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Polymer Drugs In The Clinical Stage
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Book Synopsis Polymer Drugs in the Clinical Stage by : Hiroshi Maeda
Download or read book Polymer Drugs in the Clinical Stage written by Hiroshi Maeda and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the International Symposium on Polymer Therapeutics - Recent Progress in Clinics and Future Prospects, held July 13-14, 2001, in Nara, Japan. The technology of polymer science has developed considerably during the past half-century, and this volume describes some of the aspects of this technology that will have a great impact in the future. Among these advances, for example, are gene delivery to specific disease sites and carrier polymers that respond to a stimulus or particular environment. Cancer targeted drug delivery is another focused area of this volume because of the important nature of EPR-effect of polymer drugs in tumor. Included are discussions of as many examples as possible of polymer drugs that have achieved, or are close to clinical use. The concept of "Polymer drugs" here is limited to primarily injectable and water-soluble agents, although also covered are some drugs in micellar form or liposomes. This book is intended for students and researchers in the field of pharmacology who have particular interests in drug delivery, targeting, and formulation, as well as for clinicians such as oncologists who are interested in the field. People who work at regulatory agencies should also be aware such that drugs with great potential are being developed and will be beneficial to many patients, as well as to health insurance agencies because of improved cost effectiveness.
Book Synopsis Drug Delivery Systems: Advanced Technologies Potentially Applicable in Personalised Treatment by : Jorge Coelho
Download or read book Drug Delivery Systems: Advanced Technologies Potentially Applicable in Personalised Treatment written by Jorge Coelho and published by Springer Science & Business Media. This book was released on 2013-03-15 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is part of a series dedicated to recent advances on preventive, predictive and personalised medicine (PPPM). It focuses on the theme of “Drug delivery systems: advanced technologies potentially applicable in personalised treatments”. The critical topics involving the development and preparation of effective drug delivery systems, such as: polymers available, self-assembly, nanotechnology, pharmaceutical formulations, three dimensional structures, molecular modeling, tailor-made solutions and technological tendencies, are carefully discussed. The understanding of these areas constitutes a paramount route to establish personalised and effective solutions for specific diseases and individuals.
Book Synopsis Polymer-Drug Conjugates by : Jitender Madan
Download or read book Polymer-Drug Conjugates written by Jitender Madan and published by Elsevier. This book was released on 2023-07-05 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymer-Drug Conjugates: Linker Chemistry, Protocols and Applications discusses important concepts, fundamentals and prospective applications of 'Linker Chemistry' in a clear-and-concise manner. The book provides vital information on chemical entities binding with the drug-polymer complex for targeted drug delivery systems. It highlights roles and significance, different classes and synthetic protocols as well as mechanisms of chemical bond formation in drug-polymer conjugation in drug delivery, also offering insights into the mechanism of polymer interaction with linker and drug molecules by biodegradable chemical bonding. The protocol of binding with drug molecules is clearly explained and justified with case studies, helping researchers and advanced students in the pharmaceutical sciences understand fundamentals involved and related aspects in molecule designing for effective therapeutic benefits. - Covers mechanism, protocol and therapeutic significance of Polymer-Drug Conjugates - Outlines updated methods and techniques to enumerate conjugation with related case studies - Includes comprehensive compilation of marketed and clinical trial drugs conjugated with polymers or linkers
Author :Francesco M. Veronese Publisher :Springer Science & Business Media ISBN 13 :3764386797 Total Pages :289 pages Book Rating :4.7/5 (643 download)
Book Synopsis PEGylated Protein Drugs: Basic Science and Clinical Applications by : Francesco M. Veronese
Download or read book PEGylated Protein Drugs: Basic Science and Clinical Applications written by Francesco M. Veronese and published by Springer Science & Business Media. This book was released on 2009-12-30 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: PEGylation technology and key applications are introduced by this topical volume. Basic physical and chemical properties of PEG as basis for altering/improving in vivo behaviour of PEG-conjugates such as increased stability, improved PK/PD, and decreased immunogenicity, are discussed. Furthermore, chemical and enzymatic strategies for the coupling and the conjugate characterization are reported. Following chapters describe approved and marketed PEG-proteins and PEG-oligonucleotides as well as conjugates in various stages of clinical development.
Book Synopsis Biodegradable Polymers in Clinical Use and Clinical Development by : Abraham J. Domb
Download or read book Biodegradable Polymers in Clinical Use and Clinical Development written by Abraham J. Domb and published by John Wiley & Sons. This book was released on 2011-05-12 with total page 594 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on biodegradable polymers that are already in clinical use or under clinical development. Synthetic and natural polymers will be included. This excludes polymers that have been investigated and did not reach clinical development. The purpose of this book is to provide updated status of the polymers that are clinical use and those that are now being developed for clinical use and hopefully will reach the clinic during the next 5 years. The book provides information that of interest to academics and practicing researchers including chemists, biologists and bioengineers and users: physicians, pharmacists.
Book Synopsis Nanocarriers for Drug Delivery by : Shyam Mohapatra
Download or read book Nanocarriers for Drug Delivery written by Shyam Mohapatra and published by Elsevier. This book was released on 2018-10-05 with total page 702 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nano-carriers for Drug Delivery: Nanoscience and Nanotechnology in Drug Delivery presents recent discoveries in research on the pharmaceutical applications of the various types of nanosystem-based drug delivery systems. As many nanosystems have reached the market over the past decade, this book proves their benefits to patients. It explores these new carriers and the advances in drug delivery they have facilitated. Reflecting the interdisciplinary nature of the subject matter, the book includes experts from different fields, and with various backgrounds and expertise. It will appeal to researchers and students from different disciplines, such as materials science, technology and various biomedical fields. Coverage includes industrial applications that bridge the gap between lab-based research and practical industrial use. The resulting work is a reference and practical source of guidance for researchers, students and scientists working in the fields of nanotechnology, materials science and technology and biomedical science. - Enables readers from different fields to access recent research and protocols across traditional boundaries - Focuses on protocols and techniques, as well as the knowledge base of the field, thus enabling those in R&D to learn about, and successfully deploy, cutting-edge techniques - Includes sections on nanocarrier systems
Book Synopsis Drug Delivery in Oncology by : Felix Kratz
Download or read book Drug Delivery in Oncology written by Felix Kratz and published by John Wiley & Sons. This book was released on 2013-09-30 with total page 1828 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this first authoritative overview on modern cancer chemotherapy 121 international specialists have contributed their experience and recent data for what is likely to become the gold standard in the field. The authors summarize knowledge gained over the past decade, from basic concepts to successful applications in the clinic, covering active and passive targeting strategies as well as tissue-specific approaches. All current and future targeted delivery systems are discussed, from ligand-based to antibody-based polymer-based systems, right up to micro- and nanoparticulate systems. A special section covers the delivery of nucleic acid therapeutics, such as siRNA, miRNA and antisense nucleotides. In each case, a description of the basic technique is followed by a discussion of the latest preclinical and clinical developments in the field. By virtue of its clear and didactic structure, rich illustrative material and summary chapters, this handbook and ready reference enables the efficient transfer of knowledge between different disciplines, from basic research to the clinician and vice versa. It is equally well suited for professionals, researchers and students in medical oncology and cancer biology, and is also excellent for teaching medical students the foundations of 21st century cancer chemotherapy.
Book Synopsis Hot-Melt Extrusion by : Dennis Douroumis
Download or read book Hot-Melt Extrusion written by Dennis Douroumis and published by John Wiley & Sons. This book was released on 2012-04-24 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hot-melt extrusion (HME) - melting a substance and forcing it through an orifice under controlled conditions to form a new material - is an emerging processing technology in the pharmaceutical industry for the preparation of various dosage forms and drug delivery systems, for example granules and sustained release tablets. Hot-Melt Extrusion: Pharmaceutical Applications covers the main instrumentation, operation principles and theoretical background of HME. It then focuses on HME drug delivery systems, dosage forms and clinical studies (including pharmacokinetics and bioavailability) of HME products. Finally, the book includes some recent and novel HME applications, scale -up considerations and regulatory issues. Topics covered include: principles and die design of single screw extrusion twin screw extrusion techniques and practices in the laboratory and on production scale HME developments for the pharmaceutical industry solubility parameters for prediction of drug/polymer miscibility in HME formulations the influence of plasticizers in HME applications of polymethacrylate polymers in HME HME of ethylcellulose, hypromellose, and polyethylene oxide bioadhesion properties of polymeric films produced by HME taste masking using HME clinical studies, bioavailability and pharmacokinetics of HME products injection moulding and HME processing for pharmaceutical materials laminar dispersive & distributive mixing with dissolution and applications to HME technological considerations related to scale-up of HME processes devices and implant systems by HME an FDA perspective on HME product and process understanding improved process understanding and control of an HME process with near-infrared spectroscopy Hot-Melt Extrusion: Pharmaceutical Applications is an essential multidisciplinary guide to the emerging pharmaceutical uses of this processing technology for researchers in academia and industry working in drug formulation and delivery, pharmaceutical engineering and processing, and polymers and materials science. This is the first book from our brand new series Advances in Pharmaceutical Technology. Find out more about the series here.
Book Synopsis Polymers in Drug Delivery by : Ijeoma F. Uchegbu
Download or read book Polymers in Drug Delivery written by Ijeoma F. Uchegbu and published by CRC Press. This book was released on 2006-05-19 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Together, the nano explosion and the genomic revolution are ushering in a new frontier in drug delivery. In recent years we've seen how polymers can play a crucial role in controlling the rate of drug release, enhancing solubility and uptake, and limiting degradation and toxicity. In the very near future, they may well be used to deliver gene thera
Book Synopsis Frontiers in Anti-Cancer Drug Discovery by : Atta-ur Rahman
Download or read book Frontiers in Anti-Cancer Drug Discovery written by Atta-ur Rahman and published by Bentham Science Publishers. This book was released on 2017-07-06 with total page 181 pages. Available in PDF, EPUB and Kindle. Book excerpt: Frontiers in Anti-Cancer Drug Discovery is a book series devoted to publishing the latest and the most important advances in anti-cancer drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. The book series should prove to be of interest to all pharmaceutical scientists involved in research in anti-cancer drug design and discovery. Each volume is devoted to the major advances in anti-cancer drug design and discovery. The book series is essential reading to all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field. The eighth volume of the series features chapters covering the following topics: - T cells in gastrointestinal cancers - The pharmacology of adjudin – a male contraceptive with anti-cancer properties - Manipulating the tumor microenvironment - Treatment of hepatocellular carcinoma - Gold-based compounds as potential anti-cancer drug candidates - Oral nanostructure drug delivery for anti-cancer treatment
Book Synopsis Drug Carrier Systems by : A. M. Kroon
Download or read book Drug Carrier Systems written by A. M. Kroon and published by John Wiley & Sons. This book was released on 1989 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents the main developments of the past 20 years, relating advances in systems that release the active drug in a sustained and controlled way, and new drugs that address more specifically the tissues and cells with which they are designed to interact. Considers the problems of biodistribution and biodegradation, with in-depth discussion of the selectivity and toxicity of the drugs administered by the various carrier systems. Topics covered range from antibodies, polymers, liposomes, erythrocytes and erythrocyte ghosts, to implantable infusion pumps. Acidic paper. Annotation copyrighted by Book News, Inc., Portland, OR
Book Synopsis Nanotechnology-Based Precision Tools for the Detection and Treatment of Cancer by : Chad A. Mirkin
Download or read book Nanotechnology-Based Precision Tools for the Detection and Treatment of Cancer written by Chad A. Mirkin and published by Springer. This book was released on 2015-04-20 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses emerging nanotechnology-based tools that have the potential to dramatically impact cancer research, diagnostics, and treatment. Cancer is a complex, devastating, and debilitating disease and, although much progress has been made, novel, more effective diagnostic and treatment options are still needed, especially for advanced cancers. The ultimate goal is to detect cancer early and non-invasively and to provide efficacious and targeted precision treatments that cause fewer harmful side effects. This book explains how nanotechnology can exploit the size-, shape-, and composition-dependent properties of nanomaterials to provide novel tools for precision cancer medicine. It will be of interest to researchers and professionals working in the fields of chemistry, biology, materials science and engineering, and medicine who want to learn more about this fascinating and fast-paced area of research.
Book Synopsis Polymer-Protein Conjugates by : Gianfranco Pasut
Download or read book Polymer-Protein Conjugates written by Gianfranco Pasut and published by Elsevier. This book was released on 2019-10-30 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymer–Protein Conjugates: From Pegylation and Beyond helps researchers by offering a unique reference and guide into this fascinating area. Sections cover the challenges surrounding the homogeneity of conjugates, their purity and polymer toxicity on long-term use, and how to deal with the risk of immunogenicity. These discussions help researchers design new projects by taking into account the latest innovations for safe and site selective polymer conjugation to proteins. PEG has been the gold standard and likely will play this role for many years, but alternatives are coming into the market, some of which have already been launched. After five decades of improvements, the ideas in this book are entering into a new era of innovation because of the advances in genetic engineering, biochemistry and a better understanding of the results from clinical use of PEG conjugates in humans. - Provides an overview on the state-of-the-art of protein polymer conjugation - Presents both the pros and cons of polymer-protein conjugates from the point-of-view of their clinical outcomes - Outlines advantages and potential risks of present technology based on PEG - Offers new alternatives for PEG and new approaches for on site-selective protein modification - Identifies future direction of research in this field
Book Synopsis Engineering Polymer Systems for Improved Drug Delivery by : Rebecca A. Bader
Download or read book Engineering Polymer Systems for Improved Drug Delivery written by Rebecca A. Bader and published by John Wiley & Sons. This book was released on 2014-01-17 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymers have played a critical role in the rational design and application of drug delivery systems that increase the efficacy and reduce the toxicity of new and conventional therapeutics. Beginning with an introduction to the fundamentals of drug delivery, Engineering Polymer Systems for Improved Drug Delivery explores traditional drug delivery techniques as well as emerging advanced drug delivery techniques. By reviewing many types of polymeric drug delivery systems, and including key points, worked examples and homework problems, this book will serve as a guide to for specialists and non-specialists as well as a graduate level text for drug delivery courses.
Author :Melgardt M. de Villiers Publisher :Springer Science & Business Media ISBN 13 :0387776680 Total Pages :681 pages Book Rating :4.3/5 (877 download)
Book Synopsis Nanotechnology in Drug Delivery by : Melgardt M. de Villiers
Download or read book Nanotechnology in Drug Delivery written by Melgardt M. de Villiers and published by Springer Science & Business Media. This book was released on 2008-10-29 with total page 681 pages. Available in PDF, EPUB and Kindle. Book excerpt: The reader will be introduced to various aspects of the fundamentals of nanotechnology based drug delivery systems and the application of these systems for the delivery of small molecules, proteins, peptides, oligonucleotides and genes. How these systems overcome challenges offered by biological barriers to drug absorption and drug targeting will also be described.
Book Synopsis Basic Fundamentals of Drug Delivery by :
Download or read book Basic Fundamentals of Drug Delivery written by and published by Academic Press. This book was released on 2018-11-30 with total page 812 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basic Fundamentals of Drug Delivery covers the fundamental principles, advanced methodologies and technologies employed by pharmaceutical scientists, researchers and pharmaceutical industries to transform a drug candidate or new chemical entity into a final administrable drug delivery system. The book also covers various approaches involved in optimizing the therapeutic performance of a biomolecule while designing its appropriate advanced formulation. - Provides up-to-date information on translating the physicochemical properties of drugs into drug delivery systems - Explores how drugs are administered via various routes, such as orally, parenterally, transdermally or through inhalation - Contains extensive references and further reading for course and self-study
Book Synopsis Nanostructures for Cancer Therapy by : Alexandru Mihai Grumezescu
Download or read book Nanostructures for Cancer Therapy written by Alexandru Mihai Grumezescu and published by Elsevier. This book was released on 2017-04-11 with total page 922 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanostructures for Cancer Therapy discusses the available preclinical and clinical nanoparticle technology platforms and their impact on cancer therapy, including current trends and developments in the use of nanostructured materials in chemotherapy and chemotherapeutics. In particular, coverage is given to the applications of gold nanoparticles and quantum dots in cancer therapies. In addition to the multifunctional nanomaterials involved in the treatment of cancer, other topics covered include nanocomposites that can target tumoral cells and the release of antitumoral therapeutic agents. The book is an up-to-date overview that covers the inorganic and organic nanostructures involved in the diagnostics and treatment of cancer. - Provides an examination of nanoparticle delivery systems for cancer treatment, illustrating how the use of nanotechnology can help provide more effective chemotherapeutic treatments - Examines, in detail, the different types of nanomaterials used in cancer therapy, also explaining the effect of each - Provides a cogent overview of recent developments in the use of nanostructured materials in chemotherapeutics, allowing readers to quickly familiarize themselves with this area
