographic separations, principles and types of mass spectrometers, and sample preparation for analysis; the second half outlines the main applications of this technology within clinical laboratory settings, including determination of small molecules and peptides, as well as pathogen identification. A thorough yet succinct guide to using mass spectrometry technology in the clinical laboratory, Principles and Applications of Clinical Mass Spectrometry: Small Molecules, Peptides, and Pathogens is an essential resource for chemists, pharmaceutical and biotech researchers, certain government agencies, and standardization groups. Provides concrete examples of the main applications of mass spectrometry technology Describes current capabilities of the LC- and MS-based analytical methods Details methods for successful analytical work in the field

Mass spectrometry in the clinical laboratory : general principles and guidance ; approved guideline

Author : Donald H. Chace
Publisher :
ISBN 13 : 9781562386481
Total Pages : 97 pages
Book Rating : 4.3/5 (864 download)

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Book Synopsis Mass spectrometry in the clinical laboratory : general principles and guidance ; approved guideline by : Donald H. Chace

Download or read book Mass spectrometry in the clinical laboratory : general principles and guidance ; approved guideline written by Donald H. Chace and published by . This book was released on 2007 with total page 97 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Clinical Applications of Mass Spectrometry in Biomolecular Analysis

Author : Uttam Garg
Publisher : Humana
ISBN 13 : 9781493931811
Total Pages : 0 pages
Book Rating : 4.9/5 (318 download)

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Book Synopsis Clinical Applications of Mass Spectrometry in Biomolecular Analysis by : Uttam Garg

Download or read book Clinical Applications of Mass Spectrometry in Biomolecular Analysis written by Uttam Garg and published by Humana. This book was released on 2015-11-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides stepwise instructions for the analysis of numerous clinically important analytes by mass spectrometry. Mass spectrometry offers clinical laboratory scientists a number of advantages including increased sensitivity and specificity, multiple component analysis, and no need for specialized reagents. The techniques described are a must for the measurement of many clinically relevant analytes in the fields of drug analysis, endocrinology, and inborn errors of metabolism. Each chapter provides a brief introduction about a specified analyte, followed by detailed instructions on the analytical protocol. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting edge and practical, Clinical Applications of Mass Spectrometry in Biomolecular Analysis: Methods and Protocols is a great resource for clinical laboratory scientists who are already using or thinking of bringing mass spectrometry to their laboratories.

The Use of Mass Spectrometry Technology (MALDI-TOF) in Clinical Microbiology

Author : Fernando Cobo
Publisher : Academic Press
ISBN 13 : 0128144521
Total Pages : 298 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis The Use of Mass Spectrometry Technology (MALDI-TOF) in Clinical Microbiology by : Fernando Cobo

Download or read book The Use of Mass Spectrometry Technology (MALDI-TOF) in Clinical Microbiology written by Fernando Cobo and published by Academic Press. This book was released on 2018-08-03 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Use of Mass Spectrometry Technology (MALDI-TOF) in Clinical Microbiology presents the state-of the-art for MALDI-TOF mass spectrometry. It is a key reference defining how MALDI-TOF mass spectrometry is used in clinical settings as a diagnostic tool of microbial identification and characterization that is based on the detection of a mass of molecules. The book provides updated applications of MALDI-TOF techniques in clinical microbiology, presenting the latest information available on a technology that is now used for rapid microbial identification at relatively low cost, thus offering an alternative to conventional laboratory diagnosis and proteomic identification systems. Although the main use of the technology has, until now, been identification or typing of bacteria from a positive culture, applications in the field of virology, mycology, microbacteriology and resistances are opening up new opportunities. Presents updated applications of MALDI-TOF techniques in clinical microbiology Describes the use of mass spectrometry in the lab, the principles of the technology, preparation of samples, device calibration and maintenance, treatment of microorganisms, and quality control Presents key information for researchers, including possible uses of the technology, differences between devices, how to interpret results, and future applications Covers the topic in a systematic and comprehensive manner that is useful to both clinicians and researchers

Mass Spectrometry, An Issue of Clinics in Laboratory Medicine - E-Book

Author : Nigel Clarke
Publisher : Elsevier Health Sciences
ISBN 13 : 1455712019
Total Pages : 104 pages
Book Rating : 4.4/5 (557 download)

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Book Synopsis Mass Spectrometry, An Issue of Clinics in Laboratory Medicine - E-Book by : Nigel Clarke

Download or read book Mass Spectrometry, An Issue of Clinics in Laboratory Medicine - E-Book written by Nigel Clarke and published by Elsevier Health Sciences. This book was released on 2011-10-03 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Clinics in Laboratory Medicine, Guest Edited by Nigel Clarke, MD, and Andrew Hoofnagle, MD, will focus on Mass Spectrometry, with topics including: Proteins; Peptides; Small Molecules: Toxicology; Small Molecules: Diagnostics; and Regulatory Considerations.

Mass Spectrometry in Life Sciences and Clinical Laboratory

Author : Goran Mitulović
Publisher : BoD – Books on Demand
ISBN 13 : 1838818618
Total Pages : 156 pages
Book Rating : 4.8/5 (388 download)

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Book Synopsis Mass Spectrometry in Life Sciences and Clinical Laboratory by : Goran Mitulović

Download or read book Mass Spectrometry in Life Sciences and Clinical Laboratory written by Goran Mitulović and published by BoD – Books on Demand. This book was released on 2021-06-02 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mass spectrometry is a state-of-the-art tool for basic biological research and applied clinical diagnostics. This book covers sample preparation for mass spectrometric analysis for proteomics, clinical studies, and food analysis. In addition, it explores possible directions for further developing the technology and its potential applications.

A Practical Guide to Implementing Clinical Mass Spectrometry Systems

Author : Neil Leaver
Publisher : ILM Publications
ISBN 13 : 1906799105
Total Pages : 97 pages
Book Rating : 4.9/5 (67 download)

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Book Synopsis A Practical Guide to Implementing Clinical Mass Spectrometry Systems by : Neil Leaver

Download or read book A Practical Guide to Implementing Clinical Mass Spectrometry Systems written by Neil Leaver and published by ILM Publications. This book was released on 2011 with total page 97 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mass spectrometry is becoming increasingly popular in the field of therapeutic drug monitoring. The aim of this publication is to provide practical guidance for laboratories on the implementation of mass spectrometry into a clinical service where there might be limited expertise in the technique. This guidance is the author's personal recommendation based on over ten years' experience of clinical mass spectrometry. Throughout the text, examples are given to illustrate issues that a clinical laboratory might encounter. While some examples relate to the field of immunosuppressive drug monitoring, the issues are common and relevant to any clinical application. The guidance provided is also applicable to instrumentation made by any manufacturer. This practical guide covers instrument selection through business planning to installation, risk management and validation, and includes suggestions for future prospects for this developing field.

Contemporary Practice in Clinical Chemistry

Author : William Clarke
Publisher : Academic Press
ISBN 13 : 0128158336
Total Pages : 1070 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Contemporary Practice in Clinical Chemistry by : William Clarke

Download or read book Contemporary Practice in Clinical Chemistry written by William Clarke and published by Academic Press. This book was released on 2020-06-11 with total page 1070 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contemporary Practice in Clinical Chemistry, Fourth Edition, provides a clear and concise overview of important topics in the field. This new edition is useful for students, residents and fellows in clinical chemistry and pathology, presenting an introduction and overview of the field to assist readers as they in review and prepare for board certification examinations. For new medical technologists, the book provides context for understanding the clinical utility of tests that they perform or use in other areas in the clinical laboratory. For experienced laboratorians, this revision continues to provide an opportunity for exposure to more recent trends and developments in clinical chemistry. Includes enhanced illustration and new and revised color figures Provides improved self-assessment questions and end-of-chapter assessment questions

Clinical Applications of Mass Spectrometry

Author : Uttam Garg
Publisher : Humana Press
ISBN 13 : 9781607614586
Total Pages : 0 pages
Book Rating : 4.6/5 (145 download)

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Book Synopsis Clinical Applications of Mass Spectrometry by : Uttam Garg

Download or read book Clinical Applications of Mass Spectrometry written by Uttam Garg and published by Humana Press. This book was released on 2009-12-14 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: As mass spectrometric methods now offer a level of specificity and sensitivity unrealized by spectrophotometric- and immunoassay-based methods, mass spectrometry has entered the clinical laboratory where it is being used for a wide range of applications. In Clinical Applications of Mass Spectrometry: Methods and Protocols, expert researchers provide detailed step-by-step procedures for the analysis of number of analytes of clinical importance. This versatile and expansive volume covers mass spectrometry methods for analytes including a variety of drugs, hormones, and metabolic compounds spanning the disciplines of toxicology, therapeutic drug monitoring, endocrinology, and pediatric metabolism. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include brief introductions to the analytes, lists of the necessary materials and reagents, readily reproducible analytical protocols, and detailed notes on troubleshooting and avoiding known pitfalls. Comprehensive and dependable, Clinical Applications of Mass Spectrometry: Methods and Protocols offers its readers a wide array of valuable methods for experienced mass spectrometric labs that are looking to introduce new analyses as well as for those laboratories currently considering the addition of this resourceful and vital technology.

Medical Applications of Mass Spectrometry

Author : Karoly Vekey
Publisher : Elsevier
ISBN 13 : 0080554652
Total Pages : 606 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Medical Applications of Mass Spectrometry by : Karoly Vekey

Download or read book Medical Applications of Mass Spectrometry written by Karoly Vekey and published by Elsevier. This book was released on 2011-08-11 with total page 606 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mass spectrometry is fast becoming an indispensable field for medical professionals. The mass spectrometric analysis of metabolites and proteins promises to revolutionize medical research and clinical diagnostics. As this technology rapidly enters the medical field, practicing professionals and students need to prepare to take full advantage of its capabilities. Medical Applications of Mass Spectrometry addresses the key issues in the medical applications of mass spectrometry at the level appropriate for the intended readership. It will go a long way to help the utilization of mass spectrometry in medicine. The book comprises five parts. A general overview is followed by a description of the basic sampling and separation methods in analytical chemistry. In the second part a solid foundation in mass spectrometry and modern techniques of data analysis is presented. The third part explains how mass spectrometry is used in exploring various classes of biomolecules, including proteins and lipids. In the fourth section mass spectrometry is introduced as a diagnostic tool in clinical treatment, infectious pathogen research, neonatal diagnostics, cancer, brain and allergy research, as well as in various fields of medicine: cardiology, pulmonology, neurology, psychiatric diseases, hemato-oncology, urologic diseases, gastrointestinal diseases, gynecology and pediatrics. The fifth part covers emerging applications in biomarker discovery and in mass spectrometric imaging. * Provides a broad look at how the medical field is benefiting from advances in mass spectrometry. * Guides the reader from basic principles and methods to cutting edge applications. * There is NO comparable book on the market to fill this fast growing field.

Ambient Ionization Mass Spectrometry

Author : Marek Domin
Publisher : Royal Society of Chemistry
ISBN 13 : 1849739269
Total Pages : 528 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis Ambient Ionization Mass Spectrometry by : Marek Domin

Download or read book Ambient Ionization Mass Spectrometry written by Marek Domin and published by Royal Society of Chemistry. This book was released on 2014-11-25 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ambient ionization has emerged as one of the hottest and fastest growing topics in mass spectrometry enabling sample analysis with minimal sample preparation. Introducing the subject and explaining the basic concepts and terminology, this book will provide a comprehensive, unique treatise devoted to the subject. Written by acknowledged experts, there are full descriptions on how new ionization techniques work, with an overview of their strengths, weaknesses and applications. This title will bring the reader right up to date, with both applications and theory, and will be suitable as a tutorial text for those starting in the field from a variety of disciplines.

Analytical Techniques for Clinical Chemistry

Author : Sergio Caroli
Publisher : John Wiley & Sons
ISBN 13 : 111827184X
Total Pages : 37 pages
Book Rating : 4.1/5 (182 download)

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Book Synopsis Analytical Techniques for Clinical Chemistry by : Sergio Caroli

Download or read book Analytical Techniques for Clinical Chemistry written by Sergio Caroli and published by John Wiley & Sons. This book was released on 2012-06-26 with total page 37 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discover how analytical chemistry supports the latest clinical research This book details the role played by analytical chemistry in fostering clinical research. Readers will discover how a broad range of analytical techniques support all phases of clinical research, from early stages to the implementation of practical applications. Moreover, the contributing authors' careful step-by-step guidance enables readers to better understand standardized techniques and steer clear of everyday problems that can arise in the lab. Analytical Techniques for Clinical Chemistry opens with an overview of the legal and regulatory framework governing clinical lab analysis. Next, it details the latest progress in instrumentation and applications in such fields as biomonitoring, diagnostics, food quality, biomarkers, pharmaceuticals, and forensics. Comprised of twenty-five chapters divided into three sections exploring Fundamentals, Selected Applications, and Future Trends, the book covers such critical topics as: Uncertainty in clinical chemistry measurements Metal toxicology in clinical, forensic, and chemical pathology Role of analytical chemistry in the safety of drug therapy Atomic spectrometric techniques for the analysis of clinical samples Biosensors for drug analysis Use of X-ray techniques in medical research Each chapter is written by one or more leading pioneers and experts in analytical chemistry. Contributions are based on a thorough review and analysis of the current literature as well as the authors' own firsthand experiences in the lab. References at the end of each chapter serve as a gateway to the literature, enabling readers to explore individual topics in greater depth. Presenting the latest achievements and challenges in the field, Analytical Techniques for Clinical Chemistry sets the foundation for future advances in laboratory research techniques.

MALDI-TOF and Tandem MS for Clinical Microbiology

Author : Haroun N. Shah
Publisher : John Wiley & Sons
ISBN 13 : 1118960238
Total Pages : 648 pages
Book Rating : 4.1/5 (189 download)

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Book Synopsis MALDI-TOF and Tandem MS for Clinical Microbiology by : Haroun N. Shah

Download or read book MALDI-TOF and Tandem MS for Clinical Microbiology written by Haroun N. Shah and published by John Wiley & Sons. This book was released on 2017-03-31 with total page 648 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the triumph of MALDI-TOF mass spectrometry over the past decade and provides insight into new and expanding technologies through a comprehensive range of short chapters that enable the reader to gauge their current status and how they may progress over the next decade. This book serves as a platform to consolidate current strengths of the technology and highlight new frontiers in tandem MS/MS that are likely to eventually supersede MALDI-TOF MS. Chapters discuss: Challenges of Identifying Mycobacterium to the Species level Identification of Bacteroides and Other Clinically Relevant Anaerobes Identification of Species in Mixed Microbial Populations Detection of Resistance Mechanisms Proteomics as a biomarker discovery and validation platform Determination of Antimicrobial Resistance using Tandem Mass Spectrometry

LC-MS in Drug Bioanalysis

Author : Q. Alan Xu
Publisher : Springer Science & Business Media
ISBN 13 : 1461438284
Total Pages : 476 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis LC-MS in Drug Bioanalysis by : Q. Alan Xu

Download or read book LC-MS in Drug Bioanalysis written by Q. Alan Xu and published by Springer Science & Business Media. This book was released on 2012-07-15 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical pharmacology plays an important role in today’s medicine. Due to the high sensitivity, selectivity, and affordability of a mass spectrometer (MS), the high performance liquid chromatography – mass spectrometry (LC-MS) analytical technique is widely used in the determination of drugs in human biological matrixes for clinical pharmacology. Specifically, LC-MS is used to analyze: anticancer drugs antidementia drugs antidepressant drugs antiepileptic drugs antifundal drug antimicrobial drugs antipsychotic drugs antiretroviral drugs anxiolytic/hypnotic drugs cardiac drugs drugs for addiction immunosuppressant drugs mood stabilizer drugs This book will primarily cover the various methods of validation for LC-MS techniques and applications used in modern clinical pharmacology.

Developing Norms for the Provision of Biological Laboratories in Low-Resource Contexts

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309486564
Total Pages : 121 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Developing Norms for the Provision of Biological Laboratories in Low-Resource Contexts by : National Academies of Sciences, Engineering, and Medicine

Download or read book Developing Norms for the Provision of Biological Laboratories in Low-Resource Contexts written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2019-05-01 with total page 121 pages. Available in PDF, EPUB and Kindle. Book excerpt: On June 27-28, 2018, the U.S. National Academies of Sciences, Engineering, and Medicine (the National Academies) convened an international workshop in Amsterdam, the Netherlands, on developing norms for the provision of laboratories in low-resource contexts. The U.S. Department of State's Biosecurity Engagement Program requested that the National Academies organize this workshop to engage an international group of organizations that provide funding for construction, upgrades, and maintenance of biological laboratories in countries without the means to build such labs themselves. Twenty-one people from 19 organizations participated. The intent was to advance the conversation about the identification and application of guiding principles and common norms for use by these organizations in their grants, partnerships, and aid. This publication summarizes the presentations and discussions from the workshop.