Predictive Genomics In Asthma Management Using Probabilistic Graphical Models

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Probabilistic Graphical Models for Genetics, Genomics, and Postgenomics

Author : Christine Sinoquet
Publisher : OUP Oxford
ISBN 13 : 0191019208
Total Pages : 415 pages
Book Rating : 4.1/5 (91 download)

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Book Synopsis Probabilistic Graphical Models for Genetics, Genomics, and Postgenomics by : Christine Sinoquet

Download or read book Probabilistic Graphical Models for Genetics, Genomics, and Postgenomics written by Christine Sinoquet and published by OUP Oxford. This book was released on 2014-09-18 with total page 415 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nowadays bioinformaticians and geneticists are faced with myriad high-throughput data usually presenting the characteristics of uncertainty, high dimensionality and large complexity. These data will only allow insights into this wealth of so-called 'omics' data if represented by flexible and scalable models, prior to any further analysis. At the interface between statistics and machine learning, probabilistic graphical models (PGMs) represent a powerful formalism to discover complex networks of relations. These models are also amenable to incorporating a priori biological information. Network reconstruction from gene expression data represents perhaps the most emblematic area of research where PGMs have been successfully applied. However these models have also created renewed interest in genetics in the broad sense, in particular regarding association genetics, causality discovery, prediction of outcomes, detection of copy number variations, and epigenetics. This book provides an overview of the applications of PGMs to genetics, genomics and postgenomics to meet this increased interest. A salient feature of bioinformatics, interdisciplinarity, reaches its limit when an intricate cooperation between domain specialists is requested. Currently, few people are specialists in the design of advanced methods using probabilistic graphical models for postgenomics or genetics. This book deciphers such models so that their perceived difficulty no longer hinders their use and focuses on fifteen illustrations showing the mechanisms behind the models. Probabilistic Graphical Models for Genetics, Genomics and Postgenomics covers six main themes: (1) Gene network inference (2) Causality discovery (3) Association genetics (4) Epigenetics (5) Detection of copy number variations (6) Prediction of outcomes from high-dimensional genomic data. Written by leading international experts, this is a collection of the most advanced work at the crossroads of probabilistic graphical models and genetics, genomics, and postgenomics. The self-contained chapters provide an enlightened account of the pros and cons of applying these powerful techniques.

Graphical Models, Exponential Families, and Variational Inference

Author : Martin J. Wainwright
Publisher : Now Publishers Inc
ISBN 13 : 1601981848
Total Pages : 324 pages
Book Rating : 4.6/5 (19 download)

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Book Synopsis Graphical Models, Exponential Families, and Variational Inference by : Martin J. Wainwright

Download or read book Graphical Models, Exponential Families, and Variational Inference written by Martin J. Wainwright and published by Now Publishers Inc. This book was released on 2008 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: The core of this paper is a general set of variational principles for the problems of computing marginal probabilities and modes, applicable to multivariate statistical models in the exponential family.

Bayesian Data Analysis, Third Edition

Author : Andrew Gelman
Publisher : CRC Press
ISBN 13 : 1439840954
Total Pages : 677 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Bayesian Data Analysis, Third Edition by : Andrew Gelman

Download or read book Bayesian Data Analysis, Third Edition written by Andrew Gelman and published by CRC Press. This book was released on 2013-11-01 with total page 677 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in its third edition, this classic book is widely considered the leading text on Bayesian methods, lauded for its accessible, practical approach to analyzing data and solving research problems. Bayesian Data Analysis, Third Edition continues to take an applied approach to analysis using up-to-date Bayesian methods. The authors—all leaders in the statistics community—introduce basic concepts from a data-analytic perspective before presenting advanced methods. Throughout the text, numerous worked examples drawn from real applications and research emphasize the use of Bayesian inference in practice. New to the Third Edition Four new chapters on nonparametric modeling Coverage of weakly informative priors and boundary-avoiding priors Updated discussion of cross-validation and predictive information criteria Improved convergence monitoring and effective sample size calculations for iterative simulation Presentations of Hamiltonian Monte Carlo, variational Bayes, and expectation propagation New and revised software code The book can be used in three different ways. For undergraduate students, it introduces Bayesian inference starting from first principles. For graduate students, the text presents effective current approaches to Bayesian modeling and computation in statistics and related fields. For researchers, it provides an assortment of Bayesian methods in applied statistics. Additional materials, including data sets used in the examples, solutions to selected exercises, and software instructions, are available on the book’s web page.

Cumulated Index Medicus

Author :
Publisher :
ISBN 13 :
Total Pages : 1860 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Cumulated Index Medicus by :

Download or read book Cumulated Index Medicus written by and published by . This book was released on 1999 with total page 1860 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Linkage Disequilibrium and Association Mapping

Author : Andrew R. Collins
Publisher : Humana
ISBN 13 : 9781588296696
Total Pages : 255 pages
Book Rating : 4.2/5 (966 download)

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Book Synopsis Linkage Disequilibrium and Association Mapping by : Andrew R. Collins

Download or read book Linkage Disequilibrium and Association Mapping written by Andrew R. Collins and published by Humana. This book was released on 2007-08-23 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: As researchers continue to make enormous progress in mapping disease genes, exciting, novel, and complex analyses have emerged. In this book, scientists from around the world, who are leaders in this field, contribute their vast experience and expertise to produce a comprehensive and fascinating text for researchers and clinicians alike. They provide cutting-edge analysis of the most up-to-date and preeminent information available.

Disease Control Priorities, Third Edition (Volume 6)

Author : King K. Holmes
Publisher : World Bank Publications
ISBN 13 : 1464805253
Total Pages : 1027 pages
Book Rating : 4.4/5 (648 download)

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Book Synopsis Disease Control Priorities, Third Edition (Volume 6) by : King K. Holmes

Download or read book Disease Control Priorities, Third Edition (Volume 6) written by King K. Holmes and published by World Bank Publications. This book was released on 2017-11-06 with total page 1027 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.

Global Trends 2040

Author : National Intelligence Council
Publisher : Cosimo Reports
ISBN 13 : 9781646794973
Total Pages : 158 pages
Book Rating : 4.7/5 (949 download)

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Book Synopsis Global Trends 2040 by : National Intelligence Council

Download or read book Global Trends 2040 written by National Intelligence Council and published by Cosimo Reports. This book was released on 2021-03 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The ongoing COVID-19 pandemic marks the most significant, singular global disruption since World War II, with health, economic, political, and security implications that will ripple for years to come." -Global Trends 2040 (2021) Global Trends 2040-A More Contested World (2021), released by the US National Intelligence Council, is the latest report in its series of reports starting in 1997 about megatrends and the world's future. This report, strongly influenced by the COVID-19 pandemic, paints a bleak picture of the future and describes a contested, fragmented and turbulent world. It specifically discusses the four main trends that will shape tomorrow's world: - Demographics-by 2040, 1.4 billion people will be added mostly in Africa and South Asia. - Economics-increased government debt and concentrated economic power will escalate problems for the poor and middleclass. - Climate-a hotter world will increase water, food, and health insecurity. - Technology-the emergence of new technologies could both solve and cause problems for human life. Students of trends, policymakers, entrepreneurs, academics, journalists and anyone eager for a glimpse into the next decades, will find this report, with colored graphs, essential reading.

Understanding Suicide

Author : Philippe Courtet
Publisher : Springer
ISBN 13 : 3319262823
Total Pages : 444 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Understanding Suicide by : Philippe Courtet

Download or read book Understanding Suicide written by Philippe Courtet and published by Springer. This book was released on 2016-03-05 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book international experts address a range of key current issues relating to suicide. The opening chapters discuss nosology, definitions, clinical determinants, and conceptual models of the suicide process and consider the evidence regarding potential biomarkers of suicide risk based on neuroscientific research. Adopting a neo-Durkheimian perspective, the role of various social factors in the genesis of suicidal behavior is then explored in depth. Practical user-friendly tools that facilitate risk assessment by clinicians are provided, and detailed consideration is given to efficient and innovative strategies for the prevention of suicide and the treatment of suicidal behavior, such as psychotherapy, psychopharmacological approaches, and effective organization of care, including surveillance and the use of online tools. The final part of the book focuses on the need for and development of a personalized approach within the field of suicide prevention.

The Future of the Public's Health in the 21st Century

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309133181
Total Pages : 536 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The Future of the Public's Health in the 21st Century by : Institute of Medicine

Download or read book The Future of the Public's Health in the 21st Century written by Institute of Medicine and published by National Academies Press. This book was released on 2003-02-01 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: The anthrax incidents following the 9/11 terrorist attacks put the spotlight on the nation's public health agencies, placing it under an unprecedented scrutiny that added new dimensions to the complex issues considered in this report. The Future of the Public's Health in the 21st Century reaffirms the vision of Healthy People 2010, and outlines a systems approach to assuring the nation's health in practice, research, and policy. This approach focuses on joining the unique resources and perspectives of diverse sectors and entities and challenges these groups to work in a concerted, strategic way to promote and protect the public's health. Focusing on diverse partnerships as the framework for public health, the book discusses: The need for a shift from an individual to a population-based approach in practice, research, policy, and community engagement. The status of the governmental public health infrastructure and what needs to be improved, including its interface with the health care delivery system. The roles nongovernment actors, such as academia, business, local communities and the media can play in creating a healthy nation. Providing an accessible analysis, this book will be important to public health policy-makers and practitioners, business and community leaders, health advocates, educators and journalists.

Modeling and Reasoning with Bayesian Networks

Author : Adnan Darwiche
Publisher : Cambridge University Press
ISBN 13 : 0521884381
Total Pages : 561 pages
Book Rating : 4.5/5 (218 download)

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Book Synopsis Modeling and Reasoning with Bayesian Networks by : Adnan Darwiche

Download or read book Modeling and Reasoning with Bayesian Networks written by Adnan Darwiche and published by Cambridge University Press. This book was released on 2009-04-06 with total page 561 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a thorough introduction to the formal foundations and practical applications of Bayesian networks. It provides an extensive discussion of techniques for building Bayesian networks that model real-world situations, including techniques for synthesizing models from design, learning models from data, and debugging models using sensitivity analysis. It also treats exact and approximate inference algorithms at both theoretical and practical levels. The author assumes very little background on the covered subjects, supplying in-depth discussions for theoretically inclined readers and enough practical details to provide an algorithmic cookbook for the system developer.

Online Learning and Online Convex Optimization

Author : Shai Shalev-Shwartz
Publisher : Foundations & Trends
ISBN 13 : 9781601985460
Total Pages : 88 pages
Book Rating : 4.9/5 (854 download)

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Book Synopsis Online Learning and Online Convex Optimization by : Shai Shalev-Shwartz

Download or read book Online Learning and Online Convex Optimization written by Shai Shalev-Shwartz and published by Foundations & Trends. This book was released on 2012 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt: Online Learning and Online Convex Optimization is a modern overview of online learning. Its aim is to provide the reader with a sense of some of the interesting ideas and in particular to underscore the centrality of convexity in deriving efficient online learning algorithms.

Science and Decisions

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309120462
Total Pages : 422 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Science and Decisions by : National Research Council

Download or read book Science and Decisions written by National Research Council and published by National Academies Press. This book was released on 2009-03-24 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Risk assessment has become a dominant public policy tool for making choices, based on limited resources, to protect public health and the environment. It has been instrumental to the mission of the U.S. Environmental Protection Agency (EPA) as well as other federal agencies in evaluating public health concerns, informing regulatory and technological decisions, prioritizing research needs and funding, and in developing approaches for cost-benefit analysis. However, risk assessment is at a crossroads. Despite advances in the field, risk assessment faces a number of significant challenges including lengthy delays in making complex decisions; lack of data leading to significant uncertainty in risk assessments; and many chemicals in the marketplace that have not been evaluated and emerging agents requiring assessment. Science and Decisions makes practical scientific and technical recommendations to address these challenges. This book is a complement to the widely used 1983 National Academies book, Risk Assessment in the Federal Government (also known as the Red Book). The earlier book established a framework for the concepts and conduct of risk assessment that has been adopted by numerous expert committees, regulatory agencies, and public health institutions. The new book embeds these concepts within a broader framework for risk-based decision-making. Together, these are essential references for those working in the regulatory and public health fields.

Middleton's Allergy Essentials E-Book

Author : Robyn E O'Hehir
Publisher : Elsevier Health Sciences
ISBN 13 : 0323392733
Total Pages : 421 pages
Book Rating : 4.3/5 (233 download)

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Book Synopsis Middleton's Allergy Essentials E-Book by : Robyn E O'Hehir

Download or read book Middleton's Allergy Essentials E-Book written by Robyn E O'Hehir and published by Elsevier Health Sciences. This book was released on 2015-12-09 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: For decades, health care practitioners have relied on Middleton’s Allergy as their go-to reference for comprehensive information on allergic disorders. Now Middleton’s Allergy Essentials, by Drs. Robyn E. O'Hehir, Stephen T. Holgate, and Aziz Sheikh, offers a concise resource that’s both easily accessible and highly authoritative. Perfect for clinicians in primary and secondary care settings, this practical volume covers what is most useful in your daily practice, with a strong emphasis on disease diagnosis and management. A practical approach to evaluation, differential diagnosis, and treatment of allergic disorders, focused specifically on what the non-specialist needs to know for everyday practice. Each chapter begins with a handy summary of key concepts to help you quickly identify important information. Coverage of today’s hot topics includes asthma, drug allergies, food allergies and gastrointestinal disorders, anaphylaxis, atopic dermatitis, and allergic contact dermatitis. Concise sections on mechanisms are included where relevant, keeping you up to date with this rapidly evolving field. Authored by the same internationally recognized experts that produce Middleton’s Allergy, the definitive text in the field. Ideal for physicians, residents, general and family practitioners, nurse practitioners, primary care doctors, hospitalists, general internists – anyone who is called upon to make effective diagnostic and treatment decisions regarding allergic disorders.

Ensemble Methods in Data Mining

Author : Giovanni Seni
Publisher : Morgan & Claypool Publishers
ISBN 13 : 1608452840
Total Pages : 127 pages
Book Rating : 4.6/5 (84 download)

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Book Synopsis Ensemble Methods in Data Mining by : Giovanni Seni

Download or read book Ensemble Methods in Data Mining written by Giovanni Seni and published by Morgan & Claypool Publishers. This book was released on 2010 with total page 127 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Ensemble methods have been called the most influential development in Data Mining and Machine Learning in the past decade. They combine multiple models into one usually more accurate than the best of its components. Ensembles can provide a critical boost to industrial challenges -- from investment timing to drug discovery, and fraud detection to recommendation systems -- where predictive accuracy is more vital than model interpretability. Ensembles are useful with all modeling algorithms, but this book focuses on decision trees to explain them most clearly. After describing trees and their strengths and weaknesses, the authors provide an overview of regularization -- today understood to be a key reason for the superior performance of modern ensembling algorithms. The book continues with a clear description of two recent developments: Importance Sampling (IS) and Rule Ensembles (RE). IS reveals classic ensemble methods -- bagging, random forests, and boosting -- to be special cases of a single algorithm, thereby showing how to improve their accuracy and speed. REs are linear rule models derived from decision tree ensembles. They are the most interpretable version of ensembles, which is essential to applications such as credit scoring and fault diagnosis. Lastly, the authors explain the paradox of how ensembles achieve greater accuracy on new data despite their (apparently much greater) complexity."--Publisher's website.

Innovations in Bayesian Networks

Author : Dawn E. Holmes
Publisher : Springer
ISBN 13 : 354085066X
Total Pages : 324 pages
Book Rating : 4.5/5 (48 download)

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Book Synopsis Innovations in Bayesian Networks by : Dawn E. Holmes

Download or read book Innovations in Bayesian Networks written by Dawn E. Holmes and published by Springer. This book was released on 2008-09-10 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bayesian networks currently provide one of the most rapidly growing areas of research in computer science and statistics. In compiling this volume we have brought together contributions from some of the most prestigious researchers in this field. Each of the twelve chapters is self-contained. Both theoreticians and application scientists/engineers in the broad area of artificial intelligence will find this volume valuable. It also provides a useful sourcebook for Graduate students since it shows the direction of current research.

Making Data Talk

Author : David E. Nelson (M.D.)
Publisher :
ISBN 13 : 019538153X
Total Pages : 340 pages
Book Rating : 4.1/5 (953 download)

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Book Synopsis Making Data Talk by : David E. Nelson (M.D.)

Download or read book Making Data Talk written by David E. Nelson (M.D.) and published by . This book was released on 2009 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: The demand for health information continues to increase, but the ability of health professionals to provide it clearly remains variable. The aim of this book is (1) to summarize and synthesize research on the selection and presentation of data pertinent to public health, and (2) to provide practical suggestions, based on this research summary and synthesis, on how scientists and other public health practitioners can better communicate data to the public, policy makers, and the press in typical real-world situations. Because communication is complex and no one approach works for all audiences, the authors emphasize how to communicate data "better" (and in some instances, contrast this with how to communicate data "worse"), rather than attempting a cookbook approach. The book contains a wealth of case studies and other examples to illustrate major points, and actual situations whenever possible. Key principles and recommendations are summarized at the end of each chapter. This book will stimulate interest among public health practitioners, scholars, and students to more seriously consider ways they can understand and improve communication about data and other types of scientific information with the public, policy makers, and the press. Improved data communication will increase the chances that evidence-based scientific findings can play a greater role in improving the public's health.

Graph Mining

Author : Deepayan Chakrabarti
Publisher : Morgan & Claypool Publishers
ISBN 13 : 160845116X
Total Pages : 209 pages
Book Rating : 4.6/5 (84 download)

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Book Synopsis Graph Mining by : Deepayan Chakrabarti

Download or read book Graph Mining written by Deepayan Chakrabarti and published by Morgan & Claypool Publishers. This book was released on 2012-10-01 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: What does the Web look like? How can we find patterns, communities, outliers, in a social network? Which are the most central nodes in a network? These are the questions that motivate this work. Networks and graphs appear in many diverse settings, for example in social networks, computer-communication networks (intrusion detection, traffic management), protein-protein interaction networks in biology, document-text bipartite graphs in text retrieval, person-account graphs in financial fraud detection, and others. In this work, first we list several surprising patterns that real graphs tend to follow. Then we give a detailed list of generators that try to mirror these patterns. Generators are important, because they can help with "what if" scenarios, extrapolations, and anonymization. Then we provide a list of powerful tools for graph analysis, and specifically spectral methods (Singular Value Decomposition (SVD)), tensors, and case studies like the famous "pageRank" algorithm and the "HITS" algorithm for ranking web search results. Finally, we conclude with a survey of tools and observations from related fields like sociology, which provide complementary viewpoints. Table of Contents: Introduction / Patterns in Static Graphs / Patterns in Evolving Graphs / Patterns in Weighted Graphs / Discussion: The Structure of Specific Graphs / Discussion: Power Laws and Deviations / Summary of Patterns / Graph Generators / Preferential Attachment and Variants / Incorporating Geographical Information / The RMat / Graph Generation by Kronecker Multiplication / Summary and Practitioner's Guide / SVD, Random Walks, and Tensors / Tensors / Community Detection / Influence/Virus Propagation and Immunization / Case Studies / Social Networks / Other Related Work / Conclusions