Pharmacokinetics And Adverse Effects Of Drugs

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Pharmacokinetics and Adverse Effects of Drugs

Author : Ntambwe Malangu
Publisher : BoD – Books on Demand
ISBN 13 : 1789231388
Total Pages : 164 pages
Book Rating : 4.7/5 (892 download)

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Book Synopsis Pharmacokinetics and Adverse Effects of Drugs by : Ntambwe Malangu

Download or read book Pharmacokinetics and Adverse Effects of Drugs written by Ntambwe Malangu and published by BoD – Books on Demand. This book was released on 2018-05-23 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a fruit of a collaborative work from several international scientists. It will be a useful resource for researchers, students, and clinicians. Each individual chapter could serve as a prescribed reading for postgraduate students and clinicians specializing in and practicing clinical pharmacology and toxicology, pharmacotherapy and pharmacotherapeutics, pharmacovigilance, and toxicovigilance, as well as those involved in clinical research, drug discovery, and development. Every chapter in this book discusses and provides illustrations on the theme discussed based on authors' understanding and experience while summarizing existing knowledge. In doing so, each chapter provides a new insight that would benefit a novice as well as a seasoned reader in understanding the pharmacokinetic mechanisms and risk factors involved in the occurrence of adverse effects of drugs.

Drug Transporters

Author : Martin F. Fromm
Publisher : Springer Science & Business Media
ISBN 13 : 3642145418
Total Pages : 457 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis Drug Transporters by : Martin F. Fromm

Download or read book Drug Transporters written by Martin F. Fromm and published by Springer Science & Business Media. This book was released on 2010-11-19 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is increasingly recognized that various transporter proteins are expressed throughout the body and determine absorption, tissue distribution, biliary and renal elimination of endogenous compounds and drugs and drug effects. This book will give an overview on the transporter families which are most important for drug therapy. Most chapters will focus on one transporter family highlighting tissue expression, substrates, inhibitors, knock-out mouse models and clinical studies.

Oral Drug Absorption

Author : Jennifer B. Dressman
Publisher : CRC Press
ISBN 13 : 1420077341
Total Pages : 432 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Oral Drug Absorption by : Jennifer B. Dressman

Download or read book Oral Drug Absorption written by Jennifer B. Dressman and published by CRC Press. This book was released on 2016-04-19 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oral Drug Absorption, Second Edition thoroughly examines the special equipment and methods used to test whether drugs are released adequately when administered orally. The contributors discuss methods for accurately establishing and validating in vitro/in vivo correlations for both MR and IR formulations, as well as alternative approaches for MR an

Study Guide to Accompany Drug Therapy in Nursing

Author : Diane S. Aschenbrenner
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9780781777438
Total Pages : 360 pages
Book Rating : 4.7/5 (774 download)

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Book Synopsis Study Guide to Accompany Drug Therapy in Nursing by : Diane S. Aschenbrenner

Download or read book Study Guide to Accompany Drug Therapy in Nursing written by Diane S. Aschenbrenner and published by Lippincott Williams & Wilkins. This book was released on 2005 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: The perfect companion to Drug Therapy in Nursing, Second Edition, this invaluable study partner delivers guidance on individual patient management from a nurse-as-caregiver perspective, helping you build essential knowledge and develop sound practice skills. Knowledge-building features include Top Ten Things to Know lists, key terms, multiple-choice questions, case studies, and critical thinking challenges. A "Just the Facts" feature helps deepen your understanding of essential drugs, their actions, indications, contraindications, and cautions. A "Patients Please" feature helps you put the needs of the patient first, with facts on core patient variables.

Bioenvironmental Issues Affecting Men's Reproductive and Sexual Health

Author : Suresh C Sikka
Publisher : Academic Press
ISBN 13 : 0128013133
Total Pages : 638 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Bioenvironmental Issues Affecting Men's Reproductive and Sexual Health by : Suresh C Sikka

Download or read book Bioenvironmental Issues Affecting Men's Reproductive and Sexual Health written by Suresh C Sikka and published by Academic Press. This book was released on 2017-11-14 with total page 638 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioenvironmental Issues Affecting Men's Reproductive and Sexual Health is structured into two parts related to men's reproductive and sexual health with eight sections designed to enable a logical flow of such knowledge. The book is focused on the biology of key organs involved in male reproduction and the environmental influences affecting their functions with particular emphasis on clinical aspects. Individual chapters within the book range from basic to translational aspects, but all hold clinical relevance. This is an essential reference for those working and learning in the field of human reproduction, reproductive toxicology and environmental influences on reproductive and sexual health. - Brings together the leading authorities working in the field of male reproduction and sexual health and how the environment affects these issues - Provides guidelines and reference values of various reproductive hormones, semen parameters, inclusion/exclusion criteria for clinical trials - Discover the most efficient methods by which to design clinical protocols for sperm safety studies and reproductive toxicology trials

Food-drug Interactions

Author : Fernando Ramos
Publisher :
ISBN 13 : 9781536135534
Total Pages : 279 pages
Book Rating : 4.1/5 (355 download)

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Book Synopsis Food-drug Interactions by : Fernando Ramos

Download or read book Food-drug Interactions written by Fernando Ramos and published by . This book was released on 2018 with total page 279 pages. Available in PDF, EPUB and Kindle. Book excerpt: The interaction between drugs and food is an increasingly relevant topic in clinical practice. There are numerous possibilities for interactions between drugs and food, often unknown or ignored by both health professionals and patients. The success of the care given to each patient depends, to a large extent, on the knowledge regarding the risks of associating drugs and foods. These interactions can be decisive in achieving therapeutic success due to interferences not only in the pharmacokinetics and pharmacodynamics of the drugs, with direct implications in the effectiveness and safety of the drugs, as well as in the absorption of nutrients.This aspect becomes even more relevant in patients with chronic pathology in which the coexistence of the drug/food binomial is prolonged over time.The objective of this book was to carry out a review on the main drug-food interactions and their impact on health. In this book, the most prevalent chronic pathologies in the population are referenced.In addition to an introductory chapter on this subject, the following chapters address the impact of the vehicles used in the different pharmaceutical formulations for the oral route.Taking this into account, aspects of potential interactions in the digestive and hepatic system, in diseases such as diabetes mellitus, chronic kidney disease, heart disease, dyslipidemia and cancer disease are presented. Additionally, the relevance of interactions between drugs and products of plant origin are also described.Finally, the authors present a case study, with the main focus on the evaluation of potent interactions between antihypertensive and anti-dyslipidemic drugs and foods, carried out in a community pharmacy.The authors believe that this book is of general interest, with greater relevance to health professionals, namely doctors, pharmacists, nurses and nutritionists, in order to facilitate quicker assessments of potential interactions and risks arising from the prescription of medicines and concomitant use with food.

Applied Clinical Pharmacokinetics 3/E

Author : Larry A. Bauer
Publisher : McGraw Hill Professional
ISBN 13 : 007179459X
Total Pages : 881 pages
Book Rating : 4.0/5 (717 download)

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Book Synopsis Applied Clinical Pharmacokinetics 3/E by : Larry A. Bauer

Download or read book Applied Clinical Pharmacokinetics 3/E written by Larry A. Bauer and published by McGraw Hill Professional. This book was released on 2014-01-05 with total page 881 pages. Available in PDF, EPUB and Kindle. Book excerpt: The most current, hands-on book in the field, Applied Clinical Pharmacokinetics The perfect textbook for pharmacy students learning the clinical application of pharmacokinetics, which is the mathematical tools for modifying doages. Students like that each chapter includes sample problems throughout the chapter, with a ton of practice problems at the end. Answers for the practice problems are in the back, but not detailed like the sample problems) *Changes in the 3/e includes: *All chapters updated and revised, as needed, including critical new references *Antibiotic individualization and monitoring sections increases use of pharmacodynamic parameters (Cmax/MIC, AUC24/MIC, Time above MIC) in addition to pharmacokinetic parameters to adjust dosages *Anticonvulsants section includes 5 new agents (Fosphenytoin, Lamotrigine, Levetiracetam, Oxcarbazepine, Eslicarbazepine) *Immunosuppressants section includes 1 new agent (Sirolimus), About the Book Text focuses on the latest standardized techniques and approaches to patient-specific dosing and provides up-to-date information on more recently moniotored drugs. Features Clear, useful coverage of drug dosing and drug monitoring Clear and concise summary of pharmacokinetic and pharmacodynamic concepts Practical help with calculations and equations Focus on the latest standardized techniques and approaches to patient-specific dosing Up-to-date information on more recently monitored drugs Essential information on drug dosing in special populations, including patients with renal and hepatic disease, obesity, and congestive heart failure All the information practitioners need on drug categories such as antibiotics, cardiovascular agents, anticonvulsants, and immunosuppressants Full coverage of drugs such as Aminoglycosides, Vancomycin, Digoxin, Phenytoin, Carbamazepine, Theophylline, Cyclosporine, Tacrolimus, and Lithium Student friendly approach to teaching pharmacokinetics--sample problems embedded into the text to allow for students to apply what they are learing. .

Mechanisms of Drug Toxicity

Author : H. Rašková
Publisher : Elsevier
ISBN 13 : 1483157202
Total Pages : 113 pages
Book Rating : 4.4/5 (831 download)

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Book Synopsis Mechanisms of Drug Toxicity by : H. Rašková

Download or read book Mechanisms of Drug Toxicity written by H. Rašková and published by Elsevier. This book was released on 2013-10-22 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mechanisms of Drug Toxicity, Volume 4 presents the proceedings of the 3rd International Pharmacological Meeting held in Sao Paulo, Brazil in 1966. The book discusses the drug-induced pathobiotic effects; the mechanisms of adverse reactions; and enzyme induction in the mechanism of chronic toxicity. The text also describes the influence of inducing substances on the growth of liver and microsomal electron transport systems; the quantitative aspects of chronic toxicity; and the facts and fallacies in predicting drug effects in human.

Clinical Pharmacology: Current Topics and Case Studies

Author : Markus Müller
Publisher : Springer Science & Business Media
ISBN 13 : 3709101441
Total Pages : 438 pages
Book Rating : 4.7/5 (91 download)

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Book Synopsis Clinical Pharmacology: Current Topics and Case Studies by : Markus Müller

Download or read book Clinical Pharmacology: Current Topics and Case Studies written by Markus Müller and published by Springer Science & Business Media. This book was released on 2011-02-04 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: Today we witness an eventful time in which the powerful new forces of genomics, information technology and economics are rapidly changing the science and art of medicine. This will require more specialization than ever before. However, there is also an increasing demand for an integrated approach, which is provided by the discipline of Clinical Pharmacology (CP). CP pursues a scientific goal by studying drug action in patients and volunteers, a clinical goal by administering appropriate drug therapy and a regulatory goal by assessing the risk/benefit ratio of drug candidates in drug development and reimbursement. This introduction to current topics of CP covers traditional topics of clinical drug research and trial methodology but also provides insight in current topics like genomics, imaging technology and issues in drug reimbursement. A number of concrete case studies in clinical drug research and development help to give a better understanding of the general principles of CP.

Encyclopedia of Molecular Pharmacology

Author : Stefan Offermanns
Publisher : Springer Science & Business Media
ISBN 13 : 3540389164
Total Pages : 1515 pages
Book Rating : 4.5/5 (43 download)

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Book Synopsis Encyclopedia of Molecular Pharmacology by : Stefan Offermanns

Download or read book Encyclopedia of Molecular Pharmacology written by Stefan Offermanns and published by Springer Science & Business Media. This book was released on 2008-08-14 with total page 1515 pages. Available in PDF, EPUB and Kindle. Book excerpt: An essential text, this is a fully updated second edition of a classic, now in two volumes. It provides rapid access to information on molecular pharmacology for research scientists, clinicians and advanced students. With the A-Z format of over 2,000 entries, around 350 authors provide a complete reference to the area of molecular pharmacology. The book combines the knowledge of classic pharmacology with the more recent approach of the precise analysis of the molecular mechanisms by which drugs exert their effects. Short keyword entries define common acronyms, terms and phrases. In addition, detailed essays provide in-depth information on drugs, cellular processes, molecular targets, techniques, molecular mechanisms, and general principles.

Basic and Clinical Pharmacology 15e

Author : Bertram G. Katzung
Publisher : McGraw Hill Professional
ISBN 13 : 1260452328
Total Pages : 1326 pages
Book Rating : 4.2/5 (64 download)

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Book Synopsis Basic and Clinical Pharmacology 15e by : Bertram G. Katzung

Download or read book Basic and Clinical Pharmacology 15e written by Bertram G. Katzung and published by McGraw Hill Professional. This book was released on 2020-11-22 with total page 1326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Master key pharmacological concepts and practices with the most comprehensive, authoritative guide available Doody's Core Titles for 2023! Presented in full-color and packed with hundreds of illustrations, Basic and Clinical Pharmacology is the wide-ranging, engaging guide students have counted on for decades. Organized to reflect the course sequence in many pharmacology courses and in integrated curricula, the guide covers the important concepts students need to know about the science of pharmacology and its application to clinical practice. This edition has been extensively updated to provide expanded coverage of transporters, pharmacogenomics, and new drugs Delivers the knowledge and insight needed to excel in every facet of pharmacology!. Encompasses all aspects of medical pharmacology, including botanicals and over-the-counter drugs Major revisions of the chapters on immunopharmacology, antiseizure, antipsychotic, antidepressant, antidiabetic, anti-inflammatory, and antiviral drugs, prostaglandins, and central nervous system neurotransmitters New chapter on the increasingly relevant topic of cannabis pharmacology Each chapter opens with a case study, covers drug groups and prototypes, and closes with summary tables and diagrams that encapsulate important information Revised full-color illustrations provide more information about drug mechanisms and effects and help clarify important concepts Trade Name/Generic Name tables are provided at end of each chapter for easy reference when writing a chart order or prescription Includes descriptions of important new drugs released through May 2019 New and updated coverage of general concepts relating to recently discovered receptors, receptor mechanisms, and drug transporters

Ibuprofen: Pharmacology, Therapeutics and Side Effects

Author : K. D. Rainsford
Publisher : Springer Science & Business Media
ISBN 13 : 3034804962
Total Pages : 261 pages
Book Rating : 4.0/5 (348 download)

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Book Synopsis Ibuprofen: Pharmacology, Therapeutics and Side Effects by : K. D. Rainsford

Download or read book Ibuprofen: Pharmacology, Therapeutics and Side Effects written by K. D. Rainsford and published by Springer Science & Business Media. This book was released on 2013-02-01 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ibuprofen is one of the most successful drugs used worldwide for the treatment of mild to moderate pain and various inflammatory conditions. Over the past 40 years, ibuprofen has been proven to be as safe or even safer and also as effective as the established non-steroidal anti-inflammatory drugs (NSAIDs) and the coxibs. This well-written book reviews the pharmacology, clinical uses and the various adverse effects of Ibuprofen, the disposition and unique modes of action in relation to clinical effects of the drug as well as various formulations. The use of combinations with other drugs (e.g. paracetamol, codeine, caffeine) are critically assessed and the impact of natural products and Chinese Medicines on the safety of ibuprofen.

Commonly Used Drugs

Author : Rafik Karaman
Publisher :
ISBN 13 : 9781634638289
Total Pages : 250 pages
Book Rating : 4.6/5 (382 download)

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Book Synopsis Commonly Used Drugs by : Rafik Karaman

Download or read book Commonly Used Drugs written by Rafik Karaman and published by . This book was released on 2015-04-01 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drugs (medicines) are considered either the primary therapy or an adjunct to another modality. Physicians of all specialties prescribe drugs on a daily basis, and therefore they need to understand the mode and action by which drugs exert their therapeutic effects. Written records of the use of natural products as medicinal agents date back thousands of years. However, it was not until the early 1800s that the active principles from plants were isolated. Since then thousands of drugs have been introduced to the drugs market. With advances in drug design, molecular biology and genetics, the rate of developing new potent drugs is accelerated. Due to the vast progress in drug development and discovery, medical and pharmacy students, doctors, nurses and pharmacists in training need to learn the principles of therapeutics in order to follow up with the frequent changes in the therapeutics and adapt to them. With contributions from some of my colleagues, this book provides a clear and concise overview of the most important commonly used drugs with emphasis on the pharmacology aspects necessary for a basic understanding of the subject. It reviews the concepts, clinical applications, dosage forms, bioavailability, pharmacokinetics and side effects of a large number of drugs used to alleviate pain, lower cholesterol levels, and treat bacterial infections, diabetes, osteoporosis, bleeding, psoriasis and multiple Sclerosis. This book, with over 750 references, is an excellent pharmacology text for the student who is looking to broaden his/her strengths prior to the exam. The beauty of this text is that it includes essential pharmacology concepts in a compact book that can be quickly referenced and read multiple times during the course of a student's studies. In addition, this guide assists scientists trained in molecular biology, medicinal chemistry and related fields who need to know the basic theories, principles and practical applications of pharmacology. With the addition of pharmacokinetics coverage, ways to improve the bioavailability of commonly used drugs and sections on therapeutics that will help readers identify with diseases and drug treatments, this book provides better preparation of researchers in the basics of pharmacology.

Drug Benefits and Risks

Author : Chris J. van Boxtel
Publisher : John Wiley & Sons
ISBN 13 : 9780471899273
Total Pages : 738 pages
Book Rating : 4.8/5 (992 download)

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Book Synopsis Drug Benefits and Risks by : Chris J. van Boxtel

Download or read book Drug Benefits and Risks written by Chris J. van Boxtel and published by John Wiley & Sons. This book was released on 2001-11-28 with total page 738 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is an inclusive reference exploring the scientific basis and practice of drug therapy. The key concept is to look at the balance between the benefits and risks of drugs but in this context also the social impact which drugs have in modern societies is highlighted. Taking an evidence-based approach to the problem, the practice of clinical pharmacology and pharmacotherapy in the developing as well as the developed world is examined. For this purpose the book * Covers general clinical pharmacology, pharmacology of various drug groups and the treatments specific to various diseases * Gives guidance on how doctors should act so that drugs can be used effectively and safely * Encourages the rational use of drugs in society This book brings together a large amount of excellent content that will be invaluable for anyone working within, or associated with, the field of clinical pharmacology and pharmacotherapy - undergraduates, postgraduates, regulatory authorities and the pharmaceutical industry.

Anesthetic Pharmacology

Author : Alex S. Evers
Publisher : Cambridge University Press
ISBN 13 : 1139497022
Total Pages : 2902 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Anesthetic Pharmacology by : Alex S. Evers

Download or read book Anesthetic Pharmacology written by Alex S. Evers and published by Cambridge University Press. This book was released on 2011-03-10 with total page 2902 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years our understanding of molecular mechanisms of drug action and interindividual variability in drug response has grown enormously. Meanwhile, the practice of anesthesiology has expanded to the preoperative environment and numerous locations outside the OR. Anesthetic Pharmacology: Basic Principles and Clinical Practice, 2nd edition, is an outstanding therapeutic resource in anesthesia and critical care: Section 1 introduces the principles of drug action, Section 2 presents the molecular, cellular and integrated physiology of the target organ/functional system and Section 3 reviews the pharmacology and toxicology of anesthetic drugs. The new Section 4, Therapeutics of Clinical Practice, provides integrated and comparative pharmacology and the practical application of drugs in daily clinical practice. Edited by three highly acclaimed academic anesthetic pharmacologists, with contributions from an international team of experts, and illustrated in full colour, this is a sophisticated, user-friendly resource for all practitioners providing care in the perioperative period.

Medical Pharmacology and Therapeutics E-Book

Author : Derek G. Waller
Publisher : Elsevier Health Sciences
ISBN 13 : 0702055034
Total Pages : 741 pages
Book Rating : 4.7/5 (2 download)

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Book Synopsis Medical Pharmacology and Therapeutics E-Book by : Derek G. Waller

Download or read book Medical Pharmacology and Therapeutics E-Book written by Derek G. Waller and published by Elsevier Health Sciences. This book was released on 2013-08-07 with total page 741 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers all the pharmacology you need, from basic science pharmacology and pathophysiology, through to clinical pharmacology to therapeutics, in line with the integrated approach of new medical curricula. The first section covers the basic principles, and the rest is organised by body systems. The book ends with sections on toxicity and prescribing practice. Integrates basic science pharmacology, clinical pharmacology and therapeutics Brief review of pathophysiology of major diseases Case histories and multiple choice questions (and answers) Tabular presentation of all common drugs within each class Section on further reading Kinetics chapter simplified with more practical examples Includes more on genetic issues Drug tables made more concise to make information more accessible Fully updated to reflect current clinical practice

Carbamazepine

Author : Luca Gallelli
Publisher : Nova Science Publishers
ISBN 13 : 9781629480480
Total Pages : 0 pages
Book Rating : 4.4/5 (84 download)

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Book Synopsis Carbamazepine by : Luca Gallelli

Download or read book Carbamazepine written by Luca Gallelli and published by Nova Science Publishers. This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbamazepine (CBZ), one of the most used antiepileptic drugs (AEDs), was introduced on the market in the early 1960's and ever since, it has become the most frequently prescribed drug for the treatment of several forms of epilepsy. It is also used to treat other pathologies, such as neuropathic pain and psychiatric disorders. This book provides a detailed description of this drug, evaluating all aspects of its pharmacology. CBZ pharmacokinetics is discussed, with a particular emphasis on its metabolism, side effects and drug interactions. Then the authors focus on its pharmacodynamic effects, and the most recent evidence indicating that CBZ-sodium channel interaction is not specific and ligand-gated ion channels are also affected by the drug. The role of oxacarbazepine, its main metabolite MHD, and other new drugs are explained in detail. Additionally, non-antiepileptic CBZ clinical effects and drug-drug interactions in the elderly under polytherapy are described. In conclusion, the occurrence of carbamazepine in the hydrosphere, its fate and the different technologies available for its remediation are also discussed.