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Author : Konstanze Margarete Hebeda
Publisher :
ISBN 13 :
Total Pages : 148 pages
Book Rating : 4.:/5 (379 download)
Download or read book Photodynamic Therapy of Brain Tumors (PDT) written by Konstanze Margarete Hebeda and published by . This book was released on 1995 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Thierry Patrice
Publisher : Royal Society of Chemistry
ISBN 13 : 1847551653
Total Pages : 292 pages
Book Rating : 4.8/5 (475 download)
Download or read book Photodynamic Therapy written by Thierry Patrice and published by Royal Society of Chemistry. This book was released on 2007-10-31 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: For centuries, light has been used to cure various diseases. However, it is only recently that a new medical field has arisen. Photodynamic therapy (PDT), also known as photochemotherapy, is a fast growing technique which was initially devoted to cancer care but which is now recognised as a promising treatment technique in a variety of clinical fields. Written by recognised experts, Photodynamic Therapy provides a comprehensive explanation of what PDT is and how it has developed as a technique in areas such as the detection of lung cancer and applications in dermatology, gynaecology and neurosurgery. This book is ideal both as an introduction to PDT and as an informative text for those wishing to expand their knowledge. Practitioners in biological sciences, biotechnology and medicinal and pharmaceutical chemistry will find it an invaluable source of information.
Author : Flora Fitzgerald
Publisher : Nova Biomedical Books
ISBN 13 : 9781536119121
Total Pages : 0 pages
Book Rating : 4.1/5 (191 download)
Download or read book Photodynamic Therapy (PDT) written by Flora Fitzgerald and published by Nova Biomedical Books. This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: As a new concept of cancer treatment, photodynamic therapy (PDT) has gained great attention in the last few decades. Compared to classical treatments such as surgery, chemotherapy and radiotherapy, PDT is a noninvasive, localized treatment of lesions that shows fewer side effects and has low systemic toxicity. In Chapter One, the basic mechanisms, applications and functional nanomaterials-based drug delivery systems for photodynamic therapy of cancer are reviewed. Chapter Two summarizes the application of different carbon based nanomaterials as agents for PDT and discusses current state-of-the-art use of fullerenes and their derivatives, carbon nanotubes and graphene quantum dots in PDT. Chapter Three covers the benefits and pitfalls of using chemi- and bioluminescent systems as intracellular excitation sources in PDT. Bioluminescence is a widespread natural phenomenon, which consists on emission of light resulting from the oxidation of a substrate in a reaction catalyzed by an enzyme in a biological system. Chapter Four addresses in the synthesis, characterization, and photodynamic activity of a novel hydrophobic photosensitizer 5,10,15,20-tetrakis(benzo[b]thiophene) Porphyrin (BTP) and water soluble photosensitizer 5,10,15,20-Tetrakis(7- sulfonatobenzo[b]thiophene) Porphyrin (SBTP). The authors lab is engaged in the synthesis of PDT molecules incorporating benzothiophene moiety to the meso-position of porphyrin molecules. Chapter Five discusses the Guidelines for Gastroenterological Endoscopy in Patients on Oral Antithrombotic Treatment established by the Japan Gastroenterological Endoscopy Society (JGES).These guidelines classify endoscopic interventions according to the risk of hemorrhage and specify the management of various antithrombotic drugs. Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are classified as high-risk procedures for hemorrhage, but PDT is not included in the guidelines. Because PDT causes ischemic necrosis of tumor tissue, the authors say this could possibly be performed safely in patients on oral antithrombotic therapy. The authors of Chapter Six developed a method of the initial concentration of protoporphyrin-IX in the operated removing glioblastoma tissue using the calibration curve of the fluorescent intensity and the known Pp-IX concentration in order to estimate of the more correlated with the cure rate.
Author : Thierry Patrice
Publisher : Royal Society of Chemistry
ISBN 13 : 9780854043064
Total Pages : 306 pages
Book Rating : 4.0/5 (43 download)
Download or read book Photodynamic Therapy written by Thierry Patrice and published by Royal Society of Chemistry. This book was released on 2003 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by recognised experts, Photodynamic Therapy provides a comprehensive explanation of what PDT is and how it has developed as a technique.
Author : Michael R. Hamblin
Publisher : CRC Press
ISBN 13 : 1315278162
Total Pages : 502 pages
Book Rating : 4.3/5 (152 download)
Download or read book Imaging in Photodynamic Therapy written by Michael R. Hamblin and published by CRC Press. This book was released on 2017-02-03 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the broad field of cellular, molecular, preclinical, and clinical imaging either associated with or combined with photodynamic therapy (PDT). It showcases how this approach is used clinically for cancer, infections, and diseases characterized by unwanted tissue such as atherosclerosis or blindness. Because the photosensitizers are also fluorescent, the book also addresses various imaging systems such as confocal microscopy and small animal imaging systems, and highlights how they have been used to follow and optimize treatment, and to answer important mechanistic questions. Chapters also discuss how imaging has made important contributions to clinical outcomes in skin, bladder, and brain cancers, as well as in the development of theranostic agents for detection and treatment of disease. This book provides a resource for physicians and research scientists in cell biology, microscopy, optics, molecular imaging, oncology, and drug discovery.
Author : Fabienne Dumoulin
Publisher : World Scientific Publishing Company
ISBN 13 : 9789811223549
Total Pages : 0 pages
Book Rating : 4.2/5 (235 download)
Download or read book Porphyrin Science by Women (in 3 Volumes) written by Fabienne Dumoulin and published by World Scientific Publishing Company. This book was released on 2021-01-21 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a reprint three volume set with a thematic organization of the articles of the four Women in Porphyrin Science special issues published in the Journal of Porphyrins and Phthalocyanines in 2019. All the articles were carefully arranged by the volume editors and Karl Kadish, the Journal of Porphyrins and Phthalocyanines Editor-in-Chief, in order to provide a comprehensive coverage of each topic. Volume 1 covers the biomedical aspects, applications and uses of BODIPY's, porphyrins, phthalocyanines and related derivatives, mainly for photodynamic therapy. Volume 2 covers the synthesis, characteristics and properties of these compounds, while Volume 3 is on topics related to materials, sensors, energy and catalysis. These state-of-the-art articles are contributed by women. This book will strongly contribute to the visibility of women in the field of porphyrin science.
Author : Abdul-Amir Yassine
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (133 download)
Download or read book PDT-SPACE written by Abdul-Amir Yassine and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Photodynamic Therapy (PDT) is a minimally invasive oncology treatment that uses light-activated photosensitizers to destroy tumors locally. It has been approved for a variety of superficial tumor indications such as the skin. For deep-seated tumors like brain glioma, the treatment (via interstitial light illumination with fiber optic probes) is yet to be approved due to several challenges that hinder its efficacy. Much of the research to improve interstitial PDT's (iPDT) therapeutic index has been directed towards developing targeted photosensitizers. However, another factor that highly affects iPDT efficacy is the light penetration inside the tissues, especially when the tumor is surrounded by extremelysensitive healthy tissues such as white matter in the brain. This thesis introduces PDT-SPACE, an open-source software for automatic iPDT planning. We present novel computer-aided design (CAD) algorithms to allocate powers to a set of light diffusers and determine the location and lengths of those diffusers in order to minimize the damage to surrounding organs-at-risk (OAR), while maximizing the damage to the tumor. We also generalize the power allocation algorithm to generate tailored power profiles for cylindrical diffusers to better conform the light distribution to the tumor shape and further decrease the damage. We simulate our methods onnine virtual brain tumors constructed from glioblastoma multiforme (GBM) MRI images taken from the cancer imaging archive. Through the various optimizations presented, we show that the treatment plans generated by PDT-SPACE can reduce damage to OAR by more than 70% on average compared to state-of-the-art techniques, while destroying at least 98% of the tumor. Additionally, we present several techniques utilizing machine learning to generate robust treatment plans that take into account inter-patient variations of tissue optical properties. These robust treatment plans are more adaptable to the biological uncertainties of individual patients. Finally, we show how PDT-SPACE serves as a prospective methodology to analyze the effect of different combinations of optimization parameters on iPDT efficacy for various oncological indications while avoiding the technical difficulties that come with in-vivo direct measurements. We present different treatment plans (each with its own trade-off) to treat bone metastasis resulting from colorectal cancer recurrence.
Author : Valentina Rapozzi
Publisher : Springer
ISBN 13 : 3319127306
Total Pages : 253 pages
Book Rating : 4.3/5 (191 download)
Download or read book Resistance to Photodynamic Therapy in Cancer written by Valentina Rapozzi and published by Springer. This book was released on 2014-12-11 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a comprehensive review of resistance induced by photodynamic therapy (PDT) in tumor cells. Understanding the underlying mechanisms in this process leads to the improvement of therapeutic modality, in combination with chemotherapy, immunotherapy, and radiotherapy. Photodynamic therapy is a minimally invasive therapeutic procedure that can exert a selective or preferential cytotoxic activity toward malignant cells. The procedure involves administration of an intrinsically non-toxic photosensitizing agent (PS) followed by irradiation at a wavelength corresponding to a visible absorption band of the sensitizer. In the presence of oxygen, a series of events lead to direct tumor cell death, damage to the microvasculature, and induction of a local inflammatory reaction. Studies reveal that PDT can be curative, particularly in early stage tumors and this volume explores the potential of PDT, but also reveals strategic approaches to overcome resistance in tumor cells.
Author : David Kessel
Publisher : CRC Press
ISBN 13 : 9780849358166
Total Pages : 358 pages
Book Rating : 4.3/5 (581 download)
Download or read book Photodynamic Therapy of Neoplastic Disease written by David Kessel and published by CRC Press. This book was released on 1990-05-23 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: This two-volume text provides a summary of current studies relating to the use of photosensitizing agents in the diagnosis and therapy of cancer. This interesting work describes synthesis of new sensitizers, photochemical and photobiological properties of dyes currently used for photodynamic therapy, plus those being examined with a view toward providing therapeutic advantages. It contains results and methodology from leading experts on the use of porphyrins and other photosensitizers for detection of neoplastic disease and for photodynamic therapy of neoplastic disease. The volumes focus on the major clinical and pre-clinical research groups. They also include an appended bibliography which lists all pertinent publications in this field. This easy-to-understand book is written for all workers in the field of photodynamic therapy and provides an introduction to those beginning research on some aspect of tumor photosensitization.
Author : Haini Zhang
Publisher :
ISBN 13 :
Total Pages : 36 pages
Book Rating : 4.:/5 (13 download)
Download or read book LS301 Fluorescence-guided Photodynamic Therapy of Brain Cancer Using PpIX Photosensitizer written by Haini Zhang and published by . This book was released on 2017 with total page 36 pages. Available in PDF, EPUB and Kindle. Book excerpt: Incomplete brain tumor removal always causes neurologic deficit, disease recurrence and high mortality. Protoporphyrin IX (PpIX) accumulated in glioma cells with exogenous 5-aminolevulinic acid (5-ALA) serves as contrast agent for fluorescence-guided surgery and as well as acts as a photosensitizer for photodynamic therapy (PDT). However, the accurate tumor delineation using PpIX is limited by autofluorescence and superficial penetration depth. LS301 is a tumor-targeted near-infrared (NIR) contrast agent developed in our lab which allows deeper tumor imaging and avoids autofluorescence. My project aims to investigate whether LS301 can improve PpIX mediated PDT and tumor removal surgery. We have demonstrated co-localization of LS301 and PpIX in DBT and U87-MG glioma cell lines and are currently testing the effect of LS301 on PpIX mediated PDT in vitro. We will also compare LS301-PpIX with PpIX only PDT and tumor removal in mouse models of brain cancer. This study can potentially increase efficacy of PDT and fluorescence-guided brain tumor resection.
Author : Michael R. Hamblin
Publisher : Artech House
ISBN 13 : 1596932783
Total Pages : 601 pages
Book Rating : 4.5/5 (969 download)
Download or read book Advances in Photodynamic Therapy written by Michael R. Hamblin and published by Artech House. This book was released on 2008 with total page 601 pages. Available in PDF, EPUB and Kindle. Book excerpt: With today's focus on targeted and minimally invasive therapies, photodynamic therapy (PDT) is now being studied and used to combat many disease states and to investigate critical biological questions. This groundbreaking resource brings you the latest advances in photodynamic therapy and offers you a solid understanding of the design, delivery and dosimetry of the three basic ingredients of PDT - photosensitizers, light and oxygen. The book covers novel areas of mechanistic and innovative translational approaches. Moreover, it gives you an overview of the important medical applications of PDT, including approved treatments, clinical trials, and investigated therapies for cancer and non-malignant diseases.
Author : Barbara W. Henderson
Publisher : CRC Press
ISBN 13 : 1000148017
Total Pages : 484 pages
Book Rating : 4.0/5 (1 download)
Download or read book Photodynamic Therapy written by Barbara W. Henderson and published by CRC Press. This book was released on 2020-07-24 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering all aspects of photodynamic therapy, 70 expert contributors from the fields of photochemistry, photobiology, photophysics, pharmacology, oncology and surgery, provide multidisciplinary discussions on photodynamic therapy - a rapidly-developing approach to the treatment of solid tumours.;Photodynamic Therapy: Basic Principles and Clinical Applications describes the molecular and cellular effects of photodynamic treatment; elucidates the complex events leading to photodynamics tissue destruction, particularly vascular and inflammatory responses; discusses the principles of light penetration through tissues and optical dosimetry; examines photosensitizer pharmacology and delivery systems; reviews in detail photosensitizer structure-activity relationships; illustrates novel devices that aid light dosimetry and fluorescence detection; and extensively delineates clinical applications, including early diagnosis and treatment.;A comprehensive and up-to-date reference, this book should be useful for oncologists, pharmacologists, surgeons, photobiologists, optical engineers, laser technicians, biologists, physicists, chemists and biochemists involved in cancer research, as well as graduate-level students in these disciplines.
Author : Mahmoud H. Abdel-Kader
Publisher : Springer Science & Business Media
ISBN 13 : 3642396291
Total Pages : 317 pages
Book Rating : 4.6/5 (423 download)
Download or read book Photodynamic Therapy written by Mahmoud H. Abdel-Kader and published by Springer Science & Business Media. This book was released on 2014-01-09 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: Photodynamic Therapy: From Theory to Application brings attention to an exceptional treatment strategy, which until now has not achieved the recognition and breadth of applications it deserves. The authors, all experts and pioneers in their field, discuss the history and basic principles of PDT, as well as the fundamentals of the theory, methods, and instrumentation of clinical diagnosis and treatment of cancer. Non-oncological applications such as the use of PDT in control of parasites and noxious insects are also discussed. This book serves as a standard reference for researchers and students at all levels, clinical specialists interested in the topic and those in industry exploring new areas for development. A comprehensive exposition of both the theory and application of PDT, this book fills the gaps in the current literature by bringing together both basic understanding of the process of PDT and an expanded vision of its applications.
Author : Moser
Publisher : CRC Press
ISBN 13 : 9789056991395
Total Pages : 256 pages
Book Rating : 4.9/5 (913 download)
Download or read book Photodynamic Tumor Therapy written by Moser and published by CRC Press. This book was released on 1998-04-01 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Compiles quantitative data on newly developed photosensizers for the photodynamic therapy of cancer and other modalities, which are otherwise scattered through the literature. The collection of reviews first considers the biophysical and biomedical definitions of photosensitivity and phototoxicity on the molecular and cellular level in order to standardize results. Then they group the available data on naturally occurring or chemically synthesized compounds into synoptic tables and graphs; describe methods of preparation and purity control, and application schedules to cell cultures and experimental animals; and project future applications of the approach. Distributed in the US by PTT. Annotation copyrighted by Book News, Inc., Portland, OR.
Author : Ravindra K Pandey
Publisher : World Scientific
ISBN 13 : 9814719668
Total Pages : 563 pages
Book Rating : 4.8/5 (147 download)
Download or read book Handbook Of Photodynamic Therapy: Updates On Recent Applications Of Porphyrin-based Compounds written by Ravindra K Pandey and published by World Scientific. This book was released on 2016-03-24 with total page 563 pages. Available in PDF, EPUB and Kindle. Book excerpt: The main objective of this book is to present the recent applications of photodynamic therapy (PDT) in treating cancer and other diseases. The limitations associated with current PDT agents, and the synthetic designs that have been used in various laboratories are also discussed. The utility of certain tumor-avid agent for cancer imaging (fluorescence, PET, MRI) is also summarized. The book also includes the use of delivery vehicles, including nanoparticles in improving the tumor-specificity of the desired agents. The book is basically focused on the translational approach of drug development. By providing certain specific examples, a clear concept of moving a 'product' from the bench to bed-side is also discussed.To have a clear concept of drug development the book is divided in three parts — Medicinal Chemistry, Mechanistic and Clinical studies. Each part includes the contributions from the leading scientists with extensive experience in the respective field. The handbook is assembled by renowned scientists Dr Dougherty, known as the father of PDT, Dr Kessel, well known for his contributions on mechanism of PDT and Dr Pandey for his inventions in developing improved agents for PDT and cancer-imaging.
Author : Herwig Kostron
Publisher : Royal Society of Chemistry
ISBN 13 : 1782624511
Total Pages : 680 pages
Book Rating : 4.7/5 (826 download)
Download or read book Photodynamic Medicine written by Herwig Kostron and published by Royal Society of Chemistry. This book was released on 2016 with total page 680 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Series in Photochemical and Photobiological Sciences. Photodynamic therapy (PDT) is increasingly being used amongst health practitioners in combating a variety of disease. This book reviews the current state of development of PDT, and also presents the foreseeable advancements of the field in the next decade. Practitioners in biological sciences, biotechnology and medicinal and pharmaceutical chemistry will find this book an invaluable source of information. Chapters are drawn from research discusses at the 10th International Symposium on Photodynamic Therapy and Photodiagnosis in Clinical Practice in Brixen and are written and edited by leaders in the field. Mirroring the philosophy of that meeting, this book contains an informative balance of the basic sciences and clinical applications of PDT. Following an introduction to PDT, its history, and how techniques have developed, chapter serve as a practical guide for practitioners, covering topics such as sensitizer dosage and light dosage, and examples of relevant studies. The text goes further tp explore areas outside the medical field, such as the impact of PDT on society and the environment, and the economics of therapies. This book is dedicated to the memory of Professor Giulio Jori, and expert in this field, who sadly passed away on the 23rd December 2014.
Author : Society of Photo-optical Instrumentation Engineers
Publisher : SPIE-International Society for Optical Engineering
ISBN 13 : 9780819435255
Total Pages : 160 pages
Book Rating : 4.4/5 (352 download)
Download or read book Optical Methods for Tumor Treatment and Detection written by Society of Photo-optical Instrumentation Engineers and published by SPIE-International Society for Optical Engineering. This book was released on 2000 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Signaling Pathways; Localization; New Sensitizers; ALA; Clinical PDT; Dosimetry; Vascular Responses; Imaging.
