Immuno-Psychiatry

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Author :
Publisher : Springer Nature
ISBN 13 : 303071229X
Total Pages : 438 pages
Book Rating : 4.0/5 (37 download)

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Book Synopsis Immuno-Psychiatry by : Michael Berk

Download or read book Immuno-Psychiatry written by Michael Berk and published by Springer Nature. This book was released on 2021-08-14 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a thorough and critical review of current knowledge on the role of immunology in major psychiatric disorders and its potential applications. The opening chapters offer general information on the immune influence of the brain to provide readers with a better understanding of the end of immune privilege. The book then examines possible underlying mechanisms leading to psychiatric disorders, from early infections to pro-inflammatory markers, stress, and immune genetic background, linking etiology and psychiatry. The third section describes each disorder (ie autism, schizophrenia, bipolar disorder, depression...) with an overview of underlying immune dysfunctions. Lastly, the authors discuss the innovative immune-therapies that may result from the discovery of immune system biomarkers and their associated mechanisms. A better understanding of the role of the immune system in psychiatric disorders makes it possible to identify stratification biomarkers, to explain underlying mechanisms, and to develop innovative, efficient, targeted treatment strategies and management. As such, the book is of value to clinicians, mental health professionals, mental health researchers, immunologists, industry practitioners, and various stakeholders in the mental health field.

Textbook of Immunopsychiatry

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Author :
Publisher : Cambridge University Press
ISBN 13 : 1009038362
Total Pages : 357 pages
Book Rating : 4.0/5 (9 download)

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Book Synopsis Textbook of Immunopsychiatry by : Golam Khandaker

Download or read book Textbook of Immunopsychiatry written by Golam Khandaker and published by Cambridge University Press. This book was released on 2021-09-23 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: The rapidly growing field of immunopsychiatry combines expertise and insights from immunology, psychiatry and neuroscience to understand the role of inflammation and other immune processes in causing and treating mental illness. This represents a major shift in mental health science, traditionally focused on psychological and neuronal mechanisms of depression, psychosis and dementia. This book provides the first comprehensive overview of recent, inter-disciplinary research linking disordered function of the immune system to the brain and mental illness. It offers a broad and deep perspective on the implications of immune system involvement in psychiatric disorders, including a balanced focus on basic science and clinical applications. Chapters cover the scientific evidence linking immune processes to major mental illnesses such as schizophrenia, depression, anxiety and dementia. An invaluable guide for graduate students, doctors in training, scientific researchers and others interested in the link between the immune system and mental health.

Immunopsychiatry

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Author :
Publisher : Oxford University Press, USA
ISBN 13 : 0190884460
Total Pages : 323 pages
Book Rating : 4.1/5 (98 download)

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Book Synopsis Immunopsychiatry by : Antonio L. Teixeira

Download or read book Immunopsychiatry written by Antonio L. Teixeira and published by Oxford University Press, USA. This book was released on 2019-01-18 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, a dedicated effort has been made to understand the immune dysfunction that is associated with major psychiatric disorders. The expanding knowledge of the immune system as a major homeostatic system has been very helpful in indicating new potential biomarkers and therapeutic targets to reduce the burden of psychiatric disorders. Indeed, immune cells, their secreted molecules, and cell signalling events are highly promising. Yet, the literature on immunology of psychiatric disorders is still dispersed, and only a few attempts have been made to consolidate the current knowledge in this expanding area. This book assembles and presents the available data on the immune/inflammatory dysfunction in psychiatric disorders, indicating the potential of immune mechanisms as either biomarkers or therapeutic targets, as well as discussing the challenges ahead of incorporating this knowledge into clinical practice. An international team of senior experts in the field review all psychiatric disorders in order to provide an integrated, in-depth understanding of the role of immune changes in psychiatric diseases for mental health clinicians as well as for researchers in immunology, psychiatry, neurology, and pharmacology.

Immunopsychiatry

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Author :
Publisher : Oxford University Press
ISBN 13 : 0190884479
Total Pages : 304 pages
Book Rating : 4.1/5 (98 download)

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Book Synopsis Immunopsychiatry by : Antonio L. Teixeira

Download or read book Immunopsychiatry written by Antonio L. Teixeira and published by Oxford University Press. This book was released on 2019-01-03 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, a dedicated effort has been made to understand the immune dysfunction that is associated with major psychiatric disorders. The expanding knowledge of the immune system as a major homeostatic system has been very helpful in indicating new potential biomarkers and therapeutic targets to reduce the burden of psychiatric disorders. Indeed, immune cells, their secreted molecules, and cell signalling events are highly promising. Yet, the literature on immunology of psychiatric disorders is still dispersed, and only a few attempts have been made to consolidate the current knowledge in this expanding area. This book assembles and presents the available data on the immune/inflammatory dysfunction in psychiatric disorders, indicating the potential of immune mechanisms as either biomarkers or therapeutic targets, as well as discussing the challenges ahead of incorporating this knowledge into clinical practice. An international team of senior experts in the field review all psychiatric disorders in order to provide an integrated, in-depth understanding of the role of immune changes in psychiatric diseases for mental health clinicians as well as for researchers in immunology, psychiatry, neurology, and pharmacology.

The Immune System and Mental Health

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Author :
Publisher : Academic Press
ISBN 13 : 0128113529
Total Pages : 700 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis The Immune System and Mental Health by : Hymie Anisman

Download or read book The Immune System and Mental Health written by Hymie Anisman and published by Academic Press. This book was released on 2018-07-19 with total page 700 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Immune System and Mental Health fully investigates how immune-related cellular, molecular and anatomical changes impact mental functioning. The book combines human and animal studies to reveal immunological changes related to mental-health problems. In addition, users will find comprehensive information on new research related to the microbial composition of the gut, aka, the microbiome, and how it influences brain function and mental health. Common comorbidities with mental illness and their inherent immunological or inflammatory components are also covered. Written by leaders in the field, the book synthesizes basic and clinical research to provide a thorough understanding on the role of immunity in neuropsychiatry. Sociology, psychology, psychiatry, neuroscience and genetics have provided considerable explanations and solutions to some of the most intractable mental-health problems. But researchers are increasingly relying on investigations of the immune system to identify factors that can undermine and impair mental health. This book covers devastating mental-health conditions, such as depression, anxiety, schizophrenia, and autism-like spectrum disorders. In addition, degenerative disorders of the brain, such as Parkinson’s and Alzheimer’s-like dementia are explored. Considers both basic human and animal studies that address immunological changes relating to mental health problems across the lifespan Incorporates techniques, concepts and ideas from a variety of social, behavioral and life sciences Explores the relatively new area of the microbiome and how the microbial composition of the gut influences brain function and mental health

Immunology and Psychiatry

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Author :
Publisher : Springer
ISBN 13 : 331913602X
Total Pages : 408 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Immunology and Psychiatry by : Norbert Müller

Download or read book Immunology and Psychiatry written by Norbert Müller and published by Springer. This book was released on 2015-04-20 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: Psychiatric disorders are one of the most dramatic burdens for humankind. The role of immune dysfunction in the pathophysiology of these disorders has emerged during the last years, because there has been tremendous progress in psychoneuroimmunological research. Many results are presented here by pioneers in the field. The book addresses various effects of the immune system on the pathophysiology and course of psychiatric disorders and highlights the possible future impact on treatment decisions of various psychiatric disorders, including schizophrenia and depression. The contributions cover the role of in utero immune challenges on the development of schizophrenia, the role of infections, and autoimmune diseases and mild immune activation in the development of depression and schizophrenia, the influence of immune responses in other disorders such as Tourette's, Alzheimer's, and OCD, the connections between mental and physical pain as well as between anti-inflammatory and antipsychotic drugs.​

Introduction to Psychoneuroimmunology

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Publisher : Academic Press
ISBN 13 : 0123820499
Total Pages : 336 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Introduction to Psychoneuroimmunology by : Jorge H. Daruna

Download or read book Introduction to Psychoneuroimmunology written by Jorge H. Daruna and published by Academic Press. This book was released on 2012-02-24 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Health is maintained by the coordinated operation of all the biological systems that make up the individual. The Introduction to Psychoneuroimmunology, Second Edition, presents an overview of what has been discovered by scientists regarding how bodily systems respond to environmental challenges and intercommunicate to sustain health. The book touches on the main findings from the current literature without being overly technical and complex. The result is a comprehensive overview of psychoneuroimmunology, which avoids oversimplification, but does not overwhelm the reader. Single authored for consistency of breadth and depth, with no redundancy of coverage between chapters Covers endocrine-immune modulation, neuro-immune modulation, and the enhancing or inhibiting processes of one or more systems on the others Expanded use of figures, tables, and text boxes

The Inflamed Mind

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Author :
Publisher : Picador
ISBN 13 : 1250318157
Total Pages : 256 pages
Book Rating : 4.2/5 (53 download)

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Book Synopsis The Inflamed Mind by : Edward Bullmore

Download or read book The Inflamed Mind written by Edward Bullmore and published by Picador. This book was released on 2018-12-31 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: As seen on "CBS This Morning" Worldwide, depression will be the single biggest cause of disability in the next twenty years. But treatment for it has not changed much in the last three decades. In the world of psychiatry, time has apparently stood still...until now with Edward Bullmore's The Inflamed Mind: A Radical New Approach to Depression. A Sunday Times (London) Top Ten Bestseller In this game-changing book, University of Cambridge profressor of psychiatry Edward Bullmore reveals the breakthrough new science on the link between depression and inflammation of the body and brain. He explains how and why we now know that mental disorders can have their root cause in the immune system, and outlines a future revolution in which treatments could be specifically targeted to break the vicious cycles of stress, inflammation, and depression. The Inflamed Mind goes far beyond the clinic and the lab, representing a whole new way of looking at how mind, brain, and body all work together in a sometimes misguided effort to help us survive in a hostile world. It offers insights into how we could start getting to grips with depression and other mental disorders much more effectively in the future.

Psychiatry, Psychoimmunology, and Viruses

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 3709164044
Total Pages : 156 pages
Book Rating : 4.7/5 (91 download)

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Book Synopsis Psychiatry, Psychoimmunology, and Viruses by : Norbert Müller

Download or read book Psychiatry, Psychoimmunology, and Viruses written by Norbert Müller and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains the contributions to the "3rd Expert Meeting in Psychoneuroimmunology", held in Munich, Germany in autumn 1997. Clinical psychiatrists, neuroscientists and researchers in basic immuno logy from Europe and the USA gather together annually at this new tra ditional meeting to discuss new findings and trends in the relationship between psychiatric disorders and the immune system. Pinpointed at the Munich meeting in particular were the possible influence of viral infec tions on psychiatric disorders, especially schizophrenia, and the possible pathophysiological mechanisms affecting psychiatric disorders. These mechanisms include viral-induced alteration, cytokine production, and the role of the HLA system. One chapter is devoted to the influence of viral infections during pregnancy; another to the first results of experimental therapy especial ly regarding the immune system. The immunological aspects not only of schizophrenia but also of depression, anxiety disorders, sleep and headache were also discussed at the meeting, and two further chapters cover methodological aspects related to clinical and experimental pitfalls in psychoneuroimmunology. The psychoneuroimmunology of psychiatric disorders is a rapidly expanding field, and research is increasing on the therapeutic aspects. This is reflected by one of the main themes of the "4th Expert Meeting in Psychoneuroimmunology", jointly held in autumn 1998 in Bethesda, Maryland, USA, with the Stanley Foundation Meeting in Neurovirology, devoted to therapeutic strategies deriving from psychoneuroimmunolo gical findings. The "5th Expert Meeting in Psychoneuroimmunology" will be held in 1999 in Innsbruck, Austria.

Inflammation, 4 Volume Set

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Publisher : John Wiley & Sons
ISBN 13 : 3527338993
Total Pages : 1818 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Inflammation, 4 Volume Set by : Jean-Marc Cavaillon

Download or read book Inflammation, 4 Volume Set written by Jean-Marc Cavaillon and published by John Wiley & Sons. This book was released on 2018-02-20 with total page 1818 pages. Available in PDF, EPUB and Kindle. Book excerpt: The leading reference on this topic of increasing medical relevance is unique in offering unparalleled coverage. The editors are among the most respected researchers in inflammation worldwide and here have put together a prestigious team of contributors. Starting with the molecular basis of inflammation, from cytokines via the innate immune system to the different kinds of inflammatory cells, they continue with the function of inflammation in infectious disease before devoting a large section to the relationship between inflammation and chronic diseases. The book concludes with wound and tissue healing and options for therapeutic interventions. A must have for clinicians and biomedical researchers alike.

Inflammation in Psychiatry

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Author :
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318023108
Total Pages : 218 pages
Book Rating : 4.3/5 (18 download)

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Book Synopsis Inflammation in Psychiatry by : Angelos Halaris

Download or read book Inflammation in Psychiatry written by Angelos Halaris and published by Karger Medical and Scientific Publishers. This book was released on 2013 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: An innovative and integrative avenue toward understanding and treating mental health disorders Psychoimmunology is a rapidly maturing area of scientific endeavor that provides a compelling integrative link between the immune system and its response to stress and psychiatric illness. Stress initiates pathological changes by activating the immune and endocrine systems. Inflammation is at the core of the complex and interactive systems that both contribute to and result from psychopathology. Consequently, inflammation research advances our knowledge of the pathology of depression, schizophrenia, chronic fatigue syndrome, posttraumatic stress disorder and a host of co- morbid conditions, notably diabetes, cardiovascular disease and cerebrovascular disease. The possible mechanisms underlying the bidirectionality of co-morbid medical and psychiatric disorders can be viewed as a consequence of inflammatory changes. These emerging novel concepts illustrate how the knowledge of inflammation can enable meaningful integration of psychopathology with physical co- morbidity. The innovative articles in this volume highlight the intricate link between psychiatry and psychoimmunology and underscore the central role of inflammation in furthering our understanding of the pathophysiology underlying mental health and illness.

Peripheral Markers of Immune Response in Major Psychiatric Disorders: Where Are We Now and Where Do We Want to Be?

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Author :
Publisher : Frontiers Media SA
ISBN 13 : 2889457974
Total Pages : 115 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Peripheral Markers of Immune Response in Major Psychiatric Disorders: Where Are We Now and Where Do We Want to Be? by : Błażej Misiak

Download or read book Peripheral Markers of Immune Response in Major Psychiatric Disorders: Where Are We Now and Where Do We Want to Be? written by Błażej Misiak and published by Frontiers Media SA. This book was released on 2019-04-03 with total page 115 pages. Available in PDF, EPUB and Kindle. Book excerpt: Major psychiatric disorders, including schizophrenia, bipolar disorder and major depression represent complex phenotypes with imprecise diagnostic boundaries. It has been found that these disorders can be characterized by a number of peripheral immune-inflammatory alterations, including, i.e. elevated levels of pro-inflammatory cytokines, increased levels of specific and non-specific antibodies or abnormal counts of lymphocyte subpopulations. Although it has been found that major psychiatric disorders share similar dysregulations of immune-inflammatory response, recent studies have also clearly demonstrated that some differences can be indicated. Interestingly, certain immune-inflammatory disturbances appear to be state markers, since they occur in acute relapse and normalize following pharmacological treatment, while the rest represents trait markers that remain stable regardless of treatment. It is also important to note that peripheral immune-inflammatory markers have been associated with psychopathological manifestation of major psychiatric disorders, response to treatment and long-term outcomes. However, it remains unclear what is the origin of peripheral inflammation in psychiatric disorders. To date, several mechanisms have been proposed, including the gut-brain axis dysregulation, infections in the neurodevelopmental period or immunogenetic factors. This eBook summarizes current evidence from studies investigating peripheral inflammation in schizophrenia, bipolar disorder, major depression and post-traumatic stress disorder as well as it provides future directions for the field.

Recent Advances in Psychiatry from Psycho-Neuro-Immunology Research: Autoimmunencephalitis, Autoimmune-Encephalopathy, Mild Encephalitis

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Author :
Publisher : Frontiers Media SA
ISBN 13 : 2889459500
Total Pages : 189 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Recent Advances in Psychiatry from Psycho-Neuro-Immunology Research: Autoimmunencephalitis, Autoimmune-Encephalopathy, Mild Encephalitis by : Karl Bechter

Download or read book Recent Advances in Psychiatry from Psycho-Neuro-Immunology Research: Autoimmunencephalitis, Autoimmune-Encephalopathy, Mild Encephalitis written by Karl Bechter and published by Frontiers Media SA. This book was released on 2019-08-12 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: Growing evidence derived from cerebrospinal fluid (CSF), neuropathological, imaging, genetic, and epidemiological studies link neuroinflammation and immune dysregulation to a subset of individuals with a variety of severe mental disorders (SMDs), including affective and non-affective psychotic disorders. Further, the recent discoveries of neuronal surface antibodies (NSAs) in autoimmune encephalitis (AE) presenting with diverse neuropsychiatric disorders such as psychosis and cognitive decline, among many others, provides further support to the notion that CNS autoimmunity and neuroinflammation can contribute to the neurobiology of psychiatric disturbances. Further, these immune mechanisms may contribute to a subset of patients currently diagnosed as having treatment-resistant SMDs such as schizophrenia and major depressive disorder. Additionally, mounting data indicate that various infections can serve as an immunological trigger of aberrant immune responses, presumably by causing release of excess neural antigen, thereby giving rise to NSAs or aberrant immune cellular responses to give rise to primary or secondary psychiatric disorders such as schizophrenia and those associated with AE, respectively. Collectively, these findings support the “mild encephalitis” hypothesis of SMD. The significant overlap among AE-associated psychosis, systemic autoimmune disorder-associated psychosis, and psychotic disorders associated with pathological processes involving inflammation and immune dysregulation has also prompted some authors to adopt the term “autoimmune psychosis” (AP). This term reflects that this psychosis subtype is mechanistically linked to complex neuroimmune and inflammatory signalling abnormalities that can be responsive to early immunomodulatory treatment. It also suggests that a subset of AP might represent an incomplete or “forme fruste” subtype of AE presenting with dominant or pure psychiatric symptoms mimicking primary psychiatric illnesses. Because data indicate that delayed diagnosis and treatment may lead to permanent sequelae, early recognition of AP utilizing neurodiagnostic workup (e.g., CSF analysis, neuroimaging, and EEG) and its early treatment with appropriate immunotherapy are paramount to a meaningful recovery. This eBook will provide an overview of the current knowledge and research areas from epidemiology, risk factors and diagnosis to the management of these conditions, in this rapidly emerging field, helping to bridge the gaps in knowledge that currently exist in the disciplines of Psychiatry, Neurology, and Neuroimmunology.

The Immune System

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Author :
Publisher : Oxford University Press
ISBN 13 : 019875390X
Total Pages : 145 pages
Book Rating : 4.1/5 (987 download)

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Book Synopsis The Immune System by : Paul Klenerman

Download or read book The Immune System written by Paul Klenerman and published by Oxford University Press. This book was released on 2017 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: The immune system is central to human health and the focus of much medical research. Growing understanding of the immune system, and especially the creation of immune memory (long lasting protection), which can be harnessed in the design of vaccines, have been major breakthroughs in medicine. In this Very Short Introduction, Paul Klenerman describes the immune system, and how it works in health and disease. In particular he focuses on the human immune system, considering how it evolved, the basic rules that govern its behavior, and the major health threats where it is important. The immune system comprises a series of organs, cells and chemical messengers which work together as a team to provide defence against infection. Klenerman discusses these components, the critical signals that trigger them and how they exert their protective effects, including so-called innate immune responses, which react very fast to infection, and adaptive immune responses, which have huge diversity and a capacity to recognize and defend against a massive array of micro-organisms. Klenerman also considers what happens when our immune systems fail to be activated effectively, leading to serious infections, problems with inherited diseases, and also HIV/AIDS. At the opposite extreme, as Klenerman shows, an over-exaggerated immune response leads to inflammatory diseases such as Multiple Sclerosis and Rheumatoid Arthritis, as well as allergy and asthma. Finally he looks at the Immune system v2.o - how immune therapies and vaccines can be advanced to protect us against the major diseases of the 21st century. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.

Textbook of Immunopsychiatry

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Author :
Publisher : Cambridge University Press
ISBN 13 : 110842404X
Total Pages : 357 pages
Book Rating : 4.1/5 (84 download)

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Book Synopsis Textbook of Immunopsychiatry by : Golam Khandaker

Download or read book Textbook of Immunopsychiatry written by Golam Khandaker and published by Cambridge University Press. This book was released on 2021-09-23 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: An essential book summarizing cutting-edge evidence on the role of the immune system and immunotherapies in psychiatric disorders.

Psychoneuroimmunology

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Author :
Publisher : American Psychiatric Pub
ISBN 13 : 1585628182
Total Pages : 468 pages
Book Rating : 4.5/5 (856 download)

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Book Synopsis Psychoneuroimmunology by : Karl Goodkin

Download or read book Psychoneuroimmunology written by Karl Goodkin and published by American Psychiatric Pub. This book was released on 2008-11-01 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: Psychoneuroimmunology has emerged as a discipline advancing our knowledge of the relationships among psychosocial factors, the central nervous system, the immune system, and disease. The growing volume of evidence suggests that psychological states, including exposure to stressors and the presence of depressive states, may influence health and disease by altering immunologic states. Psychoneuroimmunology, a collaborative work of 50 international experts, expands on the American Psychiatric Association's symposium on this topic to present never-before-compiled scientific research from this evolving field. Maintaining a clinical focus, this book illustrates clinical effects by examining relevant research studies and models including Psychoneuroimmunological factors involved in specific illnesses such as cervical cancer, breast cancer and HIV/AIDS The role psychoneuroimmunology plays in carcinogenesis and the progression of established tumors, as well as findings on the progression of cancer that have general clinical relevance The effects of specific psychotropic medications; the effects of life stressors, bereavement, and and social support; the response to those stressors; and stress management and psychosocial predictors of disease The impacts of gender-specific factors, diurnal variation, and behavioral genetics on the immune function The Stressor-Support-Coping model, which integrates existing psychoneuroimmunology findings and lays the groundwork for use in support group intervention This book is a first step toward organizing psychoneuroimmunology findings into coherent theoretical models and concludes with a look at future clinical applications. Complete with charts, references, and a detailed index, it is the most comprehensive source on psychoneuroimmunology.

Personalized Psychiatry

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Author :
Publisher : Academic Press
ISBN 13 : 0128131772
Total Pages : 604 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Personalized Psychiatry by : Bernhard Baune

Download or read book Personalized Psychiatry written by Bernhard Baune and published by Academic Press. This book was released on 2019-10-16 with total page 604 pages. Available in PDF, EPUB and Kindle. Book excerpt: Personalized Psychiatry presents the first book to explore this novel field of biological psychiatry that covers both basic science research and its translational applications. The book conceptualizes personalized psychiatry and provides state-of-the-art knowledge on biological and neuroscience methodologies, all while integrating clinical phenomenology relevant to personalized psychiatry and discussing important principles and potential models. It is essential reading for advanced students and neuroscience and psychiatry researchers who are investigating the prevention and treatment of mental disorders. Combines neurobiology with basic science methodologies in genomics, epigenomics and transcriptomics Demonstrates how the statistical modeling of interacting biological and clinical information could transform the future of psychiatry Addresses fundamental questions and requirements for personalized psychiatry from a basic research and translational perspective