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Author : Tomas Salmonson
Publisher :
ISBN 13 : 9789162800314
Total Pages : 66 pages
Book Rating : 4.8/5 (3 download)
Download or read book Pharmacokinetic and Pharmacodynamic Studies on Recombinant Human Erythropoietin written by Tomas Salmonson and published by . This book was released on 1990 with total page 66 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Bernd Meibohm
Publisher : John Wiley & Sons
ISBN 13 : 3527609520
Total Pages : 426 pages
Book Rating : 4.5/5 (276 download)
Download or read book Pharmacokinetics and Pharmacodynamics of Biotech Drugs written by Bernd Meibohm and published by John Wiley & Sons. This book was released on 2006-12-13 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first ever coverage of the pharmacokinetic and pharmacodynamic characteristics of biopharmaceuticals meets the need for a comprehensive book in this field. It spans all topics from lead identification right up to final-stage clinical trials. Following an introduction to the role of PK and PD in the development of biotech drugs, the book goes on to cover the basics, including the pharmacokinetics of peptides, monoclonal antibodies, antisense oligonucleotides, as well as viral and non-viral gene delivery vectors. The second section discusses such challenges and opportunities as pulmonary delivery of proteins and peptides, and the delivery of oligonucleotides. The final section considers the integration of PK and PD concepts into the biotech drug development plan, taking as case studies the preclinical and clinical drug development of tasidotin, as well as the examples of cetuximab and pegfilgrastim. The result is vital reading for all pharmaceutical researchers.
Author : Arthur J. Sytkowski
Publisher : John Wiley & Sons
ISBN 13 : 3527605436
Total Pages : 237 pages
Book Rating : 4.5/5 (276 download)
Download or read book Erythropoietin written by Arthur J. Sytkowski and published by John Wiley & Sons. This book was released on 2006-03-06 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of Epo in medical practice is increasing constantly. It has revolutionized how we think of blood transfusion in medicine and surgery. Moreover, it has become widely known to scientists, physicians, biotech and pharmaceutical executives and the general public. Additionally, the past ten years have seen important advances in our knowledge and understanding of its action both within and outside of the hematopoietic system. Until now, there has been no single source that contains up-to-date information on Epo addressing the array of subjects that this book presents. The book covers all aspects from developmental biology to specific topics such as medical applications of recombinant Epo, receptor biology, mechanisms of Epo activity, structure/activity relationship, disease states and important actions on non-hematopoietic organs and tissues, including the central nervous system, heart, gastrointestinal tract, reproductive organs and endothelium.
Author : Sankalp A. Gharat
Publisher : Springer Nature
ISBN 13 : 9819978580
Total Pages : 402 pages
Book Rating : 4.8/5 (199 download)
Download or read book Pharmacokinetics and Pharmacodynamics of Novel Drug Delivery Systems: From Basic Concepts to Applications written by Sankalp A. Gharat and published by Springer Nature. This book was released on with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Richard N. Fine
Publisher : Springer Science & Business Media
ISBN 13 : 1461549310
Total Pages : 640 pages
Book Rating : 4.4/5 (615 download)
Download or read book CAPD/CCPD in Children written by Richard N. Fine and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past quarter century there has been a renaissance of interest in the use of peritoneal dialysis as the primary dialytic modality for the treatment of children with end-stage renal disease (ESRD). The development of continuous ambulatory peritoneal dialysis (APD) has facilitated the provision of prolonged dialysis to infants, children and adolescents and has provided pediatric nephrologists worldwide with a real opportunity to administer effective dialysis therapy to all patients afflicted with ESRD. It has been more than a decade since the initial publication of CAPD/CCPD in Children. In the interim, a great deal of clinical experience with patients receiving peritoneal dialysis has been accumulated and research efforts have substantially increased our understanding of the technique. Therefore, we felt that a second edition of CAPD/CCPD in Children was propitious to update the advances of the past decade.
Author : Honghui Zhou
Publisher : John Wiley & Sons
ISBN 13 : 1118898648
Total Pages : 476 pages
Book Rating : 4.1/5 (188 download)
Download or read book ADME and Translational Pharmacokinetics / Pharmacodynamics of Therapeutic Proteins written by Honghui Zhou and published by John Wiley & Sons. This book was released on 2015-11-23 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: With an emphasis on the fundamental and practical aspects of ADME for therapeutic proteins, this book helps readers strategize, plan and implement translational research for biologic drugs. • Details cutting-edge ADME (absorption, distribution, metabolism and excretion) and PKPD (pharmacokinetic / pharmacodynamics) modeling for biologic drugs • Combines theoretical with practical aspects of ADME in biologic drug discovery and development and compares innovator biologics with biosimilar biologics and small molecules with biologics, giving a lessons-learned perspective • Includes case studies about leveraging ADME to improve biologics drug development for monoclonal antibodies, fusion proteins, pegylated proteins, ADCs, bispecifics, and vaccines • Presents regulatory expectations and industry perspectives for developing biologic drugs in USA, EU, and Japan • Provides mechanistic insight into biodistribution and target-driven pharmacokinetics in important sites of action such as tumors and the brain
Author : Ajay K. Singh
Publisher : Academic Press
ISBN 13 : 0128032480
Total Pages : 586 pages
Book Rating : 4.1/5 (28 download)
Download or read book Textbook of Nephro-Endocrinology written by Ajay K. Singh and published by Academic Press. This book was released on 2017-11-28 with total page 586 pages. Available in PDF, EPUB and Kindle. Book excerpt: Textbook of Nephro-Endocrinology, Second Edition, continues to be the definitive translational reference in the field of nephro-endocrinology, investigating both the endocrine functions of the kidneys and how the kidney acts as a target for hormones from other organ systems. It offers researchers and clinicians expert analyses of nephro-endocrine research and translation into the treatment of diseases such as anemia, chronic kidney disease (CKD), rickets, osteoporosis, and hypoparathyroidism. Changes to this edition include new chapters focused on hypercalcemia/hypocalcemia and the interaction of dialysis, chronic renal disease, and endocrine diseases. All chapters have been updated to include more preclinical data and more tables and schema that help translate this data into clinical recommendations. The section on hormones and renal insufficiency discusses insulin/diabetes, growth hormone, sex steroids, thyroid hormone, acid–base disturbances, and pregnancy. - Presents a uniquely comprehensive and cross-disciplinary look at all aspects of nephro-endocrine disorders in one reference - Investigates both the endocrine functions of the kidneys and how the kidney acts as a target for hormones from other organ systems - Offers clear translational presentations by the top endocrinologists and nephrologists in each specific hormone or functional/systems field - Features new and updated chapters that include more tables and schema to help translate preclinical data into clinical recommendations
Author : Onyekachi Ifudu
Publisher : Springer Science & Business Media
ISBN 13 : 940159998X
Total Pages : 149 pages
Book Rating : 4.4/5 (15 download)
Download or read book Renal Anemia written by Onyekachi Ifudu and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 149 pages. Available in PDF, EPUB and Kindle. Book excerpt: Is the nephrology community facilitating excess cardiovascular deaths in patients with kidney failure and anemia by treating to a subnormal hematocrit? Why have clinicians and nephrologists permitted health insurance companies and the government to decide when anemia therapy should begin in persons with progressive kidney failure? Is iron the only variable that can be manipulated to maximize response to recombinant erythropoietin? Are we using too much intravenous iron in kidney failure patients, and is oral iron supplementation worthless in sustaining iron stores during long-term erythropoietin treatment? When does left ventricular hypertrophy begin to emerge in patients with progressive renal disease and is there convincing evidence that anemia is a significant cause of LVH in this setting? Is darbepoetin alfa, a new novel, long-acting erythropoietin, really superior to recombinant erythropoietin? This book is a compilation of proceedings from a conference in Brooklyn convened to address these and other controversial and unresolved issues in renal anemia management.
Author : Horst Pagel
Publisher : Springer Science & Business Media
ISBN 13 : 3642770746
Total Pages : 318 pages
Book Rating : 4.6/5 (427 download)
Download or read book Pathophysiology and Pharmacology of Erythropoietin written by Horst Pagel and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book contains a series of about 40 articles reflecting the state-of-the-art of the topic "Pathophysiology and Pharmacology of Erythropoietin". Results from both basic research and clinical studies are described in detail. The papers show that the possible therapeutic spectrum of erythropoietin could be expanded considerably when compared with the present situation.
Author : Derek G. Waller
Publisher : Elsevier Health Sciences
ISBN 13 : 0702055034
Total Pages : 741 pages
Book Rating : 4.7/5 (2 download)
Download or read book Medical Pharmacology and Therapeutics E-Book written by Derek G. Waller and published by Elsevier Health Sciences. This book was released on 2013-08-07 with total page 741 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers all the pharmacology you need, from basic science pharmacology and pathophysiology, through to clinical pharmacology to therapeutics, in line with the integrated approach of new medical curricula. The first section covers the basic principles, and the rest is organised by body systems. The book ends with sections on toxicity and prescribing practice. Integrates basic science pharmacology, clinical pharmacology and therapeutics Brief review of pathophysiology of major diseases Case histories and multiple choice questions (and answers) Tabular presentation of all common drugs within each class Section on further reading Kinetics chapter simplified with more practical examples Includes more on genetic issues Drug tables made more concise to make information more accessible Fully updated to reflect current clinical practice
Author : Robert A. Meyers
Publisher : John Wiley & Sons
ISBN 13 : 3527687211
Total Pages : 1329 pages
Book Rating : 4.5/5 (276 download)
Download or read book Translational Medicine written by Robert A. Meyers and published by John Wiley & Sons. This book was released on 2018-03-13 with total page 1329 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference work gives a compete overview of the different stages of drug development using a translational approach. The book is structured in different parts, following the different stages in drug development. Almost half of the work is dedicated to core of drug discovery using a translational approach, the identification of appropriate targets and screening methods for the identification of compounds interacting with these targets. The rest of book covers the whole downstream pipeline after the identification of lead compounds, such as bioavailability issues, identification of appropriate drug delivery venues, production and scaling issues and preclinical trials. As has been the case with other works in the encyclopedia, the book is made up of long, comprehensive and authoritative chapters, written by outstanding researchers in the field.
Author : Walter H. Hörl
Publisher : Springer Science & Business Media
ISBN 13 : 1402022751
Total Pages : 1640 pages
Book Rating : 4.4/5 (2 download)
Download or read book Replacement of Renal Function by Dialysis written by Walter H. Hörl and published by Springer Science & Business Media. This book was released on 2013-06-05 with total page 1640 pages. Available in PDF, EPUB and Kindle. Book excerpt: The leading Textbook on the subject. A completely rewritten and up-to-date fifth edition, based upon the highly respected fourth edition, edited by C. Jacobs, C.M. Kjellstrand, K.M. Koch and J.F. Winchester. This new edition is truly global in scope and features the contributions of the top experts from around the world.
Author : Paul L. Kimmel
Publisher : Academic Press
ISBN 13 : 0128158778
Total Pages : 1392 pages
Book Rating : 4.1/5 (281 download)
Download or read book Chronic Renal Disease written by Paul L. Kimmel and published by Academic Press. This book was released on 2019-08-28 with total page 1392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic Renal Disease, Second Edition, comprehensively investigates the physiology, pathophysiology, treatment and management of chronic kidney disease (CKD). This translational reference takes an in-depth look at CKD with no coverage of dialysis or transplantation. Chapters are devoted to the scientific investigation of chronic kidney disease, the most common problems faced by nephrologists in the management of chronic kidney disease, specific illnesses in the CKD framework, and how the management of CKD in a polycystic kidney disease patient differs from other CKD patients. This award-winning reference features a series of case studies, covering both clinical aspects and pathophysiology. Questions are open ended, progressively more difficult, and repetitive across different patient clinical problems and different chapters. The cases and questions included will be useful for medical students, residency board reviews, and clinician teaching or conference preparation. - Includes case studies and questions which can be used as a teaching tool for medical students and resident - Provides coverage of classification and measurement, epidemiology, pathophysiology, complications of CKD, fluid/electrolyte disorders in CKD, CKD and systemic illnesses, clinical considerations, therapeutic considerations, and special considerations
Author : Lawrence X. Yu
Publisher : Springer
ISBN 13 : 1493912526
Total Pages : 472 pages
Book Rating : 4.4/5 (939 download)
Download or read book FDA Bioequivalence Standards written by Lawrence X. Yu and published by Springer. This book was released on 2014-09-05 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive reference provides an in-depth discussion on state-of-the-art regulatory science in bioequivalence. In sixteen chapters, the volume explores a broad range of topics pertaining to bioequivalence, including its origin and principles, statistical considerations, food effect studies, conditions for waivers of bioequivalence studies, Biopharmaceutics Classification Systems, Biopharmaceutics Drug Disposition Classification System, bioequivalence modeling/simulation and best practices in bioanalysis. It also discusses bioequivalence studies with pharmacodynamic and clinical endpoints as well as bioequivalence approaches for highly variable drugs, narrow therapeutic index drugs, liposomes, locally acting gastrointestinal drug products, topical products and nasal and inhalation products. FDA Bioequivalence Standards is written by FDA regulatory scientists who develop regulatory policies and conduct regulatory assessment of bioequivalence. As such, both practical case studies and fundamental science are highlighted in these chapters. The book is a valuable resource for scientists who work in the pharmaceutical industry, regulatory agencies and academia as well as undergraduate and graduate students looking to expand their knowledge about bioequivalence standards.
Author : Steven G. Elliott
Publisher : Springer Science & Business Media
ISBN 13 : 3764386983
Total Pages : 337 pages
Book Rating : 4.7/5 (643 download)
Download or read book Erythropoietins, Erythropoietic Factors, and Erythropoiesis written by Steven G. Elliott and published by Springer Science & Business Media. This book was released on 2009-06-05 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive one-source guide to the most current information on red blood cell formation and the action of recombinant human erythropoietins. Topics covered include: erythropoiesis, recombinant protein discovery and production, and treatment of patients with anemia. The newest theories in erythropoiesis (receptors, signaling), manufacturing, new formulations, and clinical research are discussed. The text is ideal for researchers and clinical investigators in academia, biotechnology, and pharmaceutical companies, as well as clinical research associates, clinical monitors, and physician investigators.
Author : William D. Figg
Publisher : Springer Science & Business Media
ISBN 13 : 1592597343
Total Pages : 623 pages
Book Rating : 4.5/5 (925 download)
Download or read book Handbook of Anticancer Pharmacokinetics and Pharmacodynamics written by William D. Figg and published by Springer Science & Business Media. This book was released on 2004-03-26 with total page 623 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading investigators synthesize the entire laboratory and clinical process of developing anticancer drugs to create a single indispensable reference that covers all the steps from the identification of cancer-specific targets to phase III clinical trials. These expert authors provide their best guidance on a wide variety of issues, including clinical trial design, preclinical screening, and the development and validation of bioanalytic methods. The chapters on identifying agents to test in phase III trials and on trial design for the approval of new anticancer agents offer a unique roadmap for moving an agent to NDA submission.
Author :
Publisher : ScholarlyEditions
ISBN 13 : 1481607820
Total Pages : 127 pages
Book Rating : 4.4/5 (816 download)
Download or read book Erythrocytes—Advances in Research and Application: 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 127 pages. Available in PDF, EPUB and Kindle. Book excerpt: Erythrocytes—Advances in Research and Application: 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Erythrocytes in a concise format. The editors have built Erythrocytes—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Erythrocytes in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Erythrocytes—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
