Predictive, Preventive, and Personalised Medicine: From Bench to Bedside

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Author :
Publisher : Springer Nature
ISBN 13 : 3031348842
Total Pages : 352 pages
Book Rating : 4.0/5 (313 download)

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Book Synopsis Predictive, Preventive, and Personalised Medicine: From Bench to Bedside by : Halina Podbielska

Download or read book Predictive, Preventive, and Personalised Medicine: From Bench to Bedside written by Halina Podbielska and published by Springer Nature. This book was released on 2023-12-01 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents advanced bio/medical sciences with a particular value for translating research achievements into daily medical practice in the framework of Predictive, Preventive and Personalised Medicine (3PM/PPPM). First two decades of the 21st century are characterised by epidemics of non-communicable diseases such as many hundreds of millions of patients diagnosed with cardiovascular diseases and the type 2 diabetes mellitus, breast, lung, liver and prostate malignancies, neurological, sleep, mood and eye disorders, amongst others. Consequent socio-economic burden is tremendous. Unprecedented decrease in age of maladaptive individuals has been reported. The absolute majority of expanding non-communicable disorders carry a chronic character, over a couple of years progressing from reversible suboptimal health conditions to irreversible severe pathologies and cascading collateral complications. The paradigm change from reactive to predictive preventive and personalised medicine is essential to promote population health by application of individualised patient profiling, multi-parametric analysis leading to cost-effective targeted prevention. To this end, inadequate data for risk assessment on speed and urgency of COVID-19, combined with increased globalization of human society, led to the rapid spread of COVID-19. Despite an abundance of digital methods that could be used in slowing or stopping this virus and future pandemics, the world remains unprepared, and lessons have not been learned from previous cases of pandemics. The book presents PPPM strategies which might be of great clinical utility for future pandemics. In a long-term way, a significantly improved healthcare economy is one of the clear benefits of the proposed paradigm shift; a tight collaboration between all stakeholders including scientific community, healthcare providers, patient organisations, policy-makers and educators is analysed for the smooth implementation of the 3PM concepts. Further issues linked to big data management and medical ethics have to be carefully treated in the context of application of artificial intelligence in medicine.

Anticipation and Medicine

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Author :
Publisher : Springer
ISBN 13 : 3319451421
Total Pages : 355 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Anticipation and Medicine by : Mihai Nadin

Download or read book Anticipation and Medicine written by Mihai Nadin and published by Springer. This book was released on 2016-10-22 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, practicing physicians and experts in anticipation present arguments for a new understanding of medicine. Their contributions make it clear that medicine is the decisive test for anticipation. The reader is presented with a provocative hypothesis: If medicine will align itself with the anticipatory condition of life, it can prompt the most important revolution in our time. To this end, all stakeholders—medical practitioners, patients, scientists, and technology developers—will have to engage in the conversation. The book makes the case for the transition from expensive, and only marginally effective, reactive treatment through “spare parts” (joint replacements, organ transplants) and reliance on pharmaceuticals (antibiotics, opiates) to anticipation-informed healthcare. Readers will understand why the current premise of treating various behavioral conditions (attention deficit disorder, hyperactivity, schizophrenia) through drugs has to be re-evaluated from the perspective of anticipation. In the manner practiced today, medicine generates dependence and long-lasting damage to those it is paid to help. As we better understand the nature of the living, the proactive view of healthcare, within which the science and art of healing fuse, becomes a social and political mandate.

Preventive and Predictive Genetics: Towards Personalised Medicine

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Author :
Publisher : Springer
ISBN 13 : 3319153447
Total Pages : 388 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Preventive and Predictive Genetics: Towards Personalised Medicine by : Godfrey Grech

Download or read book Preventive and Predictive Genetics: Towards Personalised Medicine written by Godfrey Grech and published by Springer. This book was released on 2015-06-24 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacogenomics supports personalized medicine by translating genome-based knowledge into clinical practice, offering enhanced benefit for patients and health-care systems at large. Current routine practice for diagnosing and treating patients is conducted by correlating parameters such as age, gender and weight with risks and expected treatment outcomes. In the new era of personalized medicine the healthcare provider is equipped with improved ability to prevent, diagnose, treat and predict outcomes on the basis of complex information sources, including genetic and genomic data. Targeted therapy and reliable prediction of expected outcomes offer patients access to better healthcare management, by way of identifying the therapies effective for the relevant patient group, avoiding prescription of unnecessary treatment and reducing the likelihood of developing adverse drug reactions.

Neurodegenerative Diseases: Integrative PPPM Approach as the Medicine of the Future

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 9400758669
Total Pages : 402 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Neurodegenerative Diseases: Integrative PPPM Approach as the Medicine of the Future by : Silvia Mandel

Download or read book Neurodegenerative Diseases: Integrative PPPM Approach as the Medicine of the Future written by Silvia Mandel and published by Springer Science & Business Media. This book was released on 2013-03-12 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will compile a collection of chapters dedicated to varied aspects of PPPM in neuropsychiatric and neurodegenerative diseases. Among the topics to be covered are: Recent advances in ALS research News about Clinical aspects and advanced therapy approaches in personalized treatment of ALS Schizophrenia: New treatments and clinical aspects Predictive, Preventive and Personalised Medicine in aging macular degeneration Advances in Multiple Sclerosis Pharmacogenetics, Tailoring Treatment Efficacy, Safety and Regimen Selection Multiple sclerosis related biomarkers: perspectives for clinical application Preventive clinical trials in brain aging: new trends & the need of guidelines MCI_ clinical guidelines in early diagnosis of dementia Alzheimer's disease: diagnostics, prognostics and the road to prevention Biomarkers for early diagnosis of Parkinson's and Alzheimer's diseases Synucleinopathies, tauopathies, TDP-43 proteinopathies and amyloidosis PSP, MSA and other parkinsonisms

Predictive, Preventive, and Personalised Medicine: From Bench to Bedside

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Author :
Publisher : Springer
ISBN 13 : 9783031348839
Total Pages : 0 pages
Book Rating : 4.3/5 (488 download)

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Book Synopsis Predictive, Preventive, and Personalised Medicine: From Bench to Bedside by : Halina Podbielska

Download or read book Predictive, Preventive, and Personalised Medicine: From Bench to Bedside written by Halina Podbielska and published by Springer. This book was released on 2023-11-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents advanced bio/medical sciences with a particular value for translating research achievements into daily medical practice in the framework of Predictive, Preventive and Personalised Medicine (3PM/PPPM). First two decades of the 21st century are characterised by epidemics of non-communicable diseases such as many hundreds of millions of patients diagnosed with cardiovascular diseases and the type 2 diabetes mellitus, breast, lung, liver and prostate malignancies, neurological, sleep, mood and eye disorders, amongst others. Consequent socio-economic burden is tremendous. Unprecedented decrease in age of maladaptive individuals has been reported. The absolute majority of expanding non-communicable disorders carry a chronic character, over a couple of years progressing from reversible suboptimal health conditions to irreversible severe pathologies and cascading collateral complications. The paradigm change from reactive to predictive preventive and personalised medicine is essential to promote population health by application of individualised patient profiling, multi-parametric analysis leading to cost-effective targeted prevention. To this end, inadequate data for risk assessment on speed and urgency of COVID-19, combined with increased globalization of human society, led to the rapid spread of COVID-19. Despite an abundance of digital methods that could be used in slowing or stopping this virus and future pandemics, the world remains unprepared, and lessons have not been learned from previous cases of pandemics. The book presents PPPM strategies which might be of great clinical utility for future pandemics. In a long-term way, a significantly improved healthcare economy is one of the clear benefits of the proposed paradigm shift; a tight collaboration between all stakeholders including scientific community, healthcare providers, patient organisations, policy-makers and educators is analysed for the smooth implementation of the 3PM concepts. Further issues linked to big data management and medical ethics have to be carefully treated in the context of application of artificial intelligence in medicine.

Clinical Molecular Diagnostics

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Author :
Publisher : Springer Nature
ISBN 13 : 9811610371
Total Pages : 889 pages
Book Rating : 4.8/5 (116 download)

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Book Synopsis Clinical Molecular Diagnostics by : Shiyang Pan

Download or read book Clinical Molecular Diagnostics written by Shiyang Pan and published by Springer Nature. This book was released on 2021-07-08 with total page 889 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the discovery of molecular biomarkers, the development of laboratory testing techniques and their clinical applications, focusing on basic research to clinical practice. It introduces new and crucial knowledge and ethics of clinical molecular diagnosis. This book emphasizes the applications of clinical molecular diagnostic test on health management, especially from different diseased organs. It lets readers to understand and realize precision healthcare.

Toward Precision Medicine

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Author :
Publisher : National Academies Press
ISBN 13 : 0309222222
Total Pages : 142 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Toward Precision Medicine by : National Research Council

Download or read book Toward Precision Medicine written by National Research Council and published by National Academies Press. This book was released on 2012-01-16 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: Motivated by the explosion of molecular data on humans-particularly data associated with individual patients-and the sense that there are large, as-yet-untapped opportunities to use this data to improve health outcomes, Toward Precision Medicine explores the feasibility and need for "a new taxonomy of human disease based on molecular biology" and develops a potential framework for creating one. The book says that a new data network that integrates emerging research on the molecular makeup of diseases with clinical data on individual patients could drive the development of a more accurate classification of diseases and ultimately enhance diagnosis and treatment. The "new taxonomy" that emerges would define diseases by their underlying molecular causes and other factors in addition to their traditional physical signs and symptoms. The book adds that the new data network could also improve biomedical research by enabling scientists to access patients' information during treatment while still protecting their rights. This would allow the marriage of molecular research and clinical data at the point of care, as opposed to research information continuing to reside primarily in academia. Toward Precision Medicine notes that moving toward individualized medicine requires that researchers and health care providers have access to very large sets of health- and disease-related data linked to individual patients. These data are also critical for developing the information commons, the knowledge network of disease, and ultimately the new taxonomy.

Personalized Medicine in Anesthesia, Pain and Perioperative Medicine

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Author :
Publisher : Springer Nature
ISBN 13 : 3030535258
Total Pages : 401 pages
Book Rating : 4.0/5 (35 download)

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Book Synopsis Personalized Medicine in Anesthesia, Pain and Perioperative Medicine by : Ali Dabbagh

Download or read book Personalized Medicine in Anesthesia, Pain and Perioperative Medicine written by Ali Dabbagh and published by Springer Nature. This book was released on 2020-09-21 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the current and future impact of cellular and molecular medicine (CMM) on anesthesiology and perioperative medicine. It covers the topic from a translational perspective and describes the relevance of CMM to daily clinical practice. Taking a bench-to-bedside approach, chapters examine topics including perioperative acute and chronic management, perioperative organ protection, and novel pharmaceuticals. Personalized Medicine in Anesthesia, Pain and Perioperative Medicine is aimed at anesthesiologists and pain physicians, and will also be of interest to pharmacists and those working in cellular and molecular medicine.

Nanoarchitectonics for Brain Drug Delivery

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Author :
Publisher : CRC Press
ISBN 13 : 1003851843
Total Pages : 381 pages
Book Rating : 4.0/5 (38 download)

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Book Synopsis Nanoarchitectonics for Brain Drug Delivery by : Anurag Kumar Singh

Download or read book Nanoarchitectonics for Brain Drug Delivery written by Anurag Kumar Singh and published by CRC Press. This book was released on 2024-02-22 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses basics of brain diseases and the role of nanobiotechnology in existing treatment options for neurodegenerative disorders. It begins with an overview of brain diseases and the need for novel drug-delivery approaches. It highlights the current route for the intranasal advanced drug-delivery systems for brain diseases. It also discusses innovative categories of drug-delivery systems, including mesoporous silica nanoparticles, polymeric nanocarriers, and lipid-based nanocarriers through multi-responsive DDSs and their implications in brain disorders. Features: Includes an overview of brain diseases and highlights the need for novel drug-delivery approaches Focuses on theoretical aspects of advanced drug-delivery systems for brain diseases including challenges and progress in nose-to-brain delivery Provides an overview of technological approaches and their implications for neurodegenerative disorders, central nervous system (CNS), and brain drug delivery in brain cancer Discusses key advances in the development of polymer nanoparticles for drug delivery to the CNS Reviews the role of herbal medicines and naturally derived polymeric nanoparticle for the treatment of neurodegenerative disorders This book is aimed at graduate students and researchers in biomedical engineering, biotechnology, drug delivery, and neurology.

Genomic and Personalized Medicine

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Publisher : Academic Press
ISBN 13 : 0123822270
Total Pages : 1343 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Genomic and Personalized Medicine by : Geoffrey S. Ginsburg

Download or read book Genomic and Personalized Medicine written by Geoffrey S. Ginsburg and published by Academic Press. This book was released on 2012-11-29 with total page 1343 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genomic and Personalized Medicine, Second Edition - winner of a 2013 Highly Commended BMA Medical Book Award for Medicine - is a major discussion of the structure, history, and applications of the field, as it emerges from the campus and lab into clinical action. As with the first edition, leading experts review the development of the new science, the current opportunities for genome-based analysis in healthcare, and the potential of genomic medicine in future healthcare. The inclusion of the latest information on diagnostic testing, population screening, disease susceptability, and pharmacogenomics makes this work an ideal companion for the many stakeholders of genomic and personalized medicine. With advancing knowledge of the genome across and outside protein-coding regions of DNA, new comprehension of genomic variation and frequencies across populations, the elucidation of advanced strategic approaches to genomic study, and above all in the elaboration of next-generation sequencing, genomic medicine has begun to achieve the much-vaunted transformative health outcomes of the Human Genome Project, almost a decade after its official completion in April 2003. Highly Commended 2013 BMA Medical Book Award for Medicine More than 100 chapters, from leading researchers, review the many impacts of genomic discoveries in clinical action, including 63 chapters new to this edition Discusses state-of-the-art genome technologies, including population screening, novel diagnostics, and gene-based therapeutics Wide and inclusive discussion encompasses the formidable ethical, legal, regulatory and social challenges related to the evolving practice of genomic medicine Clearly and beautifully illustrated with 280 color figures, and many thousands of references for further reading and deeper analysis

Financing Health Services in Developing Countries

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Publisher : World Bank Publications
ISBN 13 : 9780821309001
Total Pages : 104 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Financing Health Services in Developing Countries by : John S. Akin

Download or read book Financing Health Services in Developing Countries written by John S. Akin and published by World Bank Publications. This book was released on 1987-01-01 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report discusses several different approaches that support reforming health care services in developing countries. For some time now, health care services have been supported by government funds. As demands for improving health care services continue to increase additional demands will be placed on governments to respond. This, however, will not be easy. Slow economic growth and record budget deficits in the 1980's have forced reductions in public spending. Alternative approaches to finance health care services are needed. Such possible changes could involve: decentralization of federal government involvement; the promotion of nongovernment involvement; the imposition of user fees; and, establishing health insurance. Finally, the role of the Bank in pursuing new financing strategies is discussed.

Oxford Textbook of Global Public Health

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Publisher : Oxford University Press
ISBN 13 : 019881013X
Total Pages : 1717 pages
Book Rating : 4.1/5 (988 download)

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Book Synopsis Oxford Textbook of Global Public Health by : Roger Detels

Download or read book Oxford Textbook of Global Public Health written by Roger Detels and published by Oxford University Press. This book was released on 2017 with total page 1717 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sixth edition of the hugely successful, internationally recognised textbook on global public health and epidemiology, with 3 volumes comprehensively covering the scope, methods, and practice of the discipline

Digital Health in Focus of Predictive, Preventive and Personalised Medicine

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Author :
Publisher : Springer Nature
ISBN 13 : 3030498158
Total Pages : 176 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Digital Health in Focus of Predictive, Preventive and Personalised Medicine by : Lotfi Chaari

Download or read book Digital Health in Focus of Predictive, Preventive and Personalised Medicine written by Lotfi Chaari and published by Springer Nature. This book was released on 2020-09-30 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: The edition will cover proceedings of the second International conference on digital health Technologies (ICDHT 2019). The conference will address the topic of P4 medicine from the information technology point of view, and will be focused on the following topics: - Artificial Intelligence for health • Knowledge extraction • Decision-aid systems • Data analysis and risk prediction • Machine learning, deep learning - Health data processing • Data preprocessing, cleaning, management and mining • Computer-aided detection • Big data analysis, prediction and prevention • Cognitive algorithms for healthcare handling dynamic context management • Augmented reality, Motion detection and activity recognition - Devices, infrastructure and communication • Wearable & connected devices • Communication infrastructures, architectures and standards Blockchain for e-Health • Computing/storage infrastructures for e-Health • IoT devices & architectures for Smart Healthcare - Health information systems • Telemedicine, Teleservices • Computing/storage infrastructures for e-Health • Clinical Data Visualisation Standards - Security and privacy for e-health • Health data Analytics for Security and Privacy • E-health Software and Hardware Security • Embedded Security for e-health - Applications in P4 medicine

Comprehensive Biomarker Discovery and Validation for Clinical Application

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Author :
Publisher : Royal Society of Chemistry
ISBN 13 : 1849734364
Total Pages : 385 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis Comprehensive Biomarker Discovery and Validation for Clinical Application by : Péter Horvatovich

Download or read book Comprehensive Biomarker Discovery and Validation for Clinical Application written by Péter Horvatovich and published by Royal Society of Chemistry. This book was released on 2013-06-17 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on proteomics biomarker discovery and validation procedures from the clinical perspective. It provides an overview of current technology and the challenges encountered throughout the process. This covers all key stages, from biomarker discovery and validation, through to registration with the European and US regulatory authorities (FDA and EMEA). All the important elements (such as patient selection, sample handling, data processing, and statistical analysis) are described in detail and the reader is introduced to each topic with well-described examples or guidelines for best practice. Case studies are also included to demonstrate clinical applications. Individual chapters explain the best performing techniques for profiling complex body fluids and biomarker discovery. This includes the application of mass spectrometry imaging combined with chromatography in profiling platforms and the use of laser micro dissection and MALDI imaging to study tissues in their natural environment. Future developments needed to improve the success rate of translating biomarker discovery into useful clinical tests are also discussed. Common pitfalls and success stories are described as are the limitations of the various technologies involved. Broad and interdisciplinary in approach, this book provides an excellent source of information for industrial and academic researchers, and those managing biobanks.

Complementary and Alternative Therapies for Sleep Disorders: From Bench to Bedside

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Author :
Publisher : Frontiers Media SA
ISBN 13 : 2832556701
Total Pages : 121 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Complementary and Alternative Therapies for Sleep Disorders: From Bench to Bedside by : Guanhu Yang

Download or read book Complementary and Alternative Therapies for Sleep Disorders: From Bench to Bedside written by Guanhu Yang and published by Frontiers Media SA. This book was released on 2024-11-12 with total page 121 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sleep disorders encompass a range of conditions that can significantly impact overall health, safety, and quality of life. Symptoms of sleep disorders include excessive daytime sleepiness, irregular breathing or movements during sleep, disrupted sleep, and difficulty falling asleep. If these conditions are not promptly and effectively treated, patients often experience various physical and mental complications, such as psychiatric disorders, cardiovascular disease, stroke, type 2 diabetes, and obesity, leading to a decreased overall quality of life. Complementary and alternative therapy (CAT) presents a potential approach for the prevention and treatment of sleep disorders. It encompasses a range of management practices, including cognitive behavioral therapy, exercise, mindfulness, meditation, transcranial magnetic stimulation, yoga, herbal medicine, acupuncture, acupressure, Gua Sha, moxibustion, Qigong, Tai Chi, acupoint catgut embedding, acupotomy, nutritional supplements, and vitamin supplements. However, the adoption of CAT for sleep disorders in clinical practice faces numerous challenges due to a limited understanding of their mechanisms and clinical effects.

Flammer Syndrome

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Author :
Publisher : Springer
ISBN 13 : 3030135500
Total Pages : 373 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Flammer Syndrome by : Olga Golubnitschaja

Download or read book Flammer Syndrome written by Olga Golubnitschaja and published by Springer. This book was released on 2019-07-23 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: Unmet healthcare needs of young populations and individuals in suboptimal health conditions are the key issue of currently observed epidemics of non-communicable disorders. Moreover, an unprecedented decrease in the average age of onset of these disorders is recorded. The majority of non-communicable disorders carry a chronic character by progressing over a couple of years from a reversible suboptimal health condition to irreversible pathology with collateral complications. The time-frame between both conditions is the operational area for predictive diagnosis and identification of persons at risk by innovative screening programmes followed by the most cost-effective personalised treatment possible, namely primary prevention tailored to the person. The book propagates the paradigm change from delayed, costly but frequently ineffective medical services to the holistic approach by predictive, preventive and personalised medicine clearly demonstrating multifaceted benefits to the individual, healthcare sector and society as a whole. The book is focused on the needs of young people: teenagers, adolescents and young adults; regardless of the age, individuals in suboptimal health conditions, who are interested in remaining healthy by optimising their modifiable risk factors – both endogenous and exogenous ones; several patient cohorts demonstrating similar phenotype of Flammer syndrome. The book is based on the multi-professional expertise, scientific excellence and practical experiences of the world-acknowledged experts in Flammer syndrome, predictive diagnostics, targeted prevention and personalised medicine, amongst others. The topic of this book is particularly relevant to general practitioners, experts in non-communicable diseases, phenotyping, genotyping, multilevel diagnostics, targeted prevention, personalised medicine, as well as the readers interested in advancing their health literacy.

Medicine-Based Informatics and Engineering

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Author :
Publisher : Springer Nature
ISBN 13 : 3030878457
Total Pages : 210 pages
Book Rating : 4.0/5 (38 download)

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Book Synopsis Medicine-Based Informatics and Engineering by : Franco Simini

Download or read book Medicine-Based Informatics and Engineering written by Franco Simini and published by Springer Nature. This book was released on 2021-12-07 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book originates from the idea to adapt biomedical engineering and medical informatics to current clinical needs and proposes a paradigm shift in medical engineering, where the limitations of technology should no longer be the starting point of design, but rather the development of biomedical devices, software, and systems should stem from clinical needs and wishes. Gathering chapters written by authoritative researchers, working the interface between medicine and engineering, this book presents successful attempts of conceiving technology based on clinical practice. It reports on new strategies for medical diagnosis, rehabilitation, and eHealth, focusing on solutions to foster better quality of life through technology, with an emphasis on patients’ and clinical needs, and vulnerable populations. All in all, the book offers a reference guide and a source of inspiration for biomedical engineers, clinical scientists, physicians, and computer scientists. Yet, it also includes practical information for personnel using biomedical equipment, as well as timely insights that are expected to help health agencies and software firms in their decision-making processes.