The Genetics of Pain

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Author :
Publisher : Progress in Pain Research and
ISBN 13 :
Total Pages : 376 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The Genetics of Pain by : Jeffrey Steven Mogil

Download or read book The Genetics of Pain written by Jeffrey Steven Mogil and published by Progress in Pain Research and. This book was released on 2004 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetics more than any other biological approach can explain why some people experience more pain than others and receive less benefit from existing analgesics. Sixteen scholarly articles from international contributors describe the application of genetic techniques to the problem of pain and consider the knowledge that has so far resulted. Three themed sections review the techniques that are allowing the study of pain mechanisms at the genetic level; describe the progress being made in lab animals and humans in identifying the genes responsible for individual differences; and explore the practical and ethical issues that face pain researchers. The editor is associated with the Centre for Research on Pain, McGill U., Montreal. Annotation : 2004 Book News, Inc., Portland, OR (booknews.com).

Pain Genetics

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Author :
Publisher : John Wiley & Sons
ISBN 13 : 1118398858
Total Pages : 255 pages
Book Rating : 4.1/5 (183 download)

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Book Synopsis Pain Genetics by : Inna Belfer

Download or read book Pain Genetics written by Inna Belfer and published by John Wiley & Sons. This book was released on 2013-11-15 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pain Genetics: Basic to Translational Science is a timely synthesis of the key areas of research informing our understanding of the genetic basis of pain. The book opens with foundational information on basic genetic mechanisms underlying pain perception and progresses recently discovered complex concepts facing the field. The coverage is wide-ranging and will serves as an excellent entry point into understating the genetics of pain as well as providing a single resource for established researchers looking for a better understanding of the diverse strands of research going on in the area. With contributors painstakingly selected to provide a broad range of perspectives and research, Pain Genetics will be a valuable resource for geneticists, neuroscientists, and biomedical professionals alike.

Chasing Men on Fire

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Publisher : MIT Press
ISBN 13 : 0262037408
Total Pages : 320 pages
Book Rating : 4.2/5 (62 download)

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Book Synopsis Chasing Men on Fire by : Stephen G. Waxman

Download or read book Chasing Men on Fire written by Stephen G. Waxman and published by MIT Press. This book was released on 2018-03-09 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: A thirty-year quest, from genes to pain-signaling neurons to people with a rare genetic disorder that makes them feel they are on fire. Two soldiers, both with wounds injuring the same nerve, show very different responses: one is disabled by neuropathic pain, unable to touch the injured limb because even the lightest contact triggers excruciating discomfort; the other notices numbness but no pain at all. Could the difference lie in their genes? In this book, described in the foreword by Nobel Laureate James Rothman as “so well written that it reads like a detective novel,” Stephen Waxman recounts the search for a gene that controls pain—a search spanning more than thirty years and three continents. The story moves from genes to pain-signaling neurons that scream when they should be silent to people with a rare genetic disorder who feel they are on fire. Waxman explains that if pain-signaling neurons are injured by trauma or disease, they can become hyperactive and send pain signals to the brain even without external stimulus. Studying the hyperactive mutant pain gene in man on fire syndrome has pointed the way to molecules that produce pain more broadly within the general population, in the rest of us. Waxman's account of the many steps that led to discovery of the pain gene tells the story behind the science, of how science happens.

Epigenetics of Chronic Pain

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Publisher : Academic Press
ISBN 13 : 0128140712
Total Pages : 248 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Epigenetics of Chronic Pain by :

Download or read book Epigenetics of Chronic Pain written by and published by Academic Press. This book was released on 2018-10-29 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetics of Chronic Pain, Volume Nine, presents comprehensive information on the role of epigenetics in chronic pain sensitivity, providing a detailed, but accessible, view of the field from basic principles, to clinical application. Leading international researchers discuss essential mechanisms of chronic pain epigenetics, including the molecular processes of chromatin remodeling, histone modifications, and the microRNAs and noncoding RNAs involved in regulating genes tied to pain sensitivity. The influence of epigenetics in inflammatory, neuropathic, visceral and other pain models is examined, with data derived from epigenetic studies on peripheral and central mechanisms of pain sensitivity in animal models and clinical cases studies. The studies and case examples cited highlight therapeutic pathways of significance and next steps for researchers to develop epigenetic-based treatments for chronic pain. In recent years, epigenetic regulation of gene expression has been shown to play a central role in managing human pain sensitivity. Findings show that expression of many genes critical to increases or decreases in pain sensitivity are indeed regulated by DNA methylation and its enzymes, histone-involved chromatin remodeling, and noncoding RNAs, mainly microRNAs. Compiles all known information on epigenetic regulation of chronic pain in one volume Covers the basic functionality of epigenetic mechanisms involved in pain management, applications of recent research in understanding different types of chronic pain, and pathways for developing therapeutics Leading international researchers from across academia, clinical settings, and the pharmaceutical industry discuss epigenetics in inflammatory, neuropathic, visceral, and other pain models in-depth Enables clinicians, researchers, and pharmacologists to better understand and treat chronic pain

Genomics of Pain and Co-Morbid Symptoms

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Author :
Publisher : Springer Nature
ISBN 13 : 3030216578
Total Pages : 254 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Genomics of Pain and Co-Morbid Symptoms by : Susan G. Dorsey

Download or read book Genomics of Pain and Co-Morbid Symptoms written by Susan G. Dorsey and published by Springer Nature. This book was released on 2020-06-15 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an overview of the field of pain genomics and the genomics of related, or co-occuring, symptoms, the current state-of-the-science, and challenges that remain. It brings differing views in the field together and provides examples of translational science from using cellular and rodent models to human clinical trials. This book's structure leads the reader through the physiology of pain and genomics into how pain is studied, mechanisms of acute and chronic pain, various protocols that are used throughout the field along with the pros/cons of the current methods used, and project into the future of pain genomics. This work is intended for classroom teaching, for nurses, for novice researchers in symptom science and pain research as well as students and postdoctoral fellows.

Pain Genetics

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Publisher : Wiley-Blackwell
ISBN 13 : 9781118398876
Total Pages : 204 pages
Book Rating : 4.3/5 (988 download)

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Book Synopsis Pain Genetics by : Inna Belfer

Download or read book Pain Genetics written by Inna Belfer and published by Wiley-Blackwell. This book was released on 2013-12-13 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt:

TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades

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Author :
Publisher : CRC Press
ISBN 13 : 1420005847
Total Pages : 502 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades by : Wolfgang B. Liedtke, MD, PH.D.

Download or read book TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades written by Wolfgang B. Liedtke, MD, PH.D. and published by CRC Press. This book was released on 2006-09-29 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the progress made in this area of signaling research has yielded findings that offer the potential to dramatically impact human health and wellness. Involved in gateway activity for all five of our senses, TRP channels have been shown to respond to a wide range of st

Effects of Your Genetics on Pain

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Author :
Publisher : Createspace Independent Publishing Platform
ISBN 13 : 9781537514390
Total Pages : 394 pages
Book Rating : 4.5/5 (143 download)

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Book Synopsis Effects of Your Genetics on Pain by : William Ackerman

Download or read book Effects of Your Genetics on Pain written by William Ackerman and published by Createspace Independent Publishing Platform. This book was released on 2016-09-10 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: One's pain perception usually differs from others. This observation is why a "one size fits all" to pain treatment does not exist. This process slows down when one becomes an adult and gets progressively slower with age. Some cells like those in the brain and nerves do not continue to grow. Our bodies reflect our genetic capacity to adapt and repair, as well as tolerate the cumulative damage from disease processes. With advancing age, all of the body systems eventually demonstrate reduced efficiency, slowed building and replacement and actual loss of tissue. There is a gradual loss of bone tissue and the reduced tissue loss may be permanent. When a person is born, cells in the body duplicate rapidly which enables growth resiliency of blood vessels. A chromosome is a cell is a long strand of DNA in it. At the end of a chromosome is a telomere, which acts like a bookend. Telomeres keep chromosomes protected and prevent them from binding with other DNA. Many cells in the body need to replicate to keep the body healthy. When the telomeres fail one's health is affected and this failure is related to aging and chronic pain perception in some instances.

Pain: Causes, Concerns and Consequences

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Author :
Publisher : Bentham Science Publishers
ISBN 13 : 168108371X
Total Pages : 209 pages
Book Rating : 4.6/5 (81 download)

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Book Synopsis Pain: Causes, Concerns and Consequences by : Puneetpal Singh

Download or read book Pain: Causes, Concerns and Consequences written by Puneetpal Singh and published by Bentham Science Publishers. This book was released on 2016-11-01 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pain is a significant medical problem, as it is a factor in many diseases and debilitating conditions. The processing of pain in the body is a complex process which involves nerve signaling in the milieu of biochemical, molecular and genetic interactions occurring in the brain and other parts of the body. Pain, as a spokesperson of real and impending injury, outlives its usefulness as a warning signal and instead becomes chronic and excruciating. The transition of the realization of pain up to the cortical processing as a persistent condition represents an intricate process governed by the interaction of various factors. Research on humans and animals has led to the advent of personalized medicine where every patient can be treated according to the set of genes they possess. However, the genetic basis for pain has largely been undefined so far. Research on epigenetic alterations and micro-RNA (miRNA) in relation to the assessment and prevention of pain is still in infancy. Pain: Causes, Concerns and Consequences focuses on pain in human diseases such as cardiac and non-cardiac disorders. This compendium on pain research offers basic information and useful updates on the pathology, genetics, and biomolecular pathways that cause pain. Additionally, readers will also learn about non-pharmacological therapies for pain. The monograph is a handy guide for medical students and doctors in different divisions such as oncology, surgery, neurology, psychiatry, psychology, physiotherapy and chiropractic care. The book also serves as a guide for life science researchers who are planning to develop methods to study pain in either a clinical or laboratory setting.

Functional Pain Syndromes

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Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1496332008
Total Pages : 643 pages
Book Rating : 4.4/5 (963 download)

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Book Synopsis Functional Pain Syndromes by : Emeran A. Mayer

Download or read book Functional Pain Syndromes written by Emeran A. Mayer and published by Lippincott Williams & Wilkins. This book was released on 2015-06-01 with total page 643 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores the connection of functional pain syndromes (e.g., irritable bowel syndrome and fibromyalgia) with anxiety, depression, chronic fatigue syndrome, and posttraumatic stress disorder. The authors address possible common pathophysiologies and review a range of treatment options, from antidepressants to cognitive-behavioral therapy. Who should buy this book? Whether you are a general practitioner, specialist, or scientist, this book is essential reading. It sheds new light on the complex links between various painful syndromes and disorders.

Pain: Dynamics and Complexities

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Publisher : Oxford University Press
ISBN 13 : 0199331553
Total Pages : 306 pages
Book Rating : 4.1/5 (993 download)

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Book Synopsis Pain: Dynamics and Complexities by : Daniel M. Doleys PhD

Download or read book Pain: Dynamics and Complexities written by Daniel M. Doleys PhD and published by Oxford University Press. This book was released on 2014-02-18 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite the proliferation of pain clinics and various pain-oriented therapies, there is an absence of data supporting any substantial change in the statistics regarding the incidence, development and persistence of pain. As renowned pain clinician and scientist Daniel M. Doleys argues, there may be a need for a fundamental shift in the way we view pain. In this thoughtful work, Doleys presents the evolving concept and complex nature of pain with the intention of promoting a broadening of the existing paradigm within which pain is viewed and understood. Combining neuroscience, psychology, and philosophy of science, this book reviews the history of pain and outlines the current concepts and theories regarding the mechanisms involved in the experience of pain. Experimental and clinical research in a broad array of areas including neonatal pain, empathy and pain, psychogenic pain, and genetics and pain is summarized. The notion of pain as a disease process rather than a symptom is highlighted. Although there is a continued interest in activation of the peripheral nociceptive system as a determining factor in the experience of pain, the growing appreciation for the brain as the intimate 'pain generator' is emphasized. The definition of consciousness and conscious awareness and a theory as to how it relates to nociceptive processing is discussed. Finally, the author describes the potential benefit of incorporating some of the concepts from systems and quantum theory into our thinking about pain. The area of pain research and treatment seems on the precipice of change. This work intends to provide a glimpse of what these changes might be in the context of where pain research and therapy has come from, where it currently is, and where it might be headed.

Discovery of Novel Pain Genes Using Systems Genetics

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Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (81 download)

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Book Synopsis Discovery of Novel Pain Genes Using Systems Genetics by : Jill M. Recla

Download or read book Discovery of Novel Pain Genes Using Systems Genetics written by Jill M. Recla and published by . This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Molecular and Cell Biology of Pain

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Author :
Publisher : Academic Press
ISBN 13 : 0128014326
Total Pages : 663 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Molecular and Cell Biology of Pain by :

Download or read book Molecular and Cell Biology of Pain written by and published by Academic Press. This book was released on 2015-03-02 with total page 663 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pain is the number one reason that people seek medical attention but pain is still under- and poorly-treated world-wide. The purpose of this book is to give an up to date picture of what causes pain, how pain becomes chronic and what pharmacological targets might be manipulated to alleviate acute and chronic pain. The book will cover a wide array of topics from gene polymorphisms to voltage-gated ion channels moving from cellular biology to whole animal physiology. Written by future leaders in the pain field Covers a wide range of targets Contains provocative ideas about the future direction of the pain field.

Chronic Postsurgical Pain

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Publisher : Springer
ISBN 13 : 9783319043210
Total Pages : 0 pages
Book Rating : 4.0/5 (432 download)

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Book Synopsis Chronic Postsurgical Pain by : Gérard Mick

Download or read book Chronic Postsurgical Pain written by Gérard Mick and published by Springer. This book was released on 2014-03-06 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Primum non nocere... The fact that a surgical procedure can leave any kind of pain casts a shadow over this tenet, which is seen as the basis of medical practice and anchor of its principle ethic... It is all the more surprising in that medicine has only paid attention to this paradoxical chronic pain situation for the past few years. Clarifying the knowledge acquired in this field has become all the more urgent for any care-giver today confronted by a legitimate request from patients: Why and how can a surgical procedure, which is supposed to bring relief, leave behind an unacceptable sequela? This is the approach which the contributors to this new subject of major clinical interest invite you to follow as you work your way through this book.

Biobehavioral Approaches to Pain

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Publisher : Springer Science & Business Media
ISBN 13 : 0387783237
Total Pages : 589 pages
Book Rating : 4.3/5 (877 download)

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Book Synopsis Biobehavioral Approaches to Pain by : Rhonda J. Moore

Download or read book Biobehavioral Approaches to Pain written by Rhonda J. Moore and published by Springer Science & Business Media. This book was released on 2008-12-16 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pain is a common symptom, yet it is frequently underevaluated and undertreated. It is difficult to define, describe—and sometimes to prove. It’s pain, and suspicions of exaggerations often add further insult to a patients’ injuries. Biobehavioral Approaches to Pain translates this highly subjective experience—and its physical, psychological, social, and cultural dimensions—into practical insights key to transforming the field of pain management. This pathbreaking volume synthesizes a rich knowledge base from across disciplines, including neurobiologic, genetic, biobehavioral, clinical, narrative, substance abuse, health services,ethical and policy perspectives, for a deeper understanding of the impact of pain on individual lives and the larger society. Its international panel of contributors highlights special issues and review best practice guidelines, from placebo effects to cancer, Whiplash Associated Disorders to pain imaging to complementary medicine, phantom limb pain to gene therapies to AIDS. Among the topics covered: The distinction between acute and chronic pain: is it clinically useful? Improving clinical assessment of patients with pain. Age and sex differences in pain. The what, how and why of the placebo and nocebo effect Psychosocial and partner-assisted biopsychosocial interventions for disease-related pain Substance abuse issues in pain treatment. The personal, social and economic costs of chronic pain. Biobehavioral Approaches to Pain offers clinical and health professionals, psychologists, as well as specialists in pain management or palliative care, new directions in their ongoing dialogue with patients. Given the prevalence of pain in the general population, it should also interest researchers and students in the field of public health.

Relieving Pain in America

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Publisher : National Academies Press
ISBN 13 : 030921484X
Total Pages : 383 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Relieving Pain in America by : Institute of Medicine

Download or read book Relieving Pain in America written by Institute of Medicine and published by National Academies Press. This book was released on 2011-10-26 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic pain costs the nation up to $635 billion each year in medical treatment and lost productivity. The 2010 Patient Protection and Affordable Care Act required the Department of Health and Human Services (HHS) to enlist the Institute of Medicine (IOM) in examining pain as a public health problem. In this report, the IOM offers a blueprint for action in transforming prevention, care, education, and research, with the goal of providing relief for people with pain in America. To reach the vast multitude of people with various types of pain, the nation must adopt a population-level prevention and management strategy. The IOM recommends that HHS develop a comprehensive plan with specific goals, actions, and timeframes. Better data are needed to help shape efforts, especially on the groups of people currently underdiagnosed and undertreated, and the IOM encourages federal and state agencies and private organizations to accelerate the collection of data on pain incidence, prevalence, and treatments. Because pain varies from patient to patient, healthcare providers should increasingly aim at tailoring pain care to each person's experience, and self-management of pain should be promoted. In addition, because there are major gaps in knowledge about pain across health care and society alike, the IOM recommends that federal agencies and other stakeholders redesign education programs to bridge these gaps. Pain is a major driver for visits to physicians, a major reason for taking medications, a major cause of disability, and a key factor in quality of life and productivity. Given the burden of pain in human lives, dollars, and social consequences, relieving pain should be a national priority.

Chronic Pain Epidemiology

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Author :
Publisher : Oxford University Press, USA
ISBN 13 : 0199235767
Total Pages : 377 pages
Book Rating : 4.1/5 (992 download)

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Book Synopsis Chronic Pain Epidemiology by : Peter Croft

Download or read book Chronic Pain Epidemiology written by Peter Croft and published by Oxford University Press, USA. This book was released on 2010-09-30 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an invaluable framework and basis for thinking about chronic pain and the potential for its prevention in public health terms.