Platelets And Megakaryocytes

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Platelets and Megakaryocytes

Author : Jonathan M. Gibbins
Publisher : Springer Science & Business Media
ISBN 13 : 1592597823
Total Pages : 389 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Platelets and Megakaryocytes by : Jonathan M. Gibbins

Download or read book Platelets and Megakaryocytes written by Jonathan M. Gibbins and published by Springer Science & Business Media. This book was released on 2008-02-04 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: 12 The average human body has in the order of 10 circulating platelets. They are crucial for hemostasis, and yet excessive platelet activation is a major cause of m- bidity and mortality in western societies. It is therefore not surprising that platelets have become one of the most extensively investigated biological cell types. We are, however, far from understanding precisely how platelets become activated under physiological and pathophysiological conditions. In addition, there are large gaps in our knowledge of platelet production from their giant precursor cell, the megakar- cyte. Understanding megakaryocyte biology will be crucial for the development of platelet gene targeting. The aim of Platelets and Megakaryocytes is therefore to bring together established and recently developed techniques to provide a comprehensive guide to the study of both the platelet and the megakaryocyte. It consists of five s- tions split between two volumes. The more functional assays appear in Volume 1, whereas Volume 2 includes signaling techniques, postgenomic methods, and a n- ber of key perspectives chapters. Part I of Volume 1, Platelets and Megakaryocytes: Functional Assays, describes many well established approaches to the study of platelet function, including aggregometry, secretion, arachidonic acid metabolism, procoagulant responses, pla- let adhesion under static or flow conditions, flow cytometry, and production of microparticles. Although one would ideally wish to perform experiments with human platelets, studies within the circulation using intravital microscopy require the use of animal models, which are described in Chapter 16, vol. 1.

Platelets and Megakaryocytes

Author : Jonathan M. Gibbins
Publisher : Humana Press
ISBN 13 : 9781493985845
Total Pages : 287 pages
Book Rating : 4.9/5 (858 download)

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Book Synopsis Platelets and Megakaryocytes by : Jonathan M. Gibbins

Download or read book Platelets and Megakaryocytes written by Jonathan M. Gibbins and published by Humana Press. This book was released on 2018-08-29 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: The main aim of this fourth volume is to complement the first three volumes published in 2004 and 2012 by adding advanced methodologies and perspectives. Chapters guide readers through new techniques into the study of platelets and megakaryocytes, including new imaging approaches, new methods for platelet production in vitro, and systems biology approaches. Written in the highly successful Methods in Molecular Biology series format, methods chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and vital tips on troubleshooting or avoiding known pitfalls. Authoritative and up-to-date, Platelets and Megakaryocytes: Volume 4, Additional Protocols and Perspectives adds a wealth of new expertise for the labs of scientists working in this key biological area of study.

Platelets and Megakaryocytes

Author : Jonathan M. Gibbins
Publisher : Humana Press
ISBN 13 : 9781588290113
Total Pages : 504 pages
Book Rating : 4.2/5 (91 download)

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Book Synopsis Platelets and Megakaryocytes by : Jonathan M. Gibbins

Download or read book Platelets and Megakaryocytes written by Jonathan M. Gibbins and published by Humana Press. This book was released on 2004-08-13 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: 12 The average human body has on the order of 10 circulating platelets. They are crucial for hemostasis, and yet excessive platelet activation is a major cause of m- bidity and mortality in Western societies. It is therefore not surprising that platelets have become one of the most extensively investigated biological cell types. We are, however, far from understanding precisely how platelets become activated under physiological and pathophysiological conditions. In addition, there are large gaps in our knowledge of platelet production from their giant precursor cell, the megakar- cyte. Understanding megakaryocyte biology will be crucial for the development of platelet gene targeting. The aim of Platelets and Megakaryocytes is therefore to bring together established and recently developed techniques to provide a comprehensive guide to the study of both the platelet and the megakaryocyte. It consists of five s- tions split between two volumes. The more functional assays appear in Volume 1, whereas Volume 2 includes signaling techniques, postgenomic methods, and a n- ber of key perspectives chapters. Part I of Volume 1, Platelets and Megakaryocytes: Functional Assays, describes many well-established approaches to the study of platelet function, including aggregometry, secretion, arachidonic acid metabolism, procoagulant responses, pla- let adhesion under static or flow conditions, flow cytometry, and production of microparticles. Although one would ideally wish to perform experiments with human platelets, studies within the circulation using intravital microscopy require the use of animal models, which are described in Chapter 16, vol. 1.

Molecular and Cellular Biology of Platelet Formation

Author : Harald Schulze
Publisher : Springer
ISBN 13 : 9783319819143
Total Pages : 0 pages
Book Rating : 4.8/5 (191 download)

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Book Synopsis Molecular and Cellular Biology of Platelet Formation by : Harald Schulze

Download or read book Molecular and Cellular Biology of Platelet Formation written by Harald Schulze and published by Springer. This book was released on 2018-07-17 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gives a comprehensive insight into platelet biogenesis, platelet signal transduction, involvement of platelets in disease, the use of diverse animal models for platelet research and future perspectives in regard to platelet production and gene therapy. Being written by international experts, the book is a concise state-of-the art work in the field of platelet biogenesis, biology and research. It represents an indispensable tool for research scientists in biomedicine, vascular biology, hematopoiesis and hemostasis and specifically for scientists in platelet research, as well as for clinicians in the field of hematology and transfusion medicine.

Functional Ultrastructure

Author : Margit Pavelka
Publisher : Springer Science & Business Media
ISBN 13 : 3211993908
Total Pages : 366 pages
Book Rating : 4.2/5 (119 download)

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Book Synopsis Functional Ultrastructure by : Margit Pavelka

Download or read book Functional Ultrastructure written by Margit Pavelka and published by Springer Science & Business Media. This book was released on 2010-07-16 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: The period between 1950 and 1980 were the golden unique insights into how pathological processes affect years of transmission electron microscopy and produced cell organization. a plethora of new information on the structure of cells This information is vital to current work in which that was coupled to and followed by biochemical and the emphasis is on integrating approaches from functional studies. TEM was king and each micrograph proteomics, molecular biology, genetics, genomics, of a new object produced new information that led to molecular imaging and physiology and pathology to novel insights on cell and tissue organization and their understand cell functions and derangements in disease. functions. The quality of data represented by the images In this current era, there is a growing tendency to of cell and tissues had been perfected to a very high level substitut e modern light microscopic techniques for by the great microscopists of that era including Palade, electron microscopy, because it is less technically Porter, Fawcett, Sjostrand, Rhodin and many others. At demanding and is more readily available to researchers- present, the images that we see in leading journals for This atlas reminds us that the information obtained by the most part do not reach the same technical level and electron microscopy is invaluable and has no substitute.

Williams Hematology Hemostasis and Thrombosis

Author : Kenneth Kaushansky
Publisher : McGraw Hill Professional
ISBN 13 : 126011709X
Total Pages : 545 pages
Book Rating : 4.2/5 (61 download)

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Book Synopsis Williams Hematology Hemostasis and Thrombosis by : Kenneth Kaushansky

Download or read book Williams Hematology Hemostasis and Thrombosis written by Kenneth Kaushansky and published by McGraw Hill Professional. This book was released on 2018-01-12 with total page 545 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hemostasis and Thrombosis as only Williams can cover them A Doody’s Core Title for 2019! Featuring content derived from Williams Hematology, Ninth Edition. this concise, full-color resource delivers comprehensive and current coverage of hemostasis and thrombosis, and platelet and megakaryocyte disorders. More than a sectional reprint, the book includes updated science and treatment recommendations not found in the 2015 release of Williams Hematology, Ninth Edition. Perfect for use at the point of care, Williams Hemostasis and Thrombosis offers the most current evaluation and treatment options for patients with bleeding and thrombotic disorders. •Covers the latest advances in hemostasis and thrombosis •A handy quick summary appears at the beginning of each chapter •Discusses the physiologic basis for hemostasis and thrombosis

Platelets and Megakaryocytes

Author : Jonathan M. Gibbins
Publisher : Humana Press
ISBN 13 : 9781493958474
Total Pages : 409 pages
Book Rating : 4.9/5 (584 download)

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Book Synopsis Platelets and Megakaryocytes by : Jonathan M. Gibbins

Download or read book Platelets and Megakaryocytes written by Jonathan M. Gibbins and published by Humana Press. This book was released on 2016-08-23 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: New techniques to study cell signaling and function can develop at a staggering pace; however, many approaches are as valid today as on the day they were established. Thus, the main aim of Platelets and Megakaryocytes: Volume 3, Additional Protocols and Perspectives is to complement the first two volumes published in 2004 by adding recently developed state of the art techniques. Conveniently divided into three sections, this detailed volume covers techniques to study platelet function, approaches to investigate megakaryocyte function, and perspectives on important overall concepts in the field of megakaryocyte and platelet biology. Written in the highly successful Methods in Molecular BiologyTM series format, methods chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and vital tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Platelets and Megakaryocytes: Volume 3, Additional Protocols and Perspectives adds a wealth of new expertise for the labs of scientists working in this key biological area of study.

Thrombopoiesis and Thrombopoietins

Author : David Kuter
Publisher : Springer Science & Business Media
ISBN 13 : 1461239583
Total Pages : 411 pages
Book Rating : 4.4/5 (612 download)

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Book Synopsis Thrombopoiesis and Thrombopoietins by : David Kuter

Download or read book Thrombopoiesis and Thrombopoietins written by David Kuter and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt: David Kuter and a host of leading international researchers summarize in one volume all the knowledge of thrombopoietins (TPO) available today. The distinguished experts review the history of the search to discover TPO, describe the molecular and biological characteristics of this new molecule, and present the results of the preclinical animal experiments that will guide clinical use of this new hormone. Along the way they provide the most recent and comprehensive guide to the biology of megakaryocytes and platelets.

Megakaryocytes, Platelets, Macrophages, and Eosinophils

Author : J. Robin Harris
Publisher : Springer Science & Business Media
ISBN 13 : 1475795319
Total Pages : 363 pages
Book Rating : 4.4/5 (757 download)

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Book Synopsis Megakaryocytes, Platelets, Macrophages, and Eosinophils by : J. Robin Harris

Download or read book Megakaryocytes, Platelets, Macrophages, and Eosinophils written by J. Robin Harris and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: Blood Cell Biochemistry was initially conceived as part of the Plenum series Subcellular Biochemistry, from which it has developed into a separate series. The present volume is devoted primarily to contributions on megakaryocytes and platelets and, to a lesser extent, to macrophages and eosinophils. The book does not attempt a rigorous or total coverage of the particular topics; it represents the areas of current scientific activity and interest that were selected by the editor at the commencement of this project. In general, the approach has been similar to that adopted for Volume 1 of the series (Erythroid Cells); the same approach will be followed subsequently in Volume 3 (Lymphocytes and Granulocytes). This book opens with a developmentally oriented chapter by Janine Breton-Gorius on megakaryocyte maturation and platelet release in normal conditions, which serves to set the scene ultrastructurally for much of the data that follow. The biosynthesis and process ing of platelet glycoproteins in megakaryocytes is dealt with by Alain Duperray and his colleagues, and thereby provides an in-depth biochemical survey of the megakaryocyte. The applications and strengths of crossed immunoelectrophoresis for the study of platelet membrane proteins is then covered by Simon Karpatkin, and a detailed account of the heredity disorders of platelet function is provided by Francine Rendu and Evelyne Dupuy.

Platelets and Megakaryocytes

Author : Jonathan M. Gibbins
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (112 download)

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Book Synopsis Platelets and Megakaryocytes by : Jonathan M. Gibbins

Download or read book Platelets and Megakaryocytes written by Jonathan M. Gibbins and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Platelets in Thrombotic and Non-Thrombotic Disorders

Author : Paolo Gresele
Publisher : Springer
ISBN 13 : 3319474626
Total Pages : 1445 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Platelets in Thrombotic and Non-Thrombotic Disorders by : Paolo Gresele

Download or read book Platelets in Thrombotic and Non-Thrombotic Disorders written by Paolo Gresele and published by Springer. This book was released on 2017-03-08 with total page 1445 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews current science and applications in fields including thrombosis and hemostasis, signal transduction, and non-thrombotic conditions such as inflammation, allergy and tumor metastasis. It is a detailed, up-to-date, highly referenced text for clinical scientists and physicians, including recent developments in this rapidly expanding field. More than a scientific resource, this is also an authoritative reference and guide to the diagnosis.

The Non-Thrombotic Role of Platelets in Health and Disease

Author : Steve W. Kerrigan
Publisher : BoD – Books on Demand
ISBN 13 : 9535122088
Total Pages : 250 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis The Non-Thrombotic Role of Platelets in Health and Disease by : Steve W. Kerrigan

Download or read book The Non-Thrombotic Role of Platelets in Health and Disease written by Steve W. Kerrigan and published by BoD – Books on Demand. This book was released on 2015-11-18 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Platelets play a key role in thrombosis and haemostasis. However recent evidence clearly demonstrates that the functional role of platelets extends to many other processes in the body. With an internationally recognised list of contributing authors, The Non-Thrombotic Role of Platelets in Health and Disease, is a unique and definitive source of state-of-the-art knowledge about the additional role of platelets outside thrombosis and haemostasis. The intended audience for The Non-Thrombotic Role of Platelets in Health and Disease includes platelet biologists, microbiologists, immunologists, haematologists, oncologists, respiratory physicians, cardiologists, neurobiologists, tissue engineers, as well as students and fellows in these areas.

Veterinary Hematology - E-Book

Author : John W. Harvey
Publisher : Elsevier Health Sciences
ISBN 13 : 1437723608
Total Pages : 368 pages
Book Rating : 4.4/5 (377 download)

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Book Synopsis Veterinary Hematology - E-Book by : John W. Harvey

Download or read book Veterinary Hematology - E-Book written by John W. Harvey and published by Elsevier Health Sciences. This book was released on 2011-12-20 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Combining essential hematology content with the diagnostic features of an atlas, Veterinary Hematology: A Diagnostic Guide and Color Atlas delivers all the information you need to accurately assess and diagnose the blood diseases of common domestic animals — including dogs, cats, horses, cattle, sheep, goats, pigs, and llamas. This all-in-one resource utilizes a clinically-oriented and user-friendly approach to guide you through the processes of selecting relevant diagnostic tests, collecting and preparing samples, interpreting sample results, and determining their clinical significance. High-resolution photomicrographs, full-color illustrations, and excellent schematic drawings, tables, and quick-reference algorithms help you clearly visualize these concepts and procedures. Two books in one gives you the information of a user-friendly, clinical textbook and the diagnostic features of a color atlas in a single reference. Practical, clinically-relevant text is comprehensive and yet concise in its delivery of vital information such as: Principles and procedures that are employed in recognizing normal, abnormal, and artifactual features of blood and bone marrow samples and developing accurate diagnoses Common cytochemical stains and summary charts for interpretation Sample collection, staining procedures, and diagnostic techniques Differentiating features of malignant and benign hematologic disorders Miscellaneous cells and blood parasites and their significance in the evaluation of blood smears Hematopoietic and non-hematopoietic neoplasms High- resolution photomicrographs and excellent schematic drawings, tables, boxes and quick-reference algorithms aid your understanding of basic clinical concepts and differential diagnostic considerations. Over 800 full-color illustrations help you clearly visualize the concepts and clinical features of the blood and bone marrow — from normal cell maturation to the development of various pathologies.

Platelets and Megakaryocytes

Author : Jonathan M. Gibbins
Publisher :
ISBN 13 : 9781617793073
Total Pages : 409 pages
Book Rating : 4.7/5 (93 download)

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Book Synopsis Platelets and Megakaryocytes by : Jonathan M. Gibbins

Download or read book Platelets and Megakaryocytes written by Jonathan M. Gibbins and published by . This book was released on 2012 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt:

From Megakaryocytes to Platelets

Author : Olav Behnke
Publisher :
ISBN 13 : 9788716156396
Total Pages : 23 pages
Book Rating : 4.1/5 (563 download)

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Book Synopsis From Megakaryocytes to Platelets by : Olav Behnke

Download or read book From Megakaryocytes to Platelets written by Olav Behnke and published by . This book was released on 1998 with total page 23 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Experimental Hematology Today

Author : S. J. Baum
Publisher : Springer Science & Business Media
ISBN 13 : 1461298954
Total Pages : 247 pages
Book Rating : 4.4/5 (612 download)

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Book Synopsis Experimental Hematology Today by : S. J. Baum

Download or read book Experimental Hematology Today written by S. J. Baum and published by Springer Science & Business Media. This book was released on 2013-03-12 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is perhaps not too much of an exaggeration to claim that experimental hematology as it flourishes today originated largely from the pioneering attempts to protect lethally radiated animals (1) by shielding of hemopoietic tissues by L.O. Jacobson (9), and (2) by treatment with bone marrow suspensions by E. Lorenz and his col laborators (12). The site chosen for this annual meeting of the International Society for Experi mental Hematology is given a special historic sig nificance by the fact that it was 25 years ago that the first publication on this subject by Lorenz ap peared from his laboratory at the National Insti tutes of Health. Lorenz's discovery marked the beginning of a period which lasted until 1956, during which the protection afforded by hemopoietic cell suspensions was confirmed by many. This soon led to an intensive scientific de bate on the mechanism of this protective effect: was it due to a humoral factor produced and pro vided by the bone marrow-as Lorenz The Appearance of postulated-or to transplantation and subsequent proliferation of hemop- etic cells? This question was defini- 1 the Multipotential tively answered in 1956 by evidence from three different laboratories (7, 15, 26), which demonstrated the origin of the cells Hemopoietic in the repopulated tissues using a variety of cellu lar and immunologic markers. By the same token, these contributions marked the birth of radiation Stem Cell chimeras.

Hematopathology

Author : Faramarz Naeim
Publisher : Academic Press
ISBN 13 : 9780080919485
Total Pages : 612 pages
Book Rating : 4.9/5 (194 download)

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Book Synopsis Hematopathology by : Faramarz Naeim

Download or read book Hematopathology written by Faramarz Naeim and published by Academic Press. This book was released on 2009-03-05 with total page 612 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive, full color hematopathology reference book emphasizes immunophenotpic features, cytogenetic studies, and diagnostic molecular aspects. Hematopathology begins with introductions to morphologic evaluation of the hematopoietic tissues and principles of immunophenotyping, cytogenetics and molecular studies followed by chapters dedicated to different types of hematologic disorders. Each chapter starts with a basic overview of hematopathlogy followed by a comprehensive review of immunophenotypic, cytogenetic and molecular findings. The text is balanced with large numbers of full color images, graphs, charts, and tables to assist the reader in understanding these highly technical issues. * Emphasizes the immunophenotypic features, cytogenetic studies, and diagnostic molecular aspects of hematology * Features hundreds of images, charts and tables for the identification of hematologic disorders not only based on histopathologic features, but also with the use of advanced accessory techniques.