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Organic Chemistry Of Isotopic Labelling
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Book Synopsis Organic Chemistry of Isotopic Labelling by : James R Hanson
Download or read book Organic Chemistry of Isotopic Labelling written by James R Hanson and published by Royal Society of Chemistry. This book was released on 2019-04-05 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: The chemical synthesis of isotopically labelled compounds is a pre-requisite for many chemical, biochemical and medicinal investigations. The constraints imposed by the requirements for regiospecific labelling and, in some instances, the time-scale of the synthesis often lead to quite different synthetic strategies to those that are used for the unlabelled material. Whilst there are many specialist papers, reviews and long books devoted to particular isotopes, there is no currently available short introductory book devoted to the organic chemistry of isotopic labelling. The aim of this book is to introduce research workers to a variety of methods that have been used to achieve these synthetic labelling objectives before exploring a particular method in detail. It covers a number of different isotopes and the methods that have been used to introduce them into organic compounds. Labelling methods also provide useful undergraduate teaching examples of modern synthetic reactions and their stereochemical consequences using relatively simple substrates. The book will therefore have a wider appeal than just those involved in using isotopes in research such as environmental and pharmaceutical chemists as well as organic chemists.
Download or read book Lipidomics written by Xianlin Han and published by John Wiley & Sons. This book was released on 2016-05-02 with total page 48 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covers the area of lipidomics from fundamentals and theory to applications Presents a balanced discussion of the fundamentals, theory, experimental methods and applications of lipidomics Covers different characterizations of lipids including Glycerophospholipids; Sphingolipids; Glycerolipids and Glycolipids; and Fatty Acids and Modified Fatty Acids Includes a section on quantification of Lipids in Lipidomics such as sample preparation; factors affecting accurate quantification; and data processing and interpretation Details applications of Lipidomics Tools including for Health and Disease; Plant Lipidomics; and Lipidomics on Cellular Membranes
Book Synopsis Isotope Dilution Mass Spectrometry by : J. Ignacio Garcia Alonso
Download or read book Isotope Dilution Mass Spectrometry written by J. Ignacio Garcia Alonso and published by Royal Society of Chemistry. This book was released on 2013 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first textbook to present a comprehensive and instructive view of the theory and applications of this growing technique.
Book Synopsis Preparation of Compounds Labeled with Tritium and Carbon-14 by : Rolf Voges
Download or read book Preparation of Compounds Labeled with Tritium and Carbon-14 written by Rolf Voges and published by John Wiley & Sons. This book was released on 2009-03-12 with total page 682 pages. Available in PDF, EPUB and Kindle. Book excerpt: Compounds labeled with carbon-14 and tritium are indispensable tools for research in biomedical sciences, discovery and development of pharmaceuticals and agrochemicals. Preparation of Compounds Labeled with Tritium and Carbon-14 is a comprehensive, authoritative and up-to-date discussion of the strategies, synthetic approaches, reactions techniques, and resources for the preparation of compounds labeled with either of these isotopes. A large number of examples are presented for the use of isotopic sources and building blocks in the preparation of labeled target compounds, illustrating the range of possibilities for embedding isotopic labels in selected moieties of complex structures. Topics include: Formulation of synthetic strategies for preparing labeled compounds Isotope exchange methods and synthetic alternatives for preparing tritiated compounds In-depth discussion of carbon-14 building blocks and their utility in synthesis Preparation of enantiomerically pure isotopically labeled compounds Applications of biotransformations Preparation of Compounds Labeled with Tritium and Carbon-14 is an essential guide to the specialist strategies and tactics used by chemists to prepare compounds tagged with theradioactive atoms carbon-14 and tritium.
Book Synopsis Organic Reaction Mechanisms by : Mar Gomez-Gallego
Download or read book Organic Reaction Mechanisms written by Mar Gomez-Gallego and published by Springer. This book was released on 2014-08-23 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organic Reaction Mechanisms shows readers how to interpret the experimental data obtained from an organic reaction, and specifically how an organic reaction mechanism can be considered or rejected based on the analysis of the experimental evidence. Whilst examining a series of selected examples of mechanisms, the text focuses on real cases and discusses them in detail. The examples are arranged to elucidate key aspects of organic reaction mechanisms. The authors employ all the types of information that the authors of the original work considered useful and necessary, including spectroscopic data, kinetic and thermodynamic data, isotopic labelling and organic reactivity. The book makes an excellent primer for advanced undergraduates in chemistry who are preparing for exams and is also useful for graduate students and instructors.
Book Synopsis Tables of Spectral Data for Structure Determination of Organic Compounds by : Ernö Pretsch
Download or read book Tables of Spectral Data for Structure Determination of Organic Compounds written by Ernö Pretsch and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although numerical data are, in principle, universal, the compilations presented in this book are extensively annotated and interleaved with text. This translation of the second German edition has been prepared to facilitate the use of this work, with all its valuable detail, by the large community of English-speaking scientists. Translation has also provided an opportunity to correct and revise the text, and to update the nomenclature. Fortunately, spectroscopic data and their relationship with structure do not change much with time so one can predict that this book will, for a long period of time, continue to be very useful to organic chemists involved in the identification of organic compounds or the elucidation of their structure. Klaus Biemann Cambridge, MA, April 1983 Preface to the First German Edition Making use of the information provided by various spectroscopic tech niques has become a matter of routine for the analytically oriented organic chemist. Those who have graduated recently received extensive training in these techniques as part of the curriculum while their older colleagues learned to use these methods by necessity. One can, therefore, assume that chemists are well versed in the proper choice of the methods suitable for the solution of a particular problem and to translate the experimental data into structural information.
Download or read book Cancer Metabolomics written by Shen Hu and published by Springer Nature. This book was released on 2021-04-01 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer metabolomics is a rapidly evolving field that aims for a comprehensive dissection of the metabolic phenotypes and functional network of metabolites in human cancers. State of the art metabolomics tools have been developed and applied to studying cancer metabolism and developing metabolic targets for improved diagnosis, prognosis and therapeutic treatment of human cancers. Chapters are written by subject experts in the field of cancer metabolomics with cross-disciplinary contributions. Coverage includes advanced metabolomics technologies and methodologies, including chemical isotope labelling liquid chromatography - mass spectrometry, capillary ion chromatography - mass spectrometry, 2-D gas chromatography – mass spectrometry, capillary electrophoresis – mass spectrometry, nuclear magnetic resonance spectroscopy, shotgun lipidomics, tracer-based metabolomics, microbial metabolomics, mass spectrometry imaging for single cell metabolomics and functional metabolomics. In addition, the book highlights new discoveries in cancer metabolism such as hypoxia inducible factor pathway, isocitrate dehydrogenase 1 mutation and oncometabolites. Finally, contributors focus on the translational applications of metabolomics in human cancers such as glioma, head and neck cancer, and gastric cancer. This new volume will be a unique reference source for cancer researchers and promote applications of metabolomics in understanding cancer metabolism.
Book Synopsis Serotonin and Melatonin by : Gokare A. Ravishankar
Download or read book Serotonin and Melatonin written by Gokare A. Ravishankar and published by CRC Press. This book was released on 2016-11-18 with total page 930 pages. Available in PDF, EPUB and Kindle. Book excerpt: Serotonin and Melatonin: Their Functional Role in Plants, Food, Phytomedicine, and Human Health highlights the significance of the plant sources of serotonin and melatonin in the fields of medicine, agriculture, and food science. Over the last few decades, an enormous amount of research data has been generated on these two neurotransmitters/plant signalers. This book covers topics regarding the occurrence of serotonin and melatonin in medicinal plants and food value plants with their implications for human health, the role of serotonin and melatonin in plant growth development, functions of melatonin and serotonin in the environmental adaptation of plants, and the implications of these molecules in human disorders and treatments. This volume should appeal to scientists and other professionals engaged in basic and applied research on the relevance of serotonin and melatonin to plants, animals, and humans. Features Reviews the global scientific literature and the experimental data of the authors on the occurrence of serotonin and melatonin in medicinal and food value plants and its implications for human health Explains in detail the role of serotonin and melatonin in plant growth development Helps in understanding the complex functions of melatonin and serotonin in the environmental adaptation in plants Discusses the importance of the development of transgenic plants with high amounts of serotonin and melatonin. Describes the current understanding of serotonin and melatonin in human disorders, and also their relevance in the treatment of specific health conditions. Written by acknowledged experts from across the world
Book Synopsis The Investigation of Organic Reactions and Their Mechanisms by : Howard Maskill
Download or read book The Investigation of Organic Reactions and Their Mechanisms written by Howard Maskill and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: A range of alternative mechanisms can usually be postulated for most organic chemical reactions, and identification of the most likely requires detailed investigation. Investigation of Organic Reactions and their Mechanisms will serve as a guide for the trained chemist who needs to characterise an organic chemical reaction and investigate its mechanism, but who is not an expert in physical organic chemistry. Such an investigation will lead to an understanding of which bonds are broken, which are made, and the order in which these processes happen. This information and knowledge of the associated kinetic and thermodynamic parameters are central to the development of safe, efficient, and profitable industrial chemical processes, and to extending the synthetic utility of new chemical reactions in chemical and pharmaceutical manufacturing, and academic environments. Written as a coherent account of the principal methods currently used in mechanistic investigations, at a level accessible to academic researchers and graduate chemists in industry, the book is highly practical in approach. The contributing authors, an international group of expert practitioners of the techniques covered, illustrate their contributions by examples from their own research and from the relevant wider chemical literature. The book covers basic aspects such as product analysis, kinetics, catalysis, and investigation of reactive intermediates. It also includes material on significant recent developments, e.g. computational chemistry, calorimetry, and electrochemistry, in addition to topics of high current industrial relevance, e.g. reactions in multiphase systems, and synthetically useful reactions involving free radicals and catalysis by organometallic compounds.
Book Synopsis Isotopes in Nanoparticles by : Jordi Llop
Download or read book Isotopes in Nanoparticles written by Jordi Llop and published by CRC Press. This book was released on 2016-03-30 with total page 537 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanoparticles may be used in industrial processes, incorporated into consumer products, or applied as biomedical agents. Isotopic (radio)labeling is one of the most powerful methods for nanoparticle tracing in experimental studies. This book presents an introduction to some commonly used nanomaterials, describes various methods with which they may
Book Synopsis Drug Discovery and Evaluation: Methods in Clinical Pharmacology by : H.Gerhard Vogel
Download or read book Drug Discovery and Evaluation: Methods in Clinical Pharmacology written by H.Gerhard Vogel and published by Springer Science & Business Media. This book was released on 2010-12-15 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The effect of a new compound has to be detected by in vitro and in vivo methods of pharmacology. The activity spectrum and the potency compared to existing drugs have to be determined. As these processes can be divided up stepwise we have designed a book series "Drug Discovery and Evaluation" in the form of a recommendation document. The methods to detect drug targets are described in the first volume of this series "Pharmacological Assays" comprising classical methods as well as new technologies. Before going to man, the most suitable compound has to be selected by pharmacokinetic studies and experiments in toxicology. These preclinical methods are described in the second volume „Safety and Pharmacokinetic Assays". Only then are first studies in human beings allowed. Special rules are established for Phase I studies. Clinical pharmacokinetics are performed in parallel with human studies on tolerability and therapeutic effects. Special studies according to various populations and different therapeutic indications are necessary. These items are covered in the third volume: „Methods in Clinical Pharmacology".
Book Synopsis Advanced Organic Chemistry by : Francis A. Carey
Download or read book Advanced Organic Chemistry written by Francis A. Carey and published by Springer Science & Business Media. This book was released on 2000 with total page 844 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is part A of a new edition of a two-volume text on organic chemistry that aims to solidify and extend the student's understanding of basic concepts and to illustrate how structural changes influence mechanism and reactivity.
Book Synopsis Guidelines for Achieving High Accuracy in Isotope Dilution Mass Spectrometry (IDMS) by : Peter Bedson
Download or read book Guidelines for Achieving High Accuracy in Isotope Dilution Mass Spectrometry (IDMS) written by Peter Bedson and published by Royal Society of Chemistry. This book was released on 2007-10-31 with total page 59 pages. Available in PDF, EPUB and Kindle. Book excerpt: The isotope dilution mass spectrometry (IDMS) technique is well known and widely reported in the literature. However, its application can present considerable difficulties with regard to obtaining reliable results. Produced jointly by the Royal Society of Chemistry's Analytical Methods Committee and the Valid Analytical Measurement (VAM) programme, the aim of this book is to provide a simplified yet robust methodology, together with adequate guidance, to enable laboratories wishing to use the technique to obtain reliable data. The methodologies, for inorganic and organic mass spectrometry, which use exact and approximate matching, are illustrated with worked examples and clear diagrammatic representations. A comprehensive glossary of terms, references to key publications and an extensive IDMS bibliography are also provided. Clear and comprehensive in coverage, Guidelines for Achieving High Accuracy in Isotope Dilution Mass Spectrometry (IDMS) will provide valuable assistance to a wide variety of analytical chemists interested in applying the IDMS technique to their own measurement applications.
Book Synopsis Isotopes In Heterogeneous Catalysis by : Justin S J Hargreaves
Download or read book Isotopes In Heterogeneous Catalysis written by Justin S J Hargreaves and published by World Scientific. This book was released on 2006-04-11 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this book is to review the current, state-of-the-art application of isotopic methods to the field of heterogeneous catalysis. Isotopic studies are arguably the ultimate technique in in situ methods for heterogeneous catalysis. In this review volume, chapters have been contributed by experts in the field and the coverage includes both the application of specific isotopes — Deuterium, Tritium, Carbon-14, Sulfur-35 and Oxygen-18 - as well as isotopic techniques — determination of surface mobility, steady state transient isotope kinetic analysis, and positron emission profiling.
Book Synopsis Reactive Drug Metabolites by : Amit S. Kalgutkar
Download or read book Reactive Drug Metabolites written by Amit S. Kalgutkar and published by John Wiley & Sons. This book was released on 2012-09-06 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largest pharmaceutical companies worldwide. The first chapters trace the development of our understanding of drug metabolite toxicity, covering basic concepts and techniques in the process, while the second part details chemical toxicophores that are prone to reactive metabolite formation. This section also reviews the various drug-metabolizing enzymes that can participate in catalyzing reactive metabolite formation, including a discussion of the structure-toxicity relationships for drugs. Two chapters are dedicated to the currently hot topics of herbal constituents and IADRs. The next part covers current strategies and approaches to evaluate the reactive metabolite potential of new drug candidates, both by predictive and by bioanalytical methods. There then follows an in-depth analysis of the toxicological potential of the top 200 prescription drugs, illustrating the power and the limits of the toxicophore concept, backed by numerous case studies. Finally, a risk-benefi t approach to managing the toxicity risk of reactive metabolite-prone drugs is presented. Since the authors carefully develop the knowledge needed, from fundamental considerations to current industry standards, no degree in pharmacology is required to read this book, making it perfect for medicinal chemists without in-depth pharmacology training.
Book Synopsis Isotopes for Medicine and the Life Sciences by : Institute of Medicine
Download or read book Isotopes for Medicine and the Life Sciences written by Institute of Medicine and published by National Academies Press. This book was released on 1995-01-27 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radioactive isotopes and enriched stable isotopes are used widely in medicine, agriculture, industry, and science, where their application allows us to perform many tasks more accurately, more simply, less expensively, and more quickly than would otherwise be possible. Indeed, in many casesâ€"for example, biological tracersâ€"there is no alternative. In a stellar example of "technology transfer" that began before the term was popular, the Department of Energy (DOE) and its predecessors has supported the development and application of isotopes and their transfer to the private sector. The DOE is now at an important crossroads: Isotope production has suffered as support for DOE's laboratories has declined. In response to a DOE request, this book is an intensive examination of isotope production and availability, including the education and training of those who will be needed to sustain the flow of radioactive and stable materials from their sources to the laboratories and medical care facilities in which they are used. Chapters include an examination of enriched stable isotopes; reactor and accelerator-produced radionuclides; partnerships among industries, national laboratories, and universities; and national isotope policy.
Book Synopsis Isotope Tracers in Metabolic Research by : Robert R. Wolfe
Download or read book Isotope Tracers in Metabolic Research written by Robert R. Wolfe and published by John Wiley & Sons. This book was released on 2004-10-18 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past few years, the number of applications of tracers for in vivo biomedical studies has greatly increased. New analytical tools at the genetic and protein levels have spurred this growth, opening the door for a deeper understanding of metabolic events. This in turn promises to yield significant advances in the understanding and treatment of human disease. Now fully revised and expanded, Isotope Tracers in Metabolic Research, Second Edition is the established definitive text on stable and radioactive isotope tracers. In unique, multidisciplinary fashion, it presents comprehensive coverage of new methodological, mathematical, and theoretical approaches. This new Second Edition includes: All-new chapters on nuclear magnetic resonance, mass isotopomer analysis, and methods of protein metabolism analysis A completely updated categorized list of over 750 references Major advances in the development of mass isotopomer and positional isotopomer techniques, noninvasive isotope techniques for studying metabolic pathways, hyphenated techniques, and new tracer techniques The latest developments in quantification of DNA synthesis and mass spectrometry spurred by genome sequencing and proteomics New coverage of mathematical modeling Expanded coverage of microdialysis probes, laboratory procedures, and regulatory issues related to human studies In this complete guide to performing tracer studies, the authors systematically cover tracer selection, modeling considerations, sample derivitization, mass spectrometry analysis, and data interpretation. Problems and discussion questions highlight key points in each chapter. Isotope Tracers in Metabolic Research, Second Edition offers students and researchers a comprehensive, practical resource for utilizing the latest tracer methodologies.
