Pharmaceutical Formulation

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Pharmaceutical Formulation

Author : Geoffrey D Tovey
Publisher : Royal Society of Chemistry
ISBN 13 : 1849739412
Total Pages : 432 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis Pharmaceutical Formulation by : Geoffrey D Tovey

Download or read book Pharmaceutical Formulation written by Geoffrey D Tovey and published by Royal Society of Chemistry. This book was released on 2018-06-25 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Formulation is a key step in the drug design process, where the active drug is combined with other substances that maximise the therapeutic potential, safety and stability of the final medicinal product. Modern formulation science deals with biologics as well as small molecules. Regulatory and quality demands, in addition to advances in processing technologies, result in growing challenges as well as possibilities for the field. Pharmaceutical Formulation provides an up to date source of information for all who wish to understand the principles and practice of formulation in the drug industry. The book provides an understanding of the links between formulation theory and the practicalities of processing in a commercial environment, giving researchers the knowledge to produce effective pharmaceutical products that can be approved and manufactured. The first chapters introduce readers to different dosage forms, including oral liquid products, topical products and solid dosage forms such as tablets and capsules. Subsequent chapters cover pharmaceutical coatings, controlled release drug delivery and dosage forms designed specifically for paediatric and geriatric patients. The final chapter provides an introduction to the vital role intellectual property plays in drug development. Covering modern processing methods and recent changes in the regulatory and quality demands of the industry, Pharmaceutical Formulation is an essential, up to date resource for students and researchers working in academia and in the pharmaceutical industry.

Pharmaceutical Preformulation and Formulation

Author : Mark Gibson
Publisher : CRC Press
ISBN 13 : 1420073184
Total Pages : 560 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Pharmaceutical Preformulation and Formulation by : Mark Gibson

Download or read book Pharmaceutical Preformulation and Formulation written by Mark Gibson and published by CRC Press. This book was released on 2016-04-19 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmaceutical Preformulation and Formulation: A Practical Guide from Candidate Drug Selection to Commercial Dosage Form reflects the mounting pressure on pharmaceutical companies to accelerate the new drug development and launch process, as well as the shift from developing small molecules to the growth of biopharmaceuticals. The book meets the need for advanced information for drug preformulation and formulation and addresses the current trends in the continually evolving pharmaceutical industry. Topics include: Candidate drug selection Drug discovery and development Preformulation predictions and drug selections Product design to commercial dosage form Biopharmaceutical support in formulation Development The book is ideal for practitioners working in the pharmaceutical arena—including R&D scientists, technicians, and managers—as well as for undergraduate and postgraduate courses in industrial pharmacy and pharmaceutical technology.

Formulation Tools for Pharmaceutical Development

Author : J E Aguilar
Publisher : Elsevier
ISBN 13 : 1908818506
Total Pages : 304 pages
Book Rating : 4.9/5 (88 download)

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Book Synopsis Formulation Tools for Pharmaceutical Development by : J E Aguilar

Download or read book Formulation Tools for Pharmaceutical Development written by J E Aguilar and published by Elsevier. This book was released on 2013-09-30 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: A range of new and innovative tools used for preformulation and formulation of medicines help optimize pharmaceutical development projects. Such tools also assist with the performance evaluation of the pharmaceutical process, allowing any potential gaps to be identified. These tools can be applied in both basic research and industrial environment. Formulation tools for pharmaceutical development considers these key research and industrial tools. Nine chapters by leading contributors cover: Artificial neural networks technology to model, understand, and optimize drug formulations; ME_expert 2.0: a heuristic decision support system for microemulsions formulation development; Expert system for the development and formulation of push-pull osmotic pump tablets containing poorly water-soluble drugs; SeDeM Diagram: an expert system for preformulation, characterization and optimization of tables obtained by direct compression; New SeDeM-ODT expert system: an expert system for formulation of orodispersible tablets obtained by direct compression; and 3D-cellular automata in computer-aided design of pharmaceutical formulations: mathematical concept and F-CAD software. Coverage of artificial intelligence tools, new expert systems, understanding of pharmaceutical processes, robust development of medicines, and new ways to develop medicines Development of drugs and medicines using mathematical tools Compilation of expert system developed around the world

Handbook of Pharmaceutical Manufacturing Formulations

Author : Safaraz K. Niazi
Publisher : CRC Press
ISBN 13 : 1420081314
Total Pages : 458 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Handbook of Pharmaceutical Manufacturing Formulations by : Safaraz K. Niazi

Download or read book Handbook of Pharmaceutical Manufacturing Formulations written by Safaraz K. Niazi and published by CRC Press. This book was released on 2016-04-19 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: No other area of regulatory compliance receives more attention and scrutiny by regulatory authorities than the regulation of sterile products, for obvious reasons. With the increasing number of potent products, particularly the new line of small protein products, joining the long list of proven sterile products, the technology of manufacturing ster

Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals

Author : Feroz Jameel
Publisher : John Wiley & Sons
ISBN 13 : 0470595876
Total Pages : 986 pages
Book Rating : 4.4/5 (75 download)

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Book Synopsis Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals by : Feroz Jameel

Download or read book Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals written by Feroz Jameel and published by John Wiley & Sons. This book was released on 2010-07-13 with total page 986 pages. Available in PDF, EPUB and Kindle. Book excerpt: A real-world guide to the production and manufacturing of biopharmaceuticals While much has been written about the science of biopharmaceuticals, there is a need for practical, up-to-date information on key issues at all stages of developing and manufacturing commercially viable biopharmaceutical drug products. This book helps fill the gap in the field, examining all areas of biopharmaceuticals manufacturing, from development and formulation to production and packaging. Written by a group of experts from industry and academia, the book focuses on real-world methods for maintaining product integrity throughout the commercialization process, clearly explaining the fundamentals and essential pathways for all development stages. Coverage includes: Research and early development phase appropriate approaches for ensuring product stability Development of commercially viable formulations for liquid and lyophilized dosage forms Optimal storage, packaging, and shipping methods Case studies relating to therapeutic monoclonal antibodies, recombinant proteins, and plasma fractions Useful analysis of successful and failed products Formulation and Process Development Strategies for Manufacturing Biopharma-ceuticals is an essential resource for scientists and engineers in the pharmaceutical and biotech industries, for government and regulatory agencies, and for anyone with an interest in the latest developments in the field.

Pharmaceutical Formulation Design

Author : Usama Ahmad
Publisher : BoD – Books on Demand
ISBN 13 : 1789856620
Total Pages : 166 pages
Book Rating : 4.7/5 (898 download)

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Book Synopsis Pharmaceutical Formulation Design by : Usama Ahmad

Download or read book Pharmaceutical Formulation Design written by Usama Ahmad and published by BoD – Books on Demand. This book was released on 2020-02-05 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmaceutical formulations have evolved from simple and traditional systems to more modern and complex novel dosage forms. Formulation development is a tedious process and requires an enormous amount of effort from many different people. Developing a stable novel dosage form and further targeting it to the desired site inside the body has always been a challenge. The purpose of this book is to bring together scholarly articles that highlight recent developments and trends in pharmaceutical formulation science. Each article has been written by authors specializing in the subject area and hailing from top institutions around the world. The book has been written in a systematic and lucid style explaining all basic concepts and fundamentals in a very simple way. This book aims to serve the need of all individuals involved at any level in the pharmaceutical dosage form development. I sincerely hope that the book will be liked by inquisitive students and learned colleagues.

An Introduction to Pharmaceutical Formulation

Author : A. G. Fishburn
Publisher : Elsevier
ISBN 13 : 1483138534
Total Pages : 200 pages
Book Rating : 4.4/5 (831 download)

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Book Synopsis An Introduction to Pharmaceutical Formulation by : A. G. Fishburn

Download or read book An Introduction to Pharmaceutical Formulation written by A. G. Fishburn and published by Elsevier. This book was released on 2013-10-22 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: An Introduction to Pharmaceutical Formulation describes the various forms in which drugs may be supplied to doctors, patients, and veterinary surgeons. An account is given of the materials which may be added to drugs in order to provide formulated products, and of the methods by which formulations are assessed. The book begins with a background on pharmaceutical formulation, describing manufactured and official formulations, important criteria for a formulation, and technical advances in pharmacy during the post-war period. This is followed by separate chapters on diluents, solvents, and liquid vehicles; thickeners and binders; the chemistry and pharmacology of surface-active agents; and colors, flavors, and preservatives. Subsequent chapters cover solid, liquid, and paste formulations; controlled drug release; the stability of formulations; the importance of the container of the formulation; and large-scale manufacturing of formulated products. This book is intended primarily for students of pharmacy. It is not a textbook of practical or theoretical pharmaceutics but should be read in conjunction with other books on these subjects.

Drug Stability for Pharmaceutical Scientists

Author : Thorsteinn Loftsson
Publisher : Academic Press
ISBN 13 : 0124115624
Total Pages : 170 pages
Book Rating : 4.1/5 (241 download)

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Book Synopsis Drug Stability for Pharmaceutical Scientists by : Thorsteinn Loftsson

Download or read book Drug Stability for Pharmaceutical Scientists written by Thorsteinn Loftsson and published by Academic Press. This book was released on 2014-01-25 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Stability for Pharmaceutical Scientists is a clear and easy-to-follow guide on drug degradation in pharmaceutical formulation. This book features valuable content on both aqueous and solid drug solutions, the stability of proteins and peptides, acid-base catalyzed and solvent catalyzed reactions, how drug formulation can influence drug stability, the influence of external factors on reaction rates and much more. Full of examples of real-life formulation problems and step-by-step calculations, this book is the ideal resource for graduate students, as well as scientists in the pharmaceutical and related industries. Illustrates important theoretical concepts with numerous examples, figures, calculations, learning problems and questions for self-study and retention of material Provides answers and explanations to test your knowledge Enables you to better understand key concepts such as rate and order of reaction, reaction equilibrium, complex reaction mechanisms and more Includes an in-depth discussion of both aqueous and solid drug solutions and contains the latest international regulatory requirements on drug stability

Over the Counter Pharmaceutical Formulations

Author : David B. Braun
Publisher : William Andrew
ISBN 13 :
Total Pages : 480 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Over the Counter Pharmaceutical Formulations by : David B. Braun

Download or read book Over the Counter Pharmaceutical Formulations written by David B. Braun and published by William Andrew. This book was released on 1994-12-31 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: Each section contains brand name and supplier's formulations. Brand name sections include manufacturer, active ingredients and concentration and other ingredients. Supplier's section includes supplier, ingredients, and mixing procedure.

Handbook of Pharmaceutical Manufacturing Formulations

Author : Sarfaraz K. Niazi
Publisher : CRC Press
ISBN 13 : 1420048457
Total Pages : 256 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Handbook of Pharmaceutical Manufacturing Formulations by : Sarfaraz K. Niazi

Download or read book Handbook of Pharmaceutical Manufacturing Formulations written by Sarfaraz K. Niazi and published by CRC Press. This book was released on 2004-04-27 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: The third volume in the six-volume Handbook of Pharmaceutical Manufacturing Formulations, this book covers liquid drugs, which include formulations of non-sterile drugs administered by any route in the form of solutions (monomeric and multimeric), suspensions (powder and liquid), drops, extracts, elixirs, tinctures, paints, sprays, colloidons, emul

Excipient Applications in Formulation Design and Drug Delivery

Author : Ajit S Narang
Publisher : Springer
ISBN 13 : 3319202065
Total Pages : 681 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Excipient Applications in Formulation Design and Drug Delivery by : Ajit S Narang

Download or read book Excipient Applications in Formulation Design and Drug Delivery written by Ajit S Narang and published by Springer. This book was released on 2015-10-07 with total page 681 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, emerging trends in the design and development of drug products have indicated ever greater need for integrated characterization of excipients and in-depth understanding of their roles in drug delivery applications. This book presents a concise summary of relevant scientific and mechanistic information that can aid the use of excipients in formulation design and drug delivery applications. Each chapter is contributed by chosen experts in their respective fields, which affords truly in-depth perspective into a spectrum of excipient-focused topics. This book captures current subjects of interest – with the most up to date research updates – in the field of pharmaceutical excipients. This includes areas of interest to the biopharmaceutical industry users, students, educators, excipient manufacturers, and regulatory bodies alike.

Pharmaceutical Formulation

Author : Geoffrey D Tovey
Publisher : Royal Society of Chemistry
ISBN 13 : 178801443X
Total Pages : 432 pages
Book Rating : 4.7/5 (88 download)

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Book Synopsis Pharmaceutical Formulation by : Geoffrey D Tovey

Pharmaceutical Formulation Development of Peptides and Proteins, Second Edition

Author : Lars Hovgaard
Publisher : CRC Press
ISBN 13 : 1439853886
Total Pages : 395 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Pharmaceutical Formulation Development of Peptides and Proteins, Second Edition by : Lars Hovgaard

Download or read book Pharmaceutical Formulation Development of Peptides and Proteins, Second Edition written by Lars Hovgaard and published by CRC Press. This book was released on 2012-11-14 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: The rapid advances in recombinant DNA technology and the increasing availability of peptides and proteins with therapeutic potential are a challenge for pharmaceutical scientists who have to formulate these compounds as drug products. Pharmaceutical Formulation Development of Peptides and Proteins, Second Edition discusses the development of therapeutic peptides and proteins, from the production of active compounds via basic pre-formulation and formulation to the registration of the final product. Providing integrated solutions, this book discusses: The synthesis of peptides and the biotechnological production of proteins through recombinant DNA technology The physicochemical characteristics and stability of peptides and proteins The formulation of proteins as suspensions, solutions, and (mostly freeze-dried) solids The opportunities and challenges of non-parenteral delivery of peptides and proteins Risk factors, specifically the development of an unwanted immune response A simulation approach to describe the fate of peptides and proteins upon administration to a biological system The documentation required to register a protein-based drug Scientists in the pharmaceutical industry and academia as well as postgraduate students in pharmaceutical science will find this a valuable resource.

Sterile Drug Products

Author : Michael J. Akers
Publisher : CRC Press
ISBN 13 : 1420020560
Total Pages : 516 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Sterile Drug Products by : Michael J. Akers

Download or read book Sterile Drug Products written by Michael J. Akers and published by CRC Press. This book was released on 2016-04-19 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sterile Drug Products: Formulation, Packaging, Manufacturing, and Quality teaches the basic principles of the development and manufacture of high quality sterile dosage forms. The author has 38 years of experience in the development and manufacture of sterile dosage forms including solutions, suspensions, ophthalmics and freeze dried products. This book is based on the courses he has delivered for over three decades, to over 3000 participants, and is intended to remain relevant for the indefinite future even as new technologies and new applications of old technologies become common. This is an ideal reference book for those working directly and indirectly with sterile dosage forms, be it product development (formulation, package, process, analytical), manufacturing, quality control, quality assurance, regulatory, purchasing, or project management. This book is also intended as an educational resource for the pharmaceutical and biopharmaceutical industry and pharmacy schools, providing basic knowledge and principles in four main areas of parenteral science and technology: Product development, including formulation, packaging, and process development. Manufacturing, including basic teaching on all the primary unit operations involved in preparation of sterile products and the underlying importance of contamination control. Quality and regulatory, including the application of good manufacturing practice regulations, aseptic processing guidelines, and unique quality control testing methods for the sterile dosage form Clinical aspects, including administration, potential hazards, and biopharmaceutics of sterile products in a clinical setting.

Essentials of Pharmaceutical Preformulation

Author : Simon Gaisford
Publisher : John Wiley & Sons
ISBN 13 : 1118423240
Total Pages : 234 pages
Book Rating : 4.1/5 (184 download)

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Book Synopsis Essentials of Pharmaceutical Preformulation by : Simon Gaisford

Download or read book Essentials of Pharmaceutical Preformulation written by Simon Gaisford and published by John Wiley & Sons. This book was released on 2012-10-22 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: Essentials of Pharmaceutical Preformulation is a study guide which describes the basic principles of pharmaceutical physicochemical characterisation. Successful preformulation requires knowledge of fundamental molecular concepts (solubility, ionisation, partitioning, hygroscopicity and stability) and macroscopic properties (physical form, such as the crystalline and amorphous states, hydrates, solvates and co-crystals and powder properties), familiarity with the techniques used to measure them and appreciation of their effect on product performance, recognising that often there is a position of compromise to be reached between product stability and bioavailability. This text introduces the basic concepts and discusses their wider implication for pharmaceutical development, with reference to many case examples of current drugs and drug products. Special attention is given to the principles and best-practice of the analytical techniques that underpin preformulation (UV spectrophotometry, TLC, DSC, XRPD and HPLC). The material is presented in the typical order that would be followed when developing a medicine and maps onto the indicative pharmacy syllabus of the Royal Pharmaceutical Society of Great Britain Undergraduate-level pharmacy students and R&D / analytical scientists working in the pharmaceutical sector (with or without a pharmaceutical background) will find this text easy to follow with relevant pharmaceutical examples. Essential study guide for pharmacy and pharmaceutical science students Covers the pharmaceutical preformulation components of the Royal Pharmaceutical Society of Great Britain’s indicative syllabus Easy to follow text highlighted with relevant pharmaceutical examples Self-assessment assignments in a variety of formats Written by authors with both academic and industrial experience Companion website with further information to maximise learning

Water-Insoluble Drug Formulation

Author : Ron Liu
Publisher : CRC Press
ISBN 13 : 1351646826
Total Pages : 781 pages
Book Rating : 4.3/5 (516 download)

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Book Synopsis Water-Insoluble Drug Formulation by : Ron Liu

Download or read book Water-Insoluble Drug Formulation written by Ron Liu and published by CRC Press. This book was released on 2018-03-12 with total page 781 pages. Available in PDF, EPUB and Kindle. Book excerpt: Properties and Formulation: From Theory to Real-World Application Scientists have attributed more than 40 percent of the failures in new drug development to poor biopharmaceutical properties, particularly water insolubility. Issues surrounding water insolubility can postpone or completely derail important new drug development. Even the much-needed reformulation of currently marketed products can be significantly affected by these challenges. More recently it was reported that the percentage increased to 90% for the candidates of new chemical entities in the discovery stage and 75% for compounds under development. In the most comprehensive resource on the topic, this third edition of Water-Insoluble Drug Formulation brings together a distinguished team of experts to provide the scientific background and step-by-step guidance needed to deal with solubility issues in drug development. Twenty-three chapters systematically describe the detailed discussion on solubility theories, solubility prediction models, the aspects of preformulation, biopharmaceutics, pharmacokinetics, regulatory, and discovery support of water-insoluble drugs to various techniques used in developing delivery systems for water-insoluble drugs. This book includes more than 15 water-insoluble drug delivery systems or technologies, illustrated with case studies and featuring oral and parenteral applications. Highlighting the most current information and data available, this seminal volume reflects the significant progress that has been made in nearly all aspects of this field. The aim of this book is to provide a handy reference for pharmaceutical scientists in the handling of formulation issues related to water-insoluble drugs. In addition, this book may be useful to pharmacy and chemistry undergraduate students and pharmaceutical and biopharmaceutical graduate students to enhance their knowledge in the techniques of drug solubilization and dissolution enhancement.

How to Develop Robust Solid Oral Dosage Forms

Author : Bhavishya Mittal
Publisher : Academic Press
ISBN 13 : 0128047321
Total Pages : 190 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis How to Develop Robust Solid Oral Dosage Forms by : Bhavishya Mittal

Download or read book How to Develop Robust Solid Oral Dosage Forms written by Bhavishya Mittal and published by Academic Press. This book was released on 2016-10-05 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: How to Develop Robust Solid Oral Dosage Forms from Conception to Post-Approval uses a practical and hands-on approach to cover the development process of solid oral dosage forms in one single source. The book details all of the necessary steps from formulation through the post-approval phase and contains industry case studies, real world advice, and troubleshooting tips. By merging the latest scientific information with practical instructions, this book provides pharmaceutical scientists in formulation research and development with a concrete look at the key aspects in the development of solid oral dosage forms. Focuses on important topics, such as robustness, bioavailability, formulation design, continuous processing, stability tests, modified release dosage forms, international guidelines, process scale-up, and much more Part of the Expertise in Pharmaceutical Process Technology series edited by Michael Levin Discusses common, real-world problems and offers both theoretical and practical solutions to these everyday issues