Peripheral Markers Of Immune Response In Major Psychiatric Disorders Where Are We Now And Where Do We Want To Be

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Peripheral Markers of Immune Response in Major Psychiatric Disorders: Where Are We Now and Where Do We Want to Be?

Author : Błażej Misiak
Publisher : Frontiers Media SA
ISBN 13 : 2889457974
Total Pages : 115 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Peripheral Markers of Immune Response in Major Psychiatric Disorders: Where Are We Now and Where Do We Want to Be? by : Błażej Misiak

Download or read book Peripheral Markers of Immune Response in Major Psychiatric Disorders: Where Are We Now and Where Do We Want to Be? written by Błażej Misiak and published by Frontiers Media SA. This book was released on 2019-04-03 with total page 115 pages. Available in PDF, EPUB and Kindle. Book excerpt: Major psychiatric disorders, including schizophrenia, bipolar disorder and major depression represent complex phenotypes with imprecise diagnostic boundaries. It has been found that these disorders can be characterized by a number of peripheral immune-inflammatory alterations, including, i.e. elevated levels of pro-inflammatory cytokines, increased levels of specific and non-specific antibodies or abnormal counts of lymphocyte subpopulations. Although it has been found that major psychiatric disorders share similar dysregulations of immune-inflammatory response, recent studies have also clearly demonstrated that some differences can be indicated. Interestingly, certain immune-inflammatory disturbances appear to be state markers, since they occur in acute relapse and normalize following pharmacological treatment, while the rest represents trait markers that remain stable regardless of treatment. It is also important to note that peripheral immune-inflammatory markers have been associated with psychopathological manifestation of major psychiatric disorders, response to treatment and long-term outcomes. However, it remains unclear what is the origin of peripheral inflammation in psychiatric disorders. To date, several mechanisms have been proposed, including the gut-brain axis dysregulation, infections in the neurodevelopmental period or immunogenetic factors. This eBook summarizes current evidence from studies investigating peripheral inflammation in schizophrenia, bipolar disorder, major depression and post-traumatic stress disorder as well as it provides future directions for the field.

The Neurobiological Basis of Suicide

Author : Yogesh Dwivedi
Publisher : CRC Press
ISBN 13 : 143983881X
Total Pages : 485 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis The Neurobiological Basis of Suicide by : Yogesh Dwivedi

Download or read book The Neurobiological Basis of Suicide written by Yogesh Dwivedi and published by CRC Press. This book was released on 2012-06-25 with total page 485 pages. Available in PDF, EPUB and Kindle. Book excerpt: With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment and prevention strategies. The Neurobiological Basis of Suicide discusses the most recent findings in suicide neurobiology. Psychological, psychosocial, and cultural factors are important in determining the risk factors for suicide; however, they offer weak prediction and can be of little clinical use. Interestingly, cognitive characteristics are different among depressed suicidal and depressed nonsuicidal subjects, and could be involved in the development of suicidal behavior. The characterization of the neurobiological basis of suicide is in delineating the risk factors associated with suicide. The Neurobiological Basis of Suicide focuses on how and why these neurobiological factors are crucial in the pathogenic mechanisms of suicidal behavior and how these findings can be transformed into potential therapeutic applications.

Immunopsychiatry

Author : Antonio L. Teixeira
Publisher : Oxford University Press
ISBN 13 : 0190884479
Total Pages : 304 pages
Book Rating : 4.1/5 (98 download)

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Book Synopsis Immunopsychiatry by : Antonio L. Teixeira

Download or read book Immunopsychiatry written by Antonio L. Teixeira and published by Oxford University Press. This book was released on 2019-01-03 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, a dedicated effort has been made to understand the immune dysfunction that is associated with major psychiatric disorders. The expanding knowledge of the immune system as a major homeostatic system has been very helpful in indicating new potential biomarkers and therapeutic targets to reduce the burden of psychiatric disorders. Indeed, immune cells, their secreted molecules, and cell signalling events are highly promising. Yet, the literature on immunology of psychiatric disorders is still dispersed, and only a few attempts have been made to consolidate the current knowledge in this expanding area. This book assembles and presents the available data on the immune/inflammatory dysfunction in psychiatric disorders, indicating the potential of immune mechanisms as either biomarkers or therapeutic targets, as well as discussing the challenges ahead of incorporating this knowledge into clinical practice. An international team of senior experts in the field review all psychiatric disorders in order to provide an integrated, in-depth understanding of the role of immune changes in psychiatric diseases for mental health clinicians as well as for researchers in immunology, psychiatry, neurology, and pharmacology.

Clinical Psychometrics

Author : Per Bech
Publisher : John Wiley & Sons
ISBN 13 : 1118511824
Total Pages : 168 pages
Book Rating : 4.1/5 (185 download)

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Book Synopsis Clinical Psychometrics by : Per Bech

Download or read book Clinical Psychometrics written by Per Bech and published by John Wiley & Sons. This book was released on 2012-09-24 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical Psychometrics is an introduction to the long-term attempt to measure the psychiatric dimension of dementia, schizophrenia, mania, depression, anxiety, neuroticism, extraversion/introversion and health-related quality of life. The two psychometric procedures, classical factor analysis and modern item-response models, are presented for readers without any requirement for particular mathematical or statistical knowledge. The book is unique in this attempt and provides helpful background information for the dimensional approach that is being used in the forthcoming updates to the diagnostic classification systems, ICD-11 and DSM-5. The book is written for everyone who is interested in the origins and development of modern psychiatry, and who wants to be familiar with its practical possibilities; how it is possible to compare different individuals with each other, how one may determine the boundary between what is normal and what is disease, or how one may assess the clinical effect of the various forms of treatment, available to present day psychiatry.

Cytokines, Stress, and Depression

Author : Robert Dantzer
Publisher : Springer Science & Business Media
ISBN 13 : 0306461358
Total Pages : 334 pages
Book Rating : 4.3/5 (64 download)

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Book Synopsis Cytokines, Stress, and Depression by : Robert Dantzer

Download or read book Cytokines, Stress, and Depression written by Robert Dantzer and published by Springer Science & Business Media. This book was released on 1999-07-31 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Until a few years ago, cytokines were only known to immunologists; now these molecules have burst upon neurosciences and permeated several avenues of current research. This book examines the possible role of cytokines in mental depression, based on recent clinical and experimental data, and constitutes the first attempt to make a synthesis between the exciting new developments in cytokine research and their implications for the pathophysiology of mental disorders.

Biomarkers in Psychiatry

Author : Judith Pratt
Publisher : Springer
ISBN 13 : 3319996428
Total Pages : 437 pages
Book Rating : 4.3/5 (199 download)

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Book Synopsis Biomarkers in Psychiatry by : Judith Pratt

Download or read book Biomarkers in Psychiatry written by Judith Pratt and published by Springer. This book was released on 2019-01-05 with total page 437 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume addresses one of the Holy Grails in Psychiatry, namely the evidence for and potential to adopt ‘Biomarkers’ for prevention, diagnosis, and treatment responses in mental health conditions. It meshes together state of the art research from international renowned pre-clinical and clinical scientists to illustrate how the fields of anxiety disorders, depression, psychotic disorders, and autism spectrum disorder have advanced in recent years.

Personalized Psychiatry

Author : Bernhard Baune
Publisher : Academic Press
ISBN 13 : 0128131772
Total Pages : 604 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Personalized Psychiatry by : Bernhard Baune

Download or read book Personalized Psychiatry written by Bernhard Baune and published by Academic Press. This book was released on 2019-10-16 with total page 604 pages. Available in PDF, EPUB and Kindle. Book excerpt: Personalized Psychiatry presents the first book to explore this novel field of biological psychiatry that covers both basic science research and its translational applications. The book conceptualizes personalized psychiatry and provides state-of-the-art knowledge on biological and neuroscience methodologies, all while integrating clinical phenomenology relevant to personalized psychiatry and discussing important principles and potential models. It is essential reading for advanced students and neuroscience and psychiatry researchers who are investigating the prevention and treatment of mental disorders. Combines neurobiology with basic science methodologies in genomics, epigenomics and transcriptomics Demonstrates how the statistical modeling of interacting biological and clinical information could transform the future of psychiatry Addresses fundamental questions and requirements for personalized psychiatry from a basic research and translational perspective

Cytokine Inhibitors

Author : Gennaro Ciliberto
Publisher : CRC Press
ISBN 13 : 9780203904244
Total Pages : 392 pages
Book Rating : 4.9/5 (42 download)

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Book Synopsis Cytokine Inhibitors by : Gennaro Ciliberto

Download or read book Cytokine Inhibitors written by Gennaro Ciliberto and published by CRC Press. This book was released on 2000-11-14 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Compiling an up-to-date and detailed survey of the role cytokines play in cell-to-cell communication, development, and differentiation, this comprehensive reference highlights the medical advantages of cytokine inhibition and pursues novel methods of discovery for more potent and specific blocking agents. Investigates the pathogenic role of

Epigenetic Biomarker and Personalized Precision Medicine

Author : Jiucun Wang
Publisher : Frontiers Media SA
ISBN 13 : 2889661849
Total Pages : 485 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Epigenetic Biomarker and Personalized Precision Medicine by : Jiucun Wang

Download or read book Epigenetic Biomarker and Personalized Precision Medicine written by Jiucun Wang and published by Frontiers Media SA. This book was released on 2020-12-21 with total page 485 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Immuno-Psychiatry

Author : Michael Berk
Publisher : Springer Nature
ISBN 13 : 303071229X
Total Pages : 438 pages
Book Rating : 4.0/5 (37 download)

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Book Synopsis Immuno-Psychiatry by : Michael Berk

Download or read book Immuno-Psychiatry written by Michael Berk and published by Springer Nature. This book was released on 2021-08-14 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a thorough and critical review of current knowledge on the role of immunology in major psychiatric disorders and its potential applications. The opening chapters offer general information on the immune influence of the brain to provide readers with a better understanding of the end of immune privilege. The book then examines possible underlying mechanisms leading to psychiatric disorders, from early infections to pro-inflammatory markers, stress, and immune genetic background, linking etiology and psychiatry. The third section describes each disorder (ie autism, schizophrenia, bipolar disorder, depression...) with an overview of underlying immune dysfunctions. Lastly, the authors discuss the innovative immune-therapies that may result from the discovery of immune system biomarkers and their associated mechanisms. A better understanding of the role of the immune system in psychiatric disorders makes it possible to identify stratification biomarkers, to explain underlying mechanisms, and to develop innovative, efficient, targeted treatment strategies and management. As such, the book is of value to clinicians, mental health professionals, mental health researchers, immunologists, industry practitioners, and various stakeholders in the mental health field.

PTSD Research Quarterly

Author :
Publisher :
ISBN 13 :
Total Pages : 8 pages
Book Rating : 4.:/5 (3 download)

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Book Synopsis PTSD Research Quarterly by :

Download or read book PTSD Research Quarterly written by and published by . This book was released on 1992 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Psychotic Disorders

Author : Carol A. Tamminga MD
Publisher : Oxford University Press
ISBN 13 : 0190653299
Total Pages : 400 pages
Book Rating : 4.1/5 (96 download)

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Book Synopsis Psychotic Disorders by : Carol A. Tamminga MD

Download or read book Psychotic Disorders written by Carol A. Tamminga MD and published by Oxford University Press. This book was released on 2020-10-20 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Psychotic Disorders: Comprehensive Conceptualization and Treatments emphasizes a dimensional approach to psychosis--one of the most fascinating manifestations of altered brain behavior--that cuts across a broad array of psychiatric diagnoses from schizophrenia to affective psychosis and organic disorders like epilepsy and dementias. Written by an international roster of over seventy leading experts in the field, this volume comprehensively reviews, critiques, and integrates available knowledge on the etiology, mechanisms, and treatments of psychotic disorders, and outlines ways forward in both research and clinical practice towards more objective, mechanistically-based definitions of psychotic disorders. Chapters address topics such as psychosis phenomenology, biomarkers and treatments, the overlaps and interfaces between psychiatric disorders within the psychosis dimension, and novel disease definitions. Furthermore, the volume incorporates findings on potential mechanisms, bridges between various system levels (i.e., genetic, epigenetic, molecular and cellular, brain circuit and function, psychological, social, environmental and cultural) and their interactions, as well as the potential role in causation and/or mediation in psychotic disorders. Finally, the volume outlines a broad array of treatment approaches, from the readily available (e.g., psychopharmacology, various modalities of psychotherapy) to the experimental (e.g., cognitive interventions, neuromodulation). With a concluding section of forward perspectives conjecturing future directions and related challenges, this book aspires to stimulate new knowledge, generate novel frameworks, and carry new directions forward on psychotic disorders.

The Biological Basis of Schizophrenia

Author : G. Hemmings
Publisher : Springer Science & Business Media
ISBN 13 : 9401162069
Total Pages : 270 pages
Book Rating : 4.4/5 (11 download)

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Book Synopsis The Biological Basis of Schizophrenia by : G. Hemmings

Download or read book The Biological Basis of Schizophrenia written by G. Hemmings and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: For years lip service has been paid to a belief in a biological basis for schizophrenia, but ,nevertheless psychosocial and psychodynamic "theories" of schizophrenia have been promulgated, and these have detracted from the all important biological work, Eclecticism has ruled the day and has caused considerable confusion, As a result research in schizophrenia has not progressed as fast as it should have done and treatment has been less effective than it could otherwise have been. This book is devoted to a wholly biological approach to the problem of schizophrenia, in the hope that many more workers will enter this exciting field of research. A wide variety of topics is covered, including brain structure; the genetics, pathogenesis and treatment of schizophrenia; a consideration of dietary and immunological factors and finally a chapter on alcoholism as it seems possible that the problems of schizophrenia and addiction are linked. We are grateful to all our contributors and to MTP Press for their enthusiasm for this book. Gwynneth P Hemmings William A Hemmings XI SECTION 1: Structure 1 The brain stem reticular formation K. E. WEBSTER There can be no question that the brain stem reticular lormation no longer exercises the same fascination for neurologists that it did a quarter of a century ago.

Panic Disorder and Agoraphobia

Author : Borwin Bandelow
Publisher : Oxford University Press
ISBN 13 : 0199562296
Total Pages : 79 pages
Book Rating : 4.1/5 (995 download)

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Book Synopsis Panic Disorder and Agoraphobia by : Borwin Bandelow

Download or read book Panic Disorder and Agoraphobia written by Borwin Bandelow and published by Oxford University Press. This book was released on 2013-09 with total page 79 pages. Available in PDF, EPUB and Kindle. Book excerpt: Part of the Oxford Psychiatry Library series, this pocketbook provides a user-friendly introduction to the diagnosis, etiology, and treatment of patients with panic disorder.

Functional Somatic Symptoms in Children and Adolescents

Author : Kasia Kozlowska
Publisher : Springer Nature
ISBN 13 : 303046184X
Total Pages : 397 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Functional Somatic Symptoms in Children and Adolescents by : Kasia Kozlowska

Download or read book Functional Somatic Symptoms in Children and Adolescents written by Kasia Kozlowska and published by Springer Nature. This book was released on 2020-09-30 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book sets out the stress-system model for functional somatic symptoms in children and adolescents. The book begins by exploring the initial encounter between the paediatrician, child, and family, moves through the assessment process, including the formulation and the treatment contract, and then describes the various forms of treatment that are designed to settle the child’s dysregulated stress system. This approach both provides a new understanding of how such symptoms emerge – typically, through a history of recurrent or chronic stress, either physical or psychological – and points the way to effective assessment, management, and treatment that put the child (and family) back on the road to health and well-being.

Psychosis

Author : Kenjiro Fukao
Publisher : BoD – Books on Demand
ISBN 13 : 1839690445
Total Pages : 128 pages
Book Rating : 4.8/5 (396 download)

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Book Synopsis Psychosis by : Kenjiro Fukao

Download or read book Psychosis written by Kenjiro Fukao and published by BoD – Books on Demand. This book was released on 2022-02-02 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: Psychosis has been the central subject of psychiatric research for more than a century and yet it remains an intriguing enigma. This volume reviews the current status of research on psychosis in three different aspects, namely, phenomenology, which is the philosophical/conceptual basis of psychosis; psychopathology, which is the clinical manifestations of psychosis; and pathophysiology, which is the scientific pursuit for the mechanism of psychosis. Chapters focus on schizophrenia, covering such topics as clinical staging, negative symptoms, epigenetics, DNA methyltransferases, and more.

Neuroprogression in Psychiatry

Author : Flávio Kapczinski
Publisher : Oxford University Press
ISBN 13 : 0191090883
Total Pages : 272 pages
Book Rating : 4.1/5 (91 download)

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Book Synopsis Neuroprogression in Psychiatry by : Flávio Kapczinski

Download or read book Neuroprogression in Psychiatry written by Flávio Kapczinski and published by Oxford University Press. This book was released on 2019-03-05 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent studies regarding the neuropathology of specific neurological disorders suggest that both neurodevelopmental and neurodegenerative processes may play a role. However, in contrast to the neurodegeneration seen in neurological disorders such as Parkinson's and Alzheimer's disease, the term "neuroprogression" has been used to describe the neurodevelopmental aspect of pathological brain re-wiring that takes place in the context of severe psychiatric disorders, such as schizophrenia or bipolar disorder. Within psychiatry, patients with severe psychopathology, such as those depressed patients who eventually commit suicide, have been shown to present with increased inflammatory markers in the brain. A similar increase in inflammatory markers is also found in patients with bipolar disorders and schizophrenia. Thus, oxidative stress, inflammation, and changes in growth factors are thought to be the pathways of neuroprogression. Neuroprogression in Psychiatry provides a comprehensive summary of the current developments in the emerging field of neuroprogression. With contributions by leading researchers in the field, this book examines the role of neuroprogression across a wide range of specific psychiatric disorders, with chapters included on major depressive disorder, anxiety disorder, post-traumatic stress disorder, substance abuse, schizophrenia, and bipolar disorder.