Peptide Catalysts Including Catalytic Amyloids

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Peptide Catalysts, including Catalytic Amyloids

Author :
Publisher : Elsevier
ISBN 13 : 0443236682
Total Pages : 550 pages
Book Rating : 4.4/5 (432 download)

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Book Synopsis Peptide Catalysts, including Catalytic Amyloids by :

Download or read book Peptide Catalysts, including Catalytic Amyloids written by and published by Elsevier. This book was released on 2024-05-28 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peptide Catalysts, including Catalytic Amyloids, Volume 697 in this esteemed series, highlights new advances in the field, with this new volume presenting interesting topics on Screening of oxidative behaviors in catalytic amyloid assemblies, Catalytic amyloids derived for natural proteins, AFM-IR studies of catalytic amyloids, MD structural studies of catalytic amyloids, Characterization of crystalline, amyloid-like amino acid assemblies, Computational modeling of supramolecular peptide assemblies, and Assembly and activity of short prion-inspired peptides. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in Methods in Enzymology series Updated release includes the latest information on Peptide Catalysts, including Catalytic Amyloids

Catalysis in Peptide Chemistry

Author : Daniel Raymond Coleman
Publisher :
ISBN 13 :
Total Pages : 184 pages
Book Rating : 4.3/5 (243 download)

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Book Synopsis Catalysis in Peptide Chemistry by : Daniel Raymond Coleman

Download or read book Catalysis in Peptide Chemistry written by Daniel Raymond Coleman and published by . This book was released on 1981 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Handbook of In Vivo Chemistry in Mice

Author : Katsunori Tanaka
Publisher : John Wiley & Sons
ISBN 13 : 3527344322
Total Pages : 560 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Handbook of In Vivo Chemistry in Mice by : Katsunori Tanaka

Download or read book Handbook of In Vivo Chemistry in Mice written by Katsunori Tanaka and published by John Wiley & Sons. This book was released on 2020-04-27 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides timely, comprehensive coverage of in vivo chemical reactions within live animals This handbook summarizes the interdisciplinary expertise of both chemists and biologists performing in vivo chemical reactions within live animals. By comparing and contrasting currently available chemical and biological techniques, it serves not just as a collection of the pioneering work done in animal-based studies, but also as a technical guide to help readers decide which tools are suitable and best for their experimental needs. The Handbook of In Vivo Chemistry in Mice: From Lab to Living System introduces readers to general information about live animal experiments and detection methods commonly used for these animal models. It focuses on chemistry-based techniques to develop selective in vivo targeting methodologies, as well as strategies for in vivo chemistry and drug release. Topics include: currently available mouse models; biocompatible fluorophores; radionuclides for radiodiagnosis/radiotherapy; live animal imaging techniques such as positron emission tomography (PET) imaging; magnetic resonance imaging (MRI); ultrasound imaging; hybrid imaging; biocompatible chemical reactions; ligand-directed nucleophilic substitution chemistry; biorthogonal prodrug release strategies; and various selective targeting strategies for live animals. -Completely covers current techniques of in vivo chemistry performed in live animals -Describes general information about commonly used live animal experiments and detection methods -Focuses on chemistry-based techniques to develop selective in vivo targeting methodologies, as well as strategies for in vivo chemistry and drug release -Places emphasis on material properties required for the development of appropriate compounds to be used for imaging and therapeutic purposes in preclinical applications Handbook of In Vivo Chemistry in Mice: From Lab to Living System will be of great interest to pharmaceutical chemists, life scientists, and organic chemists. It will also appeal to those working in the pharmaceutical and biotechnology industries.

Catalytic Antibodies

Author : Sudhir Paul
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3805570996
Total Pages : 172 pages
Book Rating : 4.8/5 (55 download)

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Book Synopsis Catalytic Antibodies by : Sudhir Paul

Download or read book Catalytic Antibodies written by Sudhir Paul and published by Karger Medical and Scientific Publishers. This book was released on 2000-01-01 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume addresses fundamental questions concerning the immunological genesis of the catalytic activity in antibodies, its relationship with classical antigen binding activity, and the biochemical mechanisms involved in catalysis. The contents reflect three main challenges in the field, i.e. to delineate the biological functions of catalytic antibodies in autoimmune disease; to isolate therapy-grade antibody catalysts with sufficient specificity and turnover to permit rapid removal of microbial and tumor antigens; and to develop immunogens that recruit immature catalyst-producing B cells into the clonal selection pathway and induce adaptive improvements of the catalytic function. Well-edited and up-to-date, this book reviews the current knowledge in the field and explores ways by which natural and engineered catalytic activities can be harnessed for medical applications. It should therefore be of special interest to immunologists, biochemists, biotechnologists, rheumatologists and pathologists.

Peptide Fibrils as Supramolecular Organo Catalysts

Author : Yulia Tsifansky-Zarchin
Publisher :
ISBN 13 :
Total Pages : 126 pages
Book Rating : 4.:/5 (129 download)

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Book Synopsis Peptide Fibrils as Supramolecular Organo Catalysts by : Yulia Tsifansky-Zarchin

Download or read book Peptide Fibrils as Supramolecular Organo Catalysts written by Yulia Tsifansky-Zarchin and published by . This book was released on 2017 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The ability of enzymes to fold into unique structures drives their remarkable catalytic activity. Recently, a great effort is done in order to duplicate this high activity of natural enzymes by using simple molecules, for instance amphiphilic peptides, which can self-assemble into different structures in water, creating microenvironments that emulate the active site of enzymes. In addition, the controlled assembly of amphiphilic peptides governs their self-replicating propensity, as it promotes their own formation by self-recognition of building blocks, as was previously shown by our group. The addition of functional groups to the selfreplicating peptides may provide bi-functional systems, which will be able to selfreplicate and perform enhanced catalysis, benefiting one another (Figure 1). In this study, we have first used short dipeptides and further synthesized longer amphiphilic peptides that can readily self-assemble into elongated fibrils and catalyse hydrolysis of thioesters.. The supramolecular architectures formed by the selfassembly of the peptides was characterized using battery of techniques. The peptides were tested for the esterase-like activity using different substrates, and the difference between ester and thioester hydrolysis was tested. We observed that Fmoc-FH appears to catalyze the hydrolysis reaction of the thioester substrate better than the oxyester substrate. For control, we used molecules such as acetyl Histidine (aH) as a nonaggregating analogue. We found the the designed catalyst enhancing the catalysis as twice as fast than the control reaction. We were able to provide insights into the factors that dictate the efficiency of the catalytic reaction, and in particular to demonstrate the role of the self-assembly property upon the catalytic activity. We believe that this research will get us closer to the ability of assembling an autocatalytic-replication cycle that will carry out the both functions as well as benefiting each other. "-- abstract.

Catalytic and Autocatalytic Peptide Networks

Author : Yohei Yokobayashi
Publisher :
ISBN 13 : 9780493099156
Total Pages : 254 pages
Book Rating : 4.0/5 (991 download)

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Book Synopsis Catalytic and Autocatalytic Peptide Networks by : Yohei Yokobayashi

Download or read book Catalytic and Autocatalytic Peptide Networks written by Yohei Yokobayashi and published by . This book was released on 2001 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: The key feature that differentiates animate chemistry from inanimate chemistry is believed to lie in its complexity, the ability of the animate chemical systems to reproduce, to dynamically adapt to changes in environment, and to undergo Darwinian evolution. This thesis approaches the problem of chemical complexity using self-replicating peptides as a tool to design and construct various nonlinear chemical networks that exhibit various interesting emergent properties. In Chapter 2, an environmentally regulated replicator that adapts to the change in salt concentration is described. Chapter 3 explores the molecular ecology of two peptides that exhibit host-parasite dynamics. In Chapter 4, a minimal autocatalytic set of two nonreplicating peptides that engage in reciprocal catalysis is investigated. Finally, Chapter 5 illustrates the templating effect exerted by higher order complex, or self-assembling ligase. These results should contribute to not only to our understanding of nonlinear chemical systems, but also our ability to design de novo functional molecules especially peptides and proteins.

Supramolecular Catalysts

Author : Cheng-Yong Su
Publisher :
ISBN 13 : 9789811217791
Total Pages : 550 pages
Book Rating : 4.2/5 (177 download)

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Book Synopsis Supramolecular Catalysts by : Cheng-Yong Su

Download or read book Supramolecular Catalysts written by Cheng-Yong Su and published by . This book was released on 2020-03-13 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: The construction of catalysts by supramolecular forces has recently become a powerful tool and the role of noncovalent interactions can assist in designing new tools for the construction of effective and selective catalytic systems. It is unquestionably, vastly important to understand how different noncovalent interactions can be controlled or manipulated under appropriate reaction conditions. Supramolecular catalysts have had a tremendous impact on the syntheses of both chemical commodities and fine chemicals over the last 50 years, leading to the discovery of new reactions that were previously deemed impossible. This means that supramolecular chemistry plays a predominant role in accelerating or understanding chemical reactions.This book which addresses the above points is written by some of the leading contributors in this field and is intended for graduate students, researchers and academics working in supramolecular chemistry, organic chemistry, inorganic chemistry, and physical chemistry as well as researchers with an interest in the area of catalysis. The authors give examples illustrating the growth of the field, especially with special emphasis on new results published over the last decade. They also provide an explanation of fundamentals and topical research.

Enantioselective Organocatalysis

Author : Peter I. Dalko
Publisher : John Wiley & Sons
ISBN 13 : 3527610952
Total Pages : 559 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Enantioselective Organocatalysis by : Peter I. Dalko

Download or read book Enantioselective Organocatalysis written by Peter I. Dalko and published by John Wiley & Sons. This book was released on 2007-06-27 with total page 559 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this reference leaders at the forefront of research provide an insight into one of the hottest topics in organic synthesis, focusing on the most important enantioselective reactions. Clearly structured, each entry begins with a concise introduction, including a mechanistic discussion of the reaction, followed by preparative guidelines for newcomers, such as carefully selected working procedures with critical notes for bench chemists, rules of thumb and tips and tricks.

Introduction to Soft Matter

Author : Ian W. Hamley
Publisher : John Wiley & Sons
ISBN 13 : 1118681428
Total Pages : 304 pages
Book Rating : 4.1/5 (186 download)

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Book Synopsis Introduction to Soft Matter by : Ian W. Hamley

Download or read book Introduction to Soft Matter written by Ian W. Hamley and published by John Wiley & Sons. This book was released on 2013-03-18 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an introduction to this exciting and relativelynew subject with chapters covering natural and synthetic polymers,colloids, surfactants and liquid crystals highlighting the many andvaried applications of these materials. Written by an expert in thefield, this book will be an essential reference for people workingin both industry and academia and will aid in understanding of thisincreasingly popular topic. Contains a new chapter on biological soft matter Newly edited and updated chapters including updated coverageof recent aspects of polymer science. Contain problems at the end of each chapter to facilitateunderstanding

Life from an RNA World

Author : Michael Yarus
Publisher : Harvard University Press
ISBN 13 : 9780674050754
Total Pages : 212 pages
Book Rating : 4.0/5 (57 download)

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Book Synopsis Life from an RNA World by : Michael Yarus

Download or read book Life from an RNA World written by Michael Yarus and published by Harvard University Press. This book was released on 2010 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: A majority of evolutionary biologists believe that we now can envision our biological predecessors--not the first, but nearly the first, living beings on Earth. This book is about these vanished forebears. The era between the first rudimentary life on Earth and the appearance of more complex beings is called the RNA world. It is RNA (ribonucleic acid) long believed to be a mere biologic copier and messenger, that offers a glimpse into our ancient predecessors. To describe early RNA creatures, here called "ribocytes" or RNA cells, the author uses basics of molecular biology. He reviews our current understanding of the tree of life, examines the structure of RNA itself, explains the operation of the genetic code, and more. Courting controversy among those who question the role of ribocytes -- citing the chemical fragility of RNA and the uncertainty about the origin of an RNA synthetic apparatus -- he offers a vision of early life on Earth.

Peptide Self-Assembly and Engineering

Author : Xuehai Yan
Publisher : John Wiley & Sons
ISBN 13 : 3527841253
Total Pages : 933 pages
Book Rating : 4.5/5 (278 download)

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Book Synopsis Peptide Self-Assembly and Engineering by : Xuehai Yan

Download or read book Peptide Self-Assembly and Engineering written by Xuehai Yan and published by John Wiley & Sons. This book was released on 2024-02-09 with total page 933 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peptide Self-Assembly and Engineering State-of-the-art research in peptide self-assembly, with coverage of fundamental aspects of how peptides self-assemble and an extensive number of applications Peptide Self-Assembly and Engineering: Fundamentals, Structures, and Applications (2V set) covers the latest progresses in the field of peptide self-assembly and engineering, including the fundamental principles of peptide self-assembly, new theory of nucleation and growth, thermodynamics and kinetics, materials design rules, and precisely controlled structures and unique functions. The broad contents from this book enable readers to obtain a systematical and comprehensive knowledge in the field of peptide self-assembly and engineering. Contributed by the leading scientists and edited by a highly qualified academic and an authority in the field, Peptide Self-Assembly and Engineering includes information on: Emerging areas in peptide assembly, such as immune agents, bioelectronics, energy conversion, flexible sensors, biomimetic catalysis, and more Existing applications in biomedical engineering, nanotechnology, and photoelectronics, including tissue engineering, drug delivery, and biosensing devices History of peptide self-assembly for design of functional materials and peptides’ unique mechanical, optical, electronic, and biological properties Various solvent conditions, such as pH, ionic strength, and polarity, that can affect the structure and stability of peptide assemblies A very comprehensive reference covering the latest progresses in the field of peptide self-assembly and engineering, Peptide Self-Assembly and Engineering is an essential resource for all scientists performing research intersecting with the subject, including biochemists, biotechnologists, pharmaceutical chemists, protein chemists, materials scientists, and medicinal chemists.

Towards New Bioinorganic Hybrid Catalysts Based on Amyloid Fibres

Author : Marie Hoarau
Publisher :
ISBN 13 :
Total Pages : 242 pages
Book Rating : 4.:/5 (13 download)

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Book Synopsis Towards New Bioinorganic Hybrid Catalysts Based on Amyloid Fibres by : Marie Hoarau

Download or read book Towards New Bioinorganic Hybrid Catalysts Based on Amyloid Fibres written by Marie Hoarau and published by . This book was released on 2016 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developing sustainable alternatives to catalytic systems developed to date is a key point of the Green Chemistry Principles. Among the different existing approaches, the artificial metalloenzyme strategy aims at combining the efficiency of enzymes with the versatility of chemical catalysts. In this context, we turned our interest in developing a new type of bioinorganic hybrid catalysts through incorporation of coordination complexes in amyloid fibres. These protein aggregates display unique mechanical properties that make them good candidates for applications in catalysis. In a first part, our work consisted in overexpressing amyloid-[beta]peptides in Escherichia coli. A new purification procedure was set up that allowed to obtain peptides in a few steps. A series of organic ligands was synthesized, as well as the corresponding Cu(II), Fe(II) and Ru(II) complexes. The interaction between amyloid fibres and metal complexes was assessed, using a set of techniques (UV-Visible, Fluorescence, NMR...). Docking studies were also conducted by molecular modelling to acquire further insights in the interaction. Finally, catalytic experiments were performed with Fe(II) complexes, showing high conversion rates for styrene oxidation reaction. Preliminary results on the final hybrid systems show that the catalytic activity of metal complexes is maintained upon incorporation within fibres. This constitutes a proof of concept for the elaboration of hybrid catalysts based on amyloid fibres.

The Emergence of Life

Author : Pier Luigi Luisi
Publisher : Cambridge University Press
ISBN 13 : 1139455648
Total Pages : 268 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis The Emergence of Life by : Pier Luigi Luisi

Download or read book The Emergence of Life written by Pier Luigi Luisi and published by Cambridge University Press. This book was released on 2006-07-13 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: The origin of life from inanimate matter has been the focus of much research for decades, both experimentally and philosophically. Luisi takes the reader through the consecutive stages from prebiotic chemistry to synthetic biology, uniquely combining both approaches. This book presents a systematic course discussing the successive stages of self-organisation, emergence, self-replication, autopoiesis, synthetic compartments and construction of cellular models, in order to demonstrate the spontaneous increase in complexity from inanimate matter to the first cellular life forms. A chapter is dedicated to each of these steps, using a number of synthetic and biological examples. With end-of-chapter review questions to aid reader comprehension, this book will appeal to graduate students and academics researching the origin of life and related areas such as evolutionary biology, biochemistry, molecular biology, biophysics and natural sciences.

Privileged Chiral Ligands and Catalysts

Author : Qi-Lin Zhou
Publisher : John Wiley & Sons
ISBN 13 : 3527635211
Total Pages : 670 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Privileged Chiral Ligands and Catalysts by : Qi-Lin Zhou

Download or read book Privileged Chiral Ligands and Catalysts written by Qi-Lin Zhou and published by John Wiley & Sons. This book was released on 2011-02-10 with total page 670 pages. Available in PDF, EPUB and Kindle. Book excerpt: Catalytic asymmetric synthesis has been one of the most active research areas in chemistry (Nobel Prize in 2001). The development of efficient chiral catalysts plays a crucial role in asymmetric catalysis. Although many chiral ligands/catalysts have been developed in the past decades, the most efficient catalysts are derived from a few core structures, called "privileged chiral catalysts". This ultimate "must have" and long awaited reference for every chemist working in the field of asymmetric catalysis starts with the core structure of the catalysts, explaining why a certain ligand or catalyst is so successful. It describes in detail the history, the basic structural characteristics, and the applications of these "privileged catalysts". This novel presentation provides readers with a much deeper insight into the topic and makes it a must-have for organic chemists, catalytic chemists, chemists working with/on organometallics, chemists in industry, and libraries. From the contents: * BINAP * Bisphosphacycles - From DuPhos and BPE to a Diverse Set of Broadly Applied Ligands * Josiphos Ligands: From Discovery to Technical Applications * Chiral Spiro Ligands * Chiral Bisoxazoline Ligands * PHOX Ligands * Chiral Salen Complexes * BINOL * TADDOLate Ligands * Cinchona Alkaloids * Proline Derivatives

Bifunctional Helical Peptide Catalysts for Enzyme-like Reactivity and Selectivity and Selective Stapling of Natural Amino Acid Residues with Hydrophilic Squaric Acid Derivatives

Download Bifunctional Helical Peptide Catalysts for Enzyme-like Reactivity and Selectivity and Selective Stapling of Natural Amino Acid Residues with Hydrophilic Squaric Acid Derivatives PDF Online Free

Author : Michael James Kinghorn
Publisher :
ISBN 13 :
Total Pages : 154 pages
Book Rating : 4.:/5 (117 download)

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Book Synopsis Bifunctional Helical Peptide Catalysts for Enzyme-like Reactivity and Selectivity and Selective Stapling of Natural Amino Acid Residues with Hydrophilic Squaric Acid Derivatives by : Michael James Kinghorn

Download or read book Bifunctional Helical Peptide Catalysts for Enzyme-like Reactivity and Selectivity and Selective Stapling of Natural Amino Acid Residues with Hydrophilic Squaric Acid Derivatives written by Michael James Kinghorn and published by . This book was released on 2019 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: Studies were also conducted into the stabilization of peptide secondary structure via covalent linking of nucleophilic amino acid side chains with squaric acid residues. Under mild conditions, stapling of nitrogen, sulfur and oxygen residues can readily be achieved in either organic or aqueous media. Squaric acid staples display pH selectivity for specific side chains and selective removal of diester staples (diserine staple) is demonstrated with methylamine. This new method for peptide stapling is shown to dramatically increase the proteolytic stability of eIF4E cancer inhibitor proteins, which typically are prone to quick degradation. Tyrosidine and RGD peptide analogues were synthesized and cyclized on resin in order to provide a new pathway to macrocyclization of antibacterial and integrin binding cyclic peptides.

Nanoscale Assembly

Author : Wilhelm T.S. Huck
Publisher : Springer Science & Business Media
ISBN 13 : 0387256563
Total Pages : 249 pages
Book Rating : 4.3/5 (872 download)

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Book Synopsis Nanoscale Assembly by : Wilhelm T.S. Huck

Download or read book Nanoscale Assembly written by Wilhelm T.S. Huck and published by Springer Science & Business Media. This book was released on 2006-07-11 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanotechnology has received tremendous interest over the last decade, not only from the scientific community but also from a business perspective and from the general public. Although nanotechnology is still at the largely unexplored frontier of science, it has the potential for extremely exciting technological innovations that will have an enormous impact on areas as diverse as information technology, medicine, energy supply and probably many others. The miniturization of devices and structures will impact the speed of devices and information storage capacity. More importantly, though, nanotechnology should lead to completely new functional devices as nanostructures have fundamentally different physical properties that are governed by quantum effects. When nanometer sized features are fabricated in materials that are currently used in electronic, magnetic, and optical applications, quantum behavior will lead to a set of unprecedented properties. The interactions of nanostructures with biological materials are largely unexplored. Future work in this direction should yield enabling technologies that allows the study and direct manipulation of biological processes at the (sub) cellular level.

Peptide Self-Assembly

Author : Bradley L. Nilsson
Publisher : Humana
ISBN 13 : 9781493978090
Total Pages : 0 pages
Book Rating : 4.9/5 (78 download)

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Book Synopsis Peptide Self-Assembly by : Bradley L. Nilsson

Download or read book Peptide Self-Assembly written by Bradley L. Nilsson and published by Humana. This book was released on 2018-05-10 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume details methods and protocols on b-sheet assemblies and collagen. Divided into three parts chapters focus on expanding use of solid-state NMR as a powerful method to enhance structural understanding of self-assembled peptide materials, methods for the design, synthesis, and application of self-assembled peptide materials, and structural and mechanistic analyses of pathological amyloid systems that provide novel ways to assess function of the various possible aggregates as well to determine how the structure of these materials correlates to function/dysfunction in the biological context. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Peptide Self-Assembly: Methods and Protocols aims to capture modern methods that span the breadth of the exciting and expanding field of peptide self-assembly.