Pathophysiology Of Ischemia Reperfusion Injury And Use Of Fingolimod In Cardioprotection

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Pathophysiology of Ischemia Reperfusion Injury and Use of Fingolimod in Cardioprotection

Author : Naseer Ahmed
Publisher : Academic Press
ISBN 13 : 0128182539
Total Pages : 142 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Pathophysiology of Ischemia Reperfusion Injury and Use of Fingolimod in Cardioprotection by : Naseer Ahmed

Download or read book Pathophysiology of Ischemia Reperfusion Injury and Use of Fingolimod in Cardioprotection written by Naseer Ahmed and published by Academic Press. This book was released on 2019-05-30 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pathophysiology of Ischemia-Reperfusion Injury and Use of Fingolimod in Cardioprotection is a deep examination into the mechanisms of myocardial ischemiareperfusion injury and role of fingolimod as a cardioprotective agent through its antioxidant, anti-apoptotic and anti-inflammatory effects. Dr. Ahmed explore the physiology and pathophysiology of myocardial metabolism under normal and ischemic conditions and focused on pharmacological cardioprotection. They provide a concise, yet rigorous discussion of Ischemia-Reperfusion Injury, Myocardial Ischemia during Circulatory Arrest, Myocardial Reperfusion, Myocardial Protection related to Ischemia-Reperfusion Injury and Role of Fingolimod in Cardioprotection.Pathophysiology of Ischemia-Reperfusion Injury and Use of Fingolimod in Cardioprotection is ideal for researchers, cardiovascular scientists, and clinical pharmacologists to further work in this challenging area and apply this knowledge to clinical trials for cardioprotection. - Provides detailed and critical analysis of the latest research in the field from molecular basis to potential clinical relevance - Examines the effect of fingolimod/sphingosine 1-phosphate in cardioprotection, pointing to future myocardial preventative strategies

Novel Therapeutic Targets and Emerging Treatments for Fibrosis

Author : Chrishan S. Samuel
Publisher : Frontiers Media SA
ISBN 13 : 2889453723
Total Pages : 162 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Novel Therapeutic Targets and Emerging Treatments for Fibrosis by : Chrishan S. Samuel

Download or read book Novel Therapeutic Targets and Emerging Treatments for Fibrosis written by Chrishan S. Samuel and published by Frontiers Media SA. This book was released on 2018-01-12 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: For decades we have known that the overgrowth, hardening and scarring of tissues (so-called fibrosis) represents the final common pathway and best histological predictor of disease progression in most organs. Fibrosis is the culmination of both excess extracellular matrix deposition due to ongoing or severe injury, and a failure to regenerate. An inadequate wound repair process ultimately results in organ failure through a loss of function, and is therefore a major cause of morbidity and mortality in disease affecting both multiple and individual organs. Whilst the pathology of fibrosis and its significance are well understood, until recently we have known little about its molecular regulation. Current therapies are often indirect and non-specific, and only slow progression by a matter of months. The recent identification of novel therapeutic targets, and the development of new treatment strategies based on them, offers the exciting prospect of more efficacious therapies to treat this debilitating disorder. This Research Topic therefore compromises several up-to-date mini-reviews on currently known and emerging therapeutic targets for fibrosis including: the Transforming Growth Factor (TGF)-family; epigenetic factors; Angiotensin II type 2 (AT2) receptors; mineralocorticoid receptors; adenosine receptors; caveolins; and the sphingosine kinase/sphingosine 1-phosphate and notch signaling pathways. In each case, mechanistic insights into how each of these factors contribute to regulating fibrosis progression are described, along with how they can be targeted (by existing drugs, small molecules or other mimetics) to prevent and/or reverse fibrosis and its contribution to tissue dysfunction and failure. Two additional reviews will discuss various anti-fibrotic therapies that have demonstrated efficacy at the experimental level, but are not yet clinically approved; and the therapeutic potential vs limitations of stem cell-based therapies for reducing fibrosis while facilitating tissue repair. Finally, this Research Topic concludes with a clinical perspective of various anti-fibrotic therapies for cardiovascular disease (CVD), outlining limitations of currently used therapies, the pipeline of anti-fibrotics for CVD and why so many anti-fibrotic drugs have failed at the clinical level.

Cardiovascular Toxicity Associated with Cancer Treatment: Strategies for Diagnosis, Management and Cardioprotection

Author : Zhi-Ren Zhang
Publisher : Frontiers Media SA
ISBN 13 : 2832508006
Total Pages : 225 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Cardiovascular Toxicity Associated with Cancer Treatment: Strategies for Diagnosis, Management and Cardioprotection by : Zhi-Ren Zhang

Download or read book Cardiovascular Toxicity Associated with Cancer Treatment: Strategies for Diagnosis, Management and Cardioprotection written by Zhi-Ren Zhang and published by Frontiers Media SA. This book was released on 2022-11-30 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Inflammation - Volume 1 - 2020

Author : Dr. Jyotirmay Biswas
Publisher : ChanRe Publishers
ISBN 13 : 8195241506
Total Pages : 242 pages
Book Rating : 4.1/5 (952 download)

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Book Synopsis Inflammation - Volume 1 - 2020 by : Dr. Jyotirmay Biswas

Download or read book Inflammation - Volume 1 - 2020 written by Dr. Jyotirmay Biswas and published by ChanRe Publishers. This book was released on 2021-08-15 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: 'Inﬂammation book' is published under the aegis of the Society of Inﬂammation Research, which is an endeavor to disseminate knowledge about inﬂammation. This book provides the latest information on cutting-edge research concerning inﬂammation, its fundamentals including the direct and indirect determinants, besides the advanced management protocols employed in clinical practice. This volume of the book deals with basic molecular aspects of antibody response in various inﬂammatory conditions like sepsis, organ transplantation, role of lipid metabolism in inﬂammation, followed by detailed description on certain disease entities caused due to inﬂammation. Each topic is dealt in detail i

Sudden arrhythmic death: from basic science to clinical practice

Author : Gareth D. Matthews
Publisher : Frontiers E-books
ISBN 13 : 2889192695
Total Pages : 137 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Sudden arrhythmic death: from basic science to clinical practice by : Gareth D. Matthews

Download or read book Sudden arrhythmic death: from basic science to clinical practice written by Gareth D. Matthews and published by Frontiers E-books. This book was released on 2014-10-02 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt: With upwards of 4.5 million deaths worldwide each year, and more than one tenth of these occurring in those with no previously documented heart disease, sudden arrhythmic death (SAD) is both a major public health burden and a highly emotive issue for society at large. Recent years have witnessed a marked expansion in our knowledge of the physiology underlying SAD, both in the context of hereditary and acquired cardiac disorders. Thanks largely to work in genetically modified animals, the growth in our understanding of mechanisms underlying arrhythmia in the hereditary channelopathies has been particularly marked. Our growing knowledge of the fundamental mechanisms underlying SAD has so far failed to spur substantial developments in clinical practice. Despite a large body of work in both humans and animals, it remains impossible to confidently identify those at high risk of SAD, making pre-emptive therapy a challenge. What is more, with the thankful exception of the implantable cardioverter-defibrillators and pharmacological agents in very specific situations, there has been depressingly little progress in finding new and effective therapies. This Research Topic aims to go some way towards bridging the gap between advances in basic science and the development and delivery of new therapies. It brings together original research contributions and review articles from key opinion leaders in the field, focusing on the direct clinical implications of the basic science research now and in the future

Mechanisms of Vascular Disease

Author : Robert Fitridge
Publisher : University of Adelaide Press
ISBN 13 : 1922064009
Total Pages : 589 pages
Book Rating : 4.9/5 (22 download)

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Book Synopsis Mechanisms of Vascular Disease by : Robert Fitridge

Download or read book Mechanisms of Vascular Disease written by Robert Fitridge and published by University of Adelaide Press. This book was released on 2011 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.

Central Nervous System Acting Drugs – Molecular Mechanisms of Neuroprotection and Neurodegeneration

Author : Nesrine Salah El Dine El Sayed
Publisher : Frontiers Media SA
ISBN 13 : 2832506615
Total Pages : 270 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Central Nervous System Acting Drugs – Molecular Mechanisms of Neuroprotection and Neurodegeneration by : Nesrine Salah El Dine El Sayed

Download or read book Central Nervous System Acting Drugs – Molecular Mechanisms of Neuroprotection and Neurodegeneration written by Nesrine Salah El Dine El Sayed and published by Frontiers Media SA. This book was released on 2023-04-14 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Lysophospholipid Receptors

Author : Jerold Chun
Publisher : John Wiley & Sons
ISBN 13 : 0470569050
Total Pages : 836 pages
Book Rating : 4.4/5 (75 download)

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Book Synopsis Lysophospholipid Receptors by : Jerold Chun

Download or read book Lysophospholipid Receptors written by Jerold Chun and published by John Wiley & Sons. This book was released on 2013-04-01 with total page 836 pages. Available in PDF, EPUB and Kindle. Book excerpt: The current state of the science supporting new research in lysophospholipids The study of lysophospholipids exploded with the discovery of cell surface receptors on both lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P). Since then, thousands of original research reports ranging from fundamental cell signaling to the physiology and pathophysiology of individual organ systems have centered on lysophospholipids. This book draws together and analyzes the current literature to provide readers with a state-of-the-science review as well as current techniques that support research in all aspects of the field of lysophospholipid signaling. Lysophospholipid Receptors is divided into three sections: Receptors and other possible effectors Enzymes Physiology and pathophysiology Within each section, the authors explain the similarities and differences between LPA and S1P signaling. Examples are provided that demonstrate the underlying mechanisms of lysophospholipid signaling across a broad range of organ systems, such as S1P signaling in cardiovascular physiology and disease and the neural effects of LPA signaling. Extensive references at the end of each chapter provide a gateway to the literature and facilitate further research into individual topics. Each chapter has been authored by one or more leading international authorities in lysophospholipid research. Based on a thorough analysis of the current research, the authors set forth what is established science and offer their expert opinion and perspective on new and emerging areas of research, setting the stage for further investigations that will solve current problems in the field.

Vascular Development

Author : Derek J. Chadwick
Publisher : John Wiley & Sons
ISBN 13 : 0470319429
Total Pages : 260 pages
Book Rating : 4.4/5 (73 download)

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Book Synopsis Vascular Development by : Derek J. Chadwick

Download or read book Vascular Development written by Derek J. Chadwick and published by John Wiley & Sons. This book was released on 2007-08-20 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: The formation of blood vessels is an essential aspect of embryogenesis in vertebrates. It is a central feature of numerous post-embryonic processes, including tissue and organ growth and regeneration. It is also part of the pathology of tumour formation and certain inflammatory conditions. In recent years, comprehension of the molecular genetics of blood vessel formation has progressed enormously and studies in vertebrate model systems, especially the mouse and the zebrafish, have identified a common set of molecules and processes that are conserved throughout vertebrate embryogenesis while, in addition, highlighting aspects that may differ between different animal groups. The discovery in the past decade of the crucial role of new blood vessel formation for the development of cancers has generated great interest in angiogenesis (the formation of new blood vessels from pre-existing ones), with its major implications for potential cancer-control strategies. In addition, there are numerous situations where therapeutic treatments either require or would be assisted by vasculogenesis (the de novo formation of blood vessels). In particular, post-stroke therapies could include treatments that stimulate neovascularization of the affected tissues. The development of such treatments, however, requires thoroughly understanding the developmental properties of endothelial cells and the basic biology of blood vessel formation. While there are many books on angiogenesis, this unique book focuses on exactly this basic biology and explores blood vessel formation in connection with tissue development in a range of animal models. It includes detailed discussions of relevant cell biology, genetics and embryogenesis of blood vessel formation and presents insights into the cross-talk between developing blood vessels and other tissues. With contributions from vascular biologists, cell biologists and developmental biologists, a comprehensive and highly interdisciplinary volume is the outcome.

The Chemokine Receptors

Author : Jeffrey K. Harrison
Publisher : Springer Science & Business Media
ISBN 13 : 1597450200
Total Pages : 412 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis The Chemokine Receptors by : Jeffrey K. Harrison

Download or read book The Chemokine Receptors written by Jeffrey K. Harrison and published by Springer Science & Business Media. This book was released on 2007-11-17 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume, new to The Receptors series, focuses on several areas, including the birth, maturation, and structure of Chemokines; Neutrophil, Dendritic, and Lymphocyte trafficking; and Chemokine Receptors in diseases such as AIDs and lung cancer. In particular the book contains cutting-edge information ranging from basic molecular and cellular mechanisms to physiological and pathological roles of chemokines.

Nanozymology

Author : Xiyun Yan
Publisher : Springer Nature
ISBN 13 : 9811514909
Total Pages : 563 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Nanozymology by : Xiyun Yan

Download or read book Nanozymology written by Xiyun Yan and published by Springer Nature. This book was released on 2020-01-30 with total page 563 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces the new concept of “nanozyme”, which refers to nanomaterials with intrinsic enzymatic activity, rather than nanomaterials with biological enzymes incorporated on the surface. The book presents the cutting-edge advances in nanozyme, with emphasis on state-of-the-art applications in many important fields, such as in the biomedical fields and for environmental protection. The nanozyme is a totally new type of artificial enzyme and exhibits huge advantages over natural enzymes, including greater stability, low cost, versatility, simplicity, and suitability for industry. It is of interest to university researchers, R&D engineers, as well as graduate students in nanoscience and technology, and biology wishing to learn the core principles, methods, and the corresponding applications of “nanozyme”.

Regulation of Coronary Blood Flow

Author : Michitoshi Inoue
Publisher : Springer Science & Business Media
ISBN 13 : 4431683674
Total Pages : 330 pages
Book Rating : 4.4/5 (316 download)

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Book Synopsis Regulation of Coronary Blood Flow by : Michitoshi Inoue

Download or read book Regulation of Coronary Blood Flow written by Michitoshi Inoue and published by Springer Science & Business Media. This book was released on 2013-11-09 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research centering on blood flow in the heart continues to hold an important position, especially since a better understanding of the subject may help reduce the incidence of coronary arterial disease and heart attacks. This book summarizes recent advances in the field; it is the product of fruitful cooperation among international scientists who met in Japan in May, 1990 to discuss the regulation of coronary blood flow.

AMP-Activated Protein Kinase Signalling

Author : Dietbert Neumann
Publisher : MDPI
ISBN 13 : 3038976628
Total Pages : 452 pages
Book Rating : 4.0/5 (389 download)

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Book Synopsis AMP-Activated Protein Kinase Signalling by : Dietbert Neumann

Download or read book AMP-Activated Protein Kinase Signalling written by Dietbert Neumann and published by MDPI. This book was released on 2019-03-14 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: Starting from a kinase of interest, AMP-activated protein kinase (AMPK) has gone far beyond an average biomolecule. Being expressed in all mammalian cell types and probably having a counterpart in every eukaryotic cell, AMPK has attracted interest in virtually all areas of biological research. Structural and biophysical insights have greatly contributed to a molecular understanding of this kinase. From good old protein biochemistry to modern approaches, such as systems biology and advanced microscopy, all disciplines have provided important information. Thus, multiple links to cellular events and subcellular localizations have been established. Moreover, the crucial involvement of AMPK in human health and disease has been evidenced. AMPK accordingly has moved from an interesting enzyme to a pharmacological target. However, despite our extensive current knowledge about AMPK, the growing community is busier than ever. This book provides a snapshot of recent and current AMPK research with an emphasis on work providing molecular insight, including but not limited to novel physiological and pathological functions, or regulatory mechanisms. Up-to-date reviews and research articles are included.

Sustainable Agriculture Reviews 44

Author : Ankit Saneja
Publisher : Springer Nature
ISBN 13 : 3030418421
Total Pages : 278 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Sustainable Agriculture Reviews 44 by : Ankit Saneja

Download or read book Sustainable Agriculture Reviews 44 written by Ankit Saneja and published by Springer Nature. This book was released on 2020-04-30 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers nanotechnology based approaches for improving the therapeutic efficacy of natural products. It critically explores lipid nanoarchitectonics, inorganic particles and nanoemulsion based tools for delivering them. With its chapters from eminent experts working in this discipline, it is ideal for researchers and professionals working in the area.

Advances in Experimental Surgery

Author : Huifang Chen
Publisher :
ISBN 13 : 9781536127737
Total Pages : 0 pages
Book Rating : 4.1/5 (277 download)

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Book Synopsis Advances in Experimental Surgery by : Huifang Chen

Download or read book Advances in Experimental Surgery written by Huifang Chen and published by . This book was released on 2017-11 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experimental surgery is an important link for the development in clinical surgery, research and teaching. Experimental surgery was part of the most important surgical discoveries in the past century. Since 1901 nine Nobel Prizes have been awarded to the pioneers had remarkable achievements in the basic or practical surgery. In recent 20 years, experimental surgery has achieved new advances, like laparoscopic and robotic surgery, tissue engineering, and gene therapy which are widely applied in clinic surgery. The present book covers wide experimental surgery in preclinical research models subdivided in two volumes. Volume I introduces surgical basic notions, techniques, and different surgical models involved in basic experimental surgery and review the biomechanical models, ischemia/reperfusion injury models, repair and regeneration models, and organ and tissue transplantation models, respectively. Volume II introduces several specific experimental models such as laparoscopic and bariatric experimental surgical models. The second volume also introduces graft-versus-host disease, and other experimental models. Review the advances and development of recent techniques such as tissue engineering, organ preservation, wound healing and scarring, gene therapy and robotic surgery. The book documents the enormous volume of knowledge we have acquired in the field of experimental surgery. In this book, we have invited experts from the United States, Canada, France, Germany, China, Japan, Korea, UK, Sweden, Netherland, Hungary and Turkey to contribute 36 chapters in the fields of their expertise. These two volumes are the compilation of basic experimental surgery and updated advances of new development in this field that will be invaluable to surgeons, residents, graduate students, surgical researchers, physicians, immunologists, veterinarians and nurses in surgery.

Ischaemia-Reperfusion Injury

Author : Pierce A. Grace
Publisher : Wiley-Blackwell
ISBN 13 : 9780632050215
Total Pages : 400 pages
Book Rating : 4.0/5 (52 download)

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Book Synopsis Ischaemia-Reperfusion Injury by : Pierce A. Grace

Download or read book Ischaemia-Reperfusion Injury written by Pierce A. Grace and published by Wiley-Blackwell. This book was released on 1999-02-04 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ischaemia-Reperfusion Injury is concerned with the consequences of interrupting and restoring blood flow to tissues. Many common clinical conditions are caused by interruption of blood flow to tissues (eg, ischaemic heart disease, peripheral vascular disease, stroke); blood flow is also interrupted deliberately in many surgical procedures (eg, cardiac surgery, arterial surgery, transplant surgery, limb surgery with tourniquet). In treating such conditions or after performing such operations the aim of the clinician is to restore the blood supply to the ischaemic tissue. Paradoxically, restoration of blood flow to ischaemic tissues can lead to further tissue damage with the potential for severe local and systemic injury. This book focuses on the clinical, pathological and biochemical processes involved in ischaemia-reperfusion injury and gives an overview of the strategies that may be adopted to mitigate or prevent such injury. This book will be of interest to both clinicians and scientists who have to deal with or have interest in this difficult but important problem.

Organelle Contact Sites

Author : Mitsuo Tagaya
Publisher : Springer
ISBN 13 : 9811045674
Total Pages : 254 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis Organelle Contact Sites by : Mitsuo Tagaya

Download or read book Organelle Contact Sites written by Mitsuo Tagaya and published by Springer. This book was released on 2017-08-16 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the first comprehensive coverage of the quickly evolving research field of membrane contact sites (MCS). A total of 16 chapters explain their organization and role and unveil the significance of MCS for various diseases. MCS, the intracellular structures where organellar membranes come in close contact with one another, mediate the exchange of proteins, lipids, and ions. Via these functions, MCS are critical for the survival and the growth of the cell. Owing to that central role in the functioning of cells, MCS dysfunctions lead to important defects of human physiology, influence viral and bacterial infection, and cause disease such as inflammation, type II diabetes, neurodegenerative disorders, and cancer. To approach such a multifaceted topic, this volume assembles a series of chapters dealing with the full array of research about MCS and their respective roles for diseases. Most chapters also introduce the history and the state of the art of MCS research, which will initiate discussion points for the respective types of MCS for years to come. This work will appeal to all cell biologists as well as researchers on diseases that are impacted by MCS dysfunction. Additionally, it will stimulate graduate students and postdocs who will energize, drive, and develop the research field in the near future.